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Military Medical Research 2020年第1期7卷 122-124页

作者： yong-ming yao Hui Zhang Trauma Research Center Fourth Medical Center of the Chinese PLA General HospitalBeijing 100048People's Republic of China

In modern warfare,therapy for combat injury is a critical issue to improve personnel survival and battle *** limited to the severe circumstance in the distant battlefield,quick and effective treatment cannot be supplied that leads infections,sepsis,multiple organ dysfunction syndrome(MODS)and high *** get a better therapy for combat injury,we summarized several reports that associated with the mechanisms of sepsis and MODS,those published on MMR *** and colleagues reported gender difference in the outcomes of trauma,shock and *** advantageous outcome in female is due to their hormone *** accumulating reports indicated estrogen as a beneficial factor for multiple system and organs,including the central nervous system,the cardiopulmonary system,the liver,the kidneys,the immune system,and leads to better survival from *** et *** the underlying mechanisms in trauma induced sepsis,which can be concluded as an imbalance of immune response triggered by damage-associated molecular patterns(DAMPs)and other immune modifying *** also emphasize immunomodulation as a better therapeutic strategy that might be a potential benefit in regulating the host immune *** et *** revealed a crucial mechanism underlying lung epithelial and macrophage crosstalk,which involves IL-25 as a *** the injury,lung epithelial secreted IL-25 promotes TNF-αproduction in macrophage leading to acute lung injury(ALI).In addition to a mountain of cytokines,mitochondrial dysfunction in immune cell is another critical risk factor for immune dysfunction during *** morphology and function alterations in mitochondria are closely associated with inadequate ATP production,insufficient metabolism process and overloaded ROS production,which lead harm to immune cells and other tissues by triggering oxidative *** the above reports discussed mechanisms of sepsis induction after trauma and provided evide

关键词： Combat injury Sepsis Multiple organ dysfunction syndrome Estrogen Immune dysfunction Mitochondrial function Interleukin-25

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Comparison of clinical laboratory tests between bacterial sepsis and SARS-CoV-2-associated viral sepsis

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Military Medical Research 2021年第2期8卷 278-280页

作者： Chao Ren Ren-Qi yao Di Ren Ying Li yong-Wen Feng yong-ming yao Department of Critical Care Medicine the Second People’s Hospital of ShenzhenShenzhen 518035GuangdongChina Department of Critical Care Medicine the Third People’s Hospital of ShenzhenShenzhen 518020GuangdongChina Trauma Research Center the Fourth Medical Center and Medical Innovation Research Department of the Chinese PLA General HospitalBeijing 100048China

Sepsis is a life-threatening condition that is characterized by multiple organ dysfunction due to abnormal host response to various pathogens,like bacteria,fungi and *** differences between viral and bacterial sepsis are indeed of great significance to deepen the understanding of the pathogenesis of sepsis,especially under pandemics of SARS-CoV-2 infection.

关键词： Severe acute respiratory syndrom coronavirus 2 Coronavirus disease 2019 Sepsis Bacteria Virus Infection Host response

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Dysfunction of neuroendocrine system in sepsis and implication of hormone therapy

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Journal of Geriatric Cardiology 2009年第4期6卷 249-254页

作者： Qing-Hong Zhang yong-ming yao Zhi-yong Sheng Department of Microbiology and Immunology Burns Institute First Hospital Affiliated to Chinese PLA General Hospital Beijing100048 China

Sepsis and related syndromes are the major cause of multiple organ failure and death in patients with critical illnesses. Neuroendocrine dysfunction has long been thought to be an important event in sepsis. In clinic, optimal management of the hormones could alleviate severe complications in sepsis. In this article, we review the dysfunction ofneuroendocrine system as well as autonomic nervous system in sepsis, and summarize the respective therapy strategies.

关键词： sepsis neuroendocrine autonomic nervous system immunity

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Advances in the management of acute liver failure

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World Journal of Gastroenterology 2013年第41期19卷 7069-7077页

作者： Da-Wei Wang Yi-Mei Yin yong-ming yao Department of ICU Weihai Municipal Hospital Department of Ultrasound Weihai Municipal Hospital Department of Microbiology and Immunology Burns InstituteFirst HospitalAffiliated to the Chinese PLAGeneral Hospital

Acute liver failure(ALF)is an uncommon but dramatic clinical syndrome characterized by hepatic encephalopathy and a bleeding tendency due to abrupt loss of liver function caused by massive or submassive liver necrosis in a patient with a previously healthy *** causes of ALF encompass a wide variety of toxic,viral,metabolic,vascular and autoimmune insults to the liver,and identifying the correct cause can be difficult or even *** patients with ALF develop a cascade of serious complications involving almost every organ system,and death is mostly due to multi-organ failure,hemorrhage,infection,and intracranial ***,the outcome of ALF has been improved in the last 3 decades through the specific treatment for the disease of certain etiology,and the advanced intensive care *** most severely affected patients who fail to recover after treatment,rapid evaluation for transfer to a transplantation center and consideration for liver transplantation is mandatory so that transplantation can be applied before contraindications *** review focuses on the recent advances in the understanding of various contributing etiologies,the administration of etiology-specific treatment to alleviate the liver injury,and the management of complications(e.g.,encephalopathy,coagulopathy,cardiovascular instability,respiratory failure,renal failure,sepsis and metabolic disturbance)in patients with *** of the need for liver transplantation is also presented.

关键词： Acute liver failure Cerebral edema Liver transplantation

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Development of septic shock and prognostic assessment in critically ill patients with coronavirus disease outside Wuhan, China

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World Journal of Emergency Medicine 2021年第4期12卷 293-298页

作者： Ren-qi yao Chao Ren Di Ren Jin-xiu Li Ying Li Xue-yan Liu Lei Huang yong Liu Mian Peng yong-wen Feng yong-ming yao Department of Critical Care Medicine the Second People’s Hospital of ShenzhenShenzhen 518035China Trauma Research Center the Fourth Medical Center and Medical Innovation Research Department of the Chinese PLA General HospitalBeijing 100048China Department of Critical Care Medicine the Third People’s Hospital of ShenzhenShenzhen 518020China Department of Critical Care Medicine the People’s Hospital of ShenzhenShenzhen 518020China Department of Critical Care Medicine Peking University Shenzhen HospitalShenzhen 518035China Department of Critical Care Medicine Shenzhen Hospital of Southern Medical UniversityShenzhen 518110China Department of Critical Care Medicine the Third Affiliated Hospital of Shenzhen UniversityShenzhen 518001China

BACKGROUND: The study aims to illustrate the clinical characteristics and development of septic shock in intensive care unit(ICU) patients confirmed with severe acute respiratory syndrome coronavirus 2(SARS-Co V-2) infection, and to perform a comprehensive analysis of the association between septic shock and clinical outcomes in critically ill patients with coronavirus disease(COVID-19).METHODS: Patients confirmed with SARS-Co V-2 infection, who were admitted to the ICU of the Third People's Hospital of Shenzhen from January 1 to February 7, 2020, were enrolled. Clinical characteristics and outcomes were compared between patients with and without septic ***: In this study, 35 critically ill patients with COVID-19 were included. Among them, the median age was 64 years(interquartile range [IQR] 59-67 years), and 10(28.4%) patients were female. The median ICU length of stay was 16 days(IQR 8-23 days). Three(8.6%) patients died during hospitalization. Nine(25.7%) patients developed septic shock in the ICU, and these patients had a significantly higher incidence of organ dysfunction and a worse prognosis than patients without septic ***: Septic shock is associated with a poor outcome in critically ill COVID-19 patients and is one of the hallmarks of the severity of patients receiving ICU care. A dysregulated immune response, uncontrolled infl ammation, and coagulation disorders are strongly associated with the development and progression of COVID-19-related septic shock.

关键词： Severe acute respiratory syndrome coronavirus 2 Coronavirus disease Intensive care unit Septic shock Immune response

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Roles of Tregs in development of hepatocellular carcinoma:A meta-analysis

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World Journal of Gastroenterology 2014年第24期20卷 7971-7978页

作者： Hong-Qiang Zhao Wei-Min Li Zhong-Qiou Lu yong-ming yao Medical School of Chinese People’s Liberation Army Department of Hepatobiliary Surgery the 309~(th) Hospital of Chinese People’s Liberation Army Department of Emergency Care First Affiliated Hospital of Wenzhou Medical College Burns Institute First Hospital Affiliated to the Chinese PLA General Hospital

AIM: To assess systematically the association between regulatory T cells (Tregs) and hepatocellular carcinoma (HCC).

关键词： Hepatocellular carcinoma Regulatory T cells Meta-analysis Tumor escape Cellular immunity

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Is oxygen therapy beneficial for normoxemic patients with acute heart failure?A propensity score matched study

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Military Medical Research 2022年第3期9卷 265-276页

作者： Yue Yu Ren-Qi yao Yu-Feng Zhang Su-Yu Wang Wang Xi Jun-Nan Wang Xiao-Yi Huang yong-ming yao Zhi-Nong Wang Department of Cardiothoracic Surgery Changzheng HospitalNaval Medical University415 Fengyang RoadHuangpu DistrictShanghai 200003China Trauma Research Center Fourth Medical Center and Medical Innovation Research Department of the Chinese PLA General Hospital51 Fucheng RoadHaidian DistrictBeijing 100048China Department of Burn Surgery Changhai HospitalNaval Medical UniversityShanghai 200433China Medical Research Center of War Injuries and Trauma Changzheng HospitalNaval Medical UniversityShanghai 200003China Department of Pathology Changhai HospitalNaval Medical UniversityShanghai 200433China

Background:The clinical efficiency of routine oxygen therapy is uncertain in patients with acute heart failure(AHF)who do not have *** aim of this study was to investigate the association between oxygen therapy and clinical outcomes in normoxemic patients hospitalized with AHF using real-world ***:Normoxemic patients diagnosed with AHF on intensive care unit(ICU)admission from the electronic ICU(eICU)Collaborative Research Database were included in the current study,in which the study population was divided into the oxygen therapy group and the ambient air *** score matching(PSM)was applied to create a balanced covariate distribution between patients receiving supplemental oxygen and those exposed to ambient *** regression and logistic regression models were performed to assess the associations between oxygen therapy and length of stay(LOS),and all-cause in-hospital as well as ICU mortality rates,respectively.A series of sensitivity and subgroup analyses were conducted to further validate the robustness of our ***:A total of 2922 normoxemic patients with AHF were finally included in the ***,42.1%(1230/2922)patients were exposed to oxygen therapy,and 57.9%(1692/2922)patients did not receive oxygen therapy(defined as the ambient air group).After PSM analysis,1122 pairs of patients were matched:each patient receiving oxygen therapy was matched with a patient without receiving supplemental *** multivariable logistic model showed that there was no significant interaction between the ambient air and oxygen therapy for all-cause in-hospital mortality[odds ratio(OR)=1.30;95%confidence interval(CI)0.92–1.82;P=0.138]or ICU mortality(OR=1.39;95%CI 0.83–2.32;P=0.206)in the post-PSM *** addition,linear regression analysis revealed that oxygen therapy was associated with prolonged ICU LOS(OR=1.11;95%CI 1.06–1.15;P<0.001)and hospital LOS(OR=1.06;95%CI 1.01–1.10;P=0.009)after ***,the absence

关键词： Acute heart failure Death Hyperoxia Mortality Oxygen therapy

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Nuclear fragile X mental retardation-interacting protein 1-mediated ribophagy protects T lymphocytes against apoptosis in sepsis

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Burns & Trauma 2023年第1期11卷 72-90页

作者： Peng-Yue Zhao Ren-Qi yao Li-Yu Zheng yao Wu Yu-Xuan Li Ning Dong Jing-Yan Li Xiao-Hui Du yong-ming yao Translational Medicine Research Center Medical Innovation Research Division and Fourth Medical Center of the Chinese PLA General HospitalBeijing 100853China Department of General Surgery First Medical Center of the Chinese PLA General HospitalBeijing 100853China Department of Burn Surgery The First Affiliated Hospital of Naval Medical UniversityShanghai 200433China Department of Emergency The Second Hospital of Hebei Medical UniversityShijiazhuang 050000China

Background:Ribophagy is a selective autophagic process that specifically degrades dysfunctional or superfluous ribosomes to maintain cellular *** ribophagy can ameliorate the immunosuppression in sepsis similar to endoplasmic reticulum autophagy(ERphagy)and mitophagy remains *** study was conducted to investigate the activity and regulation of ribophagy in sepsis and to further explore the potential mechanism underlying the involvement of ribophagy in T-lymphocyte ***:The activity and regulation of nuclear fragile X mental retardation-interacting protein 1(NUFIP1)-mediated ribophagy in T lymphocytes during sepsis were first investigated by western blotting,laser confocal microscopy and transmission electron ***,we constructed lentivirally transfected cells and gene-defective mouse models to observe the impact of NUFIP1 deletion on T-lymphocyte apoptosis and finally explored the signaling pathway associated with T-cell mediated immune response following septic ***:Both cecal ligation and perforation-induced sepsis and lipopolysaccharide stimulation significantly induced the occurrence of ribophagy,which peaked at 24 *** NUFIP1 was knocked down,T-lymphocyte apoptosis was noticeably ***,the overexpression of NUFIP1 exerted a significant protective impact on T-lymphocyte ***,the apoptosis and immunosuppression of T lymphocytes and 1-week mortality rate in NUFIP1 gene-deficient mice were significantly increased compared with those in wild-type *** addition,the protective effect of NUFIP1-mediated ribophagy on T lymphocytes was identified to be closely related to the endoplasmic reticulum stress apoptosis pathway,and PERK-ATF4-CHOP signaling was obviously involved in downregulating T-lymphocyte apoptosis in the setting of ***:NUFIP1-mediated ribophagy can be significantly activated to alleviate T lymphocyte apoptosis through the PERK-ATF4-CHOP pathway

关键词： NUFIP1 Ribophagy Sepsis Apoptosis Immunosuppression Autophagy Mitophagy Lymphocyte Lipopolysaccharide

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Potential therapy strategy: targeting mitochondrial dysfunction in sepsis

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Military Medical Research 2019年第3期6卷 230-241页

作者： Hui Zhang yong-Wen Feng yong-ming yao Trauma Research Center First Hospital Affiliated to the Chinese PLA General HospitalFucheng Road 51Haidian DistrictBeijing 100048China Department of Critical Care Medicine the Second People’s Hospital of ShenzhenShenzhen 518035China.

Recently, the definition of sepsis was concluded to be a life-threatening organ dysfunction caused by a dysregulated host response to infection. Severe patients always present with uncorrectable hypotension or hyperlactacidemia, which is defined as septic shock. The new definition emphasizes dysregulation of the host response and multiple organ dysfunction, which is partially attributed to metabolic disorders induced by energy crisis and oxidative stress. Mitochondria are a cellular organelle that are well known as the center of energy production, and mitochondrial damage or dysfunction is commonly induced in septic settings and is a predominant factor leading to a worse prognosis. In the present review, we determine the major mitochondrial disorders from morphology to functions in sepsis. In the following, several clinical or pre-clinical assays for monitoring mitochondrial function are demonstrated according to accumulated evidence, which is the first step of specific therapy targeting to modulate mitochondrial function. Accordingly, various reagents used for regulating mitochondrial enzyme activities and promoting biogenesis have been documented, among which mitochondriatargeted cation, TPP-conjugated antioxidants are the most valuable for future trials and clinical treatment to improve mitochondrial function as they may take advantage of the prognosis associated with septic complications.

关键词： Sepsis Mitochondria Electron transfer chain Monitor Therapy strategy

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Inflammatory response and immune regulation of high mobility group box-1 protein in treatment of sepsis

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World Journal of Emergency Medicine 2010年第2期1卷 93-98页

作者： Qing-yang Liu yong-ming yao Department of Microbiology and Immunology Burns Institute First Hospital Affiliated to the Chinese People＇s Liberation Army General Hospital Beijing 100048 China

Sepsis is an infection induced systemic inflammatory response syndrome and is a major cause of morbidity as well as mortality in intensive care units. A growing body of evidence suggests that the activation of a proinflammatory cascade is responsible for the development of immune dysfunction, susceptibility to severe sepsis and septic shock. The present theories of sepsis as a dysregulated inflammatory response and immune function, as manifested by excessive release of inflammatory mediators such as high mobility group box 1 protein （HMGB1）, are supported by increasing studies employing animal models and clinical observations of sepsis. HMGB1, originally described as a DNA-binding protein and released passively by necrotic cells and actively by macrophages/monocytes, has been discovered to be one of essential cytokines that mediates the response to infection, injury and inflammation. A growing number of studies still focus on the inflammation-regulatory function and its contribution to infectious and inflammatory disorders, recent data suggest that HMGB1 formation can also markedly influence the host cell-mediated immunity, including T lymphocytes and macrophages. Here we review emerging evidence that support extracellular HMGB1 as a late mediator of septic complications, and discuss the therapeutic potential of several HMGBl-targeting agents in experimental sepsis. In addition, with the development of traditional Chinese medicine in recent years, it has been proven that traditional Chinese herbal materials and their extracts have remarkable effective in treating severe sepsis. In this review, we therefore provide some new concepts of HMGBl-targeted Chinese herbal therapies in sepsis.

关键词： Sepsis Inflammatory mediators High mobility group box 1 protein

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