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Clinical characteristics and outcomes of hypersensitivity pneumonitis: a population-based study in China

Chinese Medical Journal 2019年第11期132卷 1283-1292页

作者： Li-Jing Wang Hou-Rong Cai yong-long xiao Yang Wang Meng-Shu Cao Departm ent of Respiratory and Critical Care Medicine Nanjing Drum Tower Hospital Nanjing Medical University Nanjing Jiangsu 210008 China Department of Respiratory and Critical Care Medicine Nanjing Drum Tower Hospital Nanjing University Medical School Nanjing Jiangsu 210008 China Department of Radiology Nanjing Drum Tower Hospital Nanjing University Medical School Nanjing Jiangsu 210008 China

Backgrounds:Hypersensitivity pneumonitis (HP) is an immune-mediated interstitial lung disease (ILD) that develops in response to the inhalation of various antigens. The clinical pathologies are very complex and undetermined. The clinical features and outcomes of HP have not been fully elucidated. The aim of this study was to analyze the incidence, clinical features, and outcomes of HP patients and construct a simple clinical model for diagnosing chronic HP (CHP). Methods: The cohort study included 101 patients with HP admitted to the Nanjing Drum Tower Hospital from January 2009 to December 2017. The patients were categorized into acute HP (AHP, n = 72) and CHP (n = 29) groups according to the updated international criteria. The clinical, imaging, treatment, and follow-up data were retrospectively reviewed. All patients were followed up until December 31,2017. Statistical analysis was performed, and a clinical scoring system for CHP was constructed by SPSS 20.0 software. Results: The incidence of HP was 2.4% in ILD inpatients in our center. Patients in the CHP group were older =-2.212, P = 0.029), had more smokers (x^2 = 8.428, P = 0.004), and longer duration of symptoms (t =-4.852, P < 0.001) than those in the AHP group. Weight loss, crackles, digital clubbing, and cyanosis were more common in the CHP group than those in the AHP group (x^2 = 5.862, P < 0.001;x^2 = 8.997, P = 0.003;x^2 = 11-939, P = 0.001;and x^2 = 4.025, P = 0.045, respectively). On chest high-resolution computed tomography (HRCT), reticular patterns, traction bronchiectasis, and accompanying honeycombing were more common in CHP cases than those in AHP cases (x^2 = 101.000, P < 0.001;x^2 = 32.048, P < 0.001;a n d /2 = 36.568,P < 0.001, respectively). The clinical scoring system for CHP was established based on the clinical variables (age [A], duration of symptoms [D], smoking history [S], unidentified exposure [U], and chest HRCT [C];ADSUC)(area under the curve 0.935, 95% confidence interval: 0.883

关键词： Hypersensitivity pneumonitis Chronic Interstitial lung disease Fibrosis

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Acute exacerbation of idiopathic pulmonary fibrosis: usual interstitial pneumonitis *** usual interstitial pneumonitis pattern

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Chinese Medical Journal 2019年第18期132卷 2177-2184页

作者： Meng-Shu Cao Jian Sheng Tian-Zhen Wang xiao-Hua Qiu Dong-Mei Wang Yang Wang yong-long xiao Hou-Rong Cai Department of Respiratory and Critical Care Medicine Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Nanjing Jiangsu 210008 China Department of Respiratory and Critical Care Medicine Nanjing Drum Tower Hospital Nanjing Medical University Nanjing Jiangsu 210008 China Department of Radiology Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Nanjing Jiangsu 210008 China

Background:The prognosis of acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is very poor with a high *** aim of this study was to describe the clinical features and survival of patients with AE-IPF with usual pulmonary fibrosis (UIP) and possible UIP (P-UIP) pattern on chest high resolution computed tomography (HRCT).Methods:This retrospective study included 107 patients with AE-IPF admitted to Nanjing Drum Tower Hospital from January 2010 to December *** subjects were divided into UIP (n =86) and P-UIP group (n=21) based on chest *** variables were analyzed using Student's t test or Mann-Whimey U *** variables were analyzed using x2 ***-rank test was used for the survival *** proportional models evaluated the risk factors for AE occurrence and ***:The male,older patients,previous N-acetylcysteine use,elevated white blood cell (WBC) counts,and microbiology infection were more common in the UIP group than the P-UIP group (X2 =13.567,P < 0.001;z =-2.936,P =0.003;X2 =5.901,P =0.015;t =2.048,P =0.043;x2 =10.297,P =0.036,respectively).The percentage of AE with UIP pattern in idiopathic interstitial pneumonia (ⅡP) was significantly higher than P-UIP pattern (X2 =40.011,P < 0.001).Smoking was the risk factor for AE within 6 months after IPF diagnosis in the UIP *** cumulative proportion survival of 30-days was significantly higher in the UIP group compared with the P-UIP group (x2 =5.489,P =0.019) despite of the similar overall survival in the two *** Cox regression analysis indicated WBC count,partial pressure of oxygen in artery (PaO2)/ffactional concentration of inspired oxygen (FiOz),and computed tomography (CT) score were the independent predictors for survival in the UIP group (hazard ratio [HR]:1.070,95% confidential interval [CI]:1.027-1.114,P=0.001;HR:0.992,95% CI:0.986-0.997,P=0.002;and HR:1.649,95% CI:1.253-2.171,P < 0.001,respectively).Conclusions:AE occurrence

关键词： Idiopathic pulmonary fibrosis Acute exacerbation Usual interstitial pneumonitis

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Radial Probe Endobronchial Ultrasound-guided Lung Biopsy for Histopathological Diagnosis of Cryptogenic Organizing Pneumonia

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Chinese Medical Journal 2017年第2期130卷 236-238页

作者： Miao Ma Yan Li Hou-Rong Cai Jing-Jing Ding yong-Sheng Wang Yu-Juan Gao Jing-Hong Dai Qi Zhao yong-long xiao Fan-Qing Meng Xiang-Shan Fan Li-Yun Miao Department of Respiratory Medicine Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Nanjing Jiangsu 210008 China Department of Pathology Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Nanjing Jiangsu 210008 China

INTRODUCTIONCryptogenic organizing pneumonia （COP） is a distinct type of idiopathic interstitial pneumonia with a response rate of 65 85% on corticosteroid therapy. The difficulty of COP diagnosis is that the clinical features and the radiological findings are nonspecific. The pathological hallmark of organizing pneumonia （OP） needs to be confirmed. It can also occur in a variety of other interstitial pneumonia, infectious diseases, vasculitis, and so on. To increase the pathological reliability, larger and more tissue samples are required. According to the current classification of interstitial lung disease and guidelines, the surgical lung biopsy is recommended and is considered to be the best way of obtaining a representative lung specimen However, the invasive diagnostic procedures require general anesthesia and also increase the morbidity and mortality risks; therefore, only few patients undergo such biopsy. Thus, safer and more acceptable methods for identifying COP are urgently needed.

关键词： Bronchoscopy Cryptogenic Organizing Pneumonia Endobronchial Ultrasound Histopathological Diagnosis OrganizingPneumonia

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Clinical and Radiological Profile of Acute Fibrinous and Organizing Pneumonia： A Retrospective Study

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Chinese Medical Journal 2015年第20期128卷 2701-2706页

作者： Jing-Hong Dai Hui Li Wei Shen Li-Yun Miao yong-long xiao Mei Huang Meng-Shu Cao Yang Wang Bin Zhu Fan-Qing Meng Hou-Rong Cai Department of Respiratory Medicine The Affiliated Drum Tower Hospital ol Nanjing University Medical School Nanjing Jiangsu 210008 China Department of Radiology The Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing Jiangsu 210008 China Department of Pathology The Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing Jiangsu 210008 China

Background： Acute fibrinous and organizing pneumonia （AFOP） is a unique pathological entity with intra-alveolar fibrin in the form of ＂fibrin balls＂ and organizing pneumonia. It was divided into rare idiopathic interstitial pneumonia according to the classification notified by American Thoracic Society/European Respiratory Society in 2013. As a rare pathological entity, it is still not well known and recognized by clinicians. We reviewed the clinical features of 20 patients with AFOP diagnosed in a teaching hospital. Methods： The medical records of 20 patients with biopsy-proven diagnosis of AFOP were retrospectively reviewed. The patients＇ symptoms, duration of the disease, comorbidities, clinical laboratory data, pulmonary function testing, radiographic studies, and the response to treatment were extracted and analyzed. Results： Fever was the most common symptom and was manifested in 90% of AFOP patients. For clinical laboratory findings, systematic inflammatory indicators, including C-reactive protein and erythrocyte sedimentation rate, were significantly higher than normal ill AFOP patients. In accordance with this increased indicators, injured liver functions were common in AFOP patients. Inversely, AFOP patients had worse clinical conditions including anemia and hypoalbuminemia. For pulmonary function testing, AFOP patients showed the pattern of restrictive mixed with obstructive ventilation dysfunction. For high-resolution computerized tomography （HRCT） findings, the most common pattern for AFOP patients was lobar consolidation which was very similar to pneumonia. However, unlike pneumonia, AFOP patients responded well to glucocorticoids. Conclusion： Patients with AFOP manifest as acute inflammatory-like clinical laboratory parameters and lobar consolidation on HRCT, but respond well to steroid.

关键词： Acute Fibrinous and Organizing Pneumonia Clinical Features High-resolution Computerized Tomography InflammatoryIndicators

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疝环充填式无张力修补法治疗腹股沟疝的临床观察

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第三军医大学学报 2005年第12期27卷 1287-1287,1291页

作者：隆永效孙英信重庆市红十字会医院外科重庆400021 重庆医科大学附属第一医院外科重庆400016

腹股沟疝是外科常见病，其传统的手术方式多采用Bassini法。近年来，疝环充填式无张力修补法(mesh plug)已广泛应用于临床，其复发和早期并发症亦时有发生。为了总结经验，我院对2001-2005年1月采用疝环充填式无张力修补法治疗腹股沟疝6... 详细信息

腹股沟疝是外科常见病，其传统的手术方式多采用Bassini法。近年来，疝环充填式无张力修补法(mesh plug)已广泛应用于临床，其复发和早期并发症亦时有发生。为了总结经验，我院对2001-2005年1月采用疝环充填式无张力修补法治疗腹股沟疝62例时行分析报告如下。

关键词：疝环充填式腹股沟疝补法治疗临床观察 2001-2005年 Bassini法无张力修补法外科常见病早期并发症手术方式分析报告

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太阳能热水系统在建筑给排水设计中的应用

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工程建设与设计 2020年第9期 66-67页

作者：雍小龙浙江大学建筑设计研究院有限公司杭州310028

国民经济的快速发展,建筑规模的不断扩大,建设项目的增加,促使人们对给排水系统的要求逐步提高,这不仅需要满足人们对水的需求,还需要能够随时提供热水资源。从热水资源的供给角度看,如何更好地利用太阳能热水系统在其中起着非常重要的... 详细信息

国民经济的快速发展,建筑规模的不断扩大,建设项目的增加,促使人们对给排水系统的要求逐步提高,这不仅需要满足人们对水的需求,还需要能够随时提供热水资源。从热水资源的供给角度看,如何更好地利用太阳能热水系统在其中起着非常重要的作用,如何确保给排水系统的运行更加稳定和节能,也需要进行深入研究。

关键词：太阳能热水系统建筑给排水设计应用

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腹腔镜辅助下阴式子宫切除术对患者机体应激水平的影响

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医疗装备 2018年第12期31卷 19-20页

作者：雍小龙四川省南部县中医医院四川南充637300

目的探讨腹腔镜辅助下阴式子宫切除术对患者机体应激水平的影响。方法选择2016年4月至2017年3月收治的择期行手术治疗的良性子宫疾病患者90例,随机分为对照组和试验组,各45例。试验组行腹腔镜辅助下阴式子宫切除术;对照组行常规阴式子... 详细信息

目的探讨腹腔镜辅助下阴式子宫切除术对患者机体应激水平的影响。方法选择2016年4月至2017年3月收治的择期行手术治疗的良性子宫疾病患者90例,随机分为对照组和试验组,各45例。试验组行腹腔镜辅助下阴式子宫切除术;对照组行常规阴式子宫切除术。比较两组手术相关指标、应激反应指标。结果试验组手术相关指标、24 h应激反应指标变化均优于对照组,差异有统计学意义(P<0.05)。试验组术后并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论腹腔镜辅助下阴式子宫切除术可减轻机体应激反应,降低术后并发症发生率,改善机体功能,有利于患者术后恢复。

关键词：阴式子宫切除术腹腔镜机体应激

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建筑小区施工中节水关键技术及给水系统优化研究

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智能建筑与智慧城市 2020年第5期 81-82页

作者：雍小龙浙江大学建筑设计研究院有限公司

我国建筑小区的数量正在不断上涨,文章对在建筑小区工程中的节水技术也提出了高度的关注。分析了建筑小区节水的关键技术应用和给水系统优化期间的相关节水方式,实现建筑小区给水工程的节能与环保目标。

关键词：建筑小区节水关键技术给水系统

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Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin Li Ting Zhang Yanlin Fu Peiyan long xiao Gao Zhengwei Wang Zhizhong Guan xiaolan Qi Wei Hong Yan xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

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环保型降温微表处制备及其功效

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中国公路学报 2017年第7期30卷 9-17页

作者：王朝辉殷卫永孙晓龙王新岐冯炜长安大学公路学院陕西西安710064 天津市市政工程设计研究院天津300051

为实现路面预防性养护材料的降温及净化尾气等环境功效,以技术成熟的微表处为载体,通过掺加功能性材料制备了环保型降温微表处,采用自制的室内、外降温测试装置和净化尾气测试装置,全面评价了不同类型环保型降温微表处降温和净化尾气功... 详细信息

为实现路面预防性养护材料的降温及净化尾气等环境功效,以技术成熟的微表处为载体,通过掺加功能性材料制备了环保型降温微表处,采用自制的室内、外降温测试装置和净化尾气测试装置,全面评价了不同类型环保型降温微表处降温和净化尾气功效,系统研究了环保型降温微表处路用性能,并揭示了其微观结构及功效作用机理。结果表明:复配型(WHT+WHTA)微表处降温和净化尾气功效最优,其次为WHTA微表处和WHT微表处;环保型降温微表处降温效果随路面温度的升高逐渐增强,室外降温幅度可达5.9℃,室内降温幅度可达6.5℃;环保型降温微表处对COx,NOx及SO2气体污染物的净化效果可达43%,对PM2.5和PM10颗粒污染物的净化效果可达59%;温度变化对单一类型环保型降温微表处WHT和WHTA的净化效率影响显著,对复配型(WHT+WHTA)微表处净化效率影响相对较小;不同类型环保型降温微表处路用性能良好;功能性材料稳定、均匀地分散于乳化沥青中,并引起了材料内部化学官能团组成的变化;环保型微表处降温及净化尾气功效主要源于由基础材料自身晶体结构特征引发的功能性材料自身极化效应。

关键词：道路工程微表处降温净化尾气机理

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