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Bullous pemphigoid associated with acquired hemophilia A: A case report

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World Journal of Clinical Cases 2025年第4期13卷 28-33页

作者： Su-Ye Hu Meng-Can li Zi-Jia Hao Xu-Ya Chai Pei-Sai li Yang liu li-Xia liu Ying Xu pan-pan Yang ling-E li Department of Dermatology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina Graduate School Hebei University of Traditional Chinese MedicineShijiazhuang 050051Hebei ProvinceChina Department of Pathology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina

BACKGROUND Acquired hemophilia A (AHA) is a rare and potentially severe bleeding disordercaused by circulating autoantibodies against factor Ⅷ (FⅧ). In approximately50% of the patients, the condition is associated with autoimmune diseases,cancers, medication use, pregnancy, and the post-partum period. Bullous pemphigoid(BP) is a chronic autoimmune subepidermal blistering disease associatedwith tissue-bound and circulating autoantibodies against BP antigens 180 (BP180)and 230 (BP230). AHA-associated BP has a high mortality rate;hence, the understandingof this disease must *** SUMMARY A 69-year-old man presented with erythema, blisters, blood blisters, and crustsaccompanied by severe pruritus for more than 20 days, and ecchymosis andswelling on his left upper arm for 3 days. Pathological examination revealed asubepidermal blister that contained eosinophils. Laboratory tests showed that theBP180 autoantibody levels had increased, isolated activated partial thromboplastintime was notably prolonged (115.6 s), and coagulation FⅧ activity wasextremely low (lity rate. Therefore, its timely diagnosis and effectivetreatment are necessary.

关键词： Bullous pemphigoid Acquired hemophilia A Acquired hemophilia A FactorⅧ Case report

The role of axon guidance molecules in the pathogenesis of epilepsy

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Neural Regeneration Research 2025年第5期20卷 1244-1257页

作者： Zheng liu Chunhua pan Hao Huang Department of Neurology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Current treatments for epilepsy can only manage the symptoms of the condition but cannot alter the initial onset or halt the progression of the disease. Consequently, it is crucial to identify drugs that can target novel cellular and molecular mechanisms and mechanisms of action. Increasing evidence suggests that axon guidance molecules play a role in the structural and functional modifications of neural networks and that the dysregulation of these molecules is associated with epilepsy susceptibility. In this review, we discuss the essential role of axon guidance molecules in neuronal activity in patients with epilepsy as well as the impact of these molecules on synaptic plasticity and brain tissue remodeling. Furthermore, we examine the relationship between axon guidance molecules and neuroinflammation, as well as the structural changes in specific brain regions that contribute to the development of epilepsy. Ample evidence indicates that axon guidance molecules, including semaphorins and ephrins, play a fundamental role in guiding axon growth and the establishment of synaptic connections. Deviations in their expression or function can disrupt neuronal connections, ultimately leading to epileptic seizures. The remodeling of neural networks is a significant characteristic of epilepsy, with axon guidance molecules playing a role in the dynamic reorganization of neural circuits. This, in turn, affects synapse formation and elimination. Dysregulation of these molecules can upset the delicate balance between excitation and inhibition within a neural network, thereby increasing the risk of overexcitation and the development of epilepsy. Inflammatory signals can regulate the expression and function of axon guidance molecules, thus influencing axonal growth, axon orientation, and synaptic plasticity. The dysregulation of neuroinflammation can intensify neuronal dysfunction and contribute to the occurrence of epilepsy. This review delves into the mechanisms associated with

关键词： axon guidance drug-resistant epilepsy epilepsy nerve regeneration nervous system diseases neural pathways neuroinflammatory diseases neuronal plasticity neurons synaptic remodeling

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加装脱硫塔船舶试航活动的安全监督探讨

中国海事 2021年第2期 48-50页

作者：李永攀彭金金舟山海事局浙江舟山316000

随着很多国际航行船舶选择加装脱硫塔来应对全球限硫令,单个设备运转试航船舶艘次大量增加。该类试航活动次数频繁、航经水域通航环境复杂、参与人员较多且未经必要的培训,存在较大的安全风险。文中归纳加装脱硫塔船舶的试航活动特征,... 详细信息

随着很多国际航行船舶选择加装脱硫塔来应对全球限硫令,单个设备运转试航船舶艘次大量增加。该类试航活动次数频繁、航经水域通航环境复杂、参与人员较多且未经必要的培训,存在较大的安全风险。文中归纳加装脱硫塔船舶的试航活动特征,梳理、分析存在的安全隐患和监督难点,提出相应的管理对策和建议。

关键词：洗涤塔试航船员随船人员船厂生产水域引泊员

针刺联合中药对肥胖型多囊卵巢综合征患者肠道菌群、糖脂代谢及炎症因子水平的影响

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川北医学院学报 2021年第10期36卷 1280-1285页

作者：李东海李永攀王雪宣城市人民医院中医科安徽宣城242000 安徽中医药大学国医堂门诊部中医内科安徽合肥231000 宣城市骨科医院康复科安徽宣城242000

目的:探讨针刺联合治肾化痰中药对肥胖型多囊卵巢综合征(PCOS)患者肠道菌群、糖脂代谢及炎症因子水平的影响。方法:选取100例肥胖型PCOS患者为研究对象,按照治疗方式不同分为观察组和对照组,每组各50例。对照组口服炔雌醇环丙孕酮片治疗... 详细信息

目的:探讨针刺联合治肾化痰中药对肥胖型多囊卵巢综合征(PCOS)患者肠道菌群、糖脂代谢及炎症因子水平的影响。方法:选取100例肥胖型PCOS患者为研究对象,按照治疗方式不同分为观察组和对照组,每组各50例。对照组口服炔雌醇环丙孕酮片治疗,观察组在对照组基础上使用治肾化痰的中药联合针刺治疗。比较两组患者治疗前后糖脂代谢、炎症因子水平、肠道菌群数、肠道屏障功能指标的差异,分析肠道菌群与糖脂代谢、炎症因子及肠道屏障功能的相关性。结果:治疗前,两组肠道菌群、肠道屏障功能指标、糖脂代谢、炎症因子水平比较,差异无统计学意义(P>0.05)。治疗后,观察组糖代谢指标空腹胰岛素(FINS)、空腹血糖(FPG)、胰岛素抵抗指数(HOMA-IR)水平、脂代谢指标总胆固醇高(TC)、甘油三脂(TG)水平、肠杆菌与肠球菌菌群数、肠道屏障功能指标D-乳酸和二胺氧化酶(DAO)水平、白细胞介素-6(IL-6)、C反应蛋白(CRP)及肿瘤坏死因子-α(TNF-α)较对照组低(P<0.05),高密度脂蛋白(HDL-C)水平、乳杆菌和双歧杆菌的菌群数较对照升高(P<0.05);肠杆菌、肠球菌与肠道屏障功能、糖代谢、炎症因子及TC、TG呈正相关(P<0.05),与HDL-C呈负相关(P<0.05);乳杆菌、双歧杆菌与肠道屏障功能、糖代谢、炎症因子及TC、TG呈负相关(P<0.05),与HDL-C呈正相关(P<0.05)。结论:针刺联合中药对肥胖型PCOS患者有良好的治疗作用,可有效改善患者肠道菌群、肠道屏障功能、糖脂代谢和炎症因子水平。

关键词：肥胖型多囊卵巢综合征针刺治肾化痰中药肠道菌群糖脂代谢炎症因子

Inter-Skeleton Conductive Routes Tuning Multifunctional Conductive Foam for Electromagnetic Interference Shielding, Sensing and Thermal Management

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NANO-MICRO LETTERS 2025年第1期17卷 1-18页

作者： li, Xufeng Chen, Chunyan li, Zhenyang Yi, Peng Zou, Haihan Deng, Gao Fang, Ming He, Junzhe Sun, Xin Yu, Ronghai Shui, Jianglan pan, Caofeng liu, Xiaofang Beihang Univ Sch Mat Sci & Engn Beijing 100191 Peoples R China Beihang Univ Inst Atom Mfg Beijing 100191 Peoples R China Tianmushan Lab Xixi Octagon City Hangzhou 310023 Peoples R China Beijing Inst Environm Features Sci & Technol Electromagnet Scattering Lab Beijing 100854 Peoples R China

Unique inter-skeleton conductive films are constructed in polymer *** resistance change of the foam can reach four orders of magnitude under *** foam exhibits strain-adaptive electromagnetic interference shielding performance, anti-interference pressure sensor with high sensitivity over a wide pressure range and compression-regulated Joule heating function. Conductive polymer foam (CPF) with excellent compressibility and variable resistance has promising applications in electromagnetic interference (EMI) shielding and other integrated functions for wearable electronics. However, its insufficient change amplitude of resistance with compressive strain generally leads to a degradation of shielding performance during deformation. Here, an innovative loading strategy of conductive materials on polymer foam is proposed to significantly increase the contact probability and contact area of conductive components under compression. Unique inter-skeleton conductive films are constructed by loading alginate-decorated magnetic liquid metal on the polymethacrylate films hanged between the foam skeleton (denoted as AMLM-PM foam). Traditional point contact between conductive skeletons under compression is upgraded to planar contact between conductive films. Therefore, the resistance change of AMLM-PM reaches four orders of magnitude under compression. Moreover, the inter-skeleton conductive films can improve the mechanical strength of foam, prevent the leakage of liquid metal and increase the scattering area of EM wave. AMLM-PM foam has strain-adaptive EMI shielding performance and shows compression-enhanced shielding effectiveness, solving the problem of traditional CPFs upon compression. The upgrade of resistance response also enables foam to achieve sensitive pressure sensing over a wide pressure range and compression-regulated Joule heating function.

关键词： Inter-skeleton conductive films Conductive polymer foam liquid metal Electromagnetic interference shielding

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梯度特异材料表面对入射高斯光束的反射研究

量子光学学报 2016年第2期22卷 161-169页

作者：徐安彬宋戈李勇攀许静平羊亚平同济大学物理科学与工程学院先进微结构材料教育部重点实验室上海200092 同济大学航空航天与力学学院上海200092 上海海洋大学海洋科学学院上海201306

最近人们[1-3]提出了一类反射式梯度特异材料表面系统,此系统可以高效地将入射波转换成被束缚于材料表面的表面波,这个系统成为连接行波和表面波的一座桥梁。以往人们研究梯度特异材料表面的反射特性时多是以入射平面波为主,这里我们结... 详细信息

最近人们[1-3]提出了一类反射式梯度特异材料表面系统,此系统可以高效地将入射波转换成被束缚于材料表面的表面波,这个系统成为连接行波和表面波的一座桥梁。以往人们研究梯度特异材料表面的反射特性时多是以入射平面波为主,这里我们结合实际,以入射的高斯光束作为研究对象,讨论梯度特异材料表面对其的反射特性,尤其是高斯光束的主入射角和束腰对反射行为的影响,得到了与平面波入射不同的反射现象。对于临界角为17.2°的梯度特异材料表面,束腰为4的高斯光束以主入射角分别为0°、10°、30°入射时,我们发现随着主入射角的变大,入射高斯光束转变为表面波的比例增大;而固定主入射角为30°,我们通过改变束腰,发现束腰越大,波矢分布越窄,越接近于平面波,转变为表面波的效率就越高。在数值模拟中,反射光束出现了明显的Goos-Hansen位移现象。同时还出现了类似光栅反射的特点,即分叉现象,这是由于模拟计算时网格不能无限小,梯度特异材料表面不能模拟为折射率连续变化的材料而应该是阶跃式变化的材料。由于实际制备的梯度特异材料表面是人工微结构的排列,因此微小的阶跃式变化的梯度特异材料表面更为实际。我们的工作对于利用梯度特异材料表面将入射高斯光束转变为表面波具有指导意义。

关键词：梯度特异材料表面高斯光束束宽

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基于AIS数据约束聚类的海上交通特征分析

船海工程 2018年第1期47卷 176-179,184页

作者：李永攀刘正江蔡垚郑中义大连海事大学航海学院辽宁大连116026 舟山海事局船舶交通管理中心浙江舟山316000 交通运输部政策研究室北京100736

为识别船舶交通流,分析海上交通特征,根据海上交通工程理论和数据挖掘技术,考虑AIS数据点的多种属性约束,改进一种基于密度的聚类算法,从大量AIS数据中解析不同类型的船舶交通流,计算平均航向和航速,并选取浙沪交界复杂水域进行实例验... 详细信息

为识别船舶交通流,分析海上交通特征,根据海上交通工程理论和数据挖掘技术,考虑AIS数据点的多种属性约束,改进一种基于密度的聚类算法,从大量AIS数据中解析不同类型的船舶交通流,计算平均航向和航速,并选取浙沪交界复杂水域进行实例验证。聚类结果与实际相符,证实了算法的可行性和有效性。

关键词： DBSCAN算法船舶自动识别系统聚类分析海上交通特征

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基于多特征的垃圾微博检测方法

计算机系统应用 2017年第10期26卷 184-189页

作者：邹永潘李伟王儒敬中国科学院合肥物质科学研究院合肥智能机械研究所合肥230031 中国科学技术大学合肥230026

随着微博平台的快速发展,垃圾信息检测与过滤也面临着巨大的考验,实时精确地识别垃圾信息对于提高用户的体验以及微博平台的可持续发展意义重大.本文根据新浪微博的真实数据,提出了一种基于多特征的垃圾微博检测方法.首先,提取微博的显... 详细信息

随着微博平台的快速发展,垃圾信息检测与过滤也面临着巨大的考验,实时精确地识别垃圾信息对于提高用户的体验以及微博平台的可持续发展意义重大.本文根据新浪微博的真实数据,提出了一种基于多特征的垃圾微博检测方法.首先,提取微博的显式特征(用户特征、内容特征);然后利用文档主题生成模型(LDA)提取微博中的隐含主题特征;最后根据所提取的微博特征利用支持向量机(SVM)构建分类器.实验结果表明,该方法相比于现有方法在准确率和F1值方面都有一定的提升.

关键词：垃圾微博检测隐含狄利克雷分布支持向量机

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圆管中SH周向导波的频散特性

无损检测 2008年第10期30卷 719-720页

作者：李勇攀王寅观赵亚军同济大学声学研究所上海200092

研究了圆管中的SH周向导波的传播特性。采用柱坐标系,从纳维运动方程开始推导,得到了SH导波沿周向传播、轴向振动的频散方程。以内外半径之比分别为0.3,0.5和0.7为例,通过数值计算得到了硬铝材料圆筒的频散曲线。结果表明其高阶模式比... 详细信息

研究了圆管中的SH周向导波的传播特性。采用柱坐标系,从纳维运动方程开始推导,得到了SH导波沿周向传播、轴向振动的频散方程。以内外半径之比分别为0.3,0.5和0.7为例,通过数值计算得到了硬铝材料圆筒的频散曲线。结果表明其高阶模式比低阶模式频散显著,故在实际检测中宜选用低阶的SH导波。

关键词：超声波检测 SH周向导波频散圆管