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Modulating poststroke inflammatory mechanisms: Novel aspects of mesenchymal stem cells, extracellular vesicles and microglia

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World Journal of Stem Cells 2021年第8期13卷 1030-1048页

作者： Wen-Qiang Xin Wei Wei yong-li pan Bao-Long Cui Xin-Yu Yang Mathias Bähr Thorsten R Doeppner Department of Neurology University Medical Center GöttingenGöttingen 37075Germany Department of Neurosurgery Tianjin Medical University General HospitalTianjin 300052China

Inflammation plays an important role in the pathological process of ischemic stroke,and systemic inflammation affects patient *** resident immune cells in the brain,microglia are significantly involved in immune defense and tissue repair under various pathological conditions,including cerebral *** the differentiation of M1 and M2 microglia is certainly oversimplified,changing the activation state of microglia appears to be an intriguing therapeutic strategy for cerebral *** evidence indicates that both mesenchymal stem cells(MSCs)and MSC-derived extracellular vesicles(EVs)regulate inflammation and modify tissue repair under preclinical stroke ***,the precise mechanisms of these signaling pathways,especially in the context of the mutual interaction between MSCs or MSC-derived EVs and resident microglia,have not been sufficiently ***,this review summarizes the state-ofthe-art knowledge on MSC-and MSC-EV-mediated regulation of microglial activity under ischemic stroke conditions with respect to various signaling pathways,including cytokines,neurotrophic factors,transcription factors,and microRNAs.

关键词： Extracellular vesicles Mesenchymal stem cells Microglial activation M2 polarization Ischemic stroke

Engineering atomic Rb-N configurations to tune radical pathways for highly selective photocatalytic H2O2 synthesis coupled with biomass valorization

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Journal of Energy Chemistry 2025年第1期100卷 215-225页

作者： Jiaye li Shuang pan Yihuang Chen Qiong liu College of Chemistry and Materials Engineering Wenzhou University Guangdong Provincial Key Laboratory of Chemical Measurement and Emergency Test Technology (China) Institute of Analysis Guangdong Academy of Sciences (China National Analytical CenterGuangzhou)

Photocatalytic oxygen reduction for hydrogen peroxide （H2O2） synthesis presents a green and costeffective production ***,achieving highly selective H2O2synthesis remains challenging,necessitating precise control over free radical reaction pathways and minimizing undesirable oxidative ***,we report for the visible light-driven simultaneous co-photocatalytic reduction of O2to H2O2and oxidation of biomass using the atomic rubidium-nitride modified carbon nitride（CNRb）.The optimized CNRb catalyst demonstrates a record photoreduction rate of 8.01 mM h-1for H2O2generation and photooxidation rate of 3.75 mM h-1for furfuryl alcohol to furoic acid,achieving a remarkable solar-to-chemical conversion （SCC） efficiency of up to 2.27%.Experimental characterizations and DFT calculation disclosed that the introducing atomic Rb–N configurations allows for the high-selective generation of superoxide radicals while suppressing hydroxyl free radical *** is because the Rb–N serves as the new alternative site to perceive a stronger connection position for O2adsorption and reinforce the capability to extract protons,thereby triggering a high selective redox product *** study holds great potential in precisely regulating reactive radical processes at the atomic level,thereby paving the way for efficient synthesis of H2O2coupled with biomass valorization.

关键词： Atomic economy Radical pathway regulation Rubidium atom coordination Biomass valorization

菱形石墨炔薄膜He分离特性的密度泛函理论研究

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物理化学学报 2017年第11期33卷 2219-2226页

作者：李桂霞姜永超李鹏潘维李永平刘云杰青岛农业大学理学与信息科学学院山东青岛266109 青岛农业大学化学与药学院山东青岛266109 中国石油大学(华东)理学院山东青岛266580

氦气在科学和工业等领域中都具有不可替代的作用,其主要存在于天然气中。如何高效地从天然气中分离氦气显得至关重要。本文基于密度泛函理论(DFT)方法系统地探究了菱形石墨炔(rhombic-graphyne,R-GY)分离膜对He和其他天然气组分(Ne、Ar... 详细信息

氦气在科学和工业等领域中都具有不可替代的作用,其主要存在于天然气中。如何高效地从天然气中分离氦气显得至关重要。本文基于密度泛函理论(DFT)方法系统地探究了菱形石墨炔(rhombic-graphyne,R-GY)分离膜对He和其他天然气组分(Ne、Ar、CO_2、N_2和CH_4)的吸附、选择和渗透性能。结果表明,R-GY作为He分离膜可同时满足高选择性和高渗透率的要求。常温下,R-GY薄膜对He/Ne、He/CO_2、He/N_2、He/Ar和He/CH_4的选择性可分别达到2?10~7、3?10^(20)、9?10^(26)、7?10^(37)和5?10^(51),即使在600 K时仍可保持较高水平。此外,由于较低的扩散能垒,He穿透R-GY薄膜的渗透率在常温下可达到10^(-6) mol·m^(-2)·s^(-1)·Pa^(-1),高出工业标准近3个数量级;而其他气体组分在常温下的渗透率仅为10^(-58)-10^(-14) mol·m^(-2)·s^(-1)·Pa^(-1),气体无法渗透R-GY薄膜。

关键词：菱形石墨炔 He分离选择性渗透率密度泛函理论

Deciphering the role of mtH2O2 in hepatic ischemia-reperfusion injury mechanisms with low-background super-resolution fluorogenic probe

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Science China Chemistry 2025年第01期 297-307页

作者： Bin Fang limin Wang Haoqin li Jiaxin Zhang Yang Ding pan pan li Bo Peng Hua Bai lin li Frontiers Science Center for Flexible Electronics Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials &Engineering Northwestern Polytechnical University Institute of Flexible Electronics (IFE Future Technologies) Xiamen University

Hepatic ischemia-reperfusion injury（HIRI） is characterized by mitochondrial dysfunction and oxidative stress. Monitoring mitochondrial hydrogen peroxide（mtH2O2） levels in real-time through super-resolution imaging is crucial for elucidating its distribution in live cells and its mechanism of action during HIRI. However, low-background fluorogenic probes have been overlooked in the context of super-resolution imaging. In this study, we developed a low-background fluorogenic probe（MitoWG） with the potential for super-resolution morphology-correlated mitochondrial identification to track the fluctuates of mtH2O2in HIRI. Activation of the desirable fluorescence properties of the probe by mtH2O2was confirmed using structural illumination microscopy（SIM）, enabling high-quality mitochondrial imaging with exceptional specificity and *** in mtH2O2levels were successfully observed in both cellular and rat models of HIRI. Furthermore, we associated the decline in mitochondrial redox homeostasis with accelerated mtH2O2production during HIRI, which triggered mitophagy deficiency and led to cell death. In conclusion, Mito-WG possesses excellent photophysical and low-background properties for SIM imaging, making it a promising tool for mtH2O2tracking in HIRI research and clinical diagnosis.

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基于多视角低秩分析的电力状态不良数据检测

电子科技大学学报 2019年第3期48卷 361-365页

作者：李永攀彭伟伦门锟吴俊阳深圳供电局有限公司广东深圳518001 清华四川能源互联网研究院成都610213

随着信息化技术在智能电网的应用逐步深入,在智能电网的运维中能及时自动检测到不良数据,如网络攻击数据和设备故障数据,对电网的稳定和持续运行有着重要意义。该文提出一种基于多视角低秩分析的电力状态不良数据检测算法。该算法使用... 详细信息

随着信息化技术在智能电网的应用逐步深入,在智能电网的运维中能及时自动检测到不良数据,如网络攻击数据和设备故障数据,对电网的稳定和持续运行有着重要意义。该文提出一种基于多视角低秩分析的电力状态不良数据检测算法。该算法使用来自多个观测源的观测数据综合估计电力系统的状态,算法使用低秩模型挖掘出来自多个观测源数据间的共享本真数据,同时使用稀疏模型对不良数据建模。针对所提出的目标方程,给出了一种基于交叉迭代的优化算法。最后,在IEEE多个节点测试系统上的实验证明了该算法相对于已有算法的先进性。

关键词：网络空间安全低秩表示多视角学习电力状态估计

Imperative for long-term management and surveillance in Kawasaki disease

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World Journal of Clinical Cases 2025年第4期13卷 61-63页

作者： Yan pan Fu-yong Jiao Department of Pediatrics The First Affiliated Hospital of Yangtze UniversityJingzhou 434000Hubei ProvinceChina Shaanxi Kawasaki Disease Diagnosis and Treatment Center Children’s HospitalShaanxi Provincial People’s Hospital of Xi’an Jiaotong UniversityXi’an 710000Shaanxi ProvinceChina

Kawasaki disease(KD)is a significant pediatric vasculitis known for its potential to cause severe coronary artery *** the effectiveness of initial treatments,such as intravenous immunoglobulin,KD patients can experience long-term cardiovascular issues,as evidenced by a recent case report of an adult who suffered a ST-segment elevation myocardial infarction due to previous KD in the World Journal of Clinical *** editorial emphasizes the critical need for long-term management and regular surveillance to prevent such *** drawing on recent research and case studies,we advocate for a structured approach to follow-up care that includes routine cardiac evaluations and preventive measures.

关键词： Kawasaki disease Long-term management Coronary artery aneurysm Surveillance Preventive care

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微表处改善沥青路面性能的研究

山西建筑 2008年第5期34卷 281-282页

作者：李勇攀华南理工大学交通学院

结合河惠高速公路微表处措施试验路实体工程的摊铺,通过试验段路面性能数据的检测,重点研究了微表处措施实施后其应用效果和对沥青路面性能的改善效果。

关键词：预防性养护微表处路面性能

Clinical Observation on Insomnia Treated with Green Valley lingzhi Capsule

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Clinical Observation on Insomnia Treated with Green Valley L...

2002国际灵芝专题研讨会

作者： Ya-Min li yong-Fu pan Cai-Qin Zhou Department of Traditional Chinese Medicine, the Eastern China Hospital of Shanghai, Shanghai, China

This research observed the influence of Green Valley lingzhi Capsule (GVL) on sleep disorders of 100 oases with insomnia. GVL were given orally to 100 oases of insomnia for 1 month. The changes of total effective rate, time for falling asleep, numbers of difficulty falling asleep in 1 week, numbers of easy awakening, and actual sleep time were evaluated. After 1 month treatment with GVL, the total effective rate was 84% . Compared with before treatment, time for falling asleep after treatment was shortened significantly (P ling asleep in a week and score in numbers of easy awakening were decreased significantly (P lity of sleep in insomnia patients .

关键词： Green Valley lingzhi, Ganoderma lucidum, insomnia

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国医大师徐经世“三十二字”调肝法浅析

中华中医药杂志 2018年第6期33卷 2395-2397页

作者：汪元徐经世李永攀安徽中医药大学第一附属医院合肥230031 安徽省中西医结合医院合肥230001

国医大师徐经世教授在60余年的中医临床实践中深刻体悟中医杂病发生发展规律,提出"杂病致因在郁,重在调肝",并针对肝的生理病理特点总结提出"三十二字"调肝法,即"疏肝理气,条达木郁;理脾和胃,和煦肝木;补益肾水,清平相火;活血化瘀,燮理... 详细信息

国医大师徐经世教授在60余年的中医临床实践中深刻体悟中医杂病发生发展规律,提出"杂病致因在郁,重在调肝",并针对肝的生理病理特点总结提出"三十二字"调肝法,即"疏肝理气,条达木郁;理脾和胃,和煦肝木;补益肾水,清平相火;活血化瘀,燮理阴阳",这是徐师治疗中医杂病总的治则,无论病在何脏,由郁而致者均可按此调之,和缓中州,转枢少阳,达到抑制木郁反克取胜,从而使邪去正安。

关键词：徐经世中医杂病治则治法调肝法国医大师