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Study on blood pressure rhythm in hypertensive patients with Yin deficiency syndrome and a random forest model for predicting hypertension with Yin deficiency syndrome

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Journal of Traditional Chinese Medicine 2024年第3期44卷 564-571页

作者： ZHOU Ying LI Ping LUAN Jianwei SHEN Rui WU Yinglan XU Qiwen wang Xinyue ZHU Yao XU Xiangru LIU Zitian jiang Yuning ZHONG yong HE Yun jiang Weimin Department of Cardiology the Affiliated Hospital of Nanjing University of Chinese MedicineJiangsu Province Hospital of Traditional Chinese MedicineNanjing 210029China Department of Health Management Centre Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210002China Emergency Department Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of General Internal Medicine the Affiliated Hospital of Nanjing University of Chinese MedicineJiangsu Province Hospital of Traditional Chinese MedicineNanjing 210029China

OBJECTIVE: To investigate blood pressure rhythm(BPR)in Yin deficiency syndrome of hypertension(YDSH)patients and develop a random forest model for predicting ***: Our study was consistent with technical processes and specification for developing guidelines of Evidence-based Chinese medicine clinical practice(T/CACM 1032-2017). We enrolled 234 patients who had been diagnosed with primary hypertension without antihypertensive medications prior to the enrollment. All participants were divided into Yin deficiency group(YX, n = 74) and non-Yin deficiency group(NYX, n = 160).Participants were professionally grouped by three experienced chief Traditional Chinese Medicine(TCM)physicians according to four examinations(i.e.,inspection, listening and smelling, inquiry and palpation).We collected data on 24 h ambulatory blood pressure monitoring(ABPM) and YDSH rating scale. We divided 24 h of a day into 12 two-hour periods [Chen-Shi(7:00-9:00), Si-Shi(9:00-11:00), Wu-Shi(11:00-13:00), Wei-Shi(13:00-15:00), Shen-Shi(15:00-17:00), You-Shi(17:00-19:00), Xu-Shi(19:00-21:00), Hai-Shi(21:00-23:00), ZiShi(23:00-1:00), Chou-Shi(1:00-3:00), Yin-Shi(3:00-5:00), Mao-Shi(5:00-7:00)] according to the theory of “midnight-midday ebb flow”. We used random forest to build the diagnostic model of YDSH, with whether it was Yin deficiency syndrome as the outcome. RESULTS: Compared with NYX group, YX group had more female participants with older age, lower waist circumference, body mass index(BMI), diastolic blood pressure(DBP), and smoking and drinking rate(all P < 0.05). The YDSH rating scores of YX group [28.5(21.0-36.0)] were significantly higher than NYX group [13.0(8.0-22.0)](P < 0.001), and the typical symptoms of YX group included vexing heat in the chest, palms and soles, dizziness, dry eyes, string-like and fine pulse, soreness and weakness of lumbus and knees, palpitations, reddened cheeks, and tinnitus(all P < 0.05). The ratio of non-dipper hypertension in YX group was higher t

关键词： hypertension Yin deficiency syndrome random forest blood pressure rhythm blood pressure variability

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Engineering catalytic defects via molecular imprinting for high energy Li-S pouch cells

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National Science Review 2024年第7期11卷 239-251页

作者： Yufei Zhao Chuannan Geng Li wang Yun Cao Haotian Yang Linkai Peng Xin jiang yong Guo Xiaolin Ye Wei Lv Quan-Hong Yang Shenzhen Geim Graphene Center Engineering Laboratory for Functionalized Carbon Materials Tsinghua Shenzhen International Graduate School Tsinghua University Nanoyang Group Tianjin Key Laboratory of Advanced Carbon and Electrochemical Energy StorageSchool of Chemical Engineering and Technology and Collaborative Innovation Center of Chemical Science and Engineering(Tianjin)Tianjin University Joint School of National University of Singapore and Tianjin University International Campus of Tianjin University

Heterogeneous catalysis promises to accelerate sulfur-involved conversion reactions in lithium-sulfur batteries. Solid-state Li2S dissociation remains as the rate-limiting step because of the weakly matched solid-solid electrocatalysis interfaces. We propose an electrochemically molecular-imprinting strategy to have a metal sulfide（MS） catalyst with imprinted defects in positions from which the pre-implanted Li2S has been electrochemically removed. Such tailor-made defects enable the catalyst to bind exclusively to Li atoms in Li2S reactant and elongate the Li–S bond, thus decreasing the reaction energy barrier during charging. The imprinted Ni3S2catalyst shows the best activity due to the highest defect concentration among the MS catalysts examined. The Li2S oxidation potential is substantially reduced to 2.34 V from 2.96 V for the counterpart free of imprinted vacancies, and an Ah-level pouch cell is realized with excellent cycling performance. With a lean electrolyte/sulfur ratio of 1.80 μL mgS–1, the cell achieves a benchmarkedly high energy density beyond 500 Wh kg–1.

关键词： lithium-sulfur battery catalysts defects energy density metal sulfide

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Advanced Chronic Obstructive Pulmonary Disease： Innovative and Integrated Management Approaches

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Chinese Medical Journal 2015年第21期128卷 2952-2959页

作者： Hai-Xia Zhou Xue-Mei Ou yong-jiang Tang Lan wang Yu-Lin Feng Department of Respiratory Medicine West China Hospital Sichuan University Chengdu Sichuan 610041 China

Chronic obstructive pulmonary disease （COPD） is a leading cause of morbidity and mortality worldwide and results in an economic and social burden that is both substantial and increasing. By the year 2020, COPD will be the third leading cause of mortality and the fifth leading cause of disability worldwide, In a population based study conducted at multiple international sites, approximately 10% of participants 40 years of age or older were found to have airflow obstruction of at least moderate severity according to spirometric criteria. In China, the overall prevalence of COPD in individuals 40 years of age or older was 8.2%.m COPD is a slowly progressive respiratory disease, which, although preventable and treatable, is not curable. The final years for patients with advanced COPD are characterized by progressive functional decline, frequent exacerbations, poor quality of life, increasing dependency on informal caregivers and on the health care system. According to the literature, 5-year survival from diagnosis is estimated to be 78% in men and 72% in women with mild disease, but only 30% in men and 24% in women with advanced COPD.

关键词： Advanced Chronic Obstructive Pulmonary Disease End-of-life Care and Hospice Care Management Approaches Opioids Palliative Care Symptom Burden

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Success rate of current human-derived gastric cancer organoids establishment and influencing factors:A systematic review and meta-analysis

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1626-1646页

作者： Kai-Lin jiang Xiang-Xiang wang Xue-Jiao Liu Li-Kun Guo yong-Qi Chen Qing-Ling Jia Ke-Ming Yang jiang-Hong Ling Department of Gastroenterology Shuguang HospitalShanghai 200021China Department of Pathology Shuguang HospitalShanghai 200021China

BACKGROUND Human-derived gastric cancer organoids(GCOs)are widely used in gastric cancer research;however,the culture success rate is generally *** To explore the potential influencing factors,and the literature on successful culture rates of GCOs was reviewed using *** PubMed,Web of Science,and EMBASE were searched for *** trained researchers selected the studies and extracted *** 17.0 software was used for meta-analysis of the incidence of each outcome *** adjusted Methodological Index for Non-Randomized Studies scale was used to assess the quality of the included *** plots and Egger’s test were used to detect publication *** analyses were conducted for sex,tissue source,histo-logical classification,and the pathological tumor-node-metastasis(pTNM)cancer staging *** Eight studies with a pooled success rate of 66.6%were *** derived from women and men had success rates of 67%and 46.7%,*** from surgery or biopsy/endoscopic submucosal dissection showed success rates of 70.9%and 53.7%,*** of poorly-differentiated,moderately-differentiated and signet-ring cell cancer showed success rates of 64.6%,31%,and 32.7%,*** with pTNM stages I-II and III-IV showed success rates of 38.3%and 65.2%,respectively.Y-27632 and non-Y-27632 use showed success rates of 58.2%and 70%,*** generated with collagenase were more successful than those constructed with Liberase TH and TrypLE(72.1%vs 71%,respectively).EDTA digestion showed a 50%lower success rate than other methods(P=0.04).CONCLUSION GCO establishment rate is low and varies by sex,tissue source,histological type,and pTNM *** Y-27632,and using Liberase TH,TrypLE,or collagenase yields greater success than EDTA.

关键词： Gastric cancer organoids Human-derived organoids Gastric cancer Cell lines In vitro research models

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Deep-reinforcement-learning-based water diversion strategy

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Environmental Science and Ecotechnology 2024年第1期17卷 68-79页

作者： Qingsong jiang Jincheng Li Yanxin Sun Jilin Huang Rui Zou Wenjing Ma Huaicheng Guo Zhiyun wang yong Liu State Environmental Protection Key Laboratory of All Materials Flux in River Ecosystems College of Environmental Sciences and EngineeringPeking UniversityBeijing100871PR China Rays Computational Intelligence Lab Beijing Inteliway Environmental Ltd.Beijing100085PR China Yunnan Key Laboratory of Pollution Process and Management of Plateau Lake-Watershed Yunnan Research Academy of Eco-environmental SciencesKunming650034PR Chin

Water diversion is a common strategy to enhance water quality in eutrophic lakes by increasing available water resources and accelerating nutrient *** effectiveness depends on changes in the source water and lake ***,the challenge of optimizing water diversion remains because it is difficult to simultaneously improve lake water quality and minimize the amount of diverted ***,we propose a new approach called dynamic water diversion optimization(DWDO),which combines a comprehensive water quality model with a deep reinforcement learning *** applied DWDO to a region of Lake Dianchi,the largest eutrophic freshwater lake in China and validated *** results demonstrate that DWDO significantly reduced total nitrogen and total phosphorus concentrations in the lake by 7%and 6%,respectively,compared to previous ***,annual water diversion decreased by an impressive 75%.Through interpretable machine learning,we identified the impact of meteorological indicators and the water quality of both the source water and the lake on optimal water *** found that a single input variable could either increase or decrease water diversion,depending on its specific value,while multiple factors collectively influenced real-time adjustment of water ***,using well-designed hyperparameters,DWDO proved robust under different uncertainties in model *** training time of the model is theoretically shorter than traditional simulation-optimization algorithms,highlighting its potential to support more effective decisionmaking in water quality management.

关键词： Dynamic water diversion optimization Deep reinforcement learning Process-based model Explainable decision-making Parameter uncertainty

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韩国的金融政策与金融危机及对我国的警示

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统计研究 1999年第2期16卷 7-12页

作者：江勇王兵中南财经大学国民经济管理教研室武汉大学经济学院

金融危机的爆发对经济发展的危害是巨大的，受这次金融风暴直接冲击的国家，其经济实力普遍倒退７至１０年。其中韩国因货币贬值五成，其经济规模已由世界排名第１２位降至第１７位，人均国民生产总值由１９９６年的１０５４８美元降至... 详细信息

金融危机的爆发对经济发展的危害是巨大的，受这次金融风暴直接冲击的国家，其经济实力普遍倒退７至１０年。其中韩国因货币贬值五成，其经济规模已由世界排名第１２位降至第１７位，人均国民生产总值由１９９６年的１０５４８美元降至目前的６６６４美元，经济实力倒退了...

关键词：韩国金融政策金融危机中国教训

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Intelligent Reflecting Surface-Aided Secure and Covert Communications

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China Communications 2024年第9期21卷 1-10页

作者： Zhou Xiaobo jiang yong Xia Tingting Xia Guiyang Shen Tong School of Information and Artificial Intelligence Anhui Agricultural UniversityAnhui 230036China

This work employs intelligent reflecting surface(IRS)to enhance secure and covert communication *** formulate an optimization problem to jointly design both the reflection beamformer at IRS and transmit power at transmitter Alice in order to optimize the achievable secrecy rate at Bob subject to a covertness *** first develop a Dinkelbach-based algorithm to achieve an upper bound performance and a high-quality *** reducing the overhead and computational complexity of the Dinkelbach-based scheme,we further conceive a low-complexity algorithm in which analytical expression for the IRS reflection beamforming is derived at each *** result shows that the devised low-complexity algorithm is able to achieve similar secrecy rate performance as the Dinkelbach-based *** examination also shows that introducing an IRS into the considered system can significantly improve the secure and covert communication performance relative to the scheme without IRS.

关键词： covert communications intelligent reflecting surface physical layer security reflection beamforming

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Impact of letters to the editor and publications in 2023

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Zoological Research 2024年第1期45卷 136-137页

作者： Xiu-Ping Zhang Xue-Long jiang yong-Gang Yao Editorial Office of ZR&ZRDC Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China

A letter to the editor constitutes a short communication addressing a range of topics pertinent to the readership of a journal(Dkhar,2018).This format offers several benefits,such as timeliness,accessibility,innovation,and conciseness,thereby serving as an effective means to disseminate cuttingedge scientific *** the past five years,there has been a considerable increase in the number of letters published,representing the highest growth rate(approximately 20%)observed in the last three decades(Figure 1A).In the field of academic publishing,letters to the editor are typically more concise than typical research papers.

关键词： journal editor Figure

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Standardized ileal digestibility of amino acids in soybean meal fed to non-pregnant and pregnant sows

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Journal of Animal Science and Biotechnology 2024年第1期15卷 362-373页

作者： Ke wang Ya wang Lei Guo yong Zhuo Lun Hua Lianqiang Che Shengyu Xu Ruinan Zhang Jian Li Bin Feng Zhengfeng Fang Xuemei jiang Yan Lin De Wu Institute of Animal Nutrition Key Laboratory for Animal Disease‑Resistance Nutrition of ChinaMinistry of EducationSichuan Agricultural University211 Huimin RoadWenjiang DistrictChengdu 611130SichuanChina

Background Two studies were designed to determine standard ileal crude protein(CP)and amino acid(AA)digestibility of soybean meal(SBM)from different origins fed to non-pregnant and pregnant *** solvent-extracted SBMs from soybeans produced in the USA,Brazil,and China were *** Exp.1,eight different diets were created:a nitrogen(N)-free diet and 7 experimental diets containing SBM from different origins as the only N *** non-pregnant,multiparous sows were arranged in an 8×8 Latin square design(8 periods and 8 diets).In Exp.2,the diet formula was the same as in *** gestating sows(parity 3)were assigned to 4 different diets in a replicated 4×3 Youden square design(three periods and four diets)in mid-gestation and again in late-gestation *** When fed to non-pregnant and late-gestating sows,the standardized ileal digestibility(SID)of CP and most AAs from different SBM were not significantly different(P>0.05).When fed to mid-gestating sows,the SID values for Arg,His,Lys,Phe,Cys,Gly,Ser,and Tyr in SBM 1 were lower than in SBM 4 and 5(P<0.05),whereas SID for Leu from SBM 5 was higher than in SBM 1 and 4(P<0.05).SID values for Ile,Ala,and Asp from SBM 4 were lower than in SBM 1 and 5(P<0.05).Sows had significantly greater SID values for Lys,Ala,and Asp during mid-gestation when compared with late-gestation stages(P<0.05).Mid-gestating sows had greater SID value for Val and lower SID value for Tyr when compared with non-pregnant and late-gestating sows(P<0.01),whereas non-pregnant sows had significantly greater SID value for Met when compared with gestating sows(P<0.01).Conclusions When fed to mid-gestating sows,the SID values for most AAs varied among SBM *** SID values for Lys,Met,Val,Ala,Asp,and Tyr in SBM were affected by sow gestation *** findings provide a cornerstone for accurate SBM use in sow diets.

关键词： Amino acids Sows Soybean meal Standardized ileal digestibility

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A novel alternative for pyrogen detection based on a transgenic cell line

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1221-1229页

作者： Qing He Chuan-Fei Yu Gang Wu Kai-Qin wang yong-Bo Ni Xiao Guo Zhi-Hao Fu Lan wang De-jiang Tan Hua Gao Can wang Gang Chen Xu-Hong Chen Bo Chen Jun-Zhi wang National Institutes for Food and Drug Control BeijingChina School of Life Science and Biopharmaceutics Shenyang Pharmaceutical UniversityShenyangChina Shanghai Institute for Food and Drug Control ShanghaiChina KeyMed Biosciences Inc. ChengduChina

Pyrogen,often as a contaminant,is a key indicator affecting the safety of almost all parenteral drugs(including biologicals,chemicals,traditional Chinese medicines and medical devices).It has become a goal to completely replace the in vivo rabbit pyrogen test by using the in vitro pyrogen test based on the promoted‘reduction,replacement and refinement’principle,which has been highly considered by regulatory agencies from different *** used NF-κB,a central signalling molecule mediating inflammatory responses,as a pyrogenic marker and the monocyte line THP-1 transfected with a luciferase reporter gene regulated by NF-κB as an in vitro model to detect pyrogens by measuring the intensity of a fluorescence ***,we show that this test can quantitatively and sensitively detect endotoxin(lipopolysaccharide from different strains)and nonendotoxin(lipoteichoic acid,zymosan,peptidoglycan,lectin and glucan),has good stability in terms of NF-κB activity and cell phenotypes at 39 cell passages and can be applied to detect pyrogens in biologicals(group A&C meningococcal polysaccharide vaccine;basiliximab;rabies vaccine(Vero cells)for human use,freeze-dried;Japanese encephalitis vaccine(Vero cells),inactivated;insulin aspart injection;human albumin;recombinant human erythropoietin injection(CHO Cell)).The within-laboratory reproducibility of the test in three independent laboratories was 85%,80%and 80%and the interlaboratory reproducibility among laboratories was 83.3%,95.6%and 86.7%.The sensitivity(true positive rate)and specificity(true negative rate)of the test were 89.9%and 90.9%,*** summary,the test provides a novel alternative for pyrogen detection.

关键词： pyrogen rabbit replace

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