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Soluble intercellular adhesion molecule-1,D-lactate and diamine oxidase in patients with inflammatory bowel disease

World Journal of Gastroenterology 2009年第31期15卷 3916-3919页

作者： Wei-Bing Song yong-hui lv Zhen-Shu Zhang Ya-Nan Li Li-Ping Xiao Xin-Pei Yu Yuan-Yuan Wang Hong-Li Ji Li Ma Department of Gerontology Guangzhou General Hospital of the PLA Guangzhou 510010 Guangdong Province China The Traditional Chinese'Medical Hospital of Guangzhou City Guangzhou 510010 Guangdong Province China Institute for Digestive Diseases Nanfang Hospital Southern Medical University Guangzhou 510515 Guangdong Province China Suzhou River Cadre's Sanatorium Second Artillery Rest of the Cadres of the PLA Beijing 100086 China

AIM： To study the levels of serum soluble intercellular adhesion molecule-1 （sICAM-1）, plasma D-lactate and diamine oxidase （DAO） in patients with inflammatory bowel disease （IBD）, and the potential clinical significance. METHODS： Sixty-nine patients with IBD and 30 healthy controls were included in this study. The concentration of sICAM-1 was detected with enzyme-linked immunosorbent assay, the level of D-lactate and DAO was measured by spectroscopic analysis, and the number of white blood cells （WBC） was determined by routine procedure. RESULTS： The levels of sICAM-I, DAO, and WBC in IBD patients were significantly higher than those in the control group （P 〈 0,01）, sICAM-I in IBD patients was found to be closely related to the levels of DAO and D-lactate （212.94 ± 69.89 vs 6.35 ± 2.35, P = 0.000）, DAO 212.94 ± 69.89 vs 8.65 ± 3.54, P = 0.000） and WBC （212.94 ± 69.89 vs 7.40 ± 2.61, P = 0.000）, but no significant difference was observed between patients with ulcerative colitis and patients with Crohn＇s disease. The post-treatment levels of sICAM-I, D-lactate and WBC were significantly lower than before treatment （sICAM-I 206.57 ± 79.21 vs 146.21 ± 64.43, P = 0.000）, （D-lactate 1.46 ± 0.94 vs 0.52± 0.32, P = 0.000） and （WBC 7.24 ± 0.2.33 vs 5.21 ± 3.21, P = 0.000）. CONCLUSION： sICAM-1, D-lactate and DAO are closely related to the specific conditions of IBD, and thus could be used as a major diagnostic index.

关键词： Inflammatory bowel diseases Intercellular adhesion molecule-1 D-lactate Diamine oxidase

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Blood diagnostic and prognostic biomarkers in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第9期20卷 2556-2570页

作者： yongting lv Hongfu Li Department of Neurology Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina Department of Medical Genetics and Center for Rare disease Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina Nanhu Brain-Computer Interface Institute HangzhouZhejiang Province

Amyotrophic lateral sclerosis is a devastating neurodegenerative disease for which the current treatment approaches remain severely *** principal pathological alterations of the disease include the selective degeneration of motor neurons in the brain,brainstem,and spinal cord,as well as abnormal protein deposition in the cytoplasm of neurons and glial *** biological markers under extensive scrutiny are predominantly located in the cerebrospinal fluid,blood,and even *** these biomarke rs,neurofilament proteins and glial fibrillary acidic protein most accurately reflect the pathologic changes in the central nervous system,while creatinine and creatine kinase mainly indicate pathological alterations in the peripheral nerves and *** light chain levels serve as an indicator of neuronal axonal injury that remain stable throughout disease progression and are a promising diagnostic and prognostic biomarker with high specificity and ***,there are challenges in using neurofilament light chain to diffe rentiate amyotrophic lateral sclerosis from other central nervous system diseases with axonal *** fibrillary acidic protein predominantly reflects the degree of neuronal demyelination and is linked to non-motor symptoms of amyotrophic lateral sclerosis such as cognitive impairment,oxygen saturation,and the glomerular filtration *** DNA-binding protein 43,a pathological protein associated with amyotrophic lateral sclerosis,is emerging as a promising biomarker,particularly with advancements in exosome-related *** is currently lacking for the value of creatinine and creatine kinase as diagnostic markers;however,they show potential in predicting disease *** the vigorous progress made in the identification of amyotrophic lateral sclerosis biomarkers in recent years,the quest for definitive diagnostic and prognostic biomarke rs remains a formidable *** review summarizes the lat

关键词： amyotrophic lateral sclerosis biomarker blood biomarkers diagnosis glial fibrillary acidic protein neurofilament light chain prognosis TAR DNA-binding protein 43

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In situ polymerization of poly(3,4-ethylenedioxythiophene)protective layer towards stable zinc anode

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Nano Research 2025年第1期18卷 382-394页

作者： Debin Luo Peng Zhou Xiaowei lv Panpan Sun Xiaohua Sun Hewei Zhao College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion MaterialsChina Three Gorges UniversityYichang 443002China Hubei Three Gorges Laboratory Yichang 443007China School of Chemistry Beihang UniversityBeijing 100191China

Aqueous zinc-ion devices are considered promising candidates for energy storage due to their high safety,low cost and relatively high energy ***,the dendrite growth,hydrogen evolution reaction(HER)and corrosion of the zinc anode significantly limit the development of Zn-ion ***,an inexpensive poly(3,4-ethylenedioxythiophene)(PEDOT)protective layer was constructed in situ on the Zn surface using electropolymerization to suppress dendrite growth and side reactions,thereby enhancing the reversibility of *** and theoretical calculations revealed that this hydrophilic protective layer promotes the desolvation process of hydrated Zn^(2+)and facilitates the transport of zinc ions,thus improving the thermodynamic and kinetic properties of Zn^(2+)deposition and inhibiting interfacial side ***,the optimized PEDOT@Zn symmetric battery exhibited a cycling stability exceeding 1250 h at 0.5 mA·cm^(-2)and 0.25 mAh·cm^(-2),with a significantly reduced overpotential(from 91.8 to 35 mV).With the assistance of the PEDOT protective layer,the PEDOT@Zn//Cu battery maintained approximately 99.5%Coulombic efficiency after 450 ***-situ scanning electron microscopy(SEM)and in situ optical microscopy characterizations further confirmed that the PEDOT protective layer can effectively suppress the growth of zinc ***,the Zn-ion capacitors assembled by the PEDOT@Zn and activated carbon also demonstrated outstanding cycling stability.

关键词： zinc-ion devices zinc anode poly(3 4-ethylenedioxythiophene)(PEDOT) dendrite desolvation process

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The pivotal role of microglia in injury and the prognosis of subarachnoid hemorrhage

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Neural Regeneration Research 2025年第7期20卷 1829-1848页

作者： Wenjing Ning Shi lv Qian Wang Yuzhen Xu Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina Department of Central Laboratory The Affiliated Taian City Central Hospital of Qingdao UniversityTaianShandong ProvinceChina

Subarachnoid hemorrhage leads to a series of pathological changes,including vascular spasm,cellular apoptosis,blood–brain barrier damage,cerebral edema,and white matter ***,which are the key immune cells in the central nervous system,maintain homeostasis in the neural environment,support neurons,mediate apoptosis,participate in immune regulation,and have neuroprotective *** evidence has shown that microglia play a pivotal role in the pathogenesis of subarachnoid hemorrhage and affect the process of injury and the prognosis of subarachnoid ***,microglia play certain neuroprotective roles in the recovery phase of subarachnoid *** approaches aimed at modulating microglia function are believed to attenuate subarachnoid hemorrhage *** provides new targets and ideas for the treatment of subarachnoid ***,an in-depth and comprehensive summary of the role of microglia after subarachnoid hemorrhage is still *** review describes the activation of microglia after subarachnoid hemorrhage and their roles in the pathological processes of vasospasm,neuroinflammation,neuronal apoptosis,blood–brain barrier disruption,cerebral edema,and cerebral white matter *** also discusses the neuroprotective roles of microglia during recovery from subarachnoid hemorrhage and therapeutic advances aimed at modulating microglial function after subarachnoid ***,microglia in subarachnoid hemorrhage are targeted with TLR inhibitors,nuclear factor-κB and STAT3 pathway inhibitors,glycine/tyrosine kinases,NLRP3 signaling pathway inhibitors,Gasdermin D inhibitors,vincristine receptorαreceptor agonists,ferroptosis inhibitors,genetic modification techniques,stem cell therapies,and traditional Chinese ***,most of these are still being evaluated at the laboratory *** clinical studies and data on subarachnoid hemorrhage are required to improve the treatment of subarachnoid hemor

关键词： apoptosis blood–brain barrier brain edema microglia neuroinflammation neuron neuroprotection subarachnoid hemorrhage vasoconstriction white matter injury

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Activin A receptor type 1C single nucleotide polymorphisms associated with esophageal squamous cell carcinoma risk in Chinese population

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 39-51页

作者： Si-Yun Lin Hou Huang Jin-Jie Yu Feng Su Tian Jiang Shao-Yuan Zhang Lu lv Tao Long hui-Wen Pan Jun-Qing Qi Qiang Zhou Wei-Feng Tang Guo-Wen Ding Li-Ming Wang Li-Jie Tan Jun Yin Department of Thoracic Surgery Zhongshan Hospital Affiliated to Fudan UniversityShanghai 200032China Shanghai Key Laboratory of Clinical Geriatric Medicine Huadong Hospital Affiliated to Fudan UniversityShanghai 200040China Department of Cardiothoracic Surgery The Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002Jiangsu ProvinceChina Department of Thoracic Surgery Sichuan Cancer Hospital&InstituteChengdu 610042Sichuan ProvinceChina Department of Cardiothoracic Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210000Jiangsu ProvinceChina Department of Respiratory and Critical Care Medicine Shanghai Xuhui Central HospitalShanghai 200032China

BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and *** A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis through binding to dif-ferent *** To evaluate the correlation between single nucleotide polymorphisms(SNPs)of ACVR1C and susceptibility to esophageal squamous cell carcinoma(ESCC)in Chinese Han *** In this hospital-based cohort study,1043 ESCC patients and 1143 healthy controls were *** SNPs(rs4664229,rs4556933,rs77886248,rs77263459,rs6734630)of ACVR1C were assessed by the ligation detection reaction ***-Weinberg equilibrium test,genetic model analysis,stratified analysis,linkage disequi-librium test,and haplotype analysis were *** Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC,and those with rs77886248 TA mutant were related with higher risk,especially in older male *** the haplotype analysis,ACVR1C Trs4664229Ars4556933Trs77886248Crs77263459Ars6734630 increased risk of ESCC,while Trs4664229Grs4556933Trs77886248Crs77263459Ars6734630 was associated with lower susceptibility to *** ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC,which could provide a potential target for early diagnosis and treatment of ESCC in Chinese Han population.

关键词： Activin A receptor type 1C Single nucleotide polymorphisms Esophageal squamous cell carcinoma Genetic susceptibility Hospital-based cohort study

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Error- and loss-tolerant bundle fragment authentication for space DTNs

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Frontiers of Computer Science 2014年第6期8卷 1012-1023页

作者： Xixiang lv hui LI The National Key Lab of Integrated Services Networks Xidian University Xi'an 710071 China

To ensure the authenticity and integrity of bundles, the in-transit PDUs of bundle protocol （BP） in space delay/disruption-tolerant networks （DTNs）, the bundle security protocol specification （IRTF RFC6257） suggested using a digital signature directly over each bundle. However, when bundle fragment services are needed, this mechanism suffers from heavy computational costs, bandwidth overheads and energy consumption. In this paper, we address the fragment authentication issue for BP by exploiting the combination of RS error correction and erasure codes with the help of batch transmission characteristic of DTNs. The RS error correction and erasure codes are adopted to allow the receivers to locate the false/injected fragments and reconstruct the only one signature shared by all fragments of a bundle, even if some other fragments are lost or routed to a different path. Getting only partial authentic fragments, a DTN node is able to detect and filter the false/injected fragments, and authenticate the origin of a bundle as well. Such an approach tolerates high delays, unexpected link disruption and the BP nature of routing fragments of the same bundle possibly via different paths. The performance analysis demonstrates that both of our schemes, which follow our generic idea based on RS codes, significantly reduce bandwidth overheads and computational costs as compared to the prior works.

关键词： space-based delay tolerant networks bundle authentication information security.

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Human neural stem cell-derived extracellular vesicles protect against ischemic stroke by activating the PI3K/AKT/mTOR pathway

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Neural Regeneration Research 2025年第11期20卷 3245-3258页

作者： Jiayi Wang Mengke Zhao Dong Fu Meina Wang Chao Han Zhongyue lv Liang Wang Jing Liu Stem Cell Clinical Research Center The First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning ProvinceChina Dalian Innovation Institute of Stem Cell and Precision Medicine DalianLiaoning ProvinceChina Institute(College)of Integrative Medicine Dalian Medical UniversityDalianLiaoning ProvinceChina

Human neural stem cell-derived extracellular vesicles exhibit analogous functions to their parental cells,and can thus be used as substitutes for stem cells in stem cell therapy,thereby mitigating the risks of stem cell therapy and advancing the frontiers of stem cell-derived *** lays a foundation for the development of potentially potent new treatment modalities for ischemic ***,the precise mechanisms underlying the efficacy and safety of human neural stem cell-derived extracellular vesicles remain unclear,presenting challenges for clinical *** promote the translation of therapy based on human neural stem cell-derived extracellular vesicles from the bench to the bedside,we conducted a comprehensive preclinical study to evaluate the efficacy and safety of human neural stem cell-derived extracellular vesicles in the treatment of ischemic *** found that administration of human neural stem cell-derived extracellular vesicles to an ischemic stroke rat model reduced the volume of cerebral infarction and promoted functional recovery by alleviating neuronal *** human neural stem cell-derived extracellular vesicles reduced neuronal apoptosis by enhancing phosphorylation of phosphoinositide 3-kinase,mammalian target of rapamycin,and protein kinase B,and these effects were reversed by treatment with a phosphoinositide 3-kinase *** findings suggest that human neural stem cell-derived extracellular vesicles play a neuroprotective role in ischemic stroke through activation of phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling ***,we showed that human neural stem cell-derived extracellular vesicles have a good in vivo safety ***,human neural stem cell-derived extracellular vesicles are a promising potential agent for the treatment of ischemic stroke.

关键词： behavior exosome extracellular vesicles ischemic stroke mammalian target of rapamycin(mTOR) middle cerebral artery occlusion neural stem cells neuronal apoptosis phosphoinositide 3-kinase(PI3K) protein kinase B(AKT)

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Geochemistry,petrogenesis and tectonic significance of the late Triassic A-type granite in Fujian,South China

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Acta Geochimica 2017年第2期36卷 166-180页

作者： Dawei Cai Jingyu Zhao yong Tang hui Zhang Yunlong Liu Zhenghang lv Key Laboratory for High Temperature and High Pressure Study of the Earth's Interior Institute of Geochemistry Chinese Academy of Sciences Guiyang 550081 China University of Chinese Academy of Sciences Beijing 100049 China

The late Permian–Triassic granites in southeastern China have important tectonic significance for the evolution of South China. Here, we present the detailed geochronological, geochemical and petrological analyses for the Jinlongyan(JLY) granite in northwest Fujian Province, southeast China. LA–ICP–MS zircon U–Pb dating yielded a weighted average ^(206)Pb/^(238)U age of 224.1 ±3.3 Ma. The granite is mainly comprised of K-feldspar,plagioclase, quartz, biotite and minor amphibole. It is characterized by enrichments in Rb, Th, REEs(total REE = 295.1–694.3 ppm), and HFSEs(e.g., Zr = 289–520 ppm, Hf = 9.3–15.0 ppm, Y = 36.2–68.2 ppm) but depletions in Ba, Sr, Eu and Ti. The granite is metaluminous to weakly peraluminous and show a clear A-type granite geochemical signature with high SiO_2(70.89 wt%–75.76 wt%), total alkalis(Na_2O + K_2O = 7.51 wt%–8.72 wt%), Ga/Al ratios(10000 Ga/Al = 2.72–3.43). Insitu zircon Hf isotope analysis shows their eHf(t) values ranging from-7.2 to-3.2, with Mesoproterozoic T2DM ages(1308–1525 Ma). Whole-rock Nd isotope data show their eNd(t) values in the range of-9.5 to-9.1 and yield paleoproterozoic TDMages(1606–1985 Ma). These characteristics indicate that the JLY A-type granite magma was formed by the partial melting of Meso-Paleoproterozoic crust rocks in the Cathaysia Block. Our study of the JLY A-type granite, together with other Triassic A-type granitesin South China, defines an extensional environment in the late Triassic which probably was caused by the collision of the South China Block with Indochina Block.

关键词： A-type granite U-Pb dating Sr-Nd-Hfisotope Late Triassic Fujian Province

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Aerodynamic characteristic of a canard guided rocket

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International Journal of Modeling, Simulation, and Scientific Computing 2017年第1期8卷 1-22页

作者： yong-Chao Chen Xin-Bao Gao Min Gao hui-Miao lv Electronic Engineering Department Shijiazhuang Mechanical Engineering College No.97 Heping West RoadShijiazhuangHebei050003P.R.China

The computational fluid dynamics(CFD)numerical simulation was used to investigate the aerodynamic characteristic of a canard guided rocket based on the technology of high quality point-to-point multi-block structured *** results of numerical simula-tion and experiments showed that the method is highly credible,and the method could be used to the rockets with semblable *** canard guided rocket was designed with different noses,canards and *** N-S equations were solved numeri-cally by the finite volume method,and the multi-grid method was adopted to accelerate the *** these strategies the aerodynamic characteristics of rocket,nose,canard and fin were educed,and the change law was *** results will provide the support for the optimization of anard guided rocket in engineering design.

关键词： Aerodynamic characteristic guided rocket computational fluid dynamics

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Extrapolation reconstruction of wind pressure fields on the claddings of high-rise buildings

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Frontiers of Structural and Civil Engineering 2019年第3期13卷 653-666页

作者： Yehua SUN Guquan SONG hui lv School of Civil Engineering and Architecture Nanchang UniversityNanchang 330033China Jiangxi Institute of Economic Administrators Nanchang 330038China

Recent research about reconstruction methods mainly used the interpolation reconstruction of the fluctuating wind pressure field on the ***,to investigate wind pressure at the edge of the building,the work presented in this paper focuses on the extrapolation reconstruction of wind pressure ***,we propose an improved proper orthogonal decomposition(POD)and Kriging method with a von Karman correlation function to resolve this *** studies show that it works well for not only interpolation reconstruction but also extrapolation *** proposed method does require determination of the Hurst exponent and other parameters analysed from the original ***,the fluctuating wind fields have been characterized by the von Karman correlation function,as an a priori *** with the cubic spline method and different variogram,preliminary results suggest less time consumption and high efficiency in extrapolation reconstruction at the edge.

关键词： extrapolation reconstruction proper orthogonal decomposition Kriging method von Karman function Hurst exponent rescaled range analysis

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