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Measuring Cognitive and Psychosocial Accessibility to Modern Contraception: A Comprehensive Framework

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Health 2024年第7期16卷 578-591页

作者： Lonkila Moussa zan Clémentine Rossier Caroline Moreau INSD/ISSP Universit Joseph KI-ZERBO Ouagadougou Burkina Faso IDESO University of Geneva Geneva Switzerland Gates Institute Johns Hopkins University Baltimore United States

Nowadays, more than ever, the improvement of access to family planning (FP) has become an international goal. What constitutes access to FP? Current human rights-based contraceptive guidelines indicate that access begins as soon as women or couples express a desire to avoid pregnancy and their risk of unintended pregnancy is established. However, few studies have sought to define and measure cognitive and psychosocial access to contraception. To propose a comprehensive framework for the cognitive and psychosocial accessibility of contraception, we critically analyzed the literature on attitudes toward FP. The main dimensions that emerged were knowledge about FP, fear of side effects, approval of contraception, and contraceptive agency. We then identified and adjusted some questions that can capture these dimensions more comprehensively. As a result, we developed a questionnaire module comprising 15 questions, which was integrated into the 6th round of the PMA2020 survey in Burkina Faso in 2019. This research highlighted that previous studies have collected separate dimensions of contraceptive access, and the psychosocial dimension tended to be neglected. Our results demonstrate that it is possible to collect comprehensive data on cognitive and psychosocial dimensions of access to family planning.

关键词： Cognitive Dimensions Psychosocial Dimensions Contraception Intention To Use Side Effects

Comparative studies between humans and golden Syrian hamsters via thromboelastography

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Animal Models and Experimental Medicine 2024年第04期 570-577页

作者： Ze Yang Lili Xie Jingjing Ba Simin zan Letong Zhang Xinyi Zhang Yang Yu School of Laboratory Animal & Shandong Laboratory Animal Center Shandong First Medical University & Shandong Academy of Medical Sciences The Second Affiliated Hospital of Shandong First Medical University

Background : Thromboelastography(TEG) is a widely utilized clinical testing method for real-time monitoring of platelet function and the thrombosis process. Lipid metabolism disorders are crucial risk factors for thrombosis. The lipid metabolism characteristics of hamsters resemble those of humans more closely than mice and rats, and their relatively large blood volume makes them suitable for studying the mechanisms of thrombosis related to plasma lipid mechanisms. Whole blood samples from golden Syrian hamsters and healthy humans were obtained following standard clinical procedures. TEG was employed to evaluate coagulation factor function, fibrinogen(Fib)function, platelet function, and the fibrinolytic *** : The whole blood from hamster or healthy human was isolated following the clinical procedure, and TEG was employed to evaluate the coagulation factor function, Fib function, platelet function, and fibrinolytic system. Coagulation analysis used ACLTOP750 automatic coagulation analysis pipeline. Blood routine testing used XN-2000 automatic blood *** : TEG parameters revealed that hamsters exhibited stronger coagulation factor function than humans(reaction time [R], p = 0.0117), with stronger Fib function(alpha angle, p < 0.0001; K-time [K], p < 0.0001). Platelet function did not differ significantly(maximum amplitude [MA], p = 0.077). Hamsters displayed higher coagulation status than humans(coagulation index [CI], p = 0.0023), and the rate of blood clot dissolution in hamsters differed from that in humans(percentage lysis 30 min after MA, p = 0.02). Coagulation analysis parameters indicated that prothrombin time(PT)and activated partial thromboplastin time(APTT) were faster in hamsters than in humans(PT, p = 0.0014; APTT, p = 0.03), whereas the Fib content was significantly lower in hamsters than in humans( p < 0.0001). No significant difference was observed in thrombin time( p = 0.1949).Conclusions : In summary, TEG could be used to evalu

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新世纪诗歌场域、作者身份与当代性呈现

中国文学批评 2024年第4期40卷 177-186,190页

作者：周瓒中国社会科学院文学研究所北京100732

近年来,当代诗歌现场暗流涌动,第八届鲁迅文学奖重释了既有的诗群概念,“知识分子写作”与“民间写作”的区分不复有效,有关“未来诗学”的论争重申了“90年代诗歌”呈现与遗留的诗学问题。当前,互联网平台已然成为当代诗歌发生与传播... 详细信息

近年来,当代诗歌现场暗流涌动,第八届鲁迅文学奖重释了既有的诗群概念,“知识分子写作”与“民间写作”的区分不复有效,有关“未来诗学”的论争重申了“90年代诗歌”呈现与遗留的诗学问题。当前,互联网平台已然成为当代诗歌发生与传播的主要空间,诗人群体则因观念的分歧和写作面貌的差异而不断分化、重组。线上诗歌热点频现,线下的诗歌市场总体显得低迷,而诗歌出版却处于升温状态。这一切敦促我们从诗歌场域和诗人身份出发,考察与思考当代诗的“当代性”。具体而言,当代诗歌的显著趋向表现为民生关切、传统重塑、跨界行动、文体自觉等,而所面临的挑战又体现在新媒介语境下对诗人创造活力的考验、诗歌批评的滞后以及新科技激发的创造可能性等方面。

关键词：场域身份民生关切传统重塑跨界当代性

Identification of key genes and metabolites involved in meat quality performance in Qinchuan cattle by WGCNA

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Journal of Integrative Agriculture 2024年第11期23卷 3923-3937页

作者： Hengwei Yu Zhimei Yang Jianfang Wang Huaxuan Li Xuefeng Li Entang Liang Chugang Mei Linsen zan College of Animal Science and Technology Northwest A&F University College of Grassland Agriculture Northwest A&F University National Beef Cattle Improvement Center

Understanding the genetic and metabolic elements that impact meat quality is crucial to improving production and meeting consumer demands in the beef *** in meat quality among various muscle areas in beef cattle can impact pricing in the *** progress in genomics,the specific genes and metabolites that affect meat quality characteristics in Qinchuan cattle remain inadequately ***,this study aims to evaluate the meat quality characteristics of four specific muscle locations (tenderloin,striploin,high rib,and ribeye muscles) in Qinchuan bulls,including 10 traits (total protein content (TPC),intramuscular fat (IMF),non-esterified fatty acid (NEFA),meat color (L*,a*,and b*),shear force (SF),cooking loss (CL),pH0,and pH24).This experiment uses transcriptome,metabolome sequencing,and sophisticated analytical methodologies such as weighted gene co-expression network analysis (WGCNA) and protein–protein interaction networks (PPI) to identify the key genes and metabolites associated with specific *** findings highlight three notable genes (NDUFAB1,NDUFA12,and NDUFB7) linked to intramuscular fat (IMF),three key genes (CSRP3,ACAA3,and ACADVL) correlated with non-esterified fatty acids (NEFA),and one crucial gene (CREBBP) influencing meat *** conclusion,this investigation offers a new perspective on the differences in bovine muscle locations and contributes to the molecular understanding of bovine meat *** research endeavors could delve deeper into the identified genes and pathways to enhance beef cattle’s quality and yield.

关键词： meat quality performance WGCNA cattle transcriptome metabolome

A treatment recommendation for trichoepithelioma:Thoughts on selection of treatment timing and method

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Chinese Journal of Plastic and Reconstructive Surgery 2024年第1期6卷 37-40页

作者： Shenying Luo Shuchen Gu Ruoqing Xu En Yang Liying Tu Hsin Liang Xin Huang Jieyi Ren Tao zan Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China

In this report,we present the case of a 55-year-old woman with a 30-year history of multiple familial trichoe-pithelioma(MFT),with facial surface tumors that progressively worsened,causing ventilation *** order to improve the patient’s appearance and functional impairment,we performed a two-step surgical excision and skin grafting procedure post diagnosis through genetic *** 18-month follow-up confirmed that the effect was satisfactory without obvious *** on this outcome,we have developed a diagnosis and treat-ment process for patients with MFT,aiming to provide a reference for standardized treatment of this rare disease.

关键词： Multiple familial trichoepithelioma Trichoepithelioma CYLD gene

Mechanistic research:Selenium regulates virulence factors,reducing adhesion ability and inflammatory damage of Helicobacter pylori

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World Journal of Gastroenterology 2024年第1期30卷 91-107页

作者： Chun Qin Gan-Rong Huang Ai-Xing Guan Wen-Ting Zhou Hao Chen Pei-Pei Luo Xian-Ke Luo Yan-Qiang Huang zan-Song Huang Guangxi Technology Innovation Cooperation Base of Prevention and Control Pathogenic Microbes with Drug Resistance Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Digestive Diseases Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Key Laboratory of the Prevention and Treatment of Drug Resistant Microbial Infecting Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Pathology Wannan Medical CollegeWuhu 241002Anhui ProvinceChina Department of Gastroenterology Wujin People’s Hospital affiliated to Jiangsu UniversityChangzhou 213004Jiangsu ProvinceChina Department of Gastroenterology Guangzhou Liwan District People's HospitalGuangzhou 510370Guangdong ProvinceChina

BACKGROUND The pathogenicity of Helicobacter pylori is dependent on factors including the environment and the *** selenium is closely related to pathogenicity as an environmental factor,the specific correlation between them remains *** To investigate how selenium acts on virulence factors and reduces their *** *** strains were induced by sodium *** expression of cytotoxin-associated protein A(CagA)and vacuolating cytotoxin gene A(VacA)was determined by quantitative PCR and Western *** was used to analyze CagA,CagM,CagE,Cag1,Cag3,and CagT.C57BL/6A mice were infected with the attenuated strains subjected to sodium selenite induction,and *** colonization,inflammatory reactions,and the cell adhesion ability of *** were *** CagA and VacA expression was upregulated at first and then downregulated in the *** strains after sodium selenite *** expression was significantly and steadily downregulated after the 5th cycle(10 d).Transcriptome analysis revealed that sodium selenite altered the levels affect *** virulence factors such as CagA,CagM,CagE,Cag1,Cag3,and *** these factors,CagM and CagE expression was continuously downregulated and further downregulated after 2 h of induction with sodium ***,CagT expression was upregulated before the 3rd cycle(6 d)and significantly downregulated after the 5th ***1 and Cag3 expression was upregulated and downregulated,respectively,but no significant change was observed by the 5th cycle.C57BL/6A mice were infected with the attenuated strains subjected to sodium selenite *** extent of *** colonization in the stomach increased;however,sodium selenite also induced a mild inflammatory reaction in the gastric mucosa of ***-infected mice,and the cell adhesion ability of *** was significantly *** These results demonstrate that *** displayed virulence attenuation after

关键词： Helicobacter pylori Sodium selenite Virulence factors Adherence Inflammation

跨媒介灵韵转移、共同体微观叙事与牧歌美升华——评电视剧《我的阿勒泰》

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中国文艺评论 2024年第7期 91-103,I0004页

作者：邹赞新疆大学中国语言文学学院

电视剧《我的阿勒泰》燃爆“出圈”,成为现象级作品,其成功并非偶然,而是蕴含着三重经验:一是自觉超克文类界限,弥补原著情节叙述不注重矛盾冲突、结构相对松散的状况,尽最大可能保留了原著的神韵和气质,为散文的影视剧改编积累了宝贵经... 详细信息

电视剧《我的阿勒泰》燃爆“出圈”,成为现象级作品,其成功并非偶然,而是蕴含着三重经验:一是自觉超克文类界限,弥补原著情节叙述不注重矛盾冲突、结构相对松散的状况,尽最大可能保留了原著的神韵和气质,为散文的影视剧改编积累了宝贵经验;二是坚持现实主义文艺观,通过立体丰富的故事情节和典型形象塑造,谱写了共同体叙事的新篇章;三是影像视听语言风格追寻一种“如画美”,文本叙事达成了崇高美与牧歌美的和谐统一。此外,技术赋能助力李娟散文经典品质“出圈”,打造出具有新疆地域特色的文旅IP,为提升优秀文艺作品服务新时代“文化润疆”工作成效,提供了典型范例。

关键词：《我的阿勒泰》跨媒介改编共同体叙事如画美

De novo design of highly efficient type-Ⅰphotosensitizer based onπ-conjugated oligomer for photodynamic eradication of multidrug-resistant bacterial infections

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Chinese Chemical Letters 2024年第3期35卷 389-393页

作者： Qi Zhao Guangchao Qing Jie Yu Ying Liu Jianliang Shen Yang Luo Xingjie zan Shengliang Li State Key Laboratory of Ophthalmology Optometry and Vision ScienceSchool of Ophthalmology and OptometrySchool of Biomedical EngineeringWenzhou Medical UniversityWenzhou InstituteUniversity of Chinese Academy of SciencesOujiang Laboratory(Zhejiang Lab for Regenerative MedicineVision and Brain Health)Wenzhou 325001China College of Pharmaceutical Sciences Soochow UniversitySuzhou 215123China Center of Smart Laboratory and Molecular Medicine School of MedicineChongqing UniversityChongqing 400044China College of Life Science and Laboratory Medicine Kunming Medical UniversityKunming 650050China

Traditional photosensitizers show limited singlet oxygen generation in hypoxic infection lesions,which greatly suppress their performance in antibacterial ***,there still is lack of feasible design strategy for developing hypoxia-overcoming photosensitizers ***,radical generation ofπ-conjugated small molecules is efficiently manipulated by an individual selenium(Se)*** this strategy,the first proof-of-concept study of a Se-anchored oligo(thienyl ethynylene)(OT-Se)with high-performance superoxide radical(O_(2)^(·-))and hydroxyl radical(·OH)generation capability is present,and achieves efficient antibacterial activities towards the clinically extracted multidrug-resistant bacteria methicillin-resistant ***(MRSA)and carbapenem-resistant ***(CREC)at sub-micromolar concentration under a low white light irradiation(30 mW/cm^(2)).The water-dispersible OT-Se shows a good bacteria-anchoring capability,biocompatibility,and complete elimination of multidrug-resistant bacteria wound infection in *** work offers a strategy to boost type-I photodynamic therapy(PDT)performance for efficient antibacterial treatments,advancing the development of antibacterial agents.

关键词： Photodynamic therapy Antibacterial Type-Ⅰphotosensitizers Multidrug-resistant bacteria Conjugated oligomers

An alfalfa MYB-like transcriptional factor MsMYBH positively regulates alfalfa seedling drought resistance and undergoes MsWAV3-mediated degradation

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Journal of Integrative Plant Biology 2024年第4期66卷 683-699页

作者： Kun Shi Jia Liu Huan Liang Hongbin Dong Jinli Zhang Yuanhong Wei Le Zhou Shaopeng Wang Jiahao Zhu Mingshu Cao Chris S.Jones Dongmei Ma zan Wang College of Grassland Science and Technology China Agricultural UniversityBeijing 100193China Institute of Animal Sciences Chinese Academy of Agricultural SciencesBeijing 100193China AgResearch Grasslands Research Centre Palmerston North 4442New Zealand International Livestock Research Institute Nairobi 00100Kenya School of Ecology and Environment Ningxia UniversityYinchuan 750021China

Drought is a major threat to alfalfa(Medicago sativa L.)*** discovery of important alfalfa genes regulating drought response will facilitate breeding for drought-resistant alfalfa ***,we report a genome-wide association study of drought resistance in *** identified and functionally characterized an MYB-like transcription factor gene(MsMYBH),which increases the drought resistance in *** with the wild-types,the biomass and forage quality were enhanced in MsMYBH overexpressed *** RNA-seq,proteomics and chromatin immunoprecipitation analysis showed that MsMYBH can directly bind to the promoters of MsMCP1,MsMCP2,MsPRX1A and MsCARCAB to improve their *** outcomes of such interactions include better water balance,high photosynthetic efficiency and scavenge excess H_(2)O_(2)in response to ***,an E3 ubiquitin ligase(MsWAV3)was found to induce MsMYBH degradation under long-term drought,via the 26S proteasome ***,variable-number tandem repeats in MsMYBH promoter were characterized among a collection of germplasms,and the variation is associated with promoter ***,our findings shed light on the functions of MsMYBH and provide a pivotal gene that could be leveraged for breeding drought-resistant *** discovery also offers new insights into the mechanisms of drought resistance in alfalfa.

关键词： alfalfa drought resistance E3 ubiquitin ligase MsMYBH MsWAV3 MYB-like transcriptional factor