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Inhibitory Effect of the Extract of Phellodendron amurense Ruprecht Root on Collagen-Induced Arthritis in Mice

Chinese Journal of Integrative Medicine 2017年第10期23卷 755-762页

作者： Hyo Won Jung Kyung-ho Kim yong-Ki park Department of Herbology College of Korean Medicine Dongguk University Gyeongju (740-814) Republic of Korea Korean Medicine Research and Development Center Dongguk University Gyeongju (740-814) Republic of Korea Department of Acupuncture College of Korean Medicine Dongguk University Gyeongju (740-814) Republic of Korea

Objective： To investigate whether the dried root of Phellodendron amurense Ruprecht（Phellodendri cortex; PC） extract improves arthritic symptoms through anti-inflammatory and immune-modulatory effects in collagen-induced arthritis in mice. Methods： Rheumatoid arthritis（RA） was induced in male DBA/1 mice by immunization with type Ⅱ collagen（ColⅡ）. CIA mice were divided into 5 groups（n=10 per a group） with normal, CIA control, PC extract（50 mg/kg and 100 mg/kg）-treated, and meloxicam（50 mg/kg）-treated as the reference drug. The PC extract or meloxicam were administered orally in CIA mice once a day for 14 days after arthritis induction. Arthritic score, levels of anti-ColⅡ IgG2a antibody, prostaglandin E2（PGE2）, tumor necrosis factor（TNF）-α, and interleukin（IL）-17 in the sera of CIA mice were measured. Histopathological changes in the ankle joints of CIA mice were also analyzed by staining with hematoxylin and eosin（H and E）, safranin-O and immunohistochemistry using anti-TNF-α and anti-IL-17 antibodies. Results： The arthritic score was increased in CIA mice in a time-dependent manner, as were the serum levels of anti-ColⅡ IgG2a antibody, PGE2, TNF-α, and IL-17. however, the oral administration of PC extract at 50 and 100 mg/kg in CIA mice significantly decreased the arthritic scores, and the serum levels of anti-ColⅡ IgG2a, PGE2, TNF-α, and IL-17 compared with those in the CIA group（P〈0.05 or P〈0.01）. Furthermore, histopathological improvement of the joint architecture in CIA mice was observed after administration of PC extract. PC extract also significantly inhibited the expression of TNF-α and IL-17 in the joints of CIA mice by suppressing the expression of their m RNA and proteins. Conclusion： PC extract may improve the pathological progression of RA through the inhibition of joint destruction by synovial inflammation and immune-stimulation, therefore, it would be a potential anti-arthritic agent in RA.

关键词： Phellodendron amurense Phellodendri cortex collagen-induced arthritis anti-arthritic effect

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Predicting tumor response after preoperative chemoradiation using clinical parameters in rectal cancer

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World Journal of Gastroenterology 2011年第48期17卷 5310-5316页

作者： Chan ho park Hee Cheol Kim yong Beom Cho Seong Hyeon Yun Woo yong Lee Young Suk park Doo ho Choi ho-Kyung Chun Departmentof Surgery Samsung Medical Center Sungkyunkwan Univer-sity School of Medicine Irwon-dong 50 Gangnam-gu Seoul135-710 South Korea Division of Hematology-Oncology Depart-ment of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Irwon-dong 50 Gangnam-guSeoul 135-710 South Korea Department of Radiation Oncology SamsungMedical Center Sungkyunkwan University School of MedicineIrwon-dong 50 Gangnam-gu Seoul 135-710 South Korea

AIM: To evaluate the clinical parameters and identify a better method of predicting pathological complete response (pCR). METhoDS: We enrolled 249 patients from a database of 544 consecutive rectal cancer patients who underwent surgical resection after preoperative chemoradiation therapy (PCRT). A retrospective review of morphological characteristics was then performed to collect data regarding rectal examination findings. A scoring model to predict pCR was then created. To validate the ability of the scoring model to predict complete ***: Seventy patients (12.9%) achieved a pCR. A multivariate analysis found that pre-CRT movability (P = 0.024), post-CRT size (P = 0.018), post-CRT morphology (P = 0.023), and gross change (P = 0.009) were independent predictors of pCR. The accuracy of the scoring model was 76.8% for predicting pCR with the threshold set at 4.5. In the validation set, the accuracy was 86.7%. CONCLUSION: Gross changes and morphological findings are important predictors of pathological response. Accordingly, PCRT response is best predicted by a combination of clinical, laboratory and metabolic information.

关键词： Rectal cancer Preoperative chemoradiotherapy Downstaging Tumor regression Validation

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Retrieval of Outgoing Longwave Radiation from COMS Narrowband Infrared Imagery

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Advances in Atmospheric Sciences 2015年第3期32卷 375-388页

作者： Myung-Sook park Chang-hoi ho Heeje Cho yong-Sang ChoI School of Earth and Environmental Sciences Seoul National UniversitySeoul Korea School of Urban and Environmental Engineering Ulsan National Institute of Science & TechnologyUlsan Korea Computational Science and Technology Seoul National UniversitySeoul Korea Computational Science and Technology Seoul National UniversitySeoul Korea Department of Environmental Science and Engineering Ewha Womans UniversitySeoul Korea

hourly outgoing longwave radiation （OLR） from the geostationary satellite Communication Oceanography Meteorological Satellite （COMS） has been retrieved since June *** COMS OLR retrieval algorithms are based on regression analyses of radiative transfer simulations for spectral functions of COMS infrared *** study documents the accuracies of OLRs for future climate applications by making an intercomparison of four OLRs from one single-channel algorithm （OLR12.0 using the 12.0 μm channel） and three multiple-channel algorithms （OLR10.8＋12.0 using the 10.8 and 12.0 pm channels; OLR6.7＋10.8 using the 6.7 and 10.8 μm channels; and OLRAll using the 6.7,10.8,and 12.0 μm channels）.The COMS OLRs from these algorithms were validated with direct measurements of OLR from a broadband radiometer of the Clouds and Earth＇s Radiant Energy System （CERES） over the full COMS field of view [roughly （50°S-50°N,70°-170°E）] during April *** results show that the root-mean-square errors of COMS OLRs are 5-7 W m-2,which indicates good agreement with CERES OLR over the vast ***6.7＋10.8 and OLRAll have much smaller errors （～ 6 W m-2） than OLR12.0 and OLR10.8＋12.0 （～ 8 W m-2）.Moreover,the small errors of OLR6.7＋10.8 and OLRAll are systematic and can be readily reduced through additional mean bias correction and/or radiance *** results indicate a noteworthy role of the 6.7 μm water vapor absorption channel in improving the accuracy of the *** dependence of the accuracy of COMS OLRs on various surface,atmospheric,and observational conditions is also discussed.

关键词： outgoing longwave radiation Communication Oceanography and Meteorological Satellite Cloud and Earth's Radiant Energy System

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Optimization of an Artificial Intelligence Database and Camera Installation for Recognition of Risky Passenger Behavior in Railway Vehicles

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Computers, Materials & Continua 2025年第1期82卷 1277-1293页

作者： Min-kyeong Kim Yeong Geol Lee Won-Hee park Su-hwan Yun Tae-Soon Kwon Duckhee Lee Railroad Test&Certification Division Korea Railroad Research Institute(KRRI)Cheoldo BangmulgwanroUiwang-si16105Republic of Korea Railroad Safety Division Korea Railroad Research Institute(KRRI)Cheoldo BangmulgwanroUiwang-si16105Republic of Korea

Urban railways are vital means of public transportation in *** than 30%of metropolitan residents use the railways,and this proportion is expected to *** enhance safety,the government has mandated the installation of closed-circuit televisions in all carriages by ***,cameras still monitored *** address this limitation,we developed a dataset of risk factors and a smart detection system that enables an immediate response to any abnormal behavior and intensive monitoring *** created an innovative learning dataset that takes into account seven unique risk factors specific to Korean railway *** data collection was conducted across the Shinbundang Line of the Incheon Transportation Corporation,and the Ui-Shinseol *** observed several behavioral characteristics and assigned unique annotations to *** also considered carriage *** performance was evaluated by camera placement and *** the camera installation plan was *** dataset will find immediate applications in domestic railway *** artificial intelligence algorithms will be verified shortly.

关键词： AI railway vehicle risk factor smart detection AI training data

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Role of transcription factor acetylation n the regulation of metabolic homeostasis

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Protein & Cell 2015年第11期6卷 804-813页

作者： Joo-Man park Seong-ho Jo Mi-Young Kim Tae-Hyun Kim yong-ho Ahn Department of Biochemistry and Molecular Biology Yonsei University College of Medicine 50-1 Yonsei-ro Seodaemun-gu Seoul 120-752 Republic of Korea Brain Korea 21 PLUS Project for Medical Sciences Yonsei University College of Medicine 50-1 Yonsei-ro Seodaemun-gu Seoul 120-752 Republic of Korea

Post-translational modifications （PTMs） of transcription factors play a crucial role in regulating metabolic homeostasis. These modifications include phosphory- lation, methylation, acetylation, ubiqulUnation, SUMOy- lation, and O-GIcNAcylation. Recent studies have shed light on the importance of lysine acetylation at nonhis- tone proteins including transcription factors. Acetyla- tion of transcription factors affects subcellular distribution, DNA affinity, stability, transcriptional activity, and current investigations are aiming to further expand our understanding of the role of lysine acetyla- tion of transcription factors. In this review, we summarize recent studies that provide new insights into the role of protein lysine-acetylation in the transcriptional regulation of metabolic homeostasis.

关键词： metabolic homeostasis transcriptionfactor post-translational modification type 2 diabetesmellitus

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Acute phlegmonous gastritis complicated by delayed perforation

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World Journal of Gastroenterology 2014年第12期20卷 3383-3387页

作者： Sun Young Min yong ho Kim Won Seo park Department of Surgery Kyung Hee University School of Medicine Seoul 130-701 South Korea

Here, we report on a case of acute phlegmonous gastritis (PG) complicated by delayed perforation. A 51-year-old woman presented with severe abdominal pain and septic shock symptoms. A computed tomography scan showed diffuse thickening of the gastric wall and distention with peritoneal fluid. Although we did not find definite evidence of free air on the computed tomography (CT) scan, the patient’s clinical condition suggested diffuse peritonitis requiring surgical intervention. Exploratory laparotomy revealed a thickened gastric wall with suppurative intraperitoneal fluid in which Streptococcus pyogenes grew. There was no evidence of gastric or duodenal perforation. No further operation was performed at that time. The patient was conservatively treated with antibiotics and proton pump inhibitor, and her condition improved. however, she experienced abdominal and flank pain again on postoperative day 10. CT and esophagogastroduodenoscopy showed a large gastric ulcer with perforation. Unfortunately, although the CT showed further improvement in the thickening of the stomach and the mucosal defect, the patient’s condition did not recover until a week later, and an esophagogastroduodenoscopy taken on postoperative day 30 showed suspected gastric submucosal dissection. We performed total gastrectomy as a second operation, and the patient recovered without major complications. A pathological examination revealed a multifocal ulceration and necrosis from the mucosa to the serosa with perforation.

关键词： Phlegmonous gastritis Gastric perforation Streptococcus pyogenes

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Optical Gain Analysis of Graded InGaN/GaN Quantum-Well Lasers

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Chinese Physics Letters 2011年第7期28卷 319-322页

作者： Seoung-Hwan park yong-Tae Moon Jeong Sik Lee ho Ki Kwon Joong Seo park Doyeol Ahn Department of Electronics Engineering Catholic University of DaeguHayangKyeongsanKyeongbuk 712-702Republic of Korea SLED R&D Center LG Innotek16 Woomyeon-dongSeocho-guSeoul 137-140Republic of Korea Department of Electrical and Computer Engineering University of SeoulSeoul 130-743Republic of Korea

Optical properties of graded InGaN/GaN quantum well(QW)lasers are analyzed as improved gain media for laser diodes emitting near 500 *** results are compared with those of conventional InGaN/GaN QW *** heavy-hole effective mass around the topmost valence band is found to nearly not be affected by the inclusion of the graded *** graded InGaN/GaN QW structure shows a much larger matrix element than the conventional InGaN/GaN QW *** radiative current density dependences of the optical gain are similar to each ***,the graded QW structure is expected to have lower threshold current density than the conventional QW structure because the former has a lower threshold carrier density than the latter.

关键词： InGaN/GaN graded Lasers

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Exploring the genetic basis of pre-harvest sprouting in rice through a genome-wide association study-based haplotype analysis

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Journal of Integrative Agriculture 2024年第8期23卷 2525-2540页

作者： Myeong-Hyeon Min Aye Aye Khaing Sang-ho Chu Bhagwat Nawade yong-Jin park Department of Plant Resources College of Industrial SciencesKongju National UniversityYesan 32439Republic of Korea Department of Agronomy Yezin Agricultural UniversityNay Pyi Taw 15013Myanmar

Pre-harvest sprouting(PHS)poses a significant global challenge to cereal production,impacting both yield and *** this study,we employed genome-wide association studies(GWAS)on diverse rice accessions to identify novel PHS-associated *** assessment of 127 cultivated accessions for panicle germination(PHS)and detached grain germination(germination rate of detached grains at the 14th day(D14))revealed considerable phenotypic variation among rice *** analysis identified 91 significant signals at–log10(P-value)>5,including 15SNPs for PHS and 76 SNPs for D14.A subsequent linkage disequilibrium(LD)block-based GWAS analysis detected 227 significant SNPs for both traits,consisting of 18 nonsynonymous substitutions located on the coding regions of nine *** haplotype analysis identified 32 haplotypes,with 10 specific to cultivated accessions,19 specific to the wild type,and three shared between them.A phenotypic assessment of major haplotypes revealed significant differences between resistant(Hap1 and Hap2)and susceptible haplotypes(Hap5,Hap27,and Hap28),distinguished by a G/A SNP within a novel gene,*** identified haplotypes offer promising prospects for haplotypebased breeding aimed at enhancing PHS resistance in rice.

关键词： rice PHS dormancy germination GWAS haplotype abiotic stress

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Multidimensional Hybrid Architecture Encapsulating Cobalt Oxide Nanoparticles into Carbon Nanotube Branched Nitrogen-Doped Reduced Graphene Oxide Networks for Lithium–Sulfur Batteries

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Energy & Environmental Materials 2022年第2期5卷 555-564页

作者： Jeong Seok Yeon Young Hun Ko Tae ho park Hyunyoung park Jongsoon Kim ho Seok park School of Chemical Engineering College of EngineeringSungkyunkwan University2066Seobu-roJangan-guSuwon-si Gyeonggi-do 440-746Korea Advanced Batteries Research Center Korea Electronics Technology Institute25Saenari-roBundang-guSeongnam-si Gyeonggi-do 13509Korea Department of Energy Science Sungkyunkwan University2066Seobu-roJangan-guSuwon-si Gyeonggi-do 440-746Korea Department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences and Technology(SAIHST)Sungkyunkwan University2066SeoburoJangan-guSuwon 440-746South Korea

Lithium–sulfur batteries(LSBs)are regarded as promising candidates for the next-generation energy storage devices owing to their high-theoretical capacity(1675 mAh g^(−1))and affordable ***,several limitations of LSBs such as the lithium polysulfide shuttle,large volume expansion,and low electrical conductivity of sulfur need to be resolved for practical *** address these limitations,herein,a multidimensional architectured hybrid(Co@CNT/nG),where Co_(3)O_(4) nanoparticles are encapsulated into threedimensional(3D)porous N-doped reduced graphene oxide interconnected with carbon nanotube(CNT)branches,is synthesized through a simple pyrolysis *** synergistic effect achieved through the homogeneously distributed and encapsulated Co_(3)O_(4) nanoparticles,the interconnected CNT branches,and the 3D hierarchical porous structure and N-doping of Co@CNT/nG significantly suppresses the shuttle effect of lithium polysulfides and enhances the conversion redox kinetics for the improved sulfur *** validate this effect through various measurements including symmetric cells,Li_(2)S nucleation,shuttle currents,Tafel slopes,diffusion coefficients,and post-mortem ***,Co@CNT/nG-70S-based LSB cells achieve a high-specific capacity of 1193.1 mAh g^(−1) at 0.1 C and a low capacity decay rate of 0.030%per cycle for 700 cycles at 5 C,delivering a high areal capacity of 5.62 mAh cm^(−2) even with a loading of 6.5 mg cm^(−2).

关键词： graphene/CNT hybrid lithium-sulfur batteries multidimensional architecture nanoparticle encapsulation redox promoter

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Highly flexible and transparent conducting silver nanowire/ZnO composite film for organic solar cells

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Nano Research 2014年第9期7卷 1370-1379页

作者： Myungkwan Song Jong Hyun park Chang Su Kim Dong-ho Kim yong-Cheol Kang Sung-ho Jin Won-yong Jin Jae-Wook Kang Surface Technology Division Korea Institute of Materials Science Changwon 641-831 Republic of Korea OLED Development Group LG Display Co. Ltd. Gyeonggi-do 413-811 Republic of Korea Department of Chemistry Pukyong National University 45 Yongso-ro Nam-Gu Busan 608-737 Republic of Korea Department of Chemistry Education Graduate Department of Chemical Materials and Institute for Plastic Information and Energy Materials Pusan National University Busan 609-735 Republic of Korea The Graduate School of Flexible and Printable Electronics Polymer Materials Fusion Research Center Chonbuk National University Jeonju 561-756 Republic of Korea

High efficiency and flexible inverted organic solar cells have been fabricated using solution-processed silver nanowire/zinc oxide composite transparent electrodes. The transparent electrodes showed a low sheet resistance of -13 ff）.sq-1 and high transmittance of -93% as well as superior mechanical flexibility. Power conversion efficiencies of -7.57% and -7.21% were achieved for devices fabricated on glass and plastic substrate, respectively. Moreover, the flexible devices did not show any degradation in their performance even after being folded with a radius of-480 μm.

关键词： silver nanowire flexible transparent conductingelectrode inverted organic solar cell

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