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Association between metabolic syndrome and agerelated cataract

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International Journal of Ophthalmology(English edition) 2015年第4期8卷 804-811页

作者： Sangshin Park Eun-hee lee Center for International Health Research Rhode Island Hospital The Warren Alpert Medical School of Brown University Department of Visual Optics and Graduate School of Health Science Far East University

·AIM: To determine the effect of metabolic syndrome on age-related cataract formation.·METHODS: We analyzed data for 2852 subjects [41.8%men and 58.2% women; mean(±SD) age, 52.9 ±13.9y],taken from the Korea National Health and Nutrition Examination Survey 2008. Metabolic syndrome was diagnosed by criteria proposed by the Joint Interim Societies. Cataract was diagnosed by using the Lens Opacities Classification System III. The association between metabolic syndrome and cataract was determined using age-adjusted and multivariable logistic regression analyses.· RESULTS: In multivariable analyses, men with metabolic syndrome had a 64% increased risk of nuclear cataract [odds ratio(OR), 1.64; 95% confidence interval(CI), 1.12-2.39]. Women with metabolic syndrome had a56% increased risk of cortical cataract(OR, 1.56; 95% CI,1.06-2.30). Men and women with metabolic syndrome had a 46%(OR, 1.46; 95% CI, 1.01-2.12) and 49%(OR,1.49; 95% CI, 1.07-2.08) increased risk of any cataract,respectively. The prevalence of nuclear and any cataract significantly increased with an increasing number of disturbed metabolic components in men, and prevalence of all types of cataracts increased in women. Men using hypoglycemic medication had an increased risk of nuclear(OR, 2.62; 95% CI, 1.41-4.86) and any(OR, 2.27;95% CI, 1.14-4.51) cataract, and women using antidyslipidemia medication had an increased risk of cortical(OR, 2.18; 95% CI, 1.12-4.24) and any(OR, 2.21;95% CI, 1.14-4.26) cataract.·CONCLUSION: Metabolic syndrome and its components,such as abdominal obesity, high blood pressure, andimpaired fasting glucose, are associated with age-related cataract formation in the Korean population.

关键词： cataract metabolic syndrome obesity diabetes mellitus hypertension

A case of gouty arthritis following percutaneous radiofrequency ablation for hepatocellular carcinoma

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World Journal of Gastroenterology 2010年第6期16卷 778-781页

作者： Dae hee Choi Hyo-Suk lee Department of Internal Medicine Kangwon National University College of Medicine Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine

Percutaneous radiofrequency thermal ablation(RFA) is considered an effective technique for providing local control in the majority of Hepatocellular carcinoma(HCC) *** RFA is generally well tolerated,recent studies have reported complications associated with *** describe a case of acute gouty arthritis in a 71-year-old man with chronic renal failure who was treated with RFA for a HCC lesion and who had hepatitis B-associated cirrhosis and mild renal *** surveillance of the patient detected a 3.5 cm HCC *** the patient had declined surgery,RFA was chosen for *** the third post-procedural day,the laboratory results showed increases in his uric acid and potassium levels,which were compatible with a tumor lysis syndrome. On the 6th post-procedural day,the patient complained of new right knee *** joint aspiration revealed monosodium urate monohydrate *** made the diagnosis of acute gouty arthritis arising from tumor lysis and liver infarction caused by HCC ablation,which was aggravated by acute renal insufficiency. After adequate hydration and administration of oral colchicines,the patient's right knee pain subsided andthe uric acid serum level returned to *** is the first described case of acute gouty arthritis after RFA for a HCC lesion in a patient with underlying chronic renal *** avoid hyperuricemia and an acute attack of gout after RFA therapy for HCC,early identification of patients at risk is warranted,such as those with a large tumor,rapid tumor growth,and renal insufficiency,and preventative measures should be considered.

关键词： Radiofrequency thermal ablation Hepatocellular carcinoma Gout Tumor lysis syndrome Complications

Predicting tumor response after preoperative chemoradiation using clinical parameters in rectal cancer

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World Journal of Gastroenterology 2011年第48期17卷 5310-5316页

作者： Chan Ho Park hee Cheol Kim yong Beom Cho Seong Hyeon Yun Woo yong lee Young Suk Park Doo Ho Choi Ho-Kyung Chun Departmentof Surgery Samsung Medical Center Sungkyunkwan Univer-sity School of Medicine Irwon-dong 50 Gangnam-gu Seoul135-710 South Korea Division of Hematology-Oncology Depart-ment of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Irwon-dong 50 Gangnam-guSeoul 135-710 South Korea Department of Radiation Oncology SamsungMedical Center Sungkyunkwan University School of MedicineIrwon-dong 50 Gangnam-gu Seoul 135-710 South Korea

AIM: To evaluate the clinical parameters and identify a better method of predicting pathological complete response (pCR). METHODS: We enrolled 249 patients from a database of 544 consecutive rectal cancer patients who underwent surgical resection after preoperative chemoradiation therapy (PCRT). A retrospective review of morphological characteristics was then performed to collect data regarding rectal examination findings. A scoring model to predict pCR was then created. To validate the ability of the scoring model to predict complete ***: Seventy patients (12.9%) achieved a pCR. A multivariate analysis found that pre-CRT movability (P = 0.024), post-CRT size (P = 0.018), post-CRT morphology (P = 0.023), and gross change (P = 0.009) were independent predictors of pCR. The accuracy of the scoring model was 76.8% for predicting pCR with the threshold set at 4.5. In the validation set, the accuracy was 86.7%. CONCLUSION: Gross changes and morphological findings are important predictors of pathological response. Accordingly, PCRT response is best predicted by a combination of clinical, laboratory and metabolic information.

关键词： Rectal cancer Preoperative chemoradiotherapy Downstaging Tumor regression Validation

A paintable and adhesive hydrogel cardiac patch with sustained release of ANGPTL4 for infarcted heart repair

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Bioactive Materials 2024年第1期31卷 395-407页

作者： Mingyu lee yong Sook Kim Junggeon Park Goeun Choe Sanghun lee Bo Gyeong Kang Ju hee Jun Yoonmin Shin Minchul Kim Youngkeun Ahn Jae Young lee School of Materials Science and Engineering Gwangju Institute of Science and TechnologyGwangju61005Republic of Korea Cell Regeneration Research Center Chonnam National UniversityGwangjuRepublic of Korea Biomedical Research Institute Chonnam National University HospitalGwangjuRepublic of Korea Department of Cardiology Chonnam National University HospitalGwangjuRepublic of Korea Chonnam National University Medical School GwangjuRepublic of Korea

The infarcted heart undergoes irreversible pathological remodeling after reperfusion involving left ventricle dilation and excessive inflammatory reactions in the infarcted heart,frequently leading to fatal functional *** attempts have been made to attenuate pathological remodeling in infarcted hearts using cardiac patches and anti-inflammatory drug *** this study,we developed a paintable and adhesive hydrogel patch using dextran-aldehyde(dex-ald)and gelatin,incorporating the anti-inflammatory protein,ANGPTL4,into the hydrogel for sustained release directly to the infarcted heart to alleviate *** optimized the material composition,including polymer concentration and molecular weight,to achieve a paintable,adhesive hydrogel using 10%gelatin and 5%dex-ald,which displayed in-situ gel formation within 135 s,cardiac tissue-like modulus(40.5 kPa),suitable tissue adhesiveness(4.3 kPa),and excellent mechanical ***4 was continuously released from the gelatin/dex-ald hydrogel without substantial burst *** gelatin/dex-ald hydrogel could be conveniently painted onto the beating heart and degraded in ***,in vivo studies using animal models of acute myocardial infarction revealed that our hydrogel cardiac patch containing ANGPTL4 significantly improved heart tissue repair,evaluated by echocardiography and histological *** heart tissues treated with ANGPTL4-loaded hydrogel patches exhibited increased vascularization,reduced inflammatory macrophages,and structural maturation of cardiac *** novel hydrogel system,which allows for facile paintability,appropriate tissue adhesiveness,and sustained release of anti-inflammatory drugs,will serve as an effective platform for the repair of various tissues,including heart,muscle,and cartilage.

关键词： Cardiac patch Hydrogel Angiopoietin-like 4 Myocardial infarction

Potholeeye^(+): Deep-Learning Based Pavement Distress Detection System toward Smart Maintenance

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Computer Modeling in Engineering & Sciences 2021年第6期127卷 965-976页

作者： Juyoung Park Jung hee lee Junseong Bang Korea Expressway Corporation 77Hyeoksin8-roGimcheon-siKorea Electronics and Telecommunications Research Institute(ETRI) 218 Gajeong-roYuseong-guDaejun-siKorea University of Science&Technology(UST) 217 Gajeong-roYuseong-guDaejun-siKorea

We propose a mobile system,called Potholeeye+,for automatically monitoring the surface of a roadway and detecting the pavement distress in real-time through analysis of a ***+pre-processes the images,extracts features,and classifies the distress into a variety of types,while the road manager is *** day for a year,we have tested Potholeeye+on real highway involving real settings,a camera,a mini computer,a GPS receiver,and so ***,Potholeeye+detected the pavement distress with accuracy of 92%,precision of 87%and recall 74%averagely during driving at an average speed of 110 km/h on a real highway.

关键词： Pavement distress detection classification convolutional neural network deep learning video analysis

Asymptotic Results for Random Processes

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Acta Mathematicae Applicatae Sinica 2017年第2期33卷 363-372页

作者： hee-JIN MOON CHANG-HO HAN yong-KAB CHOI Department of Mathematics and RINS Gyeongsang National University Jinju 660-701 South Korea

In this paper we establish asymptotic results and a generalized uniform law of the iterated logarithm （LIL） for the increments of a strictly stationary random process, whose results are proved by separating linearly positive quadrant dependent （LPQD） random process and linearly negative quadrant dependent （LNQD） one, respectively.

关键词： quadrant dependence stationary random process law of the iterated logarithm

Groundwater contamination and natural attenuation capacity at a petroleum spilled facility in Korea

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Journal of Environmental Sciences 2011年第10期23卷 1650-1659页

作者： Hyun-Mi Choi Jin-yong lee Department of Geology Kangwon National University

As a remedial option, the natural attenuation capacity of a petroleum contaminated groundwater at a military facility was examined. Hydrogeological conditions, such as high water level, permeable uppermost layer and frequent heavy rainfall, were favorable to natural attenuation at this site. The changes in the concentrations of electron acceptors and donors, as well as the relevant hydrochemical conditions, indicated the occurrence of aerobic respiration, denitrification, iron reduction, manganese reduction and sulfate reduction. The calculated BTEX expressed biodegradation capacity ranged between 20.52 and 33.67 mg/L, which appeared effective for the reduction of the contaminants levels. The contribution of each electron accepting process to the total biodegradation was in the order： denitrification 〉 iron reduction 〉 sulfate reduction 〉 aerobic respiration 〉 manganese reduction. The BTEX and benzene point attenuation rates were 0.0058-0.0064 and 0.0005-0.0032 day-1, respectively, and the remediation time was 0.7-1.2 and 2.5-30 years, respectively. The BTEX and benzene bulk attenuation rates were 8.69 × 10^-4 and 1.05 × 10^-3 day-l, respectively, and the remediation times for BTEX and benzene were 7.2 and 17.5 years, respectively. However, most of the natural attenuation occurring in this site can be attributed to dilution and dispersion. Consequently, the biodegradation and natural attenuation capacities were good enough to lower the contaminants levels, but their rates appeared to be insufficient to reach the remediation goal within a reasonable time frame. Therefore, some active remedial measures would be required.

关键词： petroleum contaminated site BTEX electron acceptor expressed biodegradation capacity natural attenuation

Thin film processing and multiferroic properties of Fe-BaTiO_3 hybrid composite

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 92-95页

作者： Pan YANG Jin-song ZHU Jai-Yeoul lee hee Young lee School of Materials Science and Engineering Yeungnam University Gyeongsan 712-749 Korea National Laboratory of Solid State Microstructures Department of Physics Nanjing University Nanjing 210093 China

Multiferroic bi-layer Fe/BaTiO3 （BTO） thin films were successfully deposited on Pt（200）/MgO（100） substrates using ion beam sputter deposition （1BSD）, and the mutiferroic properties were studied at room temperature. X-ray diffraction （XRD） analyses showed that BTO films were c-axis oriented and epitaxially grown on platinum coated MgO substrates, and （110） epitaxial Fe films were subsequently grown on （001） BTO films. Fe/BTO bi-layer films showed good ferroelectric and ferromagnetic properties at room temperature and the multiferroic coupling was observed, which should be attributed to the hybridization of Fe and Ti occurring at the ferromagnetic-ferroelectric interface.

关键词： multiferroic effect ferroelectricity magnetic properties magnetoelectric effect

Emotional inference by means of Choquet integral and λ-fuzzy measurement in consideration of ambiguity of human mentality

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Journal of Central South University 2016年第1期23卷 160-168页

作者： KWON Il-kyoung lee Sang-yong Division of Computer Science & Engineering Kongju National University Department of Computer Science & Engineering Kongju National University

Research on human emotions has started to address psychological aspects of human nature and has advanced to the point of designing various models that represent them quantitatively and systematically. Based on the findings, a method is suggested for emotional space formation and emotional inference that enhance the quality and maximize the reality of emotion-based personalized services. In consideration of the subjective tendencies of individuals, AHP was adopted for the quantitative evaluation of human emotions, based on which an emotional space remodeling method is suggested in reference to the emotional model of Thayer and Plutchik, which takes into account personal emotions. In addition, Sugeno fuzzy inference, fuzzy measures, and Choquet integral were adopted for emotional inference in the remodeled personalized emotional space model. Its performance was evaluated through an experiment. Fourteen cases were analyzed with 4.0 and higher evaluation value of emotions inferred, for the evaluation of emotional similarity, through the case studies of 17 kinds of emotional inference methods. Matching results per inference method in ten cases accounting for 71% are confirmed. It is also found that the remaining two cases are inferred as adjoining emotion in the same section. In this manner, the similarity of inference results is verified.

关键词： fuzzy measure fuzzy integral emotional model emotion space AHP fuzzy inference system Choquet integral