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Association between baseline platelet count and severe adverse outcomes following percutaneous coronary intervention

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Journal of Geriatric Cardiology 2018年第5期15卷 346-355页

作者： Wan-Jun CheNG Shi-Wei YANG Fei GAO yong-he guo Zhi-Jian WANG Yu-Jie ZHOU Beijing Anzhen Hospital Affiliated to Capital Medical University Beijing lnstitute of Heart Lung and Blood Vessel Disease The Key Laboratory of Remodel- ing-related Cardiovascular Disease Ministry of Education Beijing China

Objective The aim is to evaluate the association between baseline platelet count （PC） and severe adverse outcomes following percu- taneous coronary intervention （PCI） in current real-world practice. Methods A total of 18,788 patients underwent PCI with drug-eluting stents constituted the study population. Patients were categorized as having low （〈 150 × 1000μ.L）, normal （150-300 × 1000μL）, and high （≥ 300 × 1000μL） baseline PC. The primary endpoints included in-hospital and follow-up all-cause mortality. The secondary endpoint was major bleeding requiring a blood transfusion. Results In-hospital mortality rates for patients with low, normal, and high baseline PC were 0.6%, 0.4%, and 0.4%, respectively （P = 0.259）. Similarly, mortality rates during long-term follow-up （median 23.8 months） for patients with low, normal, and high baseline PC were 0.9%, 0.6%, and 0.7%, respectively （P = 0.079）. After multivariate adjustment, patients with low or high baseline PC tended to have similar risks for both in-hospital and follow-up mortality compared with the normal group. Subgroup analyses failed to demonstrate an independent prognostic value of baseline PC in specific population groups except patients who undwent transfemoral PCI. There was also no significant difference in the incidence of major bleeding requiring a blood transfusion in the low, normal, and high groups （0.5%, 0.3%, and 0.3%, respectively; P = 0.320）. After multivariate adjustment, low or high baseline PC did not signi- ficantly increase the risk of major bleeding. Conclusion There is no significant association between baseline PC and severe adverse out- comes following PCI in current real-world practice.

关键词： Major bleeding Mortality Percutaneous coronary intervention Platelet count

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Recent progress on impact induced reaction mechanism of reactive alloys

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Defence Technology（防务技术） 2024年第7期37卷 69-95页

作者： Yansong Yang Chuanting Wang Yuanpei Meng Yue Ma Lei guo Yuan he Zhichao Sun yong he School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210094JiangsuChina

In recent years,in order to improve the destructive effectiveness of munitions,the use of new types of destructive elements is an important way to improve destructive *** a new type of reactive material,reactive alloy contains a large portion of reactive metal elements(Al,Mg,Ti,Zr,etc.),which breaks up under high-velocity impact conditions,generating a large number of high-temperature combustible fragments,which undergo a violent combustion reaction with *** with traditional metal polymers(Al-PTFE)and other reactive composites,it has higher density and strength,excellent mechanical properties and broader application ***,researchers have mainly investigated the impact energy release mechanism of reactive alloys through impact tests,and found that there are several important stages in the process of the material from fragmentation to reaction,i.e.,impact fragmentation of the material,rapid heating and combustion *** paper focuses on three problems that need to be solved in the impact-induced energy release process of reactive alloys,namely:the fragmentation mechanism and size distribution law of the fragments produced by the impact of the material on the target,the relationship between the transient temperatures and the size of the fragments,and the reaction temperatures and size thresholds of the fragments to undergo the chemical *** current status of the research of the above problems is reviewed,some potential directions to reveal the impact induced reaction mechanism of reactive alloy is discussed.

关键词： Reactive alloys Impact Fragmentation Mass and size distribution Shock temperature rise Adiabatic shear Combustion

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First-in-human evaluation of an independently developed Chinese robot-assisted system for percutaneous coronary intervention

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Journal of Geriatric Cardiology 2022年第10期19卷 743-752页

作者： Guang-Yao ZHAI Zheng CheN Rui-Fang LIU yong-he guo Jian-Long WANG Tie-Nan SUN Jing XIE Tao HUANG Yu-Jie ZHOU Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of Heart Lung and Blood Vessel DiseaseBeijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic DiseaseClinical Center for Coronary Heart DiseaseCapital Medical UniversityBeijingChina Beijing WeMed Medical Equipment Co. Ltd.BeijingChina

BACKGROUND Several studies have proved the safety and feasibility of robot-assisted percutaneous coronary intervention(PCI)in reducing the occupational hazards of interventionists while achieving precision ***,an independently developed robot-assisted system for PCI in China has not yet *** study aimed to evaluate the safety and feasibility of a robot-assisted system for elective PCI in *** This preclinical trial included 22 experimental pigs and preliminarily supported the safety and feasibility of the ETcath200 robot-assisted system for ***,eleven patients with coronary heart disease who met the inclusion criteria and had clinical indications for elective PCI were *** was performed using a robot-assisted *** primary outcomes were clinical success(defined as visual estimated residual stenosishe ability to use the robot-assisted system to complete PCI successfully without conversion to the traditional manual PCI).RESULTS Eleven patients were included in this clinical trial.A drug-eluting stent with a diameter of 3 mm(interquartile range:2.75–3.5 mm)and a length of 26 mm(interquartile range:22–28 mm)was deployed in all *** clinical success rate was 100%,with no PCI-related complications and no in-hospital or 30-day major adverse cardiovascular events,and the technical success rate was 100%.CONCLUSIONS The results strongly suggest that the use of the independently developed robot-assisted system in China for elective PCI is feasible,safe,and effective.

关键词： coronary robot system

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Research on Credit Default Swaps Pricing Considering Moral Hazard Incentive under Reduce-Form Model

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Journal of Systems Science and Systems Engineering 2024年第3期33卷 311-329页

作者： Liang Wu Kangjie he Zhe guo School of Mathematical Science Henan Institute of Science and TechnologyXinxiang453003China Public Front Office Department Industrial and Commercial Bank of ChinaZhengzhou450000China

Equilibrium pricing of credit default swaps(CDS)promotes efficient identification of credit risk in the market,which in turn leads to efficient allocation of ***,even when CDS have been priced in equilibrium,i.e.,when premiums are equal to anticipated payments,the moral hazard incentives of CDS buyers increase with CDS ***,it becomes an interesting research direction to study the impact of moral hazard incentives on the trading mechanism or pricing of derivatives(CDS).Most of the existing literature on the impact of moral hazard incentives in CDS pricing on derivatives trading mechanisms takes a macro perspective and focuses on the agreement risk *** literature exploring the analysis of the impact of moral hazard on the probability of agreement default from a micro perspective is not yet *** this in mind,this paper focuses on the mechanisms by which“fraud”,an extreme manifestation of micro-moral hazard incentives,affects the probability of *** paper introduces for the first time the concept of“claiming fraud”by credit protection buyers,which is different from the macro perspective of moral hazard incentives,and thus defines a specific extreme form of moral hazard ***,to address the intrinsic feature of the lack of economic explanatory power of the reduce-form model,this paper introduces a moral hazard incentive factor into the reduce-form model,and proposes a moral hazard state variable as a function of the asset value of the reference entity,which gives the reduce-form model strong economic explanatory power,and the default predictability is reduced by the description of the reduce-form *** terms of the object of study,this paper considers the issue of moral hazard incentives in the presence of claiming fraud in two reference entities to further explore the impact of moral hazard incentives on default protection at the micro level in terms of cyclic ***,based on the

关键词： Financial engineering moral hazard incentive claiming fraud reduce-form model probability of default calculation CDS pricing

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Effect of post rolling stress on phase transformation behavior of microalloyed dual phase steel

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Journal of Iron and Steel Research International 2024年第3期31卷 688-699页

作者： Wen-quan Sun Sheng-yi yong Tie-heng Yuan Ting-song Yang An-rui he Chao Liu Rui-chun guo National Engineering Research Center for Advanced Rolling and Intelligent Manufacturing University of Science and Technology BeijingBeijing 100083China

The slow phase transformation of microalloyed dual phase steel makes the nonuniform stress and temperature fields during the post rolling cooling process have a significant impact on the phase transformation *** the relatively slow phase transformation of DP780 steel within the microalloyed dual phase steel series,the influence of stress on the phase transformation behavior of DP780 steel was *** quantify the nonuniform thermal and stress conditions in the steel coil,a thermo-mechanical coupled finite element model of the hot-rolled strip cooling process was *** on the simulation data,DP780 steel was chosen as the research material,and Gleeble 3500 thermal simulation equipment was used for experimental *** thermal expansion curves were analyzed through regression to establish the dynamic model of DP780 steel phase transformation under ***,metallographic analysis was conducted to determine phase transformation type and grain size of DP780 *** results confirmed that the stress promotes the occurrence of semi-diffusion-type bainite ***,an appropriate level of stress facilitates the growth of bainitic grains,while the increased stress inhibits the growth of ferritic grains.

关键词： Microalloyed dual phase steel Stress Bainitic transformation Grain Finite element method

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In situ anchoring in carbon matrix of Bi_(2)O_(2)CO_(3) as a high-performance anode material for Li-ion batteries

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Rare Metals 2024年第8期43卷 3634-3646页

作者： Pu-Qiang he Jun guo Hui Huang Zhong-Cheng guo Faculty of Metallurgy and Energy Engineering Kunming University of Science and TechnologyKunming 650093China Research Center of Metallurgical Electrode Materials Engineering Technology Kunming 650106China Kunming hendera Science and Technology Co. Ltd.Kunming 650106China

Bismuth-based anode materials have been regarded as promising Li-ion batteries due to their high theoretical ***,their low conductivity and associated volume expansion inhabited their *** this work,Bi_(2)O_(2)CO_(3)@C composites were successfully synthesized by in situ anchoring of flower-like Bi_(2)O_(2)CO_(3) nanosheets on a carbon-based substrate via *** unique composited structure of Bi_2O_(2)-CO_(3)@C leads to a stable specific capacity of 547 mAh·g^(-1)after 100 cycles at a current density of 0.1 A·g^(-1).Notably,it demonstrates excellent rate capability with a specific capacity of 210 mAh·g^(-1)at 5 A·g^(-1).After 550 cycles at a current density of 0.5 A·g^(-1),a high reversible capacity of nearly 400 mAh·g^(-1)was ***,in situ X-ray diffraction measurements clearly demonstrate the conversion between Bi and Li_(3)Bi during alloying/dealloying,confirming the good electrochemical reversibility of the materials for Li *** reaction kinetics of Bi_(2)O_(2)CO_(3)@C were further investigated using galvanostatic intermittent titration ***,Bi_2O_(2)-CO_(3)@C exhibited excellent long-term stability,maintaining its high reversible capacity for over 200 cycles at a current density of 0.5 A·g^(-1)in a full cell configuration using Li_(1.20)Mn_(0.54)Ni_(0.13)Co_(0.13)O_(2) as the cathode *** result further underscores its promising potential for lithium-ion *** work may provide inspiration for the design of alloy-type negative electrode materials for high-performance rechargeable batteries.

关键词： Bi_(2)O_(2)CO_(3) Composite materials Anode materials Full batteries

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Coupled dynamic response analysis of multi-column floating offshore wind turbine with low center of gravity

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Journal of Ocean Engineering and Science 2024年第1期9卷 25-39页

作者： Jie Yang Yan-ping he yong-sheng Zhao Xiao-yan Yang guo-rong Zhang State Key Laboratory of Ocean Engineering Shanghai Jiao Tong UniversityShanghai 200240China Collaborative Innovation Center for Advanced Ship and Deep-Sea Exploration(CISSE) Shanghai Jiao Tong UniversityShanghai 200240China School of Naval Architecture Ocean&Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China Faculty of Maritime and Transportation Ningbo UniversityNingbo 315211China

To realize the application of the floating offshore wind turbine(FOWT)from deep to relatively shallow waters,a new concept of multi-column floating wind turbine platform with low center of gravity(CG)is designed and *** multi-column low CG platform is designed to support a 6MW wind turbine class and operated at a water depth of 50m in the South China *** frequency domain software WADAM and time domain software NREL-FAST are used to simulate coupled dynamic responses of the floating wind turbine system with second-order wave loads *** dynamic behaviors of multi-column low CG FOWT system under normal operation and parked conditions are *** influence of second-order wave force on the motion responses of the multi-column platform,fore-aft force and moment of the tower base and mooring force are researched *** results demonstrate that the coupled dynamic responses at rated operating condition and extreme condition meet the normal operating requirements and extreme survival requirements of FOWT system in the shallow water(50m)of South China *** addition,it is found that,the wave frequency response gradually replaces the second-order low frequency response as the main influencing factor of the coupled dynamic response of the FOWT system with the increasing severity of the sea ***,in general,the magnitude of second-order low frequency response increases with the increasing severity of the design load ***,in the subsequent design of the shallow water FOWT system,the second-order effects should be paid enough attention.

关键词： Floating offshore wind turbine Multi-column platform Second-order wave force Concept design Coupled dynamic response

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On the Strong Approximation for a Simple Reentrant Line in Light Traffic Under First-buffer First-served Service Discipline

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 823-839页

作者： Kai-ming YANG yong-jiang guo School of Science Beijing University of Posts and TelecommunicationsBeijing 100876China

For a 2-station and 3-class reentrant line under first-buffer first-served(FBFS)service discipline in light traffic,we firstly construct the strong approximations for performance measures including the queue length,workload,busy time and idle time *** on the obtained strong approximations,we use a strong approximation method to find all the law of the iterated logarithms(LILs)for the above four performance measures,which are expressed as some functions of system parameters:means and variances of interarrival and service times,and characterize the fluctuations around their fluid approximations.

关键词： reentrant line queueing network FBFS service discipline strong approximation LIL Brownian motion

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Instability mechanism of mining roadway passing through fault at different angles in kilometre-deep mine and control measures of roof cutting and NPR cables

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Journal of Mountain Science 2024年第1期21卷 236-251页

作者： SUN Xiaoming WANG Jian ZHAO Wenchao MING Jiang ZHANG yong LI Zhihu MIAO Chengyu guo Zhibiao he Manchao State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and Technology(Beijing)Beijing 100083China School of Mechanics and Civil Engineering China University of Mining and Technology(Beijing)Beijing 100083China

The angle α between the fault strike and the axial direction of the roadway produces different damage characteristics. In this paper, the research methodology includes theoretical analyses, numerical simulations and field experiments in the context of the Daqiang coal mine located in Shenyang, China. The stability control countermeasure of "pre-splitting cutting roof + NPR anchor cable"(PSCR-NPR) is simultaneously proposed. According to the different deformation characteristics of the roadway, the faults are innovatively classified into three types, with α of type I being 0°-30°, α of type II being 30°-60°, and α of type III being 60°-90°. The full-cycle stress evolution paths during mining roadway traverses across different types of faults are investigated by numerical simulation. Different pinch angles α lead to high stress concentration areas at different locations in the surrounding rock. The non-uniform stress field formed in the shallow surrounding rock is an important reason for the instability of the roadway. The pre-cracked cut top shifted the high stress region to the deep rock mass and formed a low stress region in the shallow rock mass. The high prestressing NPR anchor cable transforms the non-uniform stress field of the shallow surrounding rock into a uniform stress field. PSCR-NPR is applied in the fault-through roadway of Daqiang mine. The low stress area of the surrounding rock was enlarged by 3-7 times, and the cumulative convergence was reduced by 45%-50%. It provides a reference for the stability control of the deep fault-through mining roadway.

关键词： Kilometre-deep mine Fault Mining roadway Failure mechanism Pre-splitting cutting roof High pre-stress NPR anchor cable

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A Fractional-Order Ultra-Local Model-Based Adaptive Neural Network Sliding Mode Control of n-DOF Upper-Limb Exoskeleton With Input Deadzone

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 760-781页

作者： Dingxin he HaoPing Wang Yang Tian Yida guo the School of Automation Nanjing University of Science and TechnologyNanjing 210094China IEEE Norinco Group Institute of Navigation and Control Technology Beijing 100089China

This paper proposes an adaptive neural network sliding mode control based on fractional-order ultra-local model for n-DOF upper-limb exoskeleton in presence of uncertainties,external disturbances and input *** the model complexity and input deadzone,a fractional-order ultra-local model is proposed to formulate the original dynamic system for simple controller ***,the control gain of ultra-local model is considered as a *** fractional-order sliding mode technique is designed to stabilize the closed-loop system,while fractional-order time-delay estimation is combined with neural network to estimate the lumped ***,a fractional-order ultra-local model-based neural network sliding mode controller(FO-NNSMC) is ***,to avoid disadvantageous effect of improper gain selection on the control performance,the control gain of ultra-local model is considered as an unknown ***,the Nussbaum technique is introduced into the FO-NNSMC to deal with the stability problem with unknown ***,a fractional-order ultra-local model-based adaptive neural network sliding mode controller(FO-ANNSMC) is ***,the stability analysis of the closed-loop system with the proposed method is presented by using the Lyapunov ***,with the co-simulations on virtual prototype of 7-DOF iReHave upper-limb exoskeleton and experiments on 2-DOF upper-limb exoskeleton,the obtained compared results illustrate the effectiveness and superiority of the proposed method.

关键词： Adaptive control input deadzone model-free control n-DOF upper-limb exoskeleton neural network

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