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分级诊疗视域下城乡卫生人才竞争力协同提升的现状与思考

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中国全科医学 2016年第28期19卷 3409-3412页

作者：刘恒旸鞠永和王静成扬州大学医学院江苏省扬州市225001 江苏省苏北人民医院人力资源部江苏省苏北人民医院院长办公室

人才资源是第一资源,分级诊疗的有效实施需要一支服务能力各有侧重、优势互补的城乡卫生人才队伍。城乡卫生人才竞争力协同提升,达到一定程度下的差异性均衡,各级医疗机构卫生人才竞争力才能达到分级诊疗的要求,保障分级诊疗制度的成功... 详细信息

人才资源是第一资源,分级诊疗的有效实施需要一支服务能力各有侧重、优势互补的城乡卫生人才队伍。城乡卫生人才竞争力协同提升,达到一定程度下的差异性均衡,各级医疗机构卫生人才竞争力才能达到分级诊疗的要求,保障分级诊疗制度的成功。目前我国城乡卫生人才竞争力协同提升还存在诸多问题,本文在总结国外分级诊疗下卫生人才竞争力协同提升经验的基础上,分析了我国分级诊疗下城乡卫生人才竞争力协同提升的问题及原因,并对协同提升路径提出对策建议。

关键词：分级诊疗卫生人才竞争力提升

Characteristic changes in astrocyte properties during astrocyte-to-neuron conversion induced by NeuroD1/Ascl1/Dlx2

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Neural Regeneration Research 2025年第6期20卷 1801-1815页

作者： Qing he Zhen wang Yuchen wang Mengjie Zhu Zhile Liang Kanghong Zhang Yuge Xu Gong Chen GHM Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina

Direct in vivo conversion of astrocytes into functional new neurons induced by neural transcription factors has been recognized as a potential new therapeutic intervention for neural injury and degenerative disorders. However, a few recent studies have claimed that neural transcription factors cannot convert astrocytes into neurons, attributing the converted neurons to pre-existing neurons mis-expressing transgenes. In this study, we overexpressed three distinct neural transcription factors––NeuroD1, Ascl1, and Dlx2––in reactive astrocytes in mouse cortices subjected to stab injury, resulting in a series of significant changes in astrocyte properties. Initially, the three neural transcription factors were exclusively expressed in the nuclei of astrocytes. Over time, however, these astrocytes gradually adopted neuronal morphology, and the neural transcription factors was gradually observed in the nuclei of neuron-like cells instead of astrocytes. Furthermore,we noted that transcription factor-infected astrocytes showed a progressive decrease in the expression of astrocytic markers AQP4(astrocyte endfeet signal), CX43(gap junction signal), and S100β. Importantly, none of these changes could be attributed to transgene leakage into preexisting neurons. Therefore, our findings suggest that neural transcription factors such as NeuroD1, Ascl1, and Dlx2 can effectively convert reactive astrocytes into neurons in the adult mammalian brain.

关键词： aquaporin-4 Ascl1 astrocyte cortex Dlx2 gap junction glia-to-neuron conversion neural regeneration NeuroD1 reprogramming

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浅析工程项目管理中的组织与协调

山西建筑 2008年第6期34卷 233-234页

作者：何永旺山西通达集团

从业主项目管理的角度,介绍了项目组织协调工作的原则,通过对组织与协调作用的分析,探讨如何做好工程项目建设的组织与协调工作,从而实现工程建设的质量、进度、投资三大目标。

关键词：项目管理组织协调原则

The detection, extraction and parameter estimation of extreme-mass-ratio inspirals with deep learning

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 86-96页

作者： Qianyun Yun Wen-Biao Han Yi-Yang Guo he wang Minghui Du Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences Shanghai Astronomical Observatory Chinese Academy of Sciences School of Physics and Astronomy Shanghai Jiao Tong University School of Astronomy and Space Science University of Chinese Academy of Sciences Taiji Laboratory for Gravitational Wave Universe (Beijing/Hangzhou) University of Chinese Academy of Sciences Lanzhou Center for Theoretical Physics Key Laboratory of Theoretical Physics of Gansu Province Key Laboratory of Quantum Theory and Applications of MoE Lanzhou University Institute of Theoretical Physics & Research Center of Gravitation Lanzhou University International Centre for Theoretical Physics Asia-Pacific (ICTP-AP) University of Chinese Academy of Sciences (UCAS) Center for Gravitational Wave Experiment National Microgravity Laboratory Institute of Mechanics Chinese Academy of Sciences

One of the primary goals of space-borne gravitational wave detectors is to detect and analyze extreme-mass-ratio inspirals(EMRIs). This task is particularly challenging because EMRI signals are complex, lengthy, and faint. In this work, we introduce a2-layer convolutional neural network(CNN) approach to detect EMRI signals for space-borne detectors, achieving a true positive rate(TPR) of 96.9% at a 1% false positive rate(FPR) for signal-to-noise ratio(SNR) from 50 to 100. Especially, the key intrinsic parameters of EMRIs such as the mass, spin of the supermassive black hole(SMBH) and the initial eccentricity of the orbit can also be inferred directly by employing a neural network. The mass and spin of the SMBH can be determined at 99% and 92% respectively. This will greatly reduce the parameter spaces and computing cost for the following Bayesian parameter *** model also has a low dependency on the accuracy of the waveform model. This study underscores the potential of deep learning methods in EMRI data analysis, enabling the rapid detection of EMRI signals and efficient parameter estimation.

关键词： gravitational wave EMRIs deep-learing

Assessing the corrosion protection property of coatings loaded with corrosion inhibitors using the real-time atmospheric corrosion monitoring technique

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 119-126页

作者： Xiaoxue wang Lulu Jin Jinke wang Rongqiao wang Xiuchun Liu Kai Gao Jingli Sun yong Yuan Lingwei Ma Hongchang Qian Dawei Zhang School of Energy and Power Engineering Beihang UniversityBeijing 100191China Beijing Institute of Space Long March Vehicle Beijing 100076China National Materials Corrosion and Protection Data Center University of Science and Technology BeijingBeijing 100083China Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China Shanghai Spaceflight Precision Machinery Institute Shanghai 201600China

The atmospheric corrosion monitoring(ACM)technique has been widely employed to track the real-time corrosion behavior of metal ***,limited studies have applied ACM to the corrosion protection properties of organic *** study compared a bare epoxy coating with one containing zinc phosphate corrosion inhibitors,both applied on ACM sensors,to observe their corrosion protection properties over *** with artificial damage via scratches were exposed to immersion and alternating dry and wet environments,which allowed for monitoring galvanic corrosion currents in *** the corrosion tests,the ACM currents of the zinc phosphate/epoxy coating were considerably lower than those of the blank epoxy *** trend in ACM current variations closely matched the results obtained from regular electrochemical tests and surface *** alignment highlights the potential of the ACM technique in evaluating the corrosion protection capabilities of organic *** with the blank epoxy coating,the zinc phosphate/epoxy coating showed much-decreased ACM current values that confirmed the effective inhibition of zinc phosphate against steel corrosion beneath the damaged coating.

关键词： atmospheric corrosion monitoring technology corrosion inhibitor coating carbon steel corrosion protection

薰衣草联合音乐疗法缓解种植修复患者术中焦虑的研究

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口腔医学研究 2016年第10期32卷 1047-1050页

作者：曹勇何灏逾王亚珂广西医科大学附属口腔医院修复科广西南宁530021 武汉大学口腔医院修复科湖北武汉430079

目的:评价薰衣草联合音乐疗法对牙种植患者术中心血压、心率、及术中疼痛评估值的影响。方法:临床随机选取160名单颗牙缺失需要采用种植义齿修复患者,分为4组:A组(对照组)在常规环境下进行手术;B组(薰衣草组)在薰衣草精油气味下进行手... 详细信息

目的:评价薰衣草联合音乐疗法对牙种植患者术中心血压、心率、及术中疼痛评估值的影响。方法:临床随机选取160名单颗牙缺失需要采用种植义齿修复患者,分为4组:A组(对照组)在常规环境下进行手术;B组(薰衣草组)在薰衣草精油气味下进行手术;C组(音乐组)在音乐环境中进行手术;D组(薰衣草+音乐组)在薰衣草精油气味及音乐环境中进行手术。治疗前记录患者年龄、性别、评估牙科焦情况。术前、术中采用心电监护仪记录患者血压、心率,视觉模拟评分(Visual analogue scale VAS)法让患者描述术中术疼痛程度并记录其分值。结果:B、C、D组术中各监测点收缩压、舒张压测量值与术前比较无统计学差异;A组术中各监测点收缩压、舒张压测量值均高于术前,差异具有统计学意义(P<0.05);B、C组术中心率测量值与术前比较无统计学差异,D组黏膜缝合时心率值低于术前(P<0.05);A组术中各监测点心率测量值均高于术前,差异具有统计学意义;A组VAS评分值高于B、C、D组,差异具有统计学意义(P<0.05)。结论:薰衣草及音乐单独应用均可较好的维持牙种植患者术中的血压、心率值,减轻患者术中的疼痛评分;薰衣草及音乐联合应用可以降低牙种植患者术中的心率值。

关键词：牙种植薰衣草血压心率

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中药治疗2型糖尿病64例的疗效观察

实用医技杂志 2008年第23期15卷 3082-3083页

作者：贺永旺闫平横山县白界医院陕西横山719100 米脂县中医院陕西米脂718100

随着人们生活水平的不断提高,生活方式的不断变化,大量食用肥甘厚腻之食,引起中年肥胖日趋严重,2型糖尿病发病率逐年上升,严重威胁人类健康.

关键词： 2型糖尿病中药治疗疗效

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浙北小城镇公共空间特性与活力研究

建筑与文化 2018年第9期 94-96页

作者：陈耀贺勇王珂浙江大学建筑工程学院

文章关注促进浙北小城镇居民休闲活动的公共空间,以浙北新埭镇、梅溪镇为案例分析小城镇公共空间特性与活力的关联性,提出浙北小城镇应结合自身情况,在小规模、低成本的原则下营造高可达性、强复合性的公共空间。

关键词：公共空间小城镇特性活力

Recent Strategies and Advances in Hydrogel-Based Delivery Platforms for Bone Regeneration

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NANO-MICRO LETTERS 2025年第1期17卷 1-51页

作者： wang, Xiao Zeng, Jia Gan, Donglin Ling, Kun he, Mingfang Li, Jianshu Lu, yongping Guangyuan Cent Hosp Sci & Technol Innovat Ctr Biomed Mat & Clin Res Guangyuan Key Lab Multifunct Med Hydrogel Guangyuan 628000 Peoples R China Nanjing Normal Univ Jiangsu Collaborat Innovat Ctr Biomed Funct Mat Sch Chem & Mat Sci Jiangsu Key Lab Biofunct Mat Nanjing 210023 Peoples R China Sichuan Univ Coll Polymer Sci & Engn State Key Lab Polymer Mat Engn Chengdu 610065 Peoples R China

Recent advances in the combined delivery platform that integrate nano-/microscale carriers and with 3D hydrogel network for bone regeneration are *** strategies for bioactive molecules delivery involving nanoparticles, nanosheets, and microspheres, along with extra stimuli such as near-infrared light, temperature changes, ultrasonication, and inflammatory conditions, are *** prospects and challenges for the clinical translation and the development of nano-/microscale incorporated hydrogel-based delivery platform are discussed. Bioactive molecules have shown great promise for effectively regulating various bone formation processes, rendering them attractive therapeutics for bone regeneration. However, the widespread application of bioactive molecules is limited by their low accumulation and short half-lives in vivo. Hydrogels have emerged as ideal carriers to address these challenges, offering the potential to prolong retention times at lesion sites, extend half-lives in vivo and mitigate side effects, avoid burst release, and promote adsorption under physiological conditions. This review systematically summarizes the recent advances in the development of bioactive molecule-loaded hydrogels for bone regeneration, encompassing applications in cranial defect repair, femoral defect repair, periodontal bone regeneration, and bone regeneration with underlying diseases. Additionally, this review discusses the current strategies aimed at improving the release profiles of bioactive molecules through stimuli-responsive delivery, carrier-assisted delivery, and sequential delivery. Finally, this review elucidates the existing challenges and future directions of hydrogel encapsulated bioactive molecules in the field of bone regeneration.

关键词： Hydrogel Bone regeneration Bioactive molecules Drug delivery Nano-/microscale carriers