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Identification and Evolution of Groundwater Chemistry in the Ejin Sub-Basin of the Heihe River, Northwest China

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Pedosphere 2007年第3期17卷 331-342页

作者： SU yong-Hong feng Qi zhu Gao-feng SI Jian-Hua ZHANG Yan-Wu Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences Lanzhou730000 （China） School of Mathematics and Statistics Lanzhou University Lanzhou 730000 （China）

Hydro-chemical characteristics of groundwater and their changes as affected by human activities were studied in the Ejin Sub-Basin of the Inner Mongolia Autonomous Region, China, to understand the groundwater evolution, to identify the predominant geochemical processes taking place along the horizontal groundwater flow path, and to characterize anthropogenic factors affecting the groundwater environment based on previous data. The concentrations of major ions and total dissolved solids （TDS） in the groundwater showed a great variation, with 62.5% of the samples being brackish （TDS ≥ 1 000 mg L^-l）. The groundwater system showed a gradual hydro-chemical zonation composed of Na^＋ -HCO3^-, Na^＋ -Mg^2＋ -SO4 ^2 -Cl^-, and Na^＋ -Cl^-. The relationships among the dissolved species allowed identification of the origin of solutes and the processes that generated the observed water compositions. The dissolution of halite, dolomite, and 2- gypsum explained, in part, the presence of Na^＋, K^＋, Cl^-, SO^4 , and Ca^2＋, but other processes, such as mixing, Na^＋ exchange for Ca^2＋ and Mg^2＋, and calcite precipitation also contributed to the composition of water. Human activity, in particular large-scale water resources development associated with dramatic population growth in the last 50 years, has led to tremendous changes in the groundwater regime, which reflected in surface water runoff change, decline of groundwater table and degeneration of surface water and groundwater quality. Solving these largely anthropogenic problems requires concerted, massive and long-term efforts.

关键词： Ejin Sub-Basin groundwater quality Heihe River human impact water resources development

The Higgs signatures at the CEPC CDR baseline

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Chinese Physics C 2019年第2期43卷 5-11页

作者： Hang Zhao yong-feng zhu Cheng-Dong Fu Dan Yu Man-Qi Ruan Institute of High Energy Physics Chinese Academy of Sciences CAS Center for Excellence in Particle Physics Collaborative Innovation Center for Particles and Interactions University of Chinese Academy of Sciences

As a Higgs factory, the CEPC(Circular Electron-Positron Collider) project aims at precision measurements of the Higgs boson properties. A baseline detector concept, APODIS(A PFA Oriented Detector for the HIggS factory), has been proposed for the CEPC CDR(Conceptual Design Report) study. We explore the Higgs signatures for this baseline design with ■ Higgs events. The detector performance for reconstructing charged particles, photons and jets is quantified with H→μμ, γγ and jet final states, respectively. The resolutions of reconstructed Higgs boson mass are comparable for the different decay modes with jets in the final states. We also analyze the H→WW~* and ZZ* decay modes, where a clear separation between different decay cascades is observed.

关键词： CEPC Higgs boson full simulation

RGS4 promotes the progression of gastric cancer through the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition

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World Journal of Gastroenterology 2025年第2期31卷 113-127页

作者： Peng-Yu Chen Pei-Yao Wang Bang Liu Yang-Pu Jia Zhao-Xiong Zhang Xin Liu Dao-Han Wang yong-Jia Yan Wei-Hua Fu feng zhu Department of General Surgery Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300052China Department of General Surgery Jincheng People’s HospitalJincheng 048000Shanxi ProvinceChina

BACKGROUND Regulator of G protein signaling(RGS)proteins participate in tumor formation and metastasis by acting on theα-subunit of heterotrimeric G *** speci-fic effect of RGS,particularly RGS4,on the progression of gastric cancer(GC)is not yet *** To explore the role and underlying mechanisms of action of RGS4 in GC *** The prognostic significance of RGS4 in GC was analyzed using bioinformatics based public databases and verified by immunohistochemistry and quantitative polymerase chain reaction in 90 patients with *** assays were employed to assess the carcinogenic impact of RGS4,and the mechanism of its possible influence was detected by western blot analysis.A nude mouse xenograft model was established to study the effects of RGS4 on GC growth in *** RGS4 was highly expressed in GC tissues compared with matched adjacent normal *** RGS4 expression was correlated with increased tumor-node-metastasis stage,increased tumor grade as well as poorer overall survival in patients with *** experiments demonstrated that RGS4 knockdown suppressed GC cell proliferation,migration and ***,xenograft experiments confirmed that RGS4 silencing significantly inhibited tumor ***,RGS4 knockdown resulted in reduced phosphorylation levels of focal adhesion kinase,phosphatidyl-inositol-3-kinase,and protein kinase B,decreased vimentin and N-cadherin,and elevated *** High RGS4 expression in GC indicates a worse prognosis and RGS4 is a prognostic ***4 influences tumor progression via the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition.

关键词： Gastric cancer Prognosis Regulator of G protein signaling 4 Focal adhesion kinase Epithelial-mesenchymal transition

Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： Xiao Xiang feng Gao Yu-Gui Peng Peng Wu Zong-Lin Li Xue-feng zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

基于距离度量的关系数据库系统用户行为轮廓的挖掘

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计算机工程与应用 2003年第20期39卷 13-14,41页

作者：张勇冯玉才朱虹华中科技大学数据库与多媒体研究所武汉430074

现有的入侵检测系统大多是面向主机操作系统或网络数据包的,应用层的入侵检测例如针对数据库管理系统的入侵检测系统还非常少见。挖掘系统审计记录构造用户的行为轮廓,是异常检测的常见方法。但是传统的数据挖掘算法并没有考虑任何领域... 详细信息

现有的入侵检测系统大多是面向主机操作系统或网络数据包的,应用层的入侵检测例如针对数据库管理系统的入侵检测系统还非常少见。挖掘系统审计记录构造用户的行为轮廓,是异常检测的常见方法。但是传统的数据挖掘算法并没有考虑任何领域知识,为此引入了距离度量的概念,充分考虑数据库这一特殊应用,在挖掘算法中融入DBMS的数据结构特性和用户行为的语义特性,扩展了Apriori算法,挖掘出的频繁项集可以更精确地描述用户的行为模式。

关键词：入侵检测距离度量用户轮廓数据挖掘数据库安全

Geochemistry and Chronology of the Late Paleozoic volcanicrocks in west Tianshan Mountains, Xinjiang

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Geochemistry and Chronology of the Late Paleozoic volcanicro...

Transarterial chemoembolization combined with lenvatinib and sintilimab vs lenvatinib alone in intermediate-advanced hepatocellular carcinoma

2006年全国岩石学与地球动力学研讨会

作者： yong-feng zhu, Xuan Guo, Lifei Zhang (School of Earth and Space Sciences, Peking University, Beijing 100871, China Beijing SHRIMP Centre, Chinese Academy of Geological Sciences, 100037, China )

＜正＞The Late Paleozoic volcanic rocks in western Tianshan Mountains （Central Asia） formed the strata up to 10000m in an area of large than 30000km2. These volcanic rocks distribute in TAS plot continuously from basalt, basaltic trachyandesite, trachyandesite, trachyte, to rhyolite. The zircon SHRIMP dating shows that the zircons from basalts and trachy-andesites vary between 299

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 52-61页

作者： Fei-Da Wu Hai-feng Zhou Wei Yang Di zhu Bi-Fei Wu Hai-Bin Shi Sheng Liu Wei-Zhong Zhou Department of Interventional Radiology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is the most common form of liver cancer that has limited treatment options and a poor *** chemoembolization(TACE)is the first-line treatment for intermediate-stage HCC but can induce tumour hypoxia,thereby promoting *** studies suggested that combining TACE with anti-angiogenic therapies and immunotherapy might im-prove ***,a tyrosine kinase inhibitor,has demonstrated superior outcomes compared to sorafenib,while immune checkpoint inhibitors such as sintilimab show potential when combined with ***,the efficacy and safety of TACE combined with lenvatinib and sintilimab(TACE+SL)compared to TACE with lenvatinib alone(TACE+L)in patients with intermediate-ad-vanced HCC has not yet been *** To evaluate the efficacy and safety of TACE+SL therapy in comparison to TACE+L therapy in patients with intermediate-advanced *** A retrospective analysis was performed on patients with intermediate-advanced HCC who received TACE plus lenvatinib with or without sintilimab between September 2019 and September *** characteristics were compared,and propensity score matching was *** survival(OS),progression-free survival(PFS),and objective response rate(ORR)were evaluated between the two groups,and adverse events were *** The study included 57 patients,with 30 in the TACE+SL group and 27 in the TACE+L *** TACE+SL group demonstrated significantly improved median PFS and OS compared to the TACE+L group(PFS:14.1 months vs 9.6 months,P=0.016;OS:22.4 months vs 14.1 months,P=0.039),along with a higher ORR(70.0%vs 55.6%).After propensity score matching,30 patients were included,with the TACE+SL group again showing longer median PFS and a trend toward improved OS(PFS:14.6 months vs 9.2 months,P=0.012;OS:23.9 months vs 16.3 months,P=0.063),and a higher ORR(73.3%vs 53.3%).No severe adverse events were *** TACE+SL demonstrat

关键词： Hepatocellular carcinoma Transarterial chemoembolization Sintilimab Lenvatinib Immunotherapy Programmed cell death 1 Prognosis

抗坏血酸透析液对尿毒症患者静脉铁剂诱导的氧化应激影响

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复旦学报（医学版） 2003年第4期30卷 346-349页

作者：李素娟丁峰顾勇施雪枫朱秋毓薛骏陆福明林善锬复旦大学附属华山医院肾脏科

目的观察抗坏血酸透析液对静脉铁剂诱导的维持性血液透析患者氧化应激的影响。方法选择应用氢氧化铁蔗糖复合物治疗的维持性血液透析患者10例,分别给予抗坏血酸透析液透析和在透析过程中静脉滴注抗坏血酸进行干预,测定血浆及红细胞丙... 详细信息

目的观察抗坏血酸透析液对静脉铁剂诱导的维持性血液透析患者氧化应激的影响。方法选择应用氢氧化铁蔗糖复合物治疗的维持性血液透析患者10例,分别给予抗坏血酸透析液透析和在透析过程中静脉滴注抗坏血酸进行干预,测定血浆及红细胞丙二醛(MDA)、抗坏血酸和维生素E水平,通过计算MDA:胆固醇的曲线下面积(AUC0-180min)判断其疗效。结果氢氧化铁蔗糖复合物注射后,血糖MDA明显升高(P<0.05),60 min达高峰,抗坏血酸水平明显下降。抗坏血酸透析液可明显降低血浆MDA和AUC0-180min(P<0.05),静脉注射抗坏血酸也可降低血浆MDA,但至后期出现再次升高的趋势,其AUC0-180min与未用抗坏血酸相比无显著性差异。结论抗坏血酸透析液可明显降低维持性血液透析患者由静脉铁剂诱导的氧化应激,效果优于静脉注射途径。

关键词：尿毒症抗坏血酸透析液静脉铁剂氧化应激血液透析

Trinuclear gold-catalyzed site-selective alkylation of peptides

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Science China Chemistry 2025年第01期 249-256页

作者： Qing-Yun Fang Chengyihan Gu Yinghan Chen Wencheng Yan yong Liang Weipeng Li Chengjian zhu Jie Han Jin Xie State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic Materials Chemistry and Biomedicine Innovation Center (Chem BIC) School of Chemistry and Chemical Engineering Nanjing University Green Catalysis Center College of Chemistry Zhengzhou University State Key Laboratory of Natural Medicines China Pharmaceutical University

Selective modification of peptides has always been a challenging issue. The selective alkylation of peptides can alter the biological activity and physical properties of molecules, and it has gained significant research interest. We herein disclose an intriguing gold-catalyzed alkylation of peptides using bench-stable unactivated alkyl bromides under photoredox catalysis. A wide range of structurally diverse primary, secondary and tertiary alkyl bromides serve as effective coupling partners to precisely connect with the α-C(sp3)–H in glycine residue of peptides. This protocol demonstrates an exceptionally broad scope for alkyl halides and excellent tolerance for a wide range of useful functional groups. A series of relay transformations to construct cyclic peptides, to proceed click reaction and to realize peptide fluorescence labeling further enhance its synthetic practicality. In addition, mechanistic studies and density functional theory(DFT) calculations reveal an inner-sphere and subsequent outersphere single electron transfer(SET) mechanism.

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