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Schwann cells differentiated from skin-derived precursors provide neuroprotection via autophagy inhibition in a cellular model of Parkinson’s disease

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Neural Regeneration Research 2022年第6期17卷 1357-1363页

作者： Jia-Nan Yan Hai-Ying Zhang Jun-Rui Li Ying Chen yong-cheng jiang Jia-Bing Shen Kai-Fu Ke Xiao-Su Gu Department of Neurology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Clinical Medicine The First Clinical Medical College of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Neurology and Suzhou Clinical Research Center of Neurological Disease The Second Afflicted Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina

Autophagy has been shown to play an important role in Parkinson’s *** hypothesized that skin-derived precursor cells exhibit neuroprotective effects in Parkinson’s disease through affecting *** this study,6-hydroxydopamine-damaged SH-SY5Y cells were pretreated with a culture medium containing skin-derived precursors differentiated into Schwann cells(SKP-SCs).The results showed that the SKP-SC culture medium remarkably enhanced the activity of SH-SY5Y cells damaged by 6-hydroxydopamine,reduced excessive autophagy,increased tyrosine hydroxylase expression,reducedα-synuclein expression,reduced the autophagosome number,and activated the PI3K/AKT/mTOR *** activator rapamycin inhibited the effects of SKP-SCs,and autophagy inhibitor 3-methyladenine had the opposite *** findings confirm that SKP-SCs modulate the PI3K/AKT/mTOR pathway to inhibit autophagy,thereby exhibiting a neuroprotective effect in a cellular model of Parkinson’s *** study was approved by the Animal Ethics Committee of Laboratory Animal Center of Nantong University(approval No.S20181009-205)on October 9,2018.

关键词： alpha-synuclein autophagosomes autophagy neural regeneration neuroprotection Parkinson’s disease PI3K/AKT/mTOR pathway skin-derived precursor Schwann cells

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Neuroprotective effects of insulin-like growth factor-2 in 6-hydroxydopamine-induced cellular and mouse models of Parkinson’s disease

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Neural Regeneration Research 2023年第5期18卷 1099-1106页

作者： Hai-Ying Zhang yong-cheng jiang Jun-Rui Li Jia-Nan Yan Xin-Jue Wang Jia-Bing Shen Kai-Fu Ke Xiao-Su Gu Department of Neurology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Clinical Medicine The First Clinical Medical College of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina

Skin-derived precursor Schwann cells have been reported to play a protective role in the central nervous system. The neuroprotective effects of skin-derived precursor Schwann cells may be attributable to the release of growth factors that nourish host cells. In this study, we first established a cellular model of Parkinson’s disease using 6-hydroxydopamine. When SH-SY5 Y cells were pretreated with conditioned medium from skin-derived precursor Schwann cells, their activity was greatly increased. The addition of insulin-like growth factor-2 neutralizing antibody markedly attenuated the neuroprotective effects of skin-derived precursor Schwann cells. We also found that insulin-like growth factor-2 levels in the peripheral blood were greatly increased in patients with Parkinson’s disease and in a mouse model of Parkinson’s disease. Next, we pretreated cell models of Parkinson’s disease with insulin-like growth factor-2 and administered insulin-like growth factor-2 intranasally to a mouse model of Parkinson’s disease induced by 6-hydroxydopamine and found that the level of tyrosine hydroxylase, a marker of dopamine neurons, was markedly restored, α-synuclein aggregation decreased, and insulin-like growth factor-2 receptor downregulation was alleviated. Finally, in vitro experiments showed that insulin-like growth factor-2 activated the phosphatidylinositol 3 kinase(PI3 K)/AKT pathway. These findings suggest that the neuroprotective effects of skin-derived precursor Schwann cells on the central nervous system were achieved through insulinlike growth factor-2, and that insulin-like growth factor-2 may play a neuroprotective role through the insulin-like growth factor-2 receptor/PI3 K/AKT pathway. Therefore, insulin-like growth factor-2 may be an useful target for Parkinson’s disease treatment.

关键词： 6-hydroxydopamine alpha-synuclein insulin-like growth factor-2 receptor insulin-like growth factor-2 neurodegeneration neuroprotection Parkinson’s disease skin-derived precursor Schwann cells

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Crystallization Modulation and Holistic Passivation Enables Efficient Two‑Terminal Perovskite/CuIn(Ga)Se_(2)Tandem Solar Cells

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Nano-Micro Letters 2025年第1期17卷 205-215页

作者： Cong Geng Kuanxiang Zhang Changhua Wang Chung Hsien Wu Jiwen jiang Fei Long Liyuan Han Qifeng Han Yi‑Bing cheng yong Peng State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070People’s Republic of China Triumph Photovoltaic Materials Co. Ltd.No.1001 Yannan AvenueHigh‑Tech Development DistrictBengbuAnhui 233000People’s Republic of China College of Materials Science and Engineering Guilin University of TechnologyGuilin 541004People’s Republic of China State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Two-terminal(2-T)perovskite(PVK)/CuIn(Ga)Se_(2)(CIGS)tandem solar cells(TSCs)have been considered as an ideal tandem cell because of their best bandgap matching regarding to Shockley–Queisser(S–Q)***,the nature of the irregular rough morphology of commercial CIGS prevents people from improving tandem device *** this paper,D-homoserine lactone hydrochloride is proven to improve coverage of PVK materials on irregular rough CIGS surfaces and also passivate bulk defects by modulating the growth of PVK *** addition,the minority carriers near the PVK/C60 interface and the incompletely passivated trap states caused interface recombination.A surface reconstruction with 2-thiopheneethylammonium iodide and N,N-dimethylformamide assisted passivates the defect sites located at the surface and grain ***,LiF is used to create this field effect,repelling hole carriers away from the PVK and C60 interface and thus reducing *** a result,a 2-T PVK/CIGS tandem yielded a power conversion efficiency of 24.6%(0.16 cm^(2)),one of the highest results for 2-T PVK/CIGS TSCs to our *** validation underscores the potential of our methodology in achieving superior performance in PVK/CIGS tandem solar cells.

关键词： PVK/CIGS TSCs Irregular rough surfaces Modulating the growth PVK/C60 interface recombination

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ADS Injector-I 2 K superfluid helium cryogenic system

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Nuclear Science and Techniques 2020年第4期31卷 79-92页

作者： Rui Ge Shao-Peng Li Rui-Xiong Han Miao-Fu Xu Liang-Rui Sun Min-Jing Sang Rui Ye Zhuo Zhang Jie-Hao Zhang Xiang-Zhen Zhang Lin Bian Jian-Qin Zhang Mei Li Chang-cheng Ma Zheng-Ze Chang Tong-Xian Zhao yong-cheng jiang Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Key Laboratory of Particle Acceleration Physics and Technology CASBeijing 100049China Center for Superconducting RF and Cryogenics Institution of High Energy PhysicsBeijing 100049China

The Accelerator Driven Sub-critical(ADS)system is a strategic plan to solve the nuclear waste problem for nuclear power plants in ***-energy particle accelerators and colliders contain long strings of superconducting devices,superconducting radio frequency cavities,and magnets,which may require cooling by 2 K superfluid helium(HeliumⅡ).2 K superfluid helium cryogenic system has become a research hot spot in the field of superconducting *** this study,the ADS Injector-I 2 K cryogenic system is examined in *** cryogenic system scheme design,key equipment,and technology design,such as the 2 K Joule–Thomson(J–T)heat exchanger and cryomodules CM1+CM2 design,are examined,in addition to the commissioning and operation of the cryogenic *** ADS Injector-I 2 K cryogenic system is the first 100 W superfluid helium system designed and built independently in *** ADS proton beam reached 10 Me V at 10 m A in July 2016 and 10 Me V at 2 m A in continuous mode in January 2017 and has been operated reliably for over 15,000 h,proving that the design of ADS Injector-I 2 K cryogenic system,the key equipment,and technology research are reasonable,reliable,and meet the *** research into key technologies provides valuable engineering experience that can be helpful for future projects such as CI-ADS(China Initiative Accelerator-Driven System),SHINE(Shanghai High Repetition Rate XFEL and Extreme Light Facility),PAPS(Platform of Advanced Photon Source Technology),and CEPC(Circular Electron-Positron Collider),thereby developing national expertise in the field of superfluid helium cryogenic systems.

关键词： ADS Superfluid helium Cryogenic system Cryomodule J–T heat exchanger

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Ideal Bi‑Based Hybrid Anode Material for Ultrafast Charging of Sodium‑Ion Batteries at Extremely Low Temperatures

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Nano-Micro Letters 2025年第3期17卷 152-167页

作者： Jie Bai Jian Hui Jia Yu Wang Chun cheng Yang Qing jiang Key Laboratory of Automobile Materials(Jilin University) Ministry of EducationSchool of Materials Science and EngineeringJilin UniversityChangchun 130022People’s Republic of China

Sodium-ion batteries have emerged as competitive substitutes for low-temperature applications due to severe capacity loss and safety concerns of lithium-ion batteries at−20°C or ***,the key capability of ultrafast charging at ultralow temperature for SIBs is rarely ***,a hybrid of Bi nanoparticles embedded in carbon nanorods is demonstrated as an ideal material to address this issue,which is synthesized via a high temperature shock *** a hybrid shows an unprecedented rate performance(237.9 mAh g^(−1)at 2 A g^(−1))at−60℃,outperforming all reported SIB anode *** with a Na_(3)V_(2)(PO_(4))_(3)cathode,the energy density of the full cell can reach to 181.9 Wh kg^(−1)at−40°*** on this work,a novel strategy of high-rate activation is proposed to enhance performances of Bi-based materials in cryogenic conditions by creating new active sites for interfacial reaction under large current.

关键词： Bi nanoparticles High temperature shock High-rate activation Ultrafast charging Low-temperature sodium-ion batteries

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Analysis and calculation for stability of steel-sphere-combination tower-column of microwave and communication

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Journal of Harbin Institute of Technology(New Series) 2000年第S1期7卷 16-18页

作者： SHAO yong-song, LU cheng-jiang (School of Architectural Engineering and Design,Harbin Institute of Technology,150001,China)

The problem of the tower top swing with the roof of a building in the northem part of China is discussed together with the stipublation in the code,the analysis of reliability,the examination of stabiligy and safety a... 详细信息

关键词： stability critical stress steel structure

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Recent progress on photoactive nonprecious transition-metal complexes

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Science China Chemistry 2025年第1期68卷 46-95页

作者： Zhong-Liang Gong Hong-Jie Zhang Yan cheng Jianxun Liu Yuhan Ai Yaqin Li Zhihui Feng Qiong Zhang Shaolong Gong yong Chen Chang-jiang Yao Yuan-Yuan Zhu Liang-Jin Xu Yu-Wu Zhong CAS Key Laboratory of Photochemistry Institute of Chemistry Chinese Academy of Sciences State Key Laboratory of Structural Cemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences School of Chemistry and Chemical Engineering Anhui Key Laboratory of Advanced Catalytic Materials and Reaction EngineeringHefei University of Technology State Key Laboratory of Explosion Science and Safety Protection School of Mechatronical Engineering Beijing Institute of Technology College of Chemistry and Molecular Sciences Hubei Key Lab on Organic and Polymeric Optoelectronic Materials Wuhan University School of Chemistry and Chemical Engineering Anhui University Key Laboratory of Photochemical Conversion and Optoelectronic Materials & CAS-HKU Joint Laboratory on New Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences

Photoactive complexes of nonprecious transition metals, mainly including those in the first-row and partially the second-row of the Periodic table of elements, have received increasing attention in view of their low cost and long-term sustainability. They are recognized as promising alternatives to noble transition metal complex congeners that have been extensively studied in optoelectronic devices, artificial photosynthesis, photocatalysis, biodiagnostics, and therapeutics, etc. This review is devoted to a comprehensive summary on the classical and recent advances on photoactive nonprecious transition metal complexes, including photoactive Zr, V, Cr, Mo, and W complexes, Mn complexes and hybrids, Fe, Co, Ni, and Cu complexes, and Zn and Cd complexes and hybrids. A particular focus is given on the molecular design, modulation of photophysical and photochemical properties, and applications of the representative and lately-developed nonprecious metal complexes. In addition, a perspective on the future development in this field is provided at the end of this review.

关键词： photoactive metal complexes earth-abundant metals nonprecious metal complexes luminescence photochemistry

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Microstructure Evolution and Mechanism of Strength Development of Fly Ash Paste

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 152-163页

作者： MA Shuzhao WU Shunchuan HUANG Mingqing cheng Haiyong jiang Guanzhao NIU yonghui LIU Zemin SUN Wei Faculty of Land Resources Engineering Kunming University of Science and TechnologyKunming 650093China Zijin School of Ge-ology and Mining Fuzhou UniversityFuzhou 350108China

Three types of activators such as sodium hydroxide,calcium oxide and triethanolamine(TEA)are used to establish different activation environments to address the problems associated with the process of activating fly ash *** conducted mechanical tests and numerical simulations to understand the evolution of microstructure,and used environmental scanning electron microscopy(ESEM)and energy dispersive spectroscopy(EDS)techniques to analyze the microenvironments of the *** mechanical properties of fly ash paste under different activation conditions and the changes in the microstructure and composition were *** results revealed that under conditions of low NaOH content(1%-3%),the strength of the sample increased *** the content exceeded 4%,the rate of increase in strength *** on the results,the optimal NaOH content was identified,which was about 4%.A good activation effect,especially for short-term activation(3-7 d),was achieved using TEA under high doping *** activation effect was poor for long-term strength after 28 *** CaO content did not significantly affect the degree of activation *** maximum effect was exerted when the content of CaO was 2%.The virtual cement and concrete testing laboratory(VCCTL)was used to simulate the hydration process,and the results revealed that the use of the three types of activators accelerated the formation of Ca(OH)_(2) in the *** activators also corroded the surface of the fly ash particles,resulting in a pozzolanic *** active substances in fly ash were released efficiently,and hydration was *** pores were filled with hydration products,and the microstructure changed to form a new frame of paste filling that helped improve the strength of fly ash paste.

关键词： paste filling fly ash activator unconfined compressive strength microstructure hydration simulation

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变换光学透镜天线研究进展

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中国光学 2017年第2期10卷 164-175页

作者：曹尚文周永江程海峰国防科技大学新型陶瓷纤维及其复合材料国防科技重点实验室湖南长沙410073

龙伯透镜天线是一种独特的渐变折射率透镜天线,但因为某些缺陷其应用受到限制。近年来,人们采用变换光学方法和超材料理论设计了许多以平板龙伯透镜为代表的新型透镜天线。本文对比总结了变换光学设计透镜的3种方法,即坐标变换法、保角... 详细信息

龙伯透镜天线是一种独特的渐变折射率透镜天线,但因为某些缺陷其应用受到限制。近年来,人们采用变换光学方法和超材料理论设计了许多以平板龙伯透镜为代表的新型透镜天线。本文对比总结了变换光学设计透镜的3种方法,即坐标变换法、保角变换法和准保角变换法;指出了准保角变换法由于设计灵活、可使用全介电材料制备而更具研究和应用前景;详细阐述了准保角变换法设计透镜的原理和步骤;介绍了国内外关于透镜变换和制备具有影响力的研究成果;指出了变换光学透镜天线今后的研究方向。

关键词：透镜天线龙伯透镜变换光学超材料准保角变换法

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内燃机车涡轮增压器故障检测技术的应用

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内燃机车 2008年第11期 37-38页

作者：杨玉娇陈永疆库尔勒机务段新疆库尔勒841001

采用增压器故障检测技术预防增压器早期故障,提高机车运用的安全性和可靠性。

关键词：涡轮增压器故障检测

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