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Study on Acoustic Performance for Diatom Frustule with Nanoporous Structure

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Journal of Bionic Engineering 2023年第4期20卷 1656-1669页

作者： Fanming Meng yong Zheng Hongxia wang Lin chen College of Mechanical Engineering Hubei University of Automotive TechnologyShiyan442002China State Key Laboratory of Mechanical Transmission Chongqing UniversityChongqing400044China

The acoustic performance for the nanoporous frustule of the diatom is studied based on the computational fluid dynamics theory and acoustic theory involved.Representative Coscinodiscus sp.frustule is observed through the scanning electron microscope and modeled by the commercial software Solidworks.Further,the acoustic performance for the Coscinodiscus sp.frustule is studied at the varied depth,diameter or interval of the pore,as well as the film thickness of the fluid surrounding the Coscinodiscus sp.frustule.The numerical results show that,when the upper and lower pore diameters are separately 200 and 300 nm,the upper and lower pore depths are separately 200 and 250 nm,and both the pore interval and fluid film thickness are 500 nm,the elaborate nanoporous structure of Coscinodiscus sp.frustule can lower its acoustic power level by 17.49%,compared with that without porous structure.Meanwhile,the double-layer pore of Coscinodiscus sp.frustule can decrease its acoustic power level by 12.69%,compared with its single-layer pore structures.

关键词： Acoustic performance Nanoporous structure Diatom Computational fluid dynamics

Protective Mechanism of Electroacupuncture on Peripheral Neurotoxicity Induced by Oxaliplatin in Rats

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Chinese Journal of Integrative Medicine 2022年第9期28卷 833-839页

作者： wang Feng-jiao SHI She wang yong-qiang wang Ke FAN Shen-dong ZHANG Ya-nan FENG chen-chen JU Zi-yong College of Acumox and Tuina Shanghai University of Traditional Chinese MedicineShanghai201203China Department of Anesthesiology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai200120China Acupuncture Anesthesia Clinical Research Institute Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai200437China

Objective:To study the effect of electroacupuncture(EA)on oxaliplatin-induced peripheral neuropathy(OIPN)in rats.Methods:Male Sprague-Dawley rats were equally divided into 3 groups using a random number table:the control group,the OIRN group,and the EA(OIPN+EA)group,with 10 rats in each.The time courses of mechanical,cold sensitivity,and microcirculation blood flow intensity were determined.The morphology of the dorsal root ganglion(DRG)was observed by electron microscopic examination.The protein levels of nuclear factor E2-related factor 2(Nrf2),heme oxygenase-1(HO-1),and the transient receptor potential(TRP)protein family in DRGs were assayed by Western blot.Results:EA treatment significantly reduced mechanical allodynia and cold allodynia in OIPN rats(P<0.01).Notably,oxaliplatin treatment resulted in impaired microcirculatory blood flow and pathomorphological defects in DRGs(P<0.01).EA treatment increased the microcirculation blood flow and attenuated the pathological changes induced by oxaliplatin(P<0.01).In addition,the expression levels of Nrf2 and HO-1 were down-regulated,and the TRP protein family was over-expressed in the DRGs of OIPN rats(P<0.01).EA increased the expression levels of Nrf2 and HO-1 and decreased the level of TRP protein family in DRG(P<0.05 or P<0.01).Conclusion:EA may be a potential alternative therapy for OIPN,and its mechanism may be mainly mediated by restoring the Nrf2/HO-1 signaling pathway.

关键词： electroacupuncture oxaliplatin peripheral neuropathy dorsal root ganglion nuclear factor-erythroid-2-related factor 2

Gaussian mixture model based adaptive control for uncertain nonlinear systems with complex state constraints

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Chinese Journal of Aeronautics 2022年第5期35卷 361-373页

作者： Yuzhu BAI Rong chen yong ZHAO Yi wang College of Aerospace and Engineering National University of Defense TechnologyChangsha 410073China Nanjing Research Institute of Electronics Technology Nanjing 210000China

This paper addresses an uncertain nonlinear control system problem with complex state constraints and mismatched uncertainties.A novel Gaussian Mixture Model(GMM)based adaptive PID-Nonsingular Terminal Sliding Mode Control(NTSMC)(GMM-adaptive-PID-NTSMC)method is proposed.It is achieved by combining a GMM based adaptive potential function with a novel switching surface of PID-NTSMC.Next,the stability of the closed-loop system is proved.The main contribution of this paper is that the GMM method is applied to obtain the analytic description of the complex bounded state constraints,ensuring that the states'constraints are not violated with GMM-based adaptive potential function.The developed potential function can consider the influence of uncertainties.More importantly,the GMM-adaptive-PID-NTSMC can be generalized to control a more representative class of uncertain nonlinear systems with constrained states and mismatched uncertainties.In addition,the proposed controller enhances the robustness,and requires less control cost and reduces the steady state error with respect to the Artificial Potential Function based Nonsingular Terminal Sliding Mode Control(APF-NTSMC),GMM-NTSMC and GMM-adaptive-NTSMC.At last,numerical simulation is performed to validate the superior performance of the proposed controller.

关键词： Gaussian mixture model Nonlinear systems State constrained Terminal sliding mode control Uncertain

Signaling Mechanism for Modulation by GLP-1 and Exendin-4 of GABA Receptors on Rat Retinal Ganglion Cells

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Neuroscience Bulletin 2022年第6期38卷 622-636页

作者： Tao Zhang Hang-Ze Ruan Yong-Chen Wang Yu-Qi Shao Wei Zhou Shi-Jun Weng yong-Mei Zhong State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institutes of Brain ScienceFudan UniversityShanghai 200032.China

Glucagon-like peptide-1(GLP-1)is expressed in retinal neurons,but its role in the retina is largely unknown.Here,we demonstrated that GLP-1 or the GLP-1 receptor(GLP-1R;a G protein-coupled receptor)agonist exendin-4 suppressed-aminobutyric acid receptor(GABAR)-mediated currents through GLP-1Rs in isolated rat retinal ganglion cells(GCs).Pre-incubation with the stimulatory G protein(G,)inhibitor NF 449 abolished the exendin-4 effect.The exendin-4-induced suppression was mimicked by perfusion with 8-Br-cAMP(a cAMP analog),but was eliminated by the protein kinase A(PKA)inhibitor RpcAMP/KT-5720.The_exendin-4 effect was accompanied by an increase in[Ca2+];of GCs through the IP3-sensitive pathway and was blocked in Ca2+-free solution.Furthermore,when the activity of calmodulin(CaM)and CaMdependent protein kinase II(CaMKII)was inhibited,the exendin-4 effect was eliminated.Consistent with this,exendin-4 suppressed GABAR-mediated light-evoked inhibitory postsynaptic currents in GCs in rat retinal slices.These results suggest that exendin-4-induced suppression may be mediated by a distinct G,/cAMP-PKA/IPs/Ca+/CaM/CaMKIl signaling pathway,following the activation of GLP-1Rs.

关键词： Glucagon-like peptide-1 Exendin-4 GABA current Retinal ganglion cells Neuromodulation

Supraclinoid internal carotid artery blister-like aneurysms:hypothesized pathogenesis and microsurgical clipping outcomes

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Chinese Neurosurgical Journal 2022年第1期8卷 16-25页

作者： Shanwen chen Xin chen Bo Ning yong Cao Shuo wang Department of Neurosurgery the Hospital of Shunyi DistrictNo.3 Guangming Nan StreetShunyi DistrictBeijing 101300China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityChina National Clinical Research Center for Neurological DiseasesNo.119 South 4th Ring West RoadFengtai DistrictBeijing 100050China Department of Neurosurgery Guangzhou Red Cross HospitalJinan UniversityNo.396 Tongfu Zhong RoadHaizhu DistrictGuangzhou 510220GuangdongChina

Background:Blister-like aneurysms(BLAs)on the supraclinoid segment of the internal carotid artery(ICA)are an enigma of cerebrovascular disease.Neither has a definite pathogenesis been so far identified,nor have uniform treatment guidelines been established for them.Our aim was to develop a hypothesis regarding the evolution of BLAs according to their macroscopic morphologies and to evaluate the efficacy of microsurgical clipping.Methods:The clinical data and morphological features of 15 consecutive patients with 16 BLAs on the supraclinoid ICA were retrospectively reviewed.The treatment strategies were analyzed,and functional outcomes were evaluated using the modified Rankin scale(mRS).Favorable outcomes were defined as a mRS score of 0-2.Results:Morphologically,aneurysm growth with expansion of the aneurysm neck before the surgical procedure occurred in two ruptured and one unruptured aneurysm.Daughter bleb formation was observed in two ruptured and five unruptured aneurysms.A varied degree of parent artery sclerosis was observed in nine patients.Thirteen patients were treated with direct surgical clipping,one patient was treated with clipping and wrapping,and the remaining patient was treated with an encircling clipping graft.Favorable and unfavorable outcomes were observed in 13 and two cases,respectively.Follow-up angiograms revealed 4 cases of stenosis with respective degree of mild,30%,50%,and 80%without any neurological dysfunction.Conclusions:We suggest a hypothesis that BLAs on the supraclinoid ICA may share different evolving mechanisms between ruptured and unruptured lesions.A majority of them can be reliably and safely obliterated by direct clipping technique,except for the aneurysms accompanied with severely atherosclerotic parent walls.

关键词： Blister-like aneurysm Internal carotid artery Microsurgical clipping Morphology Prognosis

Double Ramification Cycles with Orbifold Targets

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Acta Mathematica Sinica,English Series 2022年第8期38卷 1333-1376页

作者： Bo Hui chen cheng yong DU Rui wang Department of Mathematics Sichuan UniversityChengdu 610064P.R.China School of Mathematical Sciences V.C.&V.R.Key Lab and Laurent Mathematics CenterSichuan Normal UniversityChengdu 610068P.R.China Department of Mathematics University of CaliforniaBerkeleyCA 94720-3840USA

In this paper,we consider double ramification cycles with orbifold targets.An explicit formula for double ramification cycles with orbifold targets,which is parallel to and generalizes the one known for the smooth cas... 详细信息

关键词： Root of orbifold line bundles polynomiality double ramification cycle absolute/relative orbifold Gromov–Witten theory

Potential Distribution of Seagrass Meadows Based on the MaxEnt Model in Chinese Coastal Waters

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Journal of Ocean University of China 2022年第5期21卷 1351-1361页

作者： wang Ming wang yong LIU Guangliang chen Yuhu YU Naijing Center for High Performance Computing and System Simulation Pilot National Laboratory for Marine Science and TechnologyQingdao 266200China Shandong Provincial Key Laboratory of Computer Networks Qilu University of Technology(Shandong Academy of Sciences)Jinan 250101China

Seagrass meadows are generally diverse in China and have become important ecosystem with essential functions.However,the seagrass distribution across the seawaters of China has not been evaluated,and the magnitude and direction of changes in seagrass meadows remain unclear.This study aimed to provide a nationwide seagrass distribution map and explore the dynamic changes in seagrass population under global climate change.Simulation studies were performed using the modeling software MaxEnt with 58961 occurrence records and 27 marine environmental variables to predict the potential distribution of seagrasses and calculate the area.Seven environmental variables were excluded from the modeling processes based on a correlation analysis to ensure predicted suitability.The predicted area was 790.09 km^(2),which is much larger than the known seagrass distribution in China(87.65 km^(2)).By 2100,the suitable habitat of seagrass will shift northwest and increase to 923.62 km2.Models of the sum of the individual family under-pre-dicted the national distribution of seagrasses and consistently showed a downward trend in the future.Out of all environmental vari-ables,physical parameters(e.g.,depth,land distance,and sea surface temperature)contributed the most in predicting seagrass distri-butions,and nutrients(e.g.,nitrate,phosphate)ranked among the key influential predictors for habitat suitability in our study area.This study is the first effort to fill a gap in understanding the distribution of seagrasses in China.Further studies using modeling and biological/ecological approaches are warranted.

关键词： seagrass meadows species distribution modeling global climate change Chinese coastal waters

A new genus and species of disc-bearing Labeoninae(Teleostei:Cypriniformes)from Guangxi,China

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Zoological Research 2022年第3期43卷 409-412页

作者： Zhi-Bang wang Xiao-yong chen Lan-Ping Zheng School of Chinese Materia Medica Yunnan University of Chinese MedicineKunmingYunnan 650500China Southeast Asia Biodiversity Research Institute Chinese Academy of SciencesYezinNay Pyi Taw 05282Myanmar Kunming Institute of Zoology Chinese Academy of SciencesKunmingYunnan 650223China University of Chinese Academy of Sciences Beijing 100049China

DEAR EDITOR,Guigarra cailaoensis sp.nov.,a new genus and species of Labeoninae,was collected from Guangxi Zhuang Autonomous Region,China.It differs from all other genera within Labeoninae by a unique combination of the following characters:(1)rostral cap smooth with posterior margin slightly serrated;(2)upper lip well developed and covering most of upper jaw;(3)gular disc present with crescentic torus.

关键词： slightly China. torus

A 124 dB dynamic range sigma-delta modulator applied to non-invasive EEG acquisition using chopper-modulated input-scaling-down technique

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Science China(Information Sciences) 2022年第4期65卷 23-37页

作者： Kaiquan chen Mingyi chen Longlong chenG Liang QI Guoxing wang yong LIAN Department of Micro/Nano Electronics Shanghai Jiao Tong University China Electronic Cloud Brain (Tianjin) Technology Co. Ltd.

With the advancement of brain science in recent years, the non-invasive brain-computer interfaces（BCIs） based on electroencephalogram（EEG） acquisition have been widely adopted in various brain-inspired applications. The acquisition of multi-channel microvolts EEG signals corrupted by the motion artifacts（MAs） of up to several volts poses enormous challenges to the design of analog front-end（AFE）, especially the analog-to-digital converter（ADC）, which is necessary to achieve low noise, wide dynamic range（DR）,high accuracy as well as low power. In this paper, a wide DR Σ△ modulator with chopper-modulated inputscaling-down（CM-ISD） technique has been proposed to deal with large input offset while extending dynamic range. Fabricated in 180 nm CMOS technology, the prototype occupies a core area of 0.32 mm;. With a 40 Hz input signal and 125 Hz Nyquist bandwidth, the measured signal-to-noise ratio（SNR） and signalto-noise and distortion ratio（SNDR） are 117 and 110 dB, respectively. Thanks to the proposed CM-ISD technique, the modulator is capable of withstanding a full-scale(4.5 V;) input whereas the measured DR has been extended from 99 to 124 dB. The power consumption is 2.75 mW under 5 V supply voltage,corresponding to 170.6 dB Schreier figure-of-merit（FoMS）. The multi-channel EEG acquisition has been demonstrated based on the proposed modulator, showing its potential in advanced non-invasive BCI systems.

关键词： Analog-to-digital converter (ADC) ΣΔ modulator brain computer interface electroencephalogram dynamic range motion artifacts