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Construction of acetyl-CoA and DBAT hybrid metabolic pathway for acetylation of 10-deacetylbaccatin Ⅲ to baccatin Ⅲ

Acta Pharmaceutica Sinica B 2021年第10期11卷 3322-3334页

作者： Hao Wang bo-yong zhang Ting Gong Tian-Jiao Chen Jing-Jing Chen Jin-Ling Yang Ping Zhu State Key Laboratory of Bioactive Substance and Function of Natural Medicines NHC Key Laboratory of Biosynthesis of Natural ProductsCAMS Key Laboratory of Enzyme and Biocatalysis of Natural DrugsInstitute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China

10-DeacetylbaccatinⅢ(10-DAB)C10 acetylation is an indispensable procedure for Taxol semi-synthesis,which often requires harsh conditions.10-DeacetylbaccatinⅢ-10-β-O-acetyltransferase(DBAT)catalyzes the acetylation but acetyl-CoA supply remains a key limiting *** we refactored the innate biosynthetic pathway of acetyl-CoA in Escherichia coli and obtained a chassis with acetyl-CoA productivity over three times higher than that of the host ***,we constructed a microbial cell factory by introducing DBAT gene into this chassis for efficiently converting 10-DAB into baccatinⅢ.We found that baccatinⅢcould be efficiently deacetylated into 10-DAB by DBAT with CoASH and K+under alkaline ***,we fed acetic acid to the engineered strain both for serving as a substrate of acetyl-CoA biosynthesis and for alleviating the deacetylation of baccatinⅢ.The fermentation conditions were optimized and the baccatinⅢtiters reached 2,3 and 4.6 g/L,respectively,in a 3-L bioreactor culture when 2,3 and 6 g/L of 10-DAB were *** study provides an environmentfriendly approach for the large scale 10-DAB acetylation without addition of acetyl-CoA in the industrial Taxol *** finding of DBAT deacetylase activity may broaden its application in the structural modification of pharmaceutically important lead compounds.

关键词： Microbial cell factory Biosynthetic pathway of acetyl-CoA Bioconversion of 10-deacetylbaccatinⅢto baccatinⅢ 10-DeacetylbaccatinⅢ-10-β-Oacetyltransferase Deacetylation of baccatinⅢ High-cell-density fermentation Taxol semi-synthesis

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Friction as energy dissipation process associated with superlubricity of solids

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Friction 2024年第9期12卷 2083-2088页

作者： bo zhang Saga University Saga-shi 840-8502Japan

The paper shows that work in a quantum system is quantized with energy;the quantum work is equivalent to the highest eigenenergy(the Debye energy)of the system and the superlubricity of solids is derived from the quantum *** prerequisite for the superlubricity is that the lateral force at contact surfaces in sliding is less than the Debye force so that the phonon of the solids is not excited.

关键词： superlubricity phonon friction Plank law Debye frequency

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High-temperature wetting behavior between slag and refractory

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Journal of Iron and Steel Research International 2024年第6期31卷 1304-1319页

作者： yong-xin Wang Ya-ge Li Ya-bo Gao Zhong Huang Hai-jun zhang The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina

Slag corrosion is one of the main factors of the damage of refractory,and its primary manifestations involve the melting of refractory in slag and the slag penetration into refractory,both of which are highly related to the wetting behavior between slag and *** high-temperature wettability could be characterized by parameters including the surface tension,adhesion work,and spreading coefficient of the slag on refractory surface,and it could be suppressed by altering the slag/refractory interface,thus resulting in an improved anti-corrosion *** this,the key knowledges of the slag corrosion,theory of wetting behavior and test of high-temperature contact angle were firstly ***,the major factors influencing the high-temperature slag wetting behavior were discussed based on the aspects of slag composition,refractory composition,and surface ***,the future research direction was proposed in this field.

关键词： High-temperature wetting Refractory Slag corrosion Surface tension

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Fatal progressive ascending encephalomyelitis caused by herpes B virus infection:first case from China

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World Journal of Emergency Medicine 2022年第4期13卷 330-333页

作者： Tian-peng zhang Zhen Zhao Xue-lian Sun Miao-rong Xie Feng-kui Liu yong-bo zhang Lu-xi Shen Guo-xing Wang Department of Emergency Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Neurology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China

Dear editor,Herpes B virus(BV),also known as Macacine herpesvirus 1(family:Herpesviridae,subfamily:Alphaherpesvirinae,genus:Simplexvirus),officially designated by the International Committee on the Taxonomy of Viruses,exhibits serologic cross-reactivity with other members of the genus Simplexvirus,namely HSV type 1(HSV-1),the causative agent of oral herpetic ulcers(cold sores)in humans and HSV type 2(HSV-2),the agent of human genital herpes.[1]

关键词： agent editor Alpha

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Development of a high-repetition-rate lumped-inductance kicker magnet prototype for the beam switchyard of SHINE

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Nuclear Science and Techniques 2024年第2期35卷 20-31页

作者： yong-Fang Liu Rui-Ping Wang Jin Tong bo zhang Si Chen Qi-Bing Yuan Hai-Xiao Deng Ming Gu bo Liu Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201412People’s Republic of China

The Shanghai high-repetition-rate X-ray free-electron laser and extreme light facility(SHINE)operates at a maximum repetition rate of 1 *** magnets are key components that distribute electron bunches into three different undulator lines in a bunch-by-bunch *** kicker field width must be less than the time interval between bunches.A lumpedinductance kicker prototype was developed using a vacuum chamber with a single-turn *** full magnetic field strength was 0.005 *** paper presents the requirements,design considerations,design parameters,magnetic field calculations,and measurements of the kicker *** relevant experimental results are also *** pulse width of the magnetic field was approximately 600 ns,and the maximum operation repetition rate was 1 *** developed kicker satisfies the requirements for the SHINE ***,numerous recommendations for the future optimization of kicker magnets are provided.

关键词： X-ray free-electron laser Kicker magnet Beam switchyard High repetition rate Ni-Zn ferrites

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The BEL1-like transcription factor GhBLH5-A05 participates in cotton response to drought stress

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The Crop Journal 2024年第1期12卷 177-187页

作者： Jing-bo zhang Yao Wang Shi-Peng zhang Fan Cheng yong Zheng Yang Li Xue-Bao Li Hubei Key Laboratory of Genetic Regulation and Integrative Biology School of Life SciencesCentral China Normal UniversityWuhan 430079HubeiChina College of Life Sciences Xinjiang Normal UniversityUrumqi 830017XinjiangChina

Drought stress impairs crop growth and ***1-like family transcription factors may be involved in plant response to drought stress,but little is known of the molecular mechanism by which these proteins regulate plant response and defense to drought *** we show that the BEL1-like transcription factor GhBLH5-A05 functions in cotton(Gossypium hirsutum)response and defense to drought *** of GhBLH5-A05 in cotton was induced by drought *** of GhBLH5-A05 in both Arabidopsis and cotton increased drought tolerance,whereas silencing GhBLH5-A05 in cotton resulted in elevated sensitivity to drought ***5-A05 binds to cis elements in the promoters of GhRD20-A09 and GhDREB2C-D05 to activate the expression of these ***5-A05 interacted with the KNOX transcription factor ***-expression of GhBLH5-A05 and GhKNAT6-A03 increased the transcription of GhRD20-A09 and *** conclude that GhBLH5-A05 acts as a regulatory factor with GhKNAT6-A03 functioning in cotton response to drought stress by activating the expression of the drought-responsive genes GhRD20-A09 and GhDREB2C-D05.

关键词： Cotton(Gossypium hirsutum) BEL1-like transcription factor Drought stress Transcriptional regulation Drought tolerance

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An integrated MINLP model for multi-party coordination in downstream oil supply chain

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Petroleum Science 2024年第3期21卷 2066-2079页

作者： Rui Qiu bo zhang Wei Zhao Ren-Fu Tu Man-Qiu He Qi Liao yong-Tu Liang National Engineering Laboratory for Pipeline Safety/Beijing Key Laboratory of Urban Oil and Gas Distribution Technology China University of Petroleum-BeijingFuxue Road No.18Changping DistrictBeijing102249PR China Strategy&Implementation Department PipeChinaDongtucheng Road No.5Chaoyang DistrictBeijing100013PR China

Cooperation among enterprises can bring overall and individual performance improvement,and a smooth coordination method is ***,due to the lack of customized coordination methods,cooperation in the downstream oil supply chain cannot be carried out *** paper intends to propose a multi-party coordination method to promote cooperation between oil shippers and pipeline operator by optimizing oil transportation,oil substitution and pipeline pricing *** integrated game-theoretic modeling and analysis approach is developed to characterize the operation behaviors of all stakeholders in the downstream oil supply *** proposed mixed integer nonlinear programming model constrains supply and demand capacity,transportation routes,oil substitution rules and pipeline freight *** transformation and price discretization are introduced for model linear *** experiments are carried out in the oil distribution system in South *** results show that compared to the business-as-usual scheme,the new scheme saves transportation cost by 3.48%,increases pipeline turnover by 5.7%,and reduces energy consumption and emissions by 7.66%and 6.77%.It is proved that the proposed method improves the revenue of the whole system,achieves fair revenue distribution,and also improves the energy and environmental benefits of the oil supply chain.

关键词： Downstreamoil supplychain Multi-partycoordination Cooperative game Mixed integernonlinear programming model Pipeline transportation Revenue distribution

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A variable structure passivity control method for elastic joint robots based on cascaded high-order state estimation

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Science China(Technological Sciences) 2024年第2期67卷 395-407页

作者： zhang JieXin NIE PingYun zhang bo State Key Laboratory of Mechanical System and Vibration School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai200240China

Passivity-based controllers are widely used to facilitate physical interaction between humans and elastic joint robots,as they enhance the stability of the interaction ***,the joint position tracking performance can be limited by the structures of these controllers when the system is faced with uncertainties and rough high-order system state measurements(such as joint accelerations and jerks).This study presents a variable structure passivity(VSP)control method for joint position tracking of elastic joint robots,which combines the advantages of passive control and variable structure *** method ensures the tracking error converges in a finite time,even when the system faces *** method also preserves the passivity of the ***,a cascaded observer,called CHOSSO,is also proposed to accurately estimate high-order system states,relying only on position and velocity *** observer allows independent implementation of disturbance compensation in the acceleration and jerk estimation *** particular,the observer has an enhanced ability to handle fast time-varying disturbances in physical human-robot *** effectiveness of the proposed method is verified through simulations and experiments on a lower limb rehabilitation robot equipped with elastic joints.

关键词： motion control elastic joint robot finite-time convergence high-order system state estimation physical human-robot interaction

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Automated regression test method for scientific computing libraries:Illustration with SPHinXsys

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Journal of Hydrodynamics 2024年第3期36卷 466-478页

作者： bo zhang Chi zhang Xiangyu Hu TUM School of Engineering and Design Technical University of MunichMunichGermany

Scientific computing libraries,whether in-house or open-source,have witnessed enormous progress in both engineering and scientific ***,it is important to ensure that modifications to the source code,prompted by bug fixing or new feature development,do not compromise the accuracy and functionality that have been already validated and *** paper introduces a method for establishing and implementing an automatic regression test environment,using the open-source multi-physics library SPHinXsys as an illustrative ***,a reference database for each benchmark test is generated from observed data across multiple *** comprehensive database encapsulates the maximum variation range of metrics for different strategies,including the time-averaged,ensemble-averaged,and dynamic time warping *** accounts for uncertainties arising from parallel computing,particle relaxation,physical instabilities,and ***,new results obtained after source code modifications undergo testing based on a curve-similarity comparison against the reference *** the source code is updated,the regression test is automatically executed for all test cases,providing a comprehensive assessment of the validity of the current *** regression test environment has been successfully implemented in all dynamic test cases within SPHinXsys,including fluid dynamics,solid mechanics,fluid-structure interaction,thermal and mass diffusion,reaction-diffusion,and their multi-physics couplings,and demonstrates robust capabilities in testing different *** is noted that while the current test environment is built and implemented for a particular scientific computing library,its underlying principles are generic and can be easily adapted for use with other libraries,achieving equal effectiveness.

关键词： Scientific computing open-source library verification and validation regression test automatic test environment curve similarity comparison smoothed particle hydrodynamics

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Recent advances in multifunctional shape memory photonic crystals and practical applications

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Nano Research 2024年第1期17卷 79-96页

作者： yong Qi Shufen zhang State Key Laboratory of Fine Chemicals Frontier Science Center for Smart MaterialsDalian University of TechnologyDalian 116024China

Shape memory photonic crystals(SMPCs)are smart composite materials with changeable structural color integrated by shape memory polymer and photonic *** can produce one or more temporary shapes through nanoscale deformation,memorizing current *** can be recovered to their original shapes or some intermediate states under external stimuli,accompanied by the variation of structural *** porous carriers with built-in sensing properties,SMPCs promoted the interdisciplinary development of nanophotonic technology in materials science,environmental engineering,biomedicine,chemical engineering,and ***,the recent progress on multifunctional SMPCs and practical applications,including traditional and cold programmable SMPCs,is summarized and *** primary concern is shape programming at the nanoscale that has demonstrated numerous attractive functions,including smart sensing,ink-free printing,solvent detection,reprogrammable gradient wetting,and controllable bubble transportation,under variations of the surface *** aims to figure out the nanoscale shape memory effects on structural color conversion and additional performance,inspiring the fabrication of the next generation of ***,perspectives on future research directions and applications are also *** is believed that multifunctional SMPCs are powerful nanophotonic tools for the interdisciplinary development of numerous disciplines in the future.

关键词： photonic crystal shape memory structural color cold programmable shape recovery

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