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Quantitative evaluation of hepatitis B virus mutations and hepatocellular carcinoma risk:a meta-analysis of prospective studies

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Chinese Journal of Cancer Research 2015年第5期27卷 497-508页

作者： Yang Yang Jiang-Wei Sun Long-Gang Zhao Freddie Bray yong-bing xiang School of Public Health Fudan University State Key Laboratory of Oncogene and Related Genes & Department of Epidemiology Shanghai Cancer InstituteRenji HospitalShanghai Jiaotong University School of Medicine Cancer Surveillance Section International Agency for Research on Cancer

Background： The temporal relationship between hepatitis B virus （HBV） mutations and hepatocellular carcinoma （HCC） remains unclear. Methods： We conducted a meta-analysis including cohort and nested case-control studies to prospectively examine the HCC risk associated with common variants of HBV in the PreS, Enhancer Ⅱ, basal core promoter （BCP） and precore regions. Pertinent studies were identified by searching PubMed, Web of Science and the Chinese Biological Medicine databases through to November 2014. Study-specific risk estimates were combined using fixed or random effects models depending on whether significant heterogeneity was detected. Results： Twenty prospective studies were identified, which included 8 cohort and 12 nested case-control studies. There was an increased risk of HCC associated with any PreS mutations with a pooled relative risk （RR） of 3.82 [95% confidence interval （CI）： 2.59-5.61]. The pooled-RR for PreS deletion was 3.98 （95% CI： 2.28-6.95）, which was higher than that of PreS2 start codon mutation （pooled-RR=2.63, 95% CI： 1.30-5.34）. C1653T in Enhancer Ⅱ was significantly associated with HCC risk （pooled-RR=l.83; 95% CI： 1.21-2.76）. For mutations in BCP, statistically significant pooled-RRs of HCC were obtained for T1753V （pooled- RR=2.09; 95% CI： 1.49-2.94） and AI762T/G1764A double mutations （pooled-RR=3.11; 95% CI： 2.08- 4.64）. No statistically significant association with HCC risk was observed for G1896A in the precore region （pooled-RR=0.77; 95% CI： 0.47-1.26）. Conclusions： This study demonstrated that PreS mutations, C1653T, T1753V, and A1762T/G1764A, were associated with an increased risk of HCC. Clinical practices concerning the HCC risk prediction and diagnosis may wish to focus on patients with these mutations.

关键词： Hepatitis B virus (HBV) mutation hepatocellular carcinoma (HCC) prospective study meta-analysis

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ABO blood type is associated with endometrial cancer risk in Chinese women

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Chinese Journal of Cancer 2011年第11期30卷 766-771页

作者： Wang-Hong Xu Wei Zheng yong-bing xiang Xiao-Ou Shu Department of Epidemiology School of Public Health Fudan University Key Laboratory of Public Health Safety Ministry of Education (Fudan University) Shanghai 200032 P. R. China Vanderbilt Epidemiology Center Department of Medicine and Vanderbilt-lngram Cancer Center Nashville TN 37232-8300 USA Department of Epidemiology Shanghai Cancer Institute Shanghai 200032 P. R. China.

ABO blood type has been associated with risk of several malignancies. However, results are not consistent. In this population-based case-control study including 1204 incident endometrial cancer cases and 1212 population controls, we examined the association of self-reported serologic blood type with endometrial cancer risk using a logistic regression model. Women with endometrial cancer were more likely to have blood type A. Compared to women with blood type O, the adjusted odds ratios for endometrial cancer were 1.00 [95% confidence interval (CI), 0.79-1.28] for type B, 1.24 (95% CI, 0.90-1.69) for type AB, and 1.50 (95% CI, 1.19-1.90) for type A. A significant dose-response relationship was observed for cancer risk and level of antigen A (P for trend = 0.0003). The positive association of blood type A with cancer risk was observed regardless of menopausal status, body mass index, oral contraceptive use, or family cancer history. Our results suggest that ABO blood type may be involved in the development of endometrial cancer.

关键词：子宫内膜癌 ABO血型风险妇女 logistic回归模型中国人口控制恶性肿瘤

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Global pattern and trend of liver cancer survival: a systematic review of population-based studies

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Hepatoma Research 2020年第8期6卷 78-90页

作者： Yu-Fei Jiang Zhuo-Ying Li Xiao-Wei Ji Qiu-Ming Shen Jia-Yi Tuo Hui-Yun Yuan yong-bing xiang School of Public Health Shanghai Jiaotong University School of MedicineShanghai 200025China State Key Laboratory of Oncogene and Related Genes&Department of Epidemiology Shanghai Cancer InstituteRenji HospitalShanghai Jiaotong University School of MedicineShanghai 200032China Renji Hospital Shanghai Jiaotong University School of MedicineShanghai 200032China

Aim:To describe the global pattern and trend of liver cancer survival,using data from the population-based studies or cancer ***:By searching CNKI,Wanfang Data,PubMed,Web of Science,EMBASE and *** population-based survival studies of liver cancer from 1 January 2000 to 30 April 2020 were collected and evaluated by patient gender,time period,and *** overall or age-standardized five-year relative survival rate was used to describe the pattern and changes in liver cancer survival over the past ***:Globally,the highest age-standardized five-year relative survival rate was observed in Italy(18.0%,2005-2007)and the highest overall five-year relative survival rate was observed in Korea(34.6%,2012-2016),when compared to other *** most remarkable increase in overall five-year relative survival rate can be seen in Korea(from 10.7%during 1993-1995 to 34.6%during 2012-2016).In general,worldwide,the five-year relative survival rate of younger patients with liver cancer was higher than old *** most countries,the five-year relative survival rate of liver cancer was slightly higher in women than in *** China,the overall five-year relative survival rate of liver cancer in Taiwan was higher than that in other areas,while Cixian of Hebei and Qidong of Jiangsu were ***:Over the past decades,the survival rates of liver cancer have gradually improved,but great variations are also observed ***,younger patients with liver cancer have experienced a better *** disparity in liver cancer survival was not obvious.

关键词： Primary liver cancer relative survival rate prognosis population-based study cancer registration

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Risk prediction models for hepatocellular carcinoma in different populations

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Chinese Journal of Cancer Research 2016年第2期28卷 150-160页

作者： Xiao Ma Yang Yang Hong Tu Jing Gao Yu-Ting Tan Jia-Li Zheng Freddie Bray yong-bing xiang State Key Laboratory of Oncogene and Related Genes Shanghai Cancer InstituteRenji HospitalShanghai Jiaotong University School of Medicine Department of Epidemiology Shanghai Cancer InstituteRenji HospitalShanghai Jiaotong University School of Medicine University of South Carolina Arnold School of Public HealthDepartment of Epidemiology and Biostatistics Cancer Surveillance Section International Agency for Research on Cancer

Hepatocellular carcinoma （HCC） is a malignant disease with limited therapeutic options due to its aggressive progression. It places heaW burden on most low and middle income countries to treat HCC patients. Nowadays accurate HCC risk predictions can help making decisions on the need for HCC surveillance and antiviral therapy. HCC risk prediction models based on major risk factors of HCC are useful and helpful in providing adequate surveillance strategies to individuals who have different risk levels. Several risk prediction models among cohorts of different populations for estimating HCC incidence have been presented recently by using simple, efficient, and ready-to-use parameters. Moreover, using predictive scoring systems to assess HCC development can provide suggestions to improve clinical and public health approaches, making them more cost-effective and effort-effective, for inducing personalized surveillance programs according to risk stratification. In this review, the features of risk prediction models of HCC across different populations were summarized, and the perspectives of HCC risk prediction models were discussed as well.

关键词： Risk prediction models hepatoceUular carcinoma chronic hepatitis B chronic hepatitis C cirrhosis risk factors general population cohort study

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Population attributable risks of cigarette smoking for deaths of all causes, all cancers and other chronic diseases among adults aged 40-74 years in urban Shanghai, China

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Chinese Journal of Cancer Research 2015年第1期27卷 59-65页

作者： Ying-Ying Wang Wei Zhang Hong-Lan Li Jing Gao Yu-Ting Tan Yu-Tang Gao Xiao-Ou Shu Wei Zheng yong-bing xiang School of Public Health Fudan University Shanghai Cancer Institute Renji Hospital Shanghai Jiaotong University School of Medicine Division of Epidemiology Department of Medicine Vanderbilt Epidemiology Center Vanderbilt-Ingram Cancer Center Vanderbilt University School of Medicine

Objective： To evaluate the population attributable risks （PARs） between cigarette smoking and deaths of all causes, all cancers, lung cancer and other chronic diseases in urban Shanghai. Methods： In total, 61,480 men aged 40-74 years from 2002 to 2006 and 74,941 women aged 40-70 years from 1997 to 2000 were recruited to undergo baseline surveys in urban Shanghai, with response rates of 74.0% and 92.3%, respectively. A Cox proportional hazards regression model was used to estimate relative risks （RRs） and 95% confidence intervals （95% CIs） of deaths associated with cigarette smoking. PARs and 95 % CIs for deaths were estimated from smoking exposure rates and the estimated RRs. Results： Cigarette smoking was responsible for 23.9% （95% CI： 19.4-28.3%） and 2.4% （95% Ch 1.6- 3.2%） of all deaths in men and women, respectively, in our study population. Respiratory disease had the highest PAR in men [37.5% （95% CI： 21.5-51.6%）], followed by cancer [31.3% （95% Ch 24.6-37.7%）] and cardiovascular disease （CVD） [24.1% （95% CI： 16.7-31.2%）]. While the top three PARs were 12.7% （95% CI： 6.1-19.3%）, 4.0% （95% CI： 2.4-5.6%）, and 1.1% （95% CI： 0.0-2.3%）, for respiratory disease, CVD, and cancer, respectively in women. For deaths of lung cancer, the PAR of smoking was 68.4% （95% CI： 58.2- 76.5%） in men. Conclusions： In urban Shanghai, 23.9% and 2.4% of all deaths in men and women could have been prevented if no people had smoked in the area. Effective control programs against cigarette smoking should be strongly advocated to reduce the increasing smoking-related death burden.

关键词： Population attributable risk (PAR) smoking mortality cohort study all causes death cancer death lung cancer

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Association of a single nucleotide polymorphism at 6q25.1, rs2046210, with endometrial cancer risk among Chinese women

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Chinese Journal of Cancer 2011年第2期30卷 138-143页

作者： Guoliang Li yong-bing xiang Regina Courtney Jia-Rong Cheng Bo Huang Ji-Rong Long Hui Cai Wei Zheng Xiao-Ou Shu Qiuyin Cai Division of Epidemiology and Vanderbilt Epidemiology Center Department of Medicine Vanderbilt University School of Medicine and Vanderbilt-lngram Cancer Center Nashville Tennessee 37232 USA Department of Epidemiology Shanghai Cancer Institute Shanghai 200032 P. R. China.

A recent genome-wide association study identified a new susceptibility locus for breast cancer, rs2046210, which is a single nucleotide polymorphism (SNP) located upstream of the estrogen receptor α (ESR1) gene on chromosome 6q25.1. Given that endometrial cancer shares many risk factors with breast cancer and both are related to estrogen exposure and that rs2046210 is in close proximity to the ESR1 gene, we evaluated the association of SNP rs2046210 with endometrial cancer risk among 953 cases and 947 controls in a population-based, case-control study conducted in Shanghai, China. Logistic regression models were used to derive odds ratios (ORs) and 95% confidence intervals (95% CIs) after adjusting for potential confounders. We found that the A allele of rs2046210, linked to an increased risk of breast cancer, was associated with increased but not statistically significant risk of endometrial cancer (OR = 1.16, 95% CI = 0.96-1.41 for the GA and AA genotypes compared with the GG genotype); the association was stronger among post-menopausal women (OR = 1.28, 95% CI = 1.00-1.65). The association tended to be stronger among women with higher or longer estrogen exposure than among women with relatively lower or shorter exposure to estrogen. Our study suggests that rs2046210 may play a role in the etiology of endometrial cancer. Additional studies are needed to confirm our findings.

关键词：单核苷酸多态性子宫内膜癌风险因素协会妇女 Logistic回归模型中国雌激素受体

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Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen Chen Xiaolin Zeng Le Wang Wenwu Zhang Gang Li Xing Cheng Peiqiang Su yong Wan xiang Li Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

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Multivariate synergy for heightening ionic HOF robustness and proton conductivity

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Science China Chemistry 2025年

作者： xiang-Tian Bai Li-Hui Cao Xu-yong Chen Jia-Yu Wang Zi-Ye Zhou Shaanxi Key Laboratory of Chemical Additives for Industry College of Chemistry and Chemical EngineeringShaanxi University of Science and Technology

Multicomponent crystalline materials construct more complex and diversified structures with different combinations and modes,which expands the material structure space and application *** this work,we have successfully synthesized two twocomponent ionic hydrogen-bonded organic frameworks （iHOF-32 and iHOF-33） and a three-component iHOF （iHOF-34）.Guanidine hydrochloride which is rich in N and H and has a short chain length strengthens the hydrogen bonding network of iHOF,thereby aiding in the efficient migration of *** rigid architecture of 1,1'-diamino-4,4'-bipyridine diiodide furnishes additional scaffolding for the iHOFs and enhances its robustness under harsh ***-34 accomplishes the combination of the ultra-high proton conductivity of iHOF-32 and the robustness of iHOF-33 by the synergistic interaction among the three components of *** addition,iHOF-34 was fabricated as a composite membrane with a peak proton conductivity of 1.55×10-1S cm-1,which is 3.8 times higher than that of recast Nafion,and has extensive potential in fuel *** self-assembly strategy of multicomponent HOFs opens up new avenues for constructing diverse structures while promising new opportunities for applications in the fields of proton conduction and energy storage.

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Burden of biliary tract carcinoma in China(1990–2021):Findings from the 2021 Global Burden of Disease Study

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Science Bulletin 2024年第22期69卷 3547-3557页

作者： Wei Zhang Yi-Jun Wang Jiang-Mei Liu Xu-Heng Sun Yan Jiang Fang Shen Li-Juan Shen Jing xiang Jun-Feng Zhang Lin-Hua Yang Wen-Guang Wu Tao Chen Hui Wang Min He Li-Guo Liu Wen-Qi Tao yong-Zhi Chen yong-bing xiang Mao-Lan Li Mai-Geng Zhou Ying-Bin Liu Department of Epidemiology Shanghai Cancer InstituteRenji HospitalShanghai Jiao Tong University School of MedicineShanghai 200120China Department of Biliary-Pancreatic Surgery Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200120China National Center for Chronic and Noncommunicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 100050China Department of Medical Affairs Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200120China Department of General Surgery Jiading BranchRenji HospitalShanghai Jiao Tong University School of MedicineShanghai 201800China Shanghai Key Laboratory of Systems Regulation and Clinical Translation for Cancer Shanghai 200127China State Key Laboratory of Systems Medicine for Cancer Shanghai Cancer InstituteShanghai 200127China Shanghai Cancer Institute Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200120China

Biliary tract carcinoma(BTC)is a group of malignant tumors that originate in the digestive system and occurs with a high incidence in *** consistent and comparable assessments of BTC disease burden have been conducted at national or subnational levels,and little is known about the demographic,temporal,and geographic patterns of epidemiological characteristics and disease burden of BTC in *** incidence,mortality,disability-adjusted life-years(DALYs),years of life lost(YLLs)due to premature death and years lived with disability(YLDs)of BTC were comprehensively examined by age,sex,and calendar year in the Chinese population,using the methodological framework and analytical strategies used for the 2021 Global Burden of Disease ***-age incidence increased from 17,077 to 51,720between 1990 and 2021,and the age-standardized incidence rate rose by 13.62%;all-age deaths increased from 17,251 to 37,833,but the age-standardized mortality rate fell by nearly *** DALYs rose by 89.57%while the age-standardized DALY rate fell by 23.24%.Variations of the tendencies in BTC burden were found between sexes and age *** for each provincial region indicate that coastal eastern provincial regions have higher incidence and YLD levels,whereas northern provincial regions have higher mortality,DALY,and YLL *** proportions of DALYs attributable to high body mass index(BMI)illustrate the growing attribution obesity has made,and high BMI usually puts more burden on northern provincial *** results provide evidence to support precise,targeted,and customed public health strategies aimed at enhancing biliary tract health among the Chinese population.

关键词： Biliary tract carcinoma China Global burden of disease study Disability-adjusted life-year Year of life lost due to premature death Year lived with disability

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Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

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Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi Xu Junqiu Jia Rui Mao xiang Cao Yun Xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury

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