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Agricultural Sciences in China 2009年第2期8卷 137-143页

作者： LI Yu-ling DONG yong-bin niu Su-zhen CUI Dang-qun Agronomy College Henan Agricultural University Zhengzhou 450002 P.R.China

Normal corn germplasm can be used to improve popcorn （Zea mays L.） through 1-2 backcrosses with popcorn as recurrent parents. Popping characteristics of derived lines from popcorn × dent or flint corn crosses play a determinant role in popcorn breeding. Advanced backcross QTL methods can effectively combine QTL identification and plant breeding. 220 selected BC2F2 families developed from a cross between Dan 232, a dent corn inbred line, and N04, an elite popcorn inbred line, were evaluated for three popping characteristics, popping volume, flake size, and popping rate, under two environmental conditions. Using composite interval mapping, a total of 10 significant QTLs were detected, and of these, 2 to 4 QTLs were identified for each trait. Six QTLs had favorable alleles contributed by Dan 232. Comparison with the 15 QTLs detected in the F2：3 families showed that 3 QTLs were the same in both populations. The QTLs should be redetected in generations developed through severe selection. Improved N04 and near isogenic lines could be developed from this BC2F2 population through selfing or another 1 to 2 backcrosses with N04.

关键词： Zea mays L. popcorn BC2F2 population quantitative trait loci popping characteristics

Bioturbation enhanced petrophysical properties in the Ordovician carbonate reservoir of the Tahe oilfield,Tarim Basin,NW China

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Journal of Palaeogeography 2022年第1期11卷 31-51页

作者： yong-bin niu Meng-Yuan Cheng Li-Jun Zhang Jian-Hua Zhong Sheng-Xin Liu Duan Wei Zi-Lu Xu Pei-Jun Wang Key Laboratory of Biogenic Traces and Sedimentary Minerals of Henan Province Jiaozuo 454003Henan ProvinceChina Collaborative Innovation Center of Coalbed Methane and Shale Gas for Central Plains Economic Region Henan Polytechnic UniversityJiaozuo 454003Henan ProvinceChina School of Geoscience China University of Petroleum(East China)Qingdao 266580Shandong ProvinceChina Institute of Geomechanics Chinese Academy of Geological SciencesBeijing 100081China School of Energy Resource China University of Geosciences(Beijing)Beijing 100083China Development Affairs of Tarim Oilfield PetroChinaKorla 841000Xinjiang Uygur Autonomous RegionChina

Bioturbation plays an important role in enhancing the reservoir capacity of tight *** study aims to understand the alteration mechanism and effects of bioturbation on oil and gas reservoirs,to clarify the key control factors and constraints influencing the production of *** petrophysical characteristics of bioturbation and host sediments in carbonate rocks,such as mineral composition,pore spaces,porosity and permeability,were studied based on the detailed observation and description of the Ordovician cores from the Tahe *** effect of bioturbation on petrophysical properties of carbonate rocks were carefully *** results show:(1)Two types of bioturbation,Thalassinoides-like burrows and Planolites-like burrows,mainly occur in the Ordovician cores of the Tahe oilfield,ranging from the Lower-Middle Ordovician Yingshan Formation to the Middle Ordovician Yijianfang *** burrow-fills are mainly composed of dolomite with subhedral and euhedral *** host sediments mainly consist of micrite.(2)The pores in the host sediments are poorly developed and are incapable of forming effective reservoir ***,well-developed intercrystalline pores among dolomites and microfractures in bioturbated sediments with better connectivity can form effective pore *** results of porosity and permeability show that the host sediments without bioturbation are characterized by poor porosity and ***,with the increase of bioturbation intensity,the porosity of the bioturbated sediments firstly increases and then decreases,whereas the permeability increases all the time.(3)Multiple burrows overprinted in the Ordovician carbonate rocks,forming a large-scale bioturbated carbonate rocks with lateral continuity and vertical connectivity,due to the suitable sedimentary setting,ecological conditions,favorable spatiotemporal sediment matching,and abundant organism-substrate ***,diagenesis(particular

关键词： Bioturbation Carbonate reservoir Diagenesis Ordovician Tahe oilfield Tarim Basin

High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai Yuan Zhuang Shenghua Lu Qianqian Ge Hao Li Yu Deng Hongbin Wu Xiaojian Xu Fei niu Xinlong Dong bin Zhang Baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury

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Neural Regeneration Research 2025年第8期20卷 2231-2244页

作者： Xiangzi Wang Xiaofei niu Yingkai Wang Yang Liu Cheng Yang Xuyi Chen Zhongquan Qi School of Medicine Guangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Graduate School of Tianjin University of Traditional Chinese Medicine TianjinChina Characteristic Medical Center of People’s Armed Police Forces TianjinChina Fujian Maternity and Child Health Hospital FuzhouFujian ProvinceChina

Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory *** expression of the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis exhibits significant differences before and after *** studies have revealed that the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis is closely associated with secondary inflammatory responses and the recruitment of immune cells following spinal cord injury,suggesting that this axis is a novel target and regulatory control point for *** review comprehensively examines the therapeutic strategies targeting the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis,along with the regenerative and repair mechanisms linking the axis to spinal cord ***,we summarize the upstream and downstream inflammatory signaling pathways associated with spinal cord injury and the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review primarily elaborates on therapeutic strategies that target the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the latest progress of research on antagonistic drugs,along with the approaches used to exploit new therapeutic targets within the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the development of targeted ***,there are presently no clinical studies relating to spinal cord injury that are focusing on the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review aims to provide new ideas and therapeutic strategies for the future treatment of spinal cord injury.

关键词： apoptosis C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway C-C motif chemokine receptor 2 antagonists chemokine ligand 2 chemokine receptor 2 inflammation macrophage microglia spinal cord injury therapeutic method

Bidirectional regulation of the brain-gut-microbiota axis following traumatic brain injury

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Neural Regeneration Research 2025年第8期20卷 2153-2168页

作者： Xinyu You Lin niu Jiafeng Fu Shining Ge Jiangwei Shi Yanjun Zhang Pengwei Zhuang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjinChina Haihe Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina First Teaching Hospital of Tianjin University of Traditional Chinese Medicine TianjinChina National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion TianjinChina

Traumatic brain injury is a prevalent disorder of the central nervous *** addition to primary brain parenchymal damage,the enduring biological consequences of traumatic brain injury pose long-term risks for patients with traumatic brain injury;however,the underlying pathogenesis remains unclear,and effective intervention methods are *** dysfunction is a significant consequence of traumatic brain *** the most densely innervated peripheral tissue in the body,the gut possesses multiple pathways for the establishment of a bidirectional“brain-gut axis”with the central nervous *** gut harbors a vast microbial community,and alterations of the gut niche contribute to the progression of traumatic brain injury and its unfavorable prognosis through neuronal,hormonal,and immune pathways.A comprehensive understanding of microbiota-mediated peripheral neuroimmunomodulation mechanisms is needed to enhance treatment strategies for traumatic brain injury and its associated *** comprehensively reviewed alterations in the gut microecological environment following traumatic brain injury,with a specific focus on the complex biological processes of peripheral nerves,immunity,and microbes triggered by traumatic brain injury,encompassing autonomic dysfunction,neuroendocrine disturbances,peripheral immunosuppression,increased intestinal barrier permeability,compromised responses of sensory nerves to microorganisms,and potential effector nuclei in the central nervous system influenced by gut ***,we reviewed the mechanisms underlying secondary biological injury and the dynamic pathological responses that occur following injury to enhance our current understanding of how peripheral pathways impact the outcome of patients with traumatic brain *** review aimed to propose a conceptual model for future risk assessment of central nervous system-related diseases while elucidating novel insights into the bidirectional effec

关键词： traumatic brain injury brain-gut-microbiome axis gut microbiota neuroimmune immunosuppression host defense vagal afferents bacterial infection dorsal root ganglia nociception neural circuitry

Liposomes as versatile agents for the management of traumatic and nontraumatic central nervous system disorders:drug stability,targeting efficiency,and safety

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Neural Regeneration Research 2025年第7期20卷 1883-1899页

作者： Mingyu Zhang Chunyu Xiang Renrui niu Xiaodong He Wenqi Luo Wanguo Liu Rui Gu Department of Orthopedic Surgery China-Japan Union Hospital of Jilin UniversityChangchunJilin ProvinceChina

Various nanoparticle-based drug delivery systems for the treatment of neurological disorders have been widely ***,their inability to cross the blood–brain barrier hampers the clinical translation of these therapeutic *** are nanoparticles composed of lipid bilayers,which can effectively encapsulate drugs and improve drug delivery across the blood–brain barrier and into brain tissue through their targeting and ***,they can potentially treat traumatic and nontraumatic central nervous system *** this review,we outlined the common properties and preparation methods of liposomes,including thin-film hydration,reverse-phase evaporation,solvent injection techniques,detergent removal methods,and microfluidics ***,we comprehensively discussed the current applications of liposomes in central nervous system diseases,such as Alzheimer's disease,Parkinson's disease,Huntington's disease,amyotrophic lateral sclerosis,traumatic brain injury,spinal cord injury,and brain *** studies related to liposomes are still in the laboratory stage and have not yet entered clinical ***,their application as drug delivery systems in clinical practice faces challenges such as drug stability,targeting efficiency,and ***,we proposed development strategies related to liposomes to further promote their development in neurological disease research.

关键词： Alzheimer's disease amyotrophic lateral sclerosis brain tumors central nervous system Huntington's disease liposome drug delivery neurological disorders Parkinson's disease spinal cord injury traumatic brain injury

A new micromechanical approach of micropolar continuum modeling for 2-D periodic cellular material

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Acta Mechanica Sinica 2016年第3期32卷 456-468页

作者： bin niu Jun Yan School of Mechanical Engineering Dalian University of Technology State Key Laboratory of Structural Analysis for Industrial Equipment Department of Engineering Mechanics Dalian University of Technology

In this paper, we present a new united approach to formulate the equivalent micropolar constitutive relation of two-dimensional（2-D） periodic cellular material to capture its non-local properties and to explain the size effects in its structural analysis. The new united approach takes both the displacement compatibility and the equilibrium of forces and moments into consideration, where Taylor series expansion of the displacement and rotation fields and the extended averaging procedure with an explicit enforcement of equilibrium are adopted in the micromechanical analysis of a unit *** numerical examples, the effective micropolar constants obtained in this paper and others derived in the literature are used for the equivalent micropolar continuum simulation of cellular solids. The solutions from the equivalent analysis are compared with the discrete simulation solutions of the cellular solids. It is found that the micropolar constants developed in this paper give satisfying results of equivalent analysis for the periodic cellular material.

关键词： Cellular material Micropolar continuum Size effect Equivalent property

A Nonlinear Diffusion Model for Image Restoration

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Acta Mathematicae Applicatae Sinica 2016年第3期32卷 631-646页

作者： yong-gui ZHU Xin-yan YU bin ZHANG Xiu-xiu niu School of Science Communication University of China

In this paper, we study the ill posed Perona-Malik equation of image processing[14] and the regularized P-M model i.e. C-model proposed by Catte et al.[4]. The authors present the convex compound of these two models in the form of the system of partial differential equations. The weak solution for the equations is proved in detail. The additive operator splitting （AOS） algorithm for the proposed model is also given. Finally, we show some numeric experimental results on images.

关键词： Perona-Malik model C-model weak solutions AOS algorithm

Convergence of Solutions of General Dispersive Equations Along Curve

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Chinese Annals of Mathematics,Series B 2019年第3期40卷 363-388页

作者： yong DING Yaoming niu School of Mathematical Sciences Beijing Normal UniversityLaboratory of Mathematics and Complex Systems (BNU) Ministry of Education Faculty of Mathematics Baotou Teachers' College

In this paper, the authors give the local L^2 estimate of the maximal operator S_(φ,γ)~* of the operator family {S_(t,φ,γ)} defined initially by ■which is the solution(when n = 1) of the following dispersive equations(~*) along a curve γ:■where φ : R^+→R satisfies some suitable conditions and φ((-?)^(1/2)) is a pseudo-differential operator with symbol φ(|ξ|). As a consequence of the above result, the authors give the pointwise convergence of the solution(when n = 1) of the equation(~*) along curve γ.Moreover, a global L^2 estimate of the maximal operator S_(φ,γ)~* is also given in this paper.

关键词： L^2 estimate Global maximal operator Dispersive equation Curve

Maximal estimate for solutions to a class of dispersive equation with radial initial value

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Frontiers of Mathematics in China 2017年第5期12卷 1057-1084页

作者： yong DING Yaoming niu School of Mathematical Sciences Beijing Normal University Laboratory of Mathematics and Complex Systems (BNU) Ministry of Education Beijing 100875 China Faculty of Mathematics Baotou Teachers'College Baotou 014030 China

Consider the general dispersive equation defined bywhere φ（√-△） is a pseudo-differential operator with symbol φ（｜ξ｜）. In this paper, for φ satisfying suitable growth conditions and the radial initial data f in Sobolev space, we give the local and global Lq estimate for the maximal operator S; defined by Sφf（x） = sup0〈t〈1｜St,φf（x）｜, where St,φ f is the solution of equation （＊）. These estimates imply the a.e. convergence of the solution of equation （＊）.

关键词： Dispersive equation maximal operator local estimate globalestimate