检索结果-南通市图书馆

Comprehensive molecular characterization to predict immunotherapy response in advanced biliary tract cancer: a phase II trial of pembrolizumab

引用

Oncology research 2025年第1期33卷 57-65页

作者： Ryul Kim Joo Kyung Park Minsuk Kwon Minae An jung yong Hong Joon Oh Park Sung Hee Lim Seung Tae Kim Division of Hematology-Oncology Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea. Division of Gastroenterology Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea. Department of Hematology-Oncology Ajou University School of Medicine Suwon-si Gyeonggi-do Korea. Samsung Advanced Institute of Health Science and Technology Sungkyunkwan University School of Medicine Seoul Korea.

Background:Immune checkpoint inhibitors (ICIs) are effective in a subset of patients with metastatic solid tumors. However, the patients who would benefit most from ICIs in biliary tract cancer (BTC) are still controversial.Materials and methods:We molecularly characterized tissues and blood from 32 patients with metastatic BTC treated with the ICI pembrolizumab as second-line therapy.Results:All patients had microsatellite stable (MSS) type tumors. Three of the 32 patients achieved partial response (PR), with an objective response rate (ORR) of 9.4% (95% confidence interval [CI], 2.0-25.2) and nine showed stable disease (SD), exhibiting a disease control rate (DCR) of 37.5% (95% CI, 21.1-56.3). For the 31 patients who had access to PD-1 ligand 1 (PD-L1) combined positive score (CPS) testing (cut-off value ≥1%), the ORR was not different between those who had PD-L1-positive (PD-L1+; 1/11, 9.1%) and PDL1-(2/20, 10.0%) tumors ( = 1.000). The tumor mutational burden (TMB) of PD-L1+ BTC was comparable to that of PD-L1-BTC ( = 0.630). TMB and any exonic somatic mutations were also not predictive of pembrolizumab response. Molecular analysis of blood and tumor samples demonstrated a relatively high natural killer (NK) cell proportion in the peripheral blood before pembrolizumab treatment in patients who achieved tumor response. Moreover, the tumors of these patients presented high enrichment scores for NK cells, antitumor cytokines, and Th1 signatures, and a low enrichment score for cancer-associated fibroblasts.Conclusions:This study shows the molecular characteristics associated with the efficacy of pembrolizumab in BTC of the MSS type.

关键词： Biliary tract cancer Pembrolizumab Whole-exome sequencing Whole-transcriptome sequencing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Noncommutative Versions of the Singer-Wermer Conjecture with Linear Left θ-derivations

引用

Acta Mathematica Sinica,English Series 2008年第11期24卷 1891-1900页

作者： yong Soo jung Kyoo Hong PARK Department of Mathematics Sun Moon University Asan Chungnam 336-708 Korea Department of Mathematics Education Seowon University Cheongju Chungbuk 361-742 Korea

The noncommutative Singer-Wermer conjecture states that every linear （possibly unbounded） derivation on a （possibly noncommutative） Banach algebra maps into its Jacobson radical. This conjecture is still an open q... 详细信息

关键词： linear left θ-derivation linear θ-derivation Jacobson radical nil radical

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Note on the Stability of Jordan Triple Higher Ring Derivations

引用

Acta Mathematica Sinica,English Series 2009年第12期25卷 1975-1986页

作者： Jaiok ROH yong-Soo jung Ick-Soon CHANG Department of Mathematics Hallym University Department of Mathematics Sunmoon University Department of Mathematics Mokwon University

In the present paper, we establish the stability and the superstability of a functional inequality corresponding to the functional equation fn（xyx） = ∑i＋j＋k=n fi（x）fj （y）fk（x）. In addition, we take account ... 详细信息

关键词： functional inequality Jordan triple higher ring derivation stability radical range

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hydrogen Generation from the Dissociation of Water Using Microwave Plasmas

引用

Chinese Physics Letters 2013年第6期30卷 144-147页

作者： yong Ho jung Soo Ouk Jang Hyun Jong You Plasma Technology Research Center National Fusion Research InstituteJeonbuk 573-540Korea

Hydrogen is produced by direct dissociation of water vapor,i.e.,splitting water molecules by the electrons in water plasma at low pressure(<10–50 Torr)using microwave plasma *** condition generates a high electron temperature,which facilitates the direct dissociation of water molecules.A microwave plasma source is developed,utilizing the magnetron of a microwave oven and a TE10 rectangular *** quantity of the generated hydrogen is measured using a residual gas *** electron density and temperature are measured by a Langmuir probe,and the neutral temperature is calculated from the OH line intensity.

关键词： microwave dissociation utilizing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Complexity Effective Frequency and Sidelink Synchronization Algorithm for LTE Device-to-Device Communication Systems

引用

Computers, Materials & Continua 2020年第1期62卷 443-458页

作者： yong-an jung Min-Goo Kang Young-Hwan You Department of Computer Engineering Sejong UniversitySeoulKorea Department of IT Contents Hanshin UniversityGyeonggi-doKorea

Device-to-device(D2D)communication is considered as a major challenge in the long term evolution(LTE)network wherein devices directly communicate with each *** of the key challenges in D2D sidelink is reliable and reduced-complexity *** address this issue,a computationally efficient sequential detection scheme for integer carrier frequency offset and sidelink identity is proposed in the LTE-D2D *** perform the frequency offset detection without retrieving the sidelink identity,the conjugate relation between two primary sidelink synchronization sequences is exploited,which facilitates the detection tasks of frequency offset and sidelink identity to be *** is demonstrated from simulation results that the inherent property of the sidelink synchronization sequences is effectively used for joint detection of frequency offset and sidelink identity with significantly reduced complexity,compared to existing estimation schemes.

关键词： Long term evolution device-to-device communication carrier frequency offset sidelink identity sidelink synchronization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mineralogical and petrographic analysis on the flake graphite ore from Saba Boru area in Ethiopia

引用

International Journal of Mining Science and Technology 2020年第5期30卷 715-721页

作者： Allah D.Jara Girma Woldetinsae Amha Betemariam jung yong Kim School of Materials Science and Engineering Jimma Institute of TechnologyJimma UniversityJimmaEthiopia The Ministry of Mines Petroleum and Natural GasAddis AbabaEthiopia Debre Berhan University Debre BerhanEthiopia School of Chemical Engineering Jimma Institute of TechnologyJimma UniversityJimmaEthiopia

The mineralogy and petrography of natural graphite in Saba Boru of Ethiopia indicate that there exists flake graphite with a slightly oval structured fine size according to our study on thin and polished ***,for estimating the carbon content in graphite,the ASTM-C561,the test method for ash in a graphite sample,was *** characterizing graphite,x-ray diffraction,x-ray fluorescence,inductively coupled plasma mass spectroscopy,and scanning electron microscopy were also *** analysis of ore samples determined that the average compositions are 63.35%SiO2,15.45%Al2O3,2.36%Fe2O3,2.07%K2O,less than1%others,and loss-on-ignition(LOI)in the range of^4.74%–37.42%.The total carbon content of graphitic ore ranged from 4.11%to 33.14%.Importantly,when graphite is concentrated through floatation,its average purity and recovery are 92.97%and 90.82%,***,once the graphite concentrates are treated with hydrofluoric acid,the average value attains a high grade of 96.48%***,the average ash content is 81.93%(pre-flotation)and 3.1%(post-flotation),***,after beneficiation,a silica is identified as a major gangue(85.88%),usable as a raw material for other purposes such as ***,these graphite-bearing rocks seem to be worth exploring for commercialization opportunities.

关键词： Mineralogy Petrography Flake graphite Flotation Saba Boru Ethiopia

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Purification,application and current market trend of natural graphite:A review

引用

International Journal of Mining Science and Technology 2019年第5期29卷 671-689页

作者： Allah D.Jara Amha Betemariam Girma Woldetinsae jung yong Kim School of Materials Science and Engineering Jimma Institute of TechnologyJimma UniversityJimma P.O.Box 378Ethiopia Defense Engineering College Bishoftu P.O.Box 1041Ethiopia The Ministry of Mines Petroleum and Natural GasAddis Ababa P.O.Box 486Ethiopia School of Chemical Engineering Jimma Institute of TechnologyJimma UniversityJimma P.O.Box 378Ethiopia

Graphite has a stacked planar sp2-hybridized C6 ring structure,displaying a polymorphism with rhombohedral,hexagonal,and *** on its structure-property relationship,it affords a variety of technologically innovative applications or performances in industries,such as lithium-ion batteries,fuel cells,two dimensional graphene,water purification,electronics,fiber optics,spintronics,refractories,electrical products,electric vehicles,*** monetary value of graphite depends largely on carbon content and flake ***,the physical separation of graphite from its ore body is known to be very expensive,energy intensive and ***,this study extensively describes a current purification method for producing high-quality graphite material with impurities reaching about 10–100 mg/kg,attracting a lot of end *** also describes the potential applications of graphite materials and identifies the future scope of a new market,depending on material ***,the current and future graphite-mining countries are investigated in details.

关键词： Graphite Purification Graphene Lithium-ion battery Market Technology

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Selexipag as Add-on Therapy for Patients with Pulmonary Arterial Hypertension Associated with Congenital Heart Disease:A Single-Center Retrospective Study

引用

Congenital Heart Disease 2021年第3期16卷 233-244页

作者： Se yong jung Doyoung jung Ah Young Kim Jae Hee Seol jung Min Park Jo Won jung Jae Young Choi Division of Pediatric Cardiology Congenital Heart Disease CenterSeverance Cardiovascular HospitalDepartment of PediatricsYonsei University College of MedicineSeoulKorea

Purpose:This study examined the efficacy and safety of selexipag in treating pulmonary arterial hypertension(PAH)associated with congenital heart disease(CHD).Materials and Methods:We conducted a retrospective study of patients with CHD-associated PAH,treated with selexipag since December *** adult patients(mean age,45.4 years;women,77%)were treated with selexipag as add-on *** characteristics,World Health Organization functional class,6-minute walking distance(6MWD)test results,N-terminal pro-B-type natriuretic peptide levels,echocardiographic data,and incidence of side effects were ***:The majority of patients(12/13,92.3%)experienced more than one treatment-associated complication;one patient dropped out of the study due to intolerable *** results of 6MWD test(from 299.2±56.2 m to 363.8±86.5 m,p=0.039)and tricuspid regurgitation(TR)pressure gradient(from 84.7±20.5 mmHg to 61.6±24.0 mmHg,p=0.018)improved and remained improved after selexipag treatment in 12 *** on the results of a non-invasive risk assessment,8(66.7%)patients showed improvement,3(25.0%)showed no interval change,and the status of one patient(8.3%)***,compared to patients treated with a low dosage,patients treated with a medium-to-high dosage showed a greater increase in 6MWD results(88.3±26.4 m vs.55.3±27.6 m,p=0.043)and a greater reduction in the TR pressure gradient(-33.7±10.9 mmHg vs.-12.5±12.0 mmHg,p=0.015).Conclusion:Selexipag is an efficient pulmonary vasodilator as add-on therapy in treating CHD-associated PAH.

关键词： Selexipag congenital heart disease pulmonary arterial hypertension

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Technology portfolio assessment for near-zero emission iron and steel industry in China

引用

Advances in Climate Change Research 2023年第3期14卷 469-478页

作者： Wei-Yi JIANG Tae yong jung Han-Cheng DAI Pian-Pian XIANG Graduate School of International Studies Yonsei UniversitySeoul 03722South Korea College of Environmental Science and Engineering Peking UniversityBeijing 100871China Faculty of Environment and Life Beijing University of TechnologyBeijing 100124China

China aims to peak CO_(2)emissions before 2030 and to achieve carbon neutrality before 2060;hence,industrial sectors in China are keen to figure out appropriate pathways to support the national target of carbon *** objective of this study is to explore near-zero emission pathways for the steel industry of China through a detailed technology *** innovative technology development has been simulated using the AIM-China/steel model,developed by including material-based technologies and optimal cost *** scenarios have been given in terms of different levels of production output,emission reduction and carbon ***-zero emission and carbon tax scenarios have shown that China's steel industry can achieve near-zero emission using electric furnaces and hydrogen-based direct reduction iron technologies with policy *** on these technologies,minimised production costs have been calculated,revealing that the steel produced by these technologies is ***,the feedstock cost can play a key role in these technology portfolios,especially the cost of scrap,iron ore and *** addition,the feedstock supply can have strong regional effects and can subsequently impact the allocation of steelmaking in the ***,China can achieve near-zero emissions in the steel industry,and electric furnace and hydrogen-based direct reduction iron technologies are crucial to achieving them.

关键词： Steel industry Near-zero emission Cost optimisation Climate change Carbon neutrality Technology learning

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Diffusion with a Discontinuous Potential:a Non-Linear Semigroup Approach

引用

Analysis in Theory and Applications 2021年第2期37卷 178-190页

作者： yong-jung Kim Marshall Slemrod Department of Mathematical Sciences KAIST291 Daehak-roYuseong-guDaejeon 305-701Korea Department of Mathematics University of WisconsinMadison WI 53706USA

This paper studies existence of mild solution to a sharp cut off model for contact driven tumor *** is based on application of the Crandall-Liggett theorem for w-quas-contractive semigroups on the Banach space L^(1)(Ω).Furthermore,numerical computations are provided which compare the sharp cut off model with the tumor growth model of Perthame,Quiros,and Vazquez[13].

关键词： Nonlinear semigroups tumor grow th models Hele Shaw diffusion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：