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Ratio of metastatic lymph nodes is more important for rectal cancer patients treated with preoperative chemoradiotherapy

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World Journal of Gastroenterology 2015年第11期21卷 3274-3281页

作者： In Ja Park Chang sik Yu Seok-Byung Lim yong sik Yoon Chan Wook Kim Tae Won Kim Jong Hoon Kim Jin Cheon Kim Department of colon and rectal Surgery University of Ulsan College of Medicine and Asan Medical Center Department of Medical Oncology University of Ulsan College of Medicine and Asan Medical Center Department of Radiation Oncology University of Ulsan College of Medicine and Asan Medical Center

AIM:To evaluate the predictive value of the lymph node(LN) ratio(LNR,number of metastatic LNs/ examined LNs) for recurrence in patients with rectal cancer and to compare its applicability according to preoperative chemoradiotherapy(PCRT).METHODS:From 2000 to 2009,967 patients with metastatic LNs after curative resection for locally advanced rectal cancer were *** were categorized according to PCRT(PCRT vs No PCRT).The cut-off LNR was determined based on the p N1 vs p N2 when the recommended number of LNs was *** 5-year recurrence-free survival(RFS) rates using the Kaplan-Meier method were compared according to p/yp N stage and the LNR in each ***:Among patients with the same p/yp N stage,the 5-year RFS rate differed according to the *** addition,the 5-year RFS rate was significantly different between p N and LNR groups in patients with No *** PCRT group,however,only LNR was associated with *** multivariate analysis,both p N and LNR were significant independent prognostic factors for 5-year RFS in the No PCRT *** the PCRT group,only LNR category was found to be associated with RFS(HR = 2.36,95%CI:1.31-3.84,and P = 0.001).CONCLUSION:The LNR is an important prognostic predictor of RFS in rectal cancer patients especially treated with *** p N categories could not discriminate between prognostic groups of RFS after PCRT.

关键词： Rectal cancer Preoperative chemoradiotherapy Lymph

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高温染色中C.I.分散黄54的分散行为

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国外纺织技术（纺织针织服装化纤染整） 2002年第6期 38-39页

作者： yong-sik Ghung 郑敏

由于分散染料在接近沸点时扩散速率较低,因此聚酯纤维通常在125℃～135℃范围内染色.而且由于分散染料分散性的热力学不稳定性,染料粒度随体系自由能的减少而增大.此外,染色条件下分散剂从染料颗粒表面解吸也加速了染料粒度的增大.许多... 详细信息

由于分散染料在接近沸点时扩散速率较低,因此聚酯纤维通常在125℃～135℃范围内染色.而且由于分散染料分散性的热力学不稳定性,染料粒度随体系自由能的减少而增大.此外,染色条件下分散剂从染料颗粒表面解吸也加速了染料粒度的增大.许多商品分散染料加工成亚稳态的结晶形式,它的上染率高于热稳定态的分散染料.在聚酯高温染色过程中,亚稳态形式有时能重结晶转化为稳定形式而沉积在纤维表面.

关键词：高温染色 C.I.分散黄54 分散行为分散染料织物染料分散液颗粒变化

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Cell-type continuous electromagnetic radiation system generating millimeter waves for active denial system applications

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Defence Technology（防务技术） 2022年第10期18卷 1895-1913页

作者： Sun-Hong Min Ohjoon Kwon Matlabjon Sattorov Seontae Kim In-Keun Baek Seunghyuk Park Ranjan Kumar Barik Anirban Bera Dongpyo Hong Seonmyeong Kim Bong Hwan Hong Chawon Park Sukhwal Ma Minho Kim Kyo Chul Lee yong Jin Lee Han Byul Kwon Young Joon Yoo Sang Yoon Park Gun-sik Park Korea Institute of Radiological and Medical Sciences(KIRAMS) Seoul01812South Korea Institute for Basic Science Center for Axion and Precision Physics ResearchDaejeon34141South Korea Center for THz-Driven Biomedical Systems Department of Physics and AstronomyCollege of Natural SciencesSeoul National UniversitySeoul08826South Korea Center for Applied Electromagnetic Research Advanced Institute of Convergence TechnologySuwonGyeonggi-do16229South Korea R&D Department Seoul-TeracomInc.Suwon16229South Korea Mechatronics R&D Center Samsung Electronics Co.Ltd.Hwasung18448South Korea Hanwha Corporation Gumi730-030South Korea Council of Scientific and Industrial Research Central Electronics Engineering Research InstitutePilani333031India Home Economics Education/Biosystems and Biomedical Sciences Korea UniversitySeoul02841South Korea Current affiliation of Seontae Kim:Young IN ACE 1 F60Anyangcheondong-roDongan-guAnyang-siGyeonggi-do14042South Korea.

The cell-type continuous electromagnetic radiation system is a demonstration device capable of generating high-power millimeter electromagnetic waves of a specific wavelength and observing their effects on living *** irradiates a biological sample placed in a 30×30×50 cm^(3)cell with electromagnetic waves in the 3.15-mm-wavelength region(with an output of≥1 W)and analyzes the temperature change of the sample.A vacuum electronic device-based coupled-cavity backward-wave oscillator converts the electron energy of the electron beam into radiofrequency(RF)energy and radiates it to the target through an antenna,increasing the temperature through the absorption of RF energy in the *** system causes pain and ultimately reduces combat power.A cell-type continuous electromagnetic radiation system consisting of four parts—an electromagnetic-wave generator,a highvoltage power supply,a test cell,and a system controller—generates an RF signal of≥1 W in a continuous waveform at a 95-GHz center frequency,as well as a chemical solution with a dielectric constant similar to that of the skin of a living *** increase of 5°C lasting approximately 10 s was confirmed through an experiment.

关键词： Millimeter waves Terahertz waves Coupled-cavity backward wave oscillator(CCBWO) Cell-type continuous electromagnetic radiation Active denial system(ADS) Directed-energy weapon(DEW)

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Experiments on the Integrity and Performance of the Passive Residual Heat Removal System for SMART design Using VISTA-ITL

Experiments on the Integrity and Performance of the Passive ...

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The Fifth China-Korea Workshop on Nuclear Reactor Thermal Hydraulics

作者： Byeong-Yeon Min Hyun-sik Park yong-Chul Shin Sung-Jae Yi Thermal Hydraulics Safety Research Division Korea Atomic Energy Research Institute （KAERI）989-111 Daedeok-daero Yuseong-gu Daejeon 305-353 Korea

The purpose of this paper is to verify the integrity and performance of the Passive Residual Heat Removal System （PRHRS） for SMART design during the steady state condition. The system’s overall thermal hydraulic behavior during the steady-state operation of the PRHRS of the SMART reactor was simulated using the VISTA-ITL, a small-scale integral effect test loop for SMART design. SMART’s PRHRS is a final heat sink to remove the decay heat from the nuclear reactor and the stored energy contained in structures in case of accident in the SMART plant. The PRHRS is a safety system designed with devices classified into safety levels considering a single failure. The PRHRS performance test using the VISTA-ITL is to test whether the PRHRS is operated properly when the reactor is shut down considering all the operating conditions of SMART plant. The steady-state PRHRS performance tests are divided into three conditions of 100% scaled power, 20% scaled power, and hot standby condition. The steady-state conditions were well operated to satisfy the initial test conditions presented in the test requirement and also its boundary conditions were properly simulated. The PRHRS’s natural circulation flow was formed as much as 10.1%, 11.7% and 9.1% for 100% scaled power, 20% scaled power, and hot standby condition, respectively. The experimental results show that PRHRS’s integrity and performance were well confirmed for those three conditions.

关键词： VISTA-ITL PRHRS Performance Natural Circulation .

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RUN-UP HEIGHTS OF 1983 CENTRAL EAST SEA TSUNAMI ALONG THE KOREAN PENINSULA

RUN-UP HEIGHTS OF 1983 CENTRAL EAST SEA TSUNAMI ALONG THE KO...

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第十八届国际反应堆结构力学大会

作者： Keum-Seok Kang So-Beom Jin yong-sik Cho Chong-Hak Kim Korea Electric Power Research Institute Korea Institute of Nuclear Safety Dept. of Civil Eng. Hanyang University Korea Hydro ＆ Nuclear Power Co. Ltd.

＜正＞ Tsunamis are huge but long water waves triggered by landslides, submarine volcanic explosions, or sea-bottom deformations associated with large submarine earthquakes. These tsunamis not only killed many human beings but also caused serious property damages. For example, the 1992 Flores tsunami killed more than 264 people in Indonesia and the 1993 Hokkaido tsunami in Japan killed 239 people and caused the huge run-up heights of Babi and okushiri Islands located near to Flores and Hokkaido Islands, respectively. More recently, the South Asia tsunami occurred in December 26, 2004 have killed approximately 280,000 people along the coastlines of Indonesia, Thailand, India, Sri Lanka and several African countries faced to the Indian Ocean.

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The Occurrence and Spreading Pattern of Virus Diseases on Cucumber（Cucumis sativus L.） in Korea

The Occurrence and Spreading Pattern of Virus Diseases on Cu...

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中国植物病理学会2011年学术年会

作者： Joong-Hwan Lee Seok-Hee Park Seong-yong Choi Hong-sik Shim Department of Agricultral Environment Gyeongsangbuk-do Agricultural Research and ExtentionDongho-dongDaegu702-708Republic of Korea Crop Protection Division National Academy of Agricultural ScienceRDASuwon 441-707Republic of Korea

＜正＞Cucumber which is grown during the winter season in plastic house is high valued cash crop in ***,virus disease spread widely in cucumber growing area and cause severe income ***,virus disease on cucumber were surveyed in chief producing *** 217 samples showing virus symptoms were analyzed by RT-PCR using appropriate detection *** yellow mosaic virus（ZYMV） has the highest infection rate（detected over 85%） and followed by Cucumber green mottle mosaic

关键词： Cucumber Zucchini yellow mosaic virus Cucumber green mottle mosaic virus Infection pattern

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DA-9601, a standardized extract of Artemisia asiatica, blocks TNF-α-induced IL-8 and CCL20 production by inhibiting p38 kinase and NF-κ-B pathways in human gastric epithelial cells

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World Journal of Gastroenterology 2006年第30期12卷 4850-4858页

作者： Suck-Chei Choi Eun-Ju Choi Hyun-Mee Oh SungGa Lee Jeong-Kun Lee Meung-Su Lee yong-Il Shin Suck-Jun Choi Jeong-Ryong Chae Kang-Min Lee Won-Jung Lee Jae-sik Park Chang-Yell Shin Tae-Young Oh Chang-Duk Jun Digestive Disease Research Institute Wonkwang University School of Medicine Iksan Chonbuk 570-749 Korea Department Physical Education Kunsan National University Chonbuk 573-701 Korea Department of Life Science Gwangju Institute of Science and Technology Gwangju 500-712 Korea Department of Leisure Sports Wonkwang Health Science College Iksan Chonbuk 570-749 Korea Division of Biological Sciences College of Natural Science Chonbuk National University Jeonju Chonbuk 561-756 Korea Department of Physiology Kyungpook National University School of Medicine Taegu 700-422 Korea Research Institute Dong-A Pharmaceutical Co. Ltd. Yongin 449-905 Korea

AIM: To investigate whether, or how, DA-9601, which is a new gastroprotective agent, inhibits TNF-α-induced inflammatory signals in gastric epithelial AGS cells. METHODS: Cell viability was determined by MTT assay. IL-8 and CCL20 promoter activities were determined by a luciferease reporter gene assay. NF-κB-dependent transcriptional activity was determined by I-κBαdegradation, NF-κB p65 nuclear translocation and a luciferase activity assay. IL-8 and CCL20 gene expression and protein secretion were determined by RT-PCR and an enzymelinked immunosorbent assay (ELISA). Total and phos-phorylated forms of mitogen-activated protein kinases (MAPKs) were determined by Western blot. RESULTS: Treatment of AGS cells with DA-9601 reduced TNF-α-induced IL-8 and CCL20 promoter activities, as well as their gene expression and protein release. TNF-αalso induced NF-κB-dependent transcriptional activity in AGS cells. In contrast, in cells treated with DA-9601, TNF-α-induced NF-κB activity was significantly blocked. Although all three MAP kinase family members were phosphorylated in response to TNF-α, a selective inhibitor of p38 kinase SB203580 only could inhibit both NF-κB-dependent transcriptional activity and IL-8 and CCL20 production, suggesting a potential link between p38 kinase and NF-κB-dependent pathways in AGS cells. Interestingly, DA-9601 also selectively inhibited p38 kinase phosphorylation induced by TNF-α. CONCLUSION: DA-9601 blocked TNF-α-mediated inflammatory signals by potentially modulating the p38 kinase pathway and/or a signal leading to NF-κBdependent pathways in gastric epithelial cells.

关键词： CCL20 IL-8 Artemisia asiatica DA-9601 TNF-α p38 kinase NF-κB

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Numerical Analysis of Two-Phase Flow in Inclined Channel with Downward- Facing Heated Wall

Numerical Analysis of Two-Phase Flow in Inclined Channel wit...

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The Fifth China-Korea Workshop on Nuclear Reactor Thermal Hydraulics

作者： Hae-Kyun Park Wan-sik Yeon Kwang-Hyun Bang Jungsoo Suh yong Soo Kim Department of Mechanical and Energy Systems Engineering Korea Maritime University 1 Dongsam-dong Yeongdo-gu Busan 606-791 S.Korea Advanced Power Plant Development Office KHNP Central Research Institute Korea Hydro & Nuclear Power Co.25-1 Jang-dong Yuseong-gu Daejeon 305-343 S.Korea

Wall boiling and bubble population balance equations combined with a two-fluid model are employed to predict boiling two-phase flow in an inclined channel with downward- facing heated wall. For vertical flow, these models have been highlighted by the mechanistic formulation of bubble nucleation on a vertical heated wall by the bubble sliding and lift-off formulations. For downward-facing heated wall in an inclined channel, however, the bubble nucleation and departure behaviors are affected by the large bubbles near the heated wall as vapor accumulates near the upper wall of the inclined channel. In order to observe the boiling behavior on the inclined, downward-facing heated wall, a visualization experiment was carried out with a 100 mm x 100 mm of the cross section, one meter long rectangular channel, inclined by 10 o from the horizontal plane. The size of the heated wall was 50 mm by 750 mm and the heat flux was provided by the Joule heating of the heated wall using the DC electrical current. High speed video images showed the bubble nucleation and growth, sweeping of these bubbles by a large bubble sliding near the wall. For these circumstances of wall boiling and two-phase flow in the inclined channel, the existing wall boiling model encompassing bubble growth and sliding were modified by considering the influence of large bubbles near the heated wall. Using the model developed, boiling two-phase flow in a 3 m long, inclined channel with downward-facing heated wall was analyzed.

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Comparison of Protein Profiles in Sputum between COPD and Acute Exacerbation of COPD

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Open Journal of Respiratory Diseases 2012年第2期2卷 25-30页

作者： Soo-Taek Uh Seung Ah Ko An Soo Jang Sung Woo Park yong-Hoon Kim Young-Ki Paik Choon sik Park Division of Respiratory and Allergy Medicine Soon Chun Hyang University Hospital Seoul South Korea Division of Respiratory Medicine Soonchunhyang University Chunan Hospital Asan South Korea Genome Research Center for Allergy and Respiratory Disease Soonchunhyang University Bucheon Hospital Bucheon South Korea Yonsei Proteome Research Center Department of Biochemistry and Biomedical Science College of Life Science and Biotechnology Yonsei University Seoul South Korea

Background and objective: Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation that is associated with an abnormal inflammatory response of the lung to noxious particles or gases. Cigarette smoking is the major risk factor for the development of COPD. This study evaluated the levels of cyclophilin B in sputa from patients with COPD and COPD with acute exacerbation (AECOPD). Materials and Methods: Two-dimensional electrophoresis was used for differential display proteomics. Western blotting was used to identify and quantify cyclophilin B in sputum from subjects with AECOPD and COPD. Results: Forty-nine protein spots differed in relative intensity between the AECOPD (n = 6) and COPD (n = 6) subjects. Twenty proteins showed increased expression in the sputum of AECOPD subjects, and 29 proteins were present at lower levels in AECOPD sputum compared with COPD sputum. One of these proteins was associated with cyclophilin B. Cyclophilin B concentrations were lower in sputum from subjects with COPD (n = 4) versus AECOPD (n = 4). Conclusion: The sputum proteomic analysis suggests that changes in various proteins are associated with the development of AECOPD.

关键词： Proteomics COPD Acute Exacerbation Chromatography Liquid Mass Spectrometry

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Evaluation of the relationship between dietary factors,CagA-positive Helicobacter pylori infection,and RUNX3 promoter hypermethylation in gastric cancer tissue

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World Journal of Gastroenterology 2013年第11期19卷 1778-1787页

作者： Yan-Wei Zhang Sang-yong Eom Dong-Hyuk Yim Young-Jin Song Hyo-Yung Yun Joo-Seung Park Sei-Jin Youn Byung-sik Kim yong-Dae Kim Heon Kim Department of Preventive Medicine and Medical Research Institute College of MedicineChungbuk National UniversityCheongju 361-763South Korea Department of Surgery College of MedicineChungbuk National UniversityCheongju 361-763South Korea Department of Surgery College of MedicineEulji UniversityDaejon 461-713South Korea Department of Internal Medicine College of MedicineChungbuk National UniversityCheongju 361-763South Korea Department of Surgery Asan Medical CenterCollege of MedicineUlsan UniversitySeoul 138-736South Korea

AIM:To evaluate the relationship among Helicobacter pylori(***) infection,CagA status,and dietary factors with RUNX3 promoter ***:Gastric cancer tissue samples were collected from 184 South Korean *** patients were interviewed following a semi-quantitative food frequency *** average frequencies of intake and portion sizes of 89 common food items were documented,and total intakes of calories,nutrients,vitamins,and minerals were calculated for each *** was extracted from gastric cancer tissue samples,and amplification of the HSP60 gene was performed to detect *** *** polymerase chain reaction(PCR) was used to detect the presence of the CagA ***3 gene expression was measured by reverse transcription-PCR,and RUNX3 methylation status was evaluated by methylation-specific *** odds ratios(ORs) and 95%CI associated with RUNX3 promoter hypermethylation status were estimated for each of the food groups,lifestyle factors,and the interaction between dietary and lifestyle factors with CagA status of *** ***:Overall,164 patients(89.1%) were positive for *** DNA,with the CagA gene detected in 59(36%) of these ***-positive *** all,106(57.6%) patients with gastric cancer demonstrated CpG island hypermethylation at the RUNX3 ***3 expression was undetectable in 52(43.7%) of the 119 gastric cancer tissues sampled.A high consumption of eggs may increase the risk of RUNX3 methylation in gastric cancer patients,having a mean OR of 2.15(range,1.14-4.08).A significantly increased OR of 4.28(range,1.19-15.49) was observed with a high consumption of nuts in patients with CagA-positive *** *** intakes of carbohydrate,vitamin B1,and vitamin E may decrease the risk of RUNX3 methylation in gastric cancer tissue,particularly in CagA-or ***-negative infection,with OR of 0.41(0.19-0.90),0.42(0.20-0.89),and 0.29(0.13-0.62),respectively.A high consumpt

关键词： Gastric cancer RUNX3 Helicobacter pylori CagA Dietary factors

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