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Short-term and long-term outcomes of laparoscopic vs open ileocolic resection in patients with Crohn's disease: Propensityscore matching analysis

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World Journal of Gastroenterology 2021年第41期27卷 7159-7172页

作者： Shin Jeong Pak Young Il Kim yong sik Yoon Jong Lyul Lee Jung Bok Lee Chang sik Yu Department of Colon and Rectal Surgery University of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea Department of Clinical Epidemiology and Biostatistics University of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea

BACKGROUND Laparoscopic ileocolic resection(LICR)is the preferred surgical approach for primary ileocolic Crohn’s disease(CD)because it has greater recovery benefits than open ICR(OICR).AIM To compare short-and long-term outcomes in patients who underwent LICR and *** Patients who underwent ICR for primary CD from 2006 to 2017 at a single tertiary center specializing in CD were *** who underwent LICR and OICR were subjected to propensity-score matching *** were propensityscore matched 1:1 by factors potentially associated with 30-d perioperative *** included demographic characteristics and disease-and treatment-related *** were compared using univariate and multivariate ***-term surgical recurrence-free survival(SRFS)in the two groups was determined by the Kaplan-Meier method and compared by the log-rank *** During the study period,348 patients underwent ICR,211 by the open approach and 137 ***-score matching yielded 102 pairs of *** rate of postoperative complication was significantly lower(14%versus 32%,P=0.003),postoperative hospital stay significantly shorter(8 d versus 13 d,P=0.003),and postoperative pain on day 7 significantly lower(1.4 versus 2.3,P<0.001)in propensity-score matched patients who underwent LICR than in those who underwent *** analysis showed that postoperative complications were significantly associated with preoperative treatment with biologics[odds ratio(OR):3.14,P=0.01]and an open approach to surgery(OR:2.86,P=0.005).The 5-and 10-year SRFS rates in the matched pairs were 92.9%and 83.3%,respectively,with SRFS rates not differing significantly between the OICR and LICR *** performance of additional procedures was an independent risk factor for surgical recurrence[hazard ratio(HR):3.28,P=0.02].CONCLUSION LICR yielded better short-term outcomes and postoperative recovery than OICR,with no differences in long-ter

关键词： Crohn’s disease Laparoscopic Surgery Postoperative complications Recurrence Propensity score Retrospective study

SYNCRIP controls miR-137 and striatal learning in animal models of methamphetamine abstinence

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Acta Pharmaceutica Sinica B 2022年第8期12卷 3281-3297页

作者： Baeksun Kim Sung Hyun Tag Eunjoo Nam Suji Ham Sujin Ahn Juhwan Kim Doo-Wan Cho Sangjoon Lee Young-Su Yang Seung Eun Lee yong sik Kim Il-Joo Cho Kwang Pyo Kim Su-Cheol Han Heh-In Im Convergence Research Center for Diagnosis Treatment and Care System of Dementia(DTC)Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Division of Bio-Medical Science&Technology KIST SchoolKorea University of Science and Technology(UST)Seoul 02792Republic of Korea Center for Neuroscience KISTSeoul 02792Republic of Korea Animal Model Research Center Jeonbuk Department of Inhalation ResearchKorea Institute of Toxicology(KIT)Korea Research Institute of Chemical Technology(KRICT)Jeongeup 56212Republic of Korea Research Animal Resource Center KISTSeoul 02792Republic of Korea Department of Pharmacology Seoul National University College of MedicineSeoul 03080Republic of Korea Center for BioMicrosystems KISTSeoul 02792Republic of Korea Department of Applied Chemistry Kyung Hee UniversityGyeonggi-do 17104Republic of Korea

Abstinence from prolonged psychostimulant use prompts stimulant withdrawal *** adaptations within the dorsal striatum have been considered the main hallmark of stimulant abstinence. Here we explored striatal miRNA-target interaction and its impact on circulating miRNA marker as well as behavioral dysfunctions in methamphetamine(MA) abstinence. We conducted miRNA sequencing and profiling in the nonhuman primate model of MA abstinence, followed by miRNA qPCR,LC-MS/MS proteomics, immunoassays, and behavior tests in mice. In nonhuman primates, MA abstinence triggered a lasting upregulation of miR-137 in the dorsal striatum but a simultaneous downregulation of circulating miR-137. In mice, aberrant increase in striatal miR-137-dependent inhibition of SYNCRIP essentially mediated the MA abstinence-induced reduction of circulating miR-137. Pathway modeling through experimental deduction illustrated that the MA abstinence-mediated downregulation of circulating miR-137 was caused by reduction of SYNCRIP-dependent miRNA sorting into the exosomes in the dorsal striatum. Furthermore, diminished SYNCRIP in the dorsal striatum was necessary for MA abstinence-induced behavioral bias towards egocentric spatial learning. Taken together, our data revealed circulating miR-137 as a potential blood-based marker that could reflect MA abstinence-dependent changes in striatal miR-137/SYNCRIP axis, and striatal SYNCRIP as a potential therapeutic target for striatum-associated cognitive dysfunction by MA withdrawal syndrome.

关键词： Methamphetamine Abstinence Withdrawal Striatum miR-137 SYNCRIP Biomarker Behavior

Experimental assessment of two-phase bubble pump for solar water heating

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Journal of Central South University 2012年第6期19卷 1590-1599页

作者： CHUNG Han-shik WOO Ju-sik SHIN yong-han KIM Jun-hyo JEONG Hyo-min Institute of Marine Industry Department of Mechanical and Precision EngineeringGyeongsang National University445 Inpyeong DongTongyeongGyeongsangnamdo650-160Korea Department of Mechanical and Precision Engineering Gyeongsang National University445 Inpyeong DongTongyeongGyeongsangnamdo650-160Korea Division of Marine Engineering Mokpo National Maritime UniversityHaeyangdaehang-Ro 91Mokpo-siJeollanam-do530-729Korea

The research goal is to develop a new solar water heater system(SWHS) that uses a solar bubble pump instead of an electric *** pump is powered by the steam produced from an evacuated tube ***,heat could be transferred downward from the collector to a hot water storage *** designed system consists of two sets of heat-pipe evacuated tube collectors,a solar bubble pump installed at an upper level and a water storage tank with a heat exchanger at a lower *** heads of 1 and 5 m were *** bubble pump could operate at the collector temperature of about 90-100 ℃ and vapor gage pressure of 80-90 *** is found that water circulation within the SWHS depends on the incident solar intensity and system discharge *** investigations are conducted to obtain the system thermal efficiencies from the hourly,daily and long-term performance *** thermal performance of the proposed system is compared with conventional solar water *** results show that the proposed system achieves system characteristic efficiency of 10% higher than that of the conventional systems using electric pump if taking the consumption of electric power into *** the former is a zero carbon system.

关键词：太阳能热水器气泡泵试验评价性能测试系统真空管集热器贮热水箱电力消耗电动泵

Optical Gain Analysis of Graded InGaN/GaN Quantum-Well Lasers

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Chinese Physics Letters 2011年第7期28卷 319-322页

作者： Seoung-Hwan Park yong-Tae Moon Jeong sik Lee Ho Ki Kwon Joong Seo Park Doyeol Ahn Department of Electronics Engineering Catholic University of DaeguHayangKyeongsanKyeongbuk 712-702Republic of Korea SLED R&D Center LG Innotek16 Woomyeon-dongSeocho-guSeoul 137-140Republic of Korea Department of Electrical and Computer Engineering University of SeoulSeoul 130-743Republic of Korea

Optical properties of graded InGaN/GaN quantum well(QW)lasers are analyzed as improved gain media for laser diodes emitting near 500 *** results are compared with those of conventional InGaN/GaN QW *** heavy-hole effective mass around the topmost valence band is found to nearly not be affected by the inclusion of the graded *** graded InGaN/GaN QW structure shows a much larger matrix element than the conventional InGaN/GaN QW *** radiative current density dependences of the optical gain are similar to each ***,the graded QW structure is expected to have lower threshold current density than the conventional QW structure because the former has a lower threshold carrier density than the latter.

关键词： InGaN/GaN graded Lasers

Postoperative changes of manometry after restorative proctocolectomy in Korean ulcerative colitis patients

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World Journal of Gastroenterology 2017年第31期23卷 5780-5786页

作者： se heon oh yong sik yoon jong lyul lee chan wook kim in ja park seok-byung lim chang sik yu jin cheon kim department of surgery division of colon and rectal surgery university of ulsan college of medicine asan medical center

AIM To investigate the changes of postoperative anal sphincter function and bowel frequency in Korean patients with ulcerative colitis(UC).METHODS A total of 127 patients with UC who underwent restorative proctocolectomy(RPC) during 20 years were retrospectively analyzed. The parameters of anal manometry and bowel frequency were compared according to the 6-mo intervals until 24 mo postoperatively. Manometry was used to measure the maximal squeezing pressure(MSP) and maximal resting pressure(MRP).RESULTS MSP decreased after surgery until 6 mo(157 to 142 mm Hg); thereafter, it improved and was recovered to and maintained at the preoperative value at 12 mo postoperatively(142-170 mm Hg, P < 0.001). Although the decreased MRP(65 to 56 mm Hg) improved after 18 mo(62 mm Hg), it did not completely recover to the preoperative value. The decreased rectal capacity after surgery(90 to 82 m L) gradually increased up to 150 m L at 24 mo. Although bowel frequency showed significant gradual decreases at each interval, it was stabilized after 12 mo postoperatively(6.5 times/d).CONCLUSION Postoperative changes of manometry and bowel frequency after restorative proctocolectomy in Korean patients with UC were not different from those in Western patients with UC.

关键词： Ulcerative 大肠炎外科治疗结果 Manometry 肠频率补药 proctocolectomy

Intestinal endometriosis:Diagnostic ambiguities and surgical outcomes

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World Journal of Clinical Cases 2019年第4期7卷 441-451页

作者： Jun Woo Bong Chang sik Yu Jong Lyul Lee Chan Wook Kim yong sik Yoon In Ja Park Seok-Byung Lim Jin Cheon Kim Division of Colon and Rectal Surgery Department of SurgeryUniversity of Ulsan College of Medicine and Asan Medical Center

BACKGROUND Endometriosis is a common disease for women of reproductive age. However,when it involves intestines, it is difficult to diagnose preoperatively because its symptoms overlap with other diseases and the results of evaluations can be unspecific. Thus it is important to know the clinical characteristics of intestinal endometriosis and how to exactly *** To analyze patients in whom intestinal endometriosis was diagnosed after surgical treatments, and to evaluate the clinical characteristics of preoperatively misdiagnosed *** We retrospectively reviewed the pathologic reports of 30 patients diagnosed as having intestinal endometriosis based on surgical specimens between January2000 and December 2017. We reviewed their clinical characteristics and surgical *** Twenty-three(76.6%) patients showed symptoms associated with endometriosis,with dysmenorrhea being the most common(n = 9, 30.0%). Thirteen patients(43.3%) had a history of pelvic surgeries. Ten patients(33.3%) had a history of treatment for endometriosis. Only 4 patients(13.3%) had a diagnosis of endometriosis based on endoscopic biopsy findings. According to preoperative evaluations, 13 patients(43.3%) had an initial diagnosis of pelvic endometriosis and 17 patients(56.6%) were misdiagnosed as having other diseases. The most common misdiagnosis was submucosal tumor in the large intestine(n = 8, 26.7%),followed by malignancies of the colon/rectum(n = 3, 10.0%) and ovary(n = 3,10.0%). According to the Clavien-Dindo classification, 5 complications were grade I or II and 2 complications were grade IIIa. The median follow-up period was 26.9(0.6-132.1) mo, and only 1 patient had a recurrence of *** Intestinal endometriosis is difficult to diagnose preoperatively because it mimics various intestinal diseases. Thus, if women of reproductive age have ambiguous symptoms and signs with nonspecific radiologic and/or endoscopic findings,intestinal endometriosis sho

关键词： Endometriosis Intestinal endometriosis Diagnosis Surgery Treatment

Interstitial lung disease induced by the roots of Achyranthes japonica Nakai:Three case reports

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World Journal of Clinical Cases 2021年第8期9卷 2015-2021页

作者： Do-sik Moon Sung-Ho Yoon Seung-Il Lee Sang-Gon Park yong-Sub Na Department of Pulmonology and Critical Care Medicine Chosun University HospitalGwangju 61453South Korea Department of Internal Medicine Hemato-OncologyChosun University HospitalGwangju 61453South Korea

BACKGROUND The roots of Achyranthes japonica Nakai(AJN),called“Useul-puli,”has been traditionally used to control pain and improve dysfunction in osteoarthritis patients in South *** SUMMARY We described 3 patients diagnosed with herbal medicine induced interstitial lung disease after consuming boiled the roots of *** were referred to our hospital because of the modified Medical Research Council grade 4 *** computed tomography showed bilateral ground-glass opacities with patchy *** treatment with systemic glucocorticoid therapy and discontinuation of the roots of AJN,their symptoms improved,and almost all ground-glass opacities and patchy consolidations on chest radiography and chest computed tomography *** We present three cases of interstitial lung disease induced by the roots of AJN.

关键词： Herb Interstitial lung disease Achyranthes japonica Nakai Case report

Cell-type continuous electromagnetic radiation system generating millimeter waves for active denial system applications

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Defence Technology（防务技术） 2022年第10期18卷 1895-1913页

作者： Sun-Hong Min Ohjoon Kwon Matlabjon Sattorov Seontae Kim In-Keun Baek Seunghyuk Park Ranjan Kumar Barik Anirban Bera Dongpyo Hong Seonmyeong Kim Bong Hwan Hong Chawon Park Sukhwal Ma Minho Kim Kyo Chul Lee yong Jin Lee Han Byul Kwon Young Joon Yoo Sang Yoon Park Gun-sik Park Korea Institute of Radiological and Medical Sciences(KIRAMS) Seoul01812South Korea Institute for Basic Science Center for Axion and Precision Physics ResearchDaejeon34141South Korea Center for THz-Driven Biomedical Systems Department of Physics and AstronomyCollege of Natural SciencesSeoul National UniversitySeoul08826South Korea Center for Applied Electromagnetic Research Advanced Institute of Convergence TechnologySuwonGyeonggi-do16229South Korea R&D Department Seoul-TeracomInc.Suwon16229South Korea Mechatronics R&D Center Samsung Electronics Co.Ltd.Hwasung18448South Korea Hanwha Corporation Gumi730-030South Korea Council of Scientific and Industrial Research Central Electronics Engineering Research InstitutePilani333031India Home Economics Education/Biosystems and Biomedical Sciences Korea UniversitySeoul02841South Korea Current affiliation of Seontae Kim:Young IN ACE 1 F60Anyangcheondong-roDongan-guAnyang-siGyeonggi-do14042South Korea.

The cell-type continuous electromagnetic radiation system is a demonstration device capable of generating high-power millimeter electromagnetic waves of a specific wavelength and observing their effects on living *** irradiates a biological sample placed in a 30×30×50 cm^(3)cell with electromagnetic waves in the 3.15-mm-wavelength region(with an output of≥1 W)and analyzes the temperature change of the sample.A vacuum electronic device-based coupled-cavity backward-wave oscillator converts the electron energy of the electron beam into radiofrequency(RF)energy and radiates it to the target through an antenna,increasing the temperature through the absorption of RF energy in the *** system causes pain and ultimately reduces combat power.A cell-type continuous electromagnetic radiation system consisting of four parts—an electromagnetic-wave generator,a highvoltage power supply,a test cell,and a system controller—generates an RF signal of≥1 W in a continuous waveform at a 95-GHz center frequency,as well as a chemical solution with a dielectric constant similar to that of the skin of a living *** increase of 5°C lasting approximately 10 s was confirmed through an experiment.

关键词： Millimeter waves Terahertz waves Coupled-cavity backward wave oscillator(CCBWO) Cell-type continuous electromagnetic radiation Active denial system(ADS) Directed-energy weapon(DEW)

Artificial Nanoscale Erythrocytes from Clinically Relevant Compounds for Enhancing Cancer Immunotherapy

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Nano-Micro Letters 2020年第7期12卷 156-174页

作者： Wenquan Ou Kang sik Nam Dae Hoon Park Jungho Hwang Sae Kwang Ku Chul Soon yong Jong Oh Kim Jeong Hoon Byeon College of Pharmacy Yeungnam UniversityGyeongsan 38541Republic of Korea School of Mechanical Engineering Yonsei UniversitySeoul 03722Republic of Korea College of Korean Medicine Daegu Haany UniversityGyeongsan 38610Republic of Korea School of Mechanical Engineering Yeungnam UniversityGyeongsan 38541Republic of Korea

Because of enhanced e cacy and lower side e ects,cancer immunotherapies have recently been extensively investigated in clinical trials to overcome the limitations of conventional cancer *** engineering attempts have been made to build nanosystems even including stimulus nanomaterials for the e cient delivery of antigens,adjuvants,or anticancer drugs to improve immunogenic cancer cell death,this requires huge R&D e orts and investment for clinically relevant findings to be approved for translation of the *** this end,in this study,an air–liquid two-phase electrospray was developed for stable bubble pressing under a balance between mechanical and electrical parameters of the spray to continuously produce biomimetic nanosystems consisting of only clinically relevant compounds[paclitaxel-loaded fake blood cell Eudragit particle(Eu-FBCP/PTX)]to provide a conceptual leap for the timely development of translatable chemo-immunotherapeutic *** was pursued as the e cacy of systems for delivering anticancer agents that has been mainly influenced by nanosystem shape because of its relevance to transporting behavior to organs,blood circulation,and cell–membrane *** resulting Eu-FBCP/PTX nanosystems exhibiting phagocytic and micropinocytic uptake behaviors can confer better e cacy in chemo-immunotherapeutics in the absence and presence of anti-PD-L1 antibodies than similar sized PTX-loaded spherical Eu particles(Eu-s/PTX).

关键词： Cancer immunotherapies Air–liquid two-phase electrospray Paclitaxel-loaded fake blood cell Eudragit particle Translatable chemo-immunotherapeutic nanosystems Anti-PD-L1 antibodies