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Artificial Nanoscale Erythrocytes from Clinically Relevant Compounds for Enhancing Cancer Immunotherapy

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Nano-Micro Letters 2020年第7期12卷 156-174页

作者： Wenquan Ou Kang sik Nam Dae Hoon Park Jungho Hwang Sae Kwang Ku Chul Soon yong Jong Oh Kim Jeong Hoon Byeon College of Pharmacy Yeungnam UniversityGyeongsan 38541Republic of Korea School of Mechanical Engineering Yonsei UniversitySeoul 03722Republic of Korea College of Korean Medicine Daegu Haany UniversityGyeongsan 38610Republic of Korea School of Mechanical Engineering Yeungnam UniversityGyeongsan 38541Republic of Korea

Because of enhanced e cacy and lower side e ects,cancer immunotherapies have recently been extensively investigated in clinical trials to overcome the limitations of conventional cancer *** engineering attempts have been made to build nanosystems even including stimulus nanomaterials for the e cient delivery of antigens,adjuvants,or anticancer drugs to improve immunogenic cancer cell death,this requires huge R&D e orts and investment for clinically relevant findings to be approved for translation of the *** this end,in this study,an air–liquid two-phase electrospray was developed for stable bubble pressing under a balance between mechanical and electrical parameters of the spray to continuously produce biomimetic nanosystems consisting of only clinically relevant compounds[paclitaxel-loaded fake blood cell Eudragit particle(Eu-FBCP/PTX)]to provide a conceptual leap for the timely development of translatable chemo-immunotherapeutic *** was pursued as the e cacy of systems for delivering anticancer agents that has been mainly influenced by nanosystem shape because of its relevance to transporting behavior to organs,blood circulation,and cell–membrane *** resulting Eu-FBCP/PTX nanosystems exhibiting phagocytic and micropinocytic uptake behaviors can confer better e cacy in chemo-immunotherapeutics in the absence and presence of anti-PD-L1 antibodies than similar sized PTX-loaded spherical Eu particles(Eu-s/PTX).

关键词： Cancer immunotherapies Air–liquid two-phase electrospray Paclitaxel-loaded fake blood cell Eudragit particle Translatable chemo-immunotherapeutic nanosystems Anti-PD-L1 antibodies

Cumulative incidence and risk factors for pouch adenomas associated with familial adenomatous polyposis following restorative proctocolectomy

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World Journal of Gastroenterology 2022年第30期28卷 4152-4162页

作者： Hyo Seon Ryu Chang sik Yu Young Il Kim Jong Lyul Lee Chan Wook Kim yong sik Yoon In Ja Park Seok-Byung Lim Jin Cheon Kim Division of Colon and Rectal Surgery Department of SurgeryUniversity of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea

BACKGROUND The emergence of restorative total proctocolectomy has significantly reduced the lifetime colorectal cancer risk associated with familial adenomatous polyposis(FAP).However,adenomas may develop in the ileal pouch over time and may even progress to *** evaluated the cumulative incidence,time to development,and risk factors associated with ileal pouch *** To evaluate the cumulative incidence,time to development,and risk factors associated with pouch *** In this retrospective,observational study conducted at a tertiary center,95 patients with FAP who underwent restorative proctocolectomy at our center between 1989 and 2018 were consecutively *** mean follow-up period was 88 *** Pouch adenomas were found in 24(25.3%)patients,with a median time of 52 mo to their first *** adenomas were detected in most patients(95.9%).There were no high-grade dysplasia or *** the 24 patients with pouch adenomas,13 had all detected adenomas *** the 13 patients who underwent complete adenoma removal,four(38.5%)developed *** 11(45.8%)patients with numerous polyps within the pouch,seven(63.6%)exhibited progression of pouch *** cumulative risks of pouch adenoma development at 5,10,and 15 years after pouch surgery were 15.2%,29.6%,and 44.1%,*** colorectal polyposis(with more than 1000 polyps)was a significant risk factor for pouch adenoma development(hazard ratio,2.49;95% confidence interval:1.04-5.96;P=0.041).CONCLUSION Pouch adenomas occur at a fairly high rate in association with FAP after restorative proctocolectomy,and a high colorectal polyp count is associated with pouch adenoma development.

关键词： Adenomatous polyposis coli Familial adenomatous polyposis Adenoma Intestinal polyps Proctocolectomy,restorative Ileal pouch anal anastomosis

“One stone,two birds”solvent system to fabricate microcrystalline cellulose–Ti_(3)C_(2)T_(x)nanocomposite film as a flexible dielectric and thermally conductive material

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Nano Research 2023年第2期16卷 3240-3253页

作者： yong-Zhu Yan Shuwei Li Sung Soo Park Wei-Jin Zhang Jun Seok Lee Jung Rae Kim Dong Gi Seong Chang-sik Ha Department of Polymer Science and Engineering School of Chemical EngineeringPusan National UniversityBusan 46241Republic of Korea School of Chemical and Biomolecular Engineering Pusan National UniversityBusan 46241Republic of Korea Division of Advanced Materials Engineering Dong-Eui UniversityBusan 47340Republic of Korea

A strategy for fabricating microcrystalline cellulose–Ti_(3)C_(2)T_(x)(MCC–MXene)nanocomposite films with high relative permittivity,high thermal conductivity,and excellent mechanical properties was *** MCC–MXene nanocomposite film was fabricated by casting a solution containing N,N-dimethylacetamide/lithium chloride(DMAc/LiCl)-soluble MCC and DMAcdispersible MXene nanosheets,followed by humidity control *** MXene nanosheets greatly enhanced the permittivity of the nanocomposite films owing to interfacial ***,the nanocomposite film with 20 wt.%MXene content achieved a desirable permittivity of 71.4 at 102 Hz(a 770%improvement against that of neat cellulose),while the dielectric loss only increased by 1.8 times(from 0.39 to 0.70).The obtained nanocomposite films with 20 wt.%and 30 wt.%MXene exhibited remarkable in-plane thermal conductivities of 8.523 and 9.668 W∙m^(−1)∙K^(−1),respectively,owing to the uniform dispersion and selfalignment of the MXene layered ***,the uniformly dispersed MXene nanosheets in the MCC network with interfacial interaction(hydrogen bonding)and mechanical entanglement endowed the nanocomposite films with excellent mechanical properties and ***,the thermal stability,water resistance,and antibacterial properties of the nanocomposite films were effectively improved with the introduction of ***,using DMAc/LiCl as the solvent system not only improves the compatibility between MCC and MXene but also avoids the problem of easy oxidation of MXene in aqueous *** the high stability of the MCC–MXene solution and enhanced properties of the MCC–MXene films,the proposed strategy manifests great potential for fabricating natural biomass-based dielectric materials.

关键词： Ti_(3)C_(2)T_(x) microcrystalline cellulose flexible dielectric thermally conductive N,N-dimethylacetamide/lithium chloride(DMAc/LiCl) compatibility

A critical review of the interactions between rhizosphere and biochar during the remediation of metal(loid)contaminated soils

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Biochar 2023年第1期5卷 1481-1513页

作者： Chuanfang Fan Yanshan Cui Qianru Zhang Naiyi Yin Xiaolin Cai Xiangzhou Yuan Sachini Senadheera Yoora Cho yong sik Ok College of Resources and Environment University of Chinese Academy of SciencesBeijing 101408China Research Center for Eco-Environment Sciences Chinese Academy of SciencesBeijing 100085China Korea Biochar Research Center APRU Sustainable Waste Management Program&Division of Environmental Science and Ecological EngineeringKorea UniversitySeoul 02841Republic of Korea State Key Laboratory of Efficient Utilization of Arid and Semi-Arid Arable Land in Northern China Institute of Agricultural Resources and Regional PlanningChinese Academy of Agricultural SciencesBeijing 100081China Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education School of Energy and EnvironmentSoutheast UniversityNanjing 210096China

Biochar has a large specific surface area,well-developed pore structure,abundant surface functional groups,and superior nutrient supply capacity,which is widely available and environmentally friendly with its advantages in waste resource utilization,heavy metal(loid)remediation,and carbon *** review focuses on the interactions between biochar(including raw biochar,functional biochar(modified/engineered/designer biochar),and composite biochar)and rhizosphere during the remediation of soil contaminated with heavy metal(loid)s(Pb,As,Cd,Hg,Co,Cu,Ni,Zn,Cr,etc.)and the effects of these interactions on the microbial communities and root exudates(enzymes and low-molecular-weight organic acids(LMWOAs)).In terms of microorganisms,biochar affects the composition,diversity,and structure of microbial communities through the supply of nutrients,provision of microbial colonization sites,immobilization of heavy metal(loid)s,and introduction of exogenous *** regard to root exudates,biochar provides electron transfer support between the microorganisms and exudates,regulates the secretion of enzymes to resist the oxidative stress stimulated by heavy metal(loid)s,ameliorates rhizosphere acidification caused by LMWOAs,and promotes the activity of soil *** roles and mechanisms of biochar on rhizosphere soils are discussed,as well as the challenges of biochar in the remediation of heavy metal(loid)-contaminated soils,and the issues that need to be addressed in future research are foreseen.

关键词： Green and sustainable remediation Sustainability Biochar Soil Root Heavy metal(loid)s

Direct modification of spermatogonial stem cells using lentivirus vectors in vivo leads to efficient generation of transgenic rats

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Asian Journal of Andrology 2019年第2期21卷 190-195页

作者： Bang-Jin Kim yong-Hee Kim Myeong-Geun Oh Ki-Jung Kim Sang-Eun Jung Ju-Hee Jin Sun-Uk Kim Kwan-sik Min Buom-yong Ryu Department of Animal Scienee and Technology College of Biotechnology and Natural ResourcesChung-Ang UniversityAnseongGyeonggi-do 17546Korea National Primate Research Center Korea Research Institute of Bioscienee and BiotechnologyCheongjuChungcheongbuk-do 28116Korea Futuristic Animal Resource and Research Center Korea Research Institute of Bioscience and BiotechnologyCheongjuChungcheongbuk-do 28116Korea Animal Biotechnology Graduate School of Future Con verge nee Tech no logyDepartment of Animal Life ScienceInstitute of Genetic Engi neeringHankyong National UniversityAnseongGyeon ggi-do 17579Korea Department of Cancer Biology University of PennsylvaniaPhiladelphiaPA 19104USA.

Spermatogonial stem cells(SSCs)transmit genetic information to the next progeny in ***,SSCs are a potential target for germ I i ne modifications to gen erate tran sgenic an *** this study,we report a technique for the gen erati on of tran sgenic rats by in vivo manipulation of SSCs with a high success *** in juvenile rats were transduced in vivo with high titers of lentivirus harbori ng enhan ced green fluoresce nt protei n and mated with wild-type females to create foun der *** founder rats expressed the transgene and passed on the transgene with an overall success rate of 50.0%.Subsequent generations of progeny from the founder rats both expressed and passed on the ***,direct modification of SSCs in juvenile rats is an effective means of generating transgenic rats through the male *** technology could be adapted to larger animals,in which existing methods for gene modificatio n are in adequate or in applicable,resulti ng in the gen eration of tran sge nic an imals in a variety of species.

关键词： germline modification lentivirus spermatogonial stem cell testis transgenic animal

Cost-effective screening using a two-antibody panel for detecting mismatch repair deficiency in sporadic colorectal cancer

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World Journal of Clinical Cases 2021年第24期9卷 6999-7008页

作者： Jong Beom Kim Young Il Kim yong sik Yoon Jihun Kim Seo Young Park Jong Lyul Lee Chan Wook Kim In Ja Park Seok-Byung Lim Chang sik Yu Jin Cheon Kim Division of Colon and Rectal Surgery University of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea Department of Pathology University of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea Department of Clinical Epidemiology and Biostatistics University of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea

BACKGROUND The microsatellite instability(MSI)test and immunohistochemistry(IHC)are widely used to screen DNA mismatch repair(MMR)deficiency in sporadic colorectal cancer(CRC).For IHC,a two-antibody panel of MLH1 and MSH2 or four-antibody panel of MLH1,MSH2,PMS2,and MSH6 are *** general,MSI is known as a more accurate screening test than *** To compare two-and four-antibody panels of IHC in terms of accuracy and cost benefit on the basis of MSI testing for detecting MMR *** We retrospectively analyzed patients with CRC who underwent curative surgery between 2015 and 2017 at a tertiary referral *** IHC with four antibodies and MSI tests were routinely *** sensitivity and specificity of a fourand two types of two-antibody panels(PMS2/MSH6 and MLH1/MSH2)were compared on the basis of MSI testing for detecting MMR *** High-frequency MSI was found in 5.5%(n=193)of the patients(n=3486).The sensitivities of the four-and two types of two-antibody panels were 97.4%,92.2%,and 87.6%,*** specificities of the three types of panels did not differ significantly(99.6%for the four-antibody and PMS2/MSH6 panels,99.7%for the MLH1/MSH2 panel).Based on Cohen's kappa statistic(κ),four-and twoantibody panels were in almost perfect agreement with the MSI test(κ>0.9).The costs of the MSI test and the four-and two-antibody panels of IHC were approximately$200,$160,and$80,*** Considering the cost of the four-antibody panel IHC compared to that of the twoantibody panel IHC,a two-antibody panel of PMS2/MSH6 might be the best choice in terms of balancing cost-effectiveness and accuracy.

关键词： Adenocarcinoma DNA mismatch repair Immunochemistry Monoclonal antibody Microsatellite instability Cost-effectiveness

Isolated vaginal metastasis from stage Ⅰ colon cancer: A case report

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World Journal of Clinical Cases 2020年第3期8卷 527-534页

作者： Soon Keun Kwon Chang sik Yu Shin-Wha Lee Jihun Kim Inho Song Jong Lyul Lee Chan Wook Kim yong sik Yoon In Ja Park Seok-Byung Lim Jin Cheon Kim Division of Colon and Rectal Surgery Department of SurgeryUniversity of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea Department of Obstetrics and Gynecology University of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea Department of Pathology University of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea

BACKGROUND Distant metastasis occasionally occurs in patients who have been diagnosed with colorectal cancer(CRC), but it occurs in a few patients with stage I CRC. The vagina as a metastasis site has also been reported, albeit rarely. Most reported cases of vaginal metastasis(VM) report their origin from advanced CRC. We encountered a patient who was diagnosed with isolated VM originating from stage I colon cancer(T2N0) and herein present the case of this *** SUMMARY A 63-year-old woman visited the outpatient clinic because of a positive result from a stool occult blood test. She underwent laparoscopic anterior resection and was pathologically diagnosed with stage I(T2N0) sigmoid colon cancer. Neither lymphovascular invasion nor perineural invasion was observed. Ten months following the surgery, isolated vaginal metastases were detected on gynecologic examination. The examination was performed due to vaginal spotting. A transvaginal wide excision was performed, and no other adjuvant treatment was provided after discussion with a multidisciplinary team and the ***, a new VM was discovered after 33 mo. An additional transvaginal excision was performed. To date, there has been no evidence of further disease progression. From the time of diagnosis of VM, the patient’s overall survival has been 54 *** VM can occur as a result of early-stage colorectal cancer. Surgeons should consider the possibility of VM following complaints of gynecologic symptoms following surgery.

关键词： Colorectal cancer Stage Ⅰ Vaginal metastasis Isolated metastasis Case report

New anti-mesenteric delta-shaped stapled anastomosis: Technical report with short-term postoperative outcomes in patients with Crohn’s disease

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2592-2601页

作者： Jong Lyul Lee yong sik Yoon Hyun Gu Lee Young Il Kim Min Hyun Kim Chan Wook Kim In Ja Park Seok-Byung Lim Chang sik Yu Division of Colon and Rectal Surgery Department of SurgeryUniversity of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea Department of Surgery Gangdong Kyung Hee University HospitalSeoul 05278South Korea

BACKGROUND Medical treatment for Crohn’s disease(CD)has continuously improved,which has led to a decrease in surgical recurrence *** these advancements,25%of patients will undergo repeat intestinal *** of CD com-monly occurs on the mesentery side of the anastomosis *** To compare the new anti-mesenteric side-to-side delta-shaped stapled anasto-mosis(DSA)with the conventional stapled functional end-to-end anastomosis(CSA).METHODS This retrospective study included CD patients who underwent ileo-ileal or ileo-colic anastomosis between January 2020 and December *** DSA technique employed a stapler to maintain the concept of anti-mesentery side-to-side ana-stomosis by performing a 90°vertical closure of the open window compared with the CSA *** the corner where the open window is closed,the DSA avoids forming a pouch and creates an anastomosis resembling a delta shape within the intestinal *** compared demographics,preoperative condition,operative findings,and operative outcomes for the two *** The study included 175 patients,including 92 in the DSA group and 83 in the CSA *** two groups were similar in baseline characteristics,preoperative medical treatment,and operative findings except for the Montreal classification *** 30-days postoperative complication rate was signi-ficantly lower in the DSA group compared with the CSA group(16.3%vs 32.5%,P=0.009).Ileus incidence was significantly lower in the DSA group than in the CSA group(4.3%vs 14.5%,P=0.033),and the hospital stay was shorter in the DSA group than in the CSA group(5.67±1.53 days vs 7.39±3.68 days,P=0.001).CONCLUSION The DSA technique was feasible and showed comparable postoperative outcomes with lower short-term complic-ations compared with the CSA *** studies on CD recurrence and long-term complications are warranted.

关键词： Crohn’s disease Surgery Anastomosis Complication Recurrence

Evaluation of the relationship between dietary factors,CagA-positive Helicobacter pylori infection,and RUNX3 promoter hypermethylation in gastric cancer tissue

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World Journal of Gastroenterology 2013年第11期19卷 1778-1787页

作者： Yan-Wei Zhang Sang-yong Eom Dong-Hyuk Yim Young-Jin Song Hyo-Yung Yun Joo-Seung Park Sei-Jin Youn Byung-sik Kim yong-Dae Kim Heon Kim Department of Preventive Medicine and Medical Research Institute College of MedicineChungbuk National UniversityCheongju 361-763South Korea Department of Surgery College of MedicineChungbuk National UniversityCheongju 361-763South Korea Department of Surgery College of MedicineEulji UniversityDaejon 461-713South Korea Department of Internal Medicine College of MedicineChungbuk National UniversityCheongju 361-763South Korea Department of Surgery Asan Medical CenterCollege of MedicineUlsan UniversitySeoul 138-736South Korea

AIM:To evaluate the relationship among Helicobacter pylori(***) infection,CagA status,and dietary factors with RUNX3 promoter ***:Gastric cancer tissue samples were collected from 184 South Korean *** patients were interviewed following a semi-quantitative food frequency *** average frequencies of intake and portion sizes of 89 common food items were documented,and total intakes of calories,nutrients,vitamins,and minerals were calculated for each *** was extracted from gastric cancer tissue samples,and amplification of the HSP60 gene was performed to detect *** *** polymerase chain reaction(PCR) was used to detect the presence of the CagA ***3 gene expression was measured by reverse transcription-PCR,and RUNX3 methylation status was evaluated by methylation-specific *** odds ratios(ORs) and 95%CI associated with RUNX3 promoter hypermethylation status were estimated for each of the food groups,lifestyle factors,and the interaction between dietary and lifestyle factors with CagA status of *** ***:Overall,164 patients(89.1%) were positive for *** DNA,with the CagA gene detected in 59(36%) of these ***-positive *** all,106(57.6%) patients with gastric cancer demonstrated CpG island hypermethylation at the RUNX3 ***3 expression was undetectable in 52(43.7%) of the 119 gastric cancer tissues sampled.A high consumption of eggs may increase the risk of RUNX3 methylation in gastric cancer patients,having a mean OR of 2.15(range,1.14-4.08).A significantly increased OR of 4.28(range,1.19-15.49) was observed with a high consumption of nuts in patients with CagA-positive *** *** intakes of carbohydrate,vitamin B1,and vitamin E may decrease the risk of RUNX3 methylation in gastric cancer tissue,particularly in CagA-or ***-negative infection,with OR of 0.41(0.19-0.90),0.42(0.20-0.89),and 0.29(0.13-0.62),respectively.A high consumpt

关键词： Gastric cancer RUNX3 Helicobacter pylori CagA Dietary factors