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Effect of Ni and Mn on the Mechanical Properties of 22Cr Microduplex Stainless Steel

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Acta Metallurgica Sinica(English Letters) 2015年第1期28卷 32-38页

作者： Jun-Young Park yong-sik Ahn Department of Materials Science and Engineering Pukyong National University

The tensile properties of 22Cr–2Ni–4Mn–0.2N micro-duplex stainless steels with different Ni and Mn contents were investigated. Duplex stainless steels were vacuum induction melted and hot rolled, then annealed at 1,000–1,100 °C, at which temperature both the austenite and ferrite phases were stable. The volume fraction of the ferrite phase was markedly affected by the alloying elements of Mn and Ni; 1 wt% of Mn was equivalent to 0.4 wt% of Ni. All of the steels tested at room temperature showed the common strain-hardening behavior, while the steels tested at lower temperatures（-30 or-50 °C）showed a distinct inflection point in their stress–strain curves, which resulted from the transformation of the austenite to straininduced martensite. The onset strain（e0） of the inflection point in the stress–strain curve depended on the Md30 value of the steel. Testing at lower temperatures resulted in smaller e0 and consequently higher strengths and fracture strains（ef）. The tensile behavior was examined from the perspective of austenite stability of the micro-duplex stainless steels with the different Ni and Mn contents.

关键词： Duplex stainless steel Microstructure Mechanical property Alloy composition

Recent applications of chemosensitivity tests for colorectal cancer treatment

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World Journal of Gastroenterology 2014年第44期20卷 16398-16408页

作者： yong sik Yoon Jin Cheon Kim Department of Surgery University of Ulsan College of Medicine Institute of Innovative Cancer Research and Asan Institute for Life Sciences Asan Medical Center

The evaluation of therapeutic efficacy is necessary to predict the outcome of patients with metastatic colorectal cancer(CRC). In these patients, there is a critical need for predictive chemosensitivity assays and biomarkers to optimize efficacy and minimize toxicity. The introduction of targeted agents has improved the progression-free survival and overall survival of patients with metastatic disease. However, approximately 50% of patients do not show a positive response to chemotherapy and the selection of patients likely to respond to a specific regimen remains challenging. Cell culturebased chemosensitivity tests use autologous viable tumor cells to evaluate susceptibility to specific agents in vitro and predict their direct effects. Adenosine triphosphate-based assays and methyl thiazolyl-diphenyltetrazolium bromide-based assays are used widely as sensitivity tests because of their short assay period, technical simplicity, and the requirement of small amount of specimen. Among protein- and gene-based chemosensitivity assays, assessment of KRAS mutation status predicts the response to epidermal growth factor receptor-targeted therapy in CRC patients. The validation of predictive and prognostic markers enables the selection of therapeutic regimens with optimal efficacy and minimal toxicity for each patient, which has been termed personalized treatment. This review summarizes currently available predictive and prognostic chemosensitivity tests for metastatic CRC.

关键词： Colorectal adenocarcinomas Colorectal cancer Chemotherapy In vitro assays Molecular targeted therapy Individualized therapy

Paleo-shoreline changes in moraine dammed lake Khagiin Khar, Khentey Mountains, Central Mongolia

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Journal of Mountain Science 2019年第6期16卷 1215-1230页

作者： OH Jeong-sik SEONG Yeong Bae HONG Seongchan YU Byung yong Department of Geography Education Korea UniversityAnam-Ro 145Seongbuk-GuSeoul 02841Korea AMS Laboratory Advanced Analysis CenterKorea Institute of Science and TechnologySeoul 02791Korea

The formation and evolution of glacier moraine-dammed lakes are closely related to past glacier expansion and retreat. Geomorphic markers such as lacustrine terraces and beach ridges observed in these lakes provide important evidence for regional paleoenvironment reconstruction. We document the magnitude of paleo-shoreline fluctuations and timings of highstands of lake water by using cosmogenic 10Be surface exposure dating and optically stimulated luminescence(OSL) dating on samples collected from lacustrine sediment and bedrock strath in Lake Khagiin Khar. The lake was initially impounded by glacier moraine at the Global Last Glacial maximum(gLGM;21–19 ka), and the lake reached its maximum paleo-shoreline level of 1840 m at sea level(a.s.l.). At that time, the stored lake water amount was up to seven times greater and the surface area was three times larger than the present values. The paleolake experienced higher shoreline levels at 1832, 1822, and 1817 m a.s.l. and reached the present lake level after 0.4 ka. We interpret that decrease in the paleolake level was caused by spillover. The increase in melt water after the gLGM and the Late Glacial exceeded the storage threshold of the lake, and the paleolake water overflowed across the lowest drainage divides. The lake spilled over across the lowest bedrock ridge at 15.9 ± 0.6 ka, and the outlet was incised since that time at a rate of 3.72 ± 0.15 mm/yr. The initial stream of the Khiidiin Pass River was disturbed by LGM moraine damming and was rerouted into the present course running through moraine after the spillover at 15.9 ± 0.6 ka.

关键词： Moraine-dammed lake Lake Khagiin Khar Shoreline Spillover 10Be exposure dating

Long-term outcome of stem cell transplantation with and without anti-tumor necrotic factor therapy in perianal fistula with Crohn’s disease

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World Journal of Stem Cells 2024年第3期16卷 257-266页

作者： Min Young Park yong sik Yoon Jae Ha Park Jong Lyul Lee Chang sik Yu Division of Colon and Rectal Surgery Department of SurgeryYonsei University College of MedicineSeoul 03722South Korea Division of Colon and Rectal Surgery Department of SurgeryUniversity of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea

BACKGROUND Stem cell transplantation is a promising therapeutic option for curing perianal fistula in Crohn’s disease(CD).Anti-tumor necrotic factor(TNF)therapy combined with drainage procedure is effective as ***,previous studies are limited to proving whether the combination treatment of biologics and stem cell transplantation improves the effect of fistula *** This study aimed to evaluate the long-term outcomes of stem cell transplantation and compare Crohn’s perianal fistula(CPF)closure rates after stem cell transplantation with and without anti-TNF therapy,and to identify the factors affecting CPF closure and *** The patients with CD who underwent stem cell transplantation for treating perianal fistula in our institution between Jun 2014 and December 2022 were *** data were compared according to anti-TNF therapy and CPF *** A total of 65 patients were *** median age of females was 26 years(range:21-31)and that of males was 29(44.6%).The mean follow-up duration was 65.88±32.65 months,and complete closure was observed in 50(76.9%)*** closure rates were similar after stem cell transplantation with and without anti-TNF therapy(66.7%vs 81.6%at 3 year,P=0.098).The patients with fistula closure had short fistulous tract and infrequent proctitis and anorectal stricture(P=0.027,0.002,and 0.008,respectively).Clinical factors such as complexity,number of fistulas,presence of concurrent abscess,and medication were not significant for *** cumulative 1-,2-,and 3-year closure rates were 66.2%,73.8%,and 75.4%,*** Anti-TNF therapy does not increase CPF closure rates in patients with stem cell ***,both refractory and non-refractory CPF have similar closure rates after additional anti-TNF *** tract length,proctitis,and anal stricture are risk factors for non-closure in patients with CPF after stem cell transplantation.

关键词： Crohn’s disease Anus Fistula Stem cell transplantation Tumor necrosis factor-alpha inhibitors Infliximab

Clinicopathological features of familial adenomatous polyposis in Korean patients

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World Journal of Gastroenterology 2016年第17期22卷 4380-4388页

作者： Sung Min Jung yong sik Yoon Seok-Byeong Lim Chang sik Yu Jin Cheon Kim Division of Colon and Rectal Surgery Department of Surgery University of Ulsan College of Medicine Seoul 05505 South Korea Asan Medical Center Seoul 05505 South Korea

AIM: To identify prognostic factors and to correlate APC mutations with clinical features, including extracolic manifestations. METHODS: One hundred thirty-five patients who underwent surgical procedures for familial adenomatous polyposis(FAP) were included. FAP was diagnosed when the number of adenomatous polyps was > 100. Data related to patient, extracoloic manifestations, cancer characteristics, operative procedure, follow up and surveillance were collected. APC mutation testing was performed in the 30 most recent patients. DNA was extracted from peripheral blood and polymerase chain reaction products using 31 primer pairs on APC gene were sequenced. A retrospective study was performed to investigate a causal relationship between prognosis and feature of ***: The mean age of the 51 patients with colorectal cancer(CRC) was older than that of those without CRC(30.5 vs 36.9, P = 0.002). Older individuals were more likely to have colon cancer at the time of FAP diagnosis [odds ratio, 4.75(95%CI: 1.71-13.89) and 5.91(1.76-22.12) for 40-49 years and age > 50 vs age < 30). The number of confirmed deaths was 13 and the median age at death was 40 years(range, 27 to 85 years). Ten of the deaths(76.9%) were from CRC. Another cause of two cases of death were desmoid tumors(15.4%). Development of cancer on remnant rectal or ileal mucosa after surgery was not observed. The APC mutation testing revealed 23 pathogenic mutations and one likely pathogenic mutation, among which were four novel mutations. The correlation between mutational status and clinical manifestations was investigated. Mutations that could prodict poor prognosis were at codon 1309 which located on mutation cluster region, codon 1465 and codon ***: Identification of APC mutations should aid in the diagnosis and counseling of family members in terms of early diagnosis and management of FAP.

关键词： Adenomatous polyposis coli Colorectal neoplasms APC gene Prognosis Survival

Relief of YAP-mediated inhibition by IKKε promotes innate antiviral immunity

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Cellular & Molecular Immunology 2018年第6期15卷 642-644页

作者： Nayoung Kim Yun-yong Park Chul Hyun Joo Hun sik Kim Department of Convergence Medicine Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Korea Asan Institute for Life Sciences Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Korea Department of Microbiology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Korea Department of Biomedical Sciences Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Korea

The innate immune response to invading viruses is critical for the mounting of protective immunity,in which type I interferons(IFN),for example,IFN-αandβ,are potent effector molecules.1 Most cell types,particularly fibroblasts and epithelial cells,produce IFN-β,whereas hematopoietic cells,notably plasmacytoid dendritic cells,are the predominant sources of IFN-α.IFNs potently stimulate a variety of innate and adaptive immune cells,including macrophages,NK cells and T *** binding of type I IFN to its cognate receptor triggers the activation of the Janus kinase signal transducer and activator of transcription pathway,which results in the transcription of IFNstimulated genes that play key roles in host resistance to viral infections.

关键词： immunity protective mount

Effect of barley straw biochar application on greenhouse gas emissions from upland soil for Chinese cabbage cultivation in short-term laboratory experiments

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Journal of Mountain Science 2016年第4期13卷 693-702页

作者： Se-Won KANG Dong-Cheol SEO yong-Hwa CHEONG Ju-Wang PARK Jong-Hwan PARK Hang-Won KANG Ki-Do PARK yong sik OK Ju-sik CHO Department of Medicinal & Industrial Crops Korea National College of Agriculture and Fisheries Division of Applied Life Science (BK21 Program) & Institute of Agriculture and Life Sciences Gyeongsang National University Department of Bio-environmental Sciences Sunchon National University National Institute of Crop Science Rural Development Association Korea Biochar Research Center & Department of Biological Environment Kangwon National University

Chinese cabbage was cultivated in upland soil with the addition of biochar in order to investigate the potential for reduction of greenhouse gas emissions. Barley straw biochar(BSB) was introduced in a Wagner pot(1/5000a) in amounts of 0(BSB0, control), 100(BSB100), 300(BSB300), and 500(BSB500) kg 10a^(-1). After the addition of BSB into the upland soil, carbon dioxide(CO_2) emission increased while methane(CH_4) and nitrous oxide(N_2O) emissions decreased. The highest CO2 flux was measured for the BSB500 sample,(84.6 g m^(-2)) followed by BSB300, BSB100, and BSB0 in decreasing order. Relative to those of control, the total CH_4 flux and N_2O flux for the BSB500 treatment were lower by 31.6% and 26.1%, respectively. The global warming potential(GWP) of the treatment without biochar was 281.4 g CO_2 m-2 and those for treatments with biochar were in the range from 194.1 to 224.9 g CO_2 m^(-2). Therefore, introducing BSB into upland soil to cultivate Chinese cabbages can reduce the global warming potential.

关键词： Biochar Carbon dioxide Methane Nitrous oxide Global warming

Recent advances in controlled modification of the size and morphology of metal-organic frameworks

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Nano Research 2018年第9期11卷 4441-4467页

作者： Botao Liu Kowsalya Vellingiri Sang-Hee Jo Pawao Kumar yong sik Ok Ki-Hyun Kim Department of Civil & Environmental Engineering Hanyang University 222 Wangsimni-Ro Seou104763 Republic of Korea Environmental and Water Resources Engineering Division Department of Civil Engineering IITMadras Chennoi 600 036 India Department of Nano Science and Materials Central University ofJammu Jammu J & K- 180011 India Korea Biochar Research Center O-Jeong Eco-Resilience Institute (OJERI) & Division of Environmental Science and Ecological Engineering Korea University Seou102841 Republic of Korea

Advances in metal-organic frameworks （lVIOFs） resulted in significant contributions to diverse applications such as carbon capture, gas storage, heat transformation and separation along with emerging applications toward catalysis, medical imaging, drug deliver~ and sensing. The unique in situ and ex situ structural features of MOFs can be tailored by conceptual selection of the organic （e.g., ligand） and inorganic （e.g., metal） components. Here, we provide a comprehensive review on the synthesis and characterization of MOFs, particularly with respect to controlling their size and morphology. A better understanding of the specific size and morphological parameters of MOFs will help initiate a new era for their real-world applications. Most importantly, this assessment will help develop novel synthesis methods for MOFs and their hybrid/porous materials counterparts with considerably improved properties in targeted applications.

关键词： metal-organic frameworks smart materials novel synthesis advanced materials composite materials green chemistry

Short-term and long-term outcomes of laparoscopic vs open ileocolic resection in patients with Crohn's disease: Propensityscore matching analysis

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World Journal of Gastroenterology 2021年第41期27卷 7159-7172页

作者： Shin Jeong Pak Young Il Kim yong sik Yoon Jong Lyul Lee Jung Bok Lee Chang sik Yu Department of Colon and Rectal Surgery University of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea Department of Clinical Epidemiology and Biostatistics University of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea

BACKGROUND Laparoscopic ileocolic resection(LICR)is the preferred surgical approach for primary ileocolic Crohn’s disease(CD)because it has greater recovery benefits than open ICR(OICR).AIM To compare short-and long-term outcomes in patients who underwent LICR and *** Patients who underwent ICR for primary CD from 2006 to 2017 at a single tertiary center specializing in CD were *** who underwent LICR and OICR were subjected to propensity-score matching *** were propensityscore matched 1:1 by factors potentially associated with 30-d perioperative *** included demographic characteristics and disease-and treatment-related *** were compared using univariate and multivariate ***-term surgical recurrence-free survival(SRFS)in the two groups was determined by the Kaplan-Meier method and compared by the log-rank *** During the study period,348 patients underwent ICR,211 by the open approach and 137 ***-score matching yielded 102 pairs of *** rate of postoperative complication was significantly lower(14%versus 32%,P=0.003),postoperative hospital stay significantly shorter(8 d versus 13 d,P=0.003),and postoperative pain on day 7 significantly lower(1.4 versus 2.3,P<0.001)in propensity-score matched patients who underwent LICR than in those who underwent *** analysis showed that postoperative complications were significantly associated with preoperative treatment with biologics[odds ratio(OR):3.14,P=0.01]and an open approach to surgery(OR:2.86,P=0.005).The 5-and 10-year SRFS rates in the matched pairs were 92.9%and 83.3%,respectively,with SRFS rates not differing significantly between the OICR and LICR *** performance of additional procedures was an independent risk factor for surgical recurrence[hazard ratio(HR):3.28,P=0.02].CONCLUSION LICR yielded better short-term outcomes and postoperative recovery than OICR,with no differences in long-ter

关键词： Crohn’s disease Laparoscopic Surgery Postoperative complications Recurrence Propensity score Retrospective study