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Association between cytochrome CYP17A1, CYP3A4, and CYP3A43 polymorphisms and prostate cancer risk and aggressiveness in a Korean study population

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Asian Journal of Andrology 2015年第2期17卷 285-291,I0010页

作者： Jun Hyun Han yong seong Lee Hae Jong Kim Shin Young Lee Soon Chul Myung Department of Urology Hallym University Dongtan Sacred Heart Hospital Hwaseong-si 445-170 Korea Department of Urology Hallym University Kangnam Sacred Heart Hospital Seoul 150-950 Korea Advanced Urogenital Disease Research Center Chung-Ang University College of Medicine Seoul 156-756 Korea Research Institute for Translational System Biomics Chung-Ang University College of Medicine Seoul 156-756 Korea Department of Urology Seoul Medical Center Seoul 131-865 Korea Department of Urology Chung-Ang University Hospital Seou1156-756 Korea.

In this study, we evaluated genetic variants of the androgen metabolism genes CYP17A1, CYP3A4, and CYP3A43 to determine whether they play a role in the development of prostate cancer （PCa） in Korean men. The study population included 240 pathologically diagnosed cases of PCa and 223 age-matched controls. Among the 789 singie-nucleotide polymorphism （SNP） database variants detected, 129 were reported in two Asian groups （Han Chinese and Japanese） in the HapMap database. Only 21 polymorphisms of CYP17A1, CYP3A4, and CYP3A43 were selected based on linkage disequilibrium in Asians （d = 1）, locations （SNPs in exons were preferred）, and amino acid changes and were assessed. In addition, we performed haplotype analysis for the 21 SNPs in CYP17A1, CYP3A4, and CYP3A43 genes. To determine the association between genotype and haplotype distributions of patients and controls, logistic analyses were carried out, controlling for age. Twelve sequence variants and five major haplotypes were identified in CYP17A1. Five sequence variants and two major haplotypes were identified in CYP3A4. Four sequence variants and four major haplotypes were observed in CYP3A43. CYP17A1 haplotype-2 （Ht-2）（odds ratio [OR], 1.51; 95% confidence interval [Cl], 1.04-2,18） was associated with PCa susceptibility. CYP3A4 Ht-2 （OR. 1.87; 95% CI. 1.02-3.43） was associated with PCa metastatic potential according to tumor stage, rs17115149 （OR： 1.96; 95% Ch 1.04-3.68） and CYP17A1 Ht-4 （OR： 2.01; 95% Ch 1.07-4.11） showed a significant association with histologic aggressiveness according to Gleason score. Genetic variants of CYP17A1 and CYP3A4 may play a role in the development of PCa in Korean men.

关键词： androgens CYP17A1 CYP3A4 CYP3A43 genetics prostatic neoplasms

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Resveratrol prevents hypoxia-induced retinal ganglion cell death related with ErbB2

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International Journal of Ophthalmology(English edition) 2022年第3期15卷 394-400页

作者： Hyemin seong Joo Yeon Jeong Jinhyun Ryu Juyeong Park yong‑Seop Han Hyun-Kyung Cho seong Jae Kim Jong Moon Park Sang Soo Kang seong Wook Seo Department of Ophthalmology Institute of Health SciencesCollege of MedicineGyeongsang National UniversityJinjuGyeongnam 52727Republic of Korea Department of Anatomy and Convergence Medical Science Institute of Health SciencesCollege of MedicineGyeongsang National UniversityJinjuGyeongnam 52727Republic of Korea Department of Ophthalmology Gyeongsang National University Changwon HospitalGyeongsang National UniversityCollege of MedicineChangwon 51472Republic of Korea

AIM: To confirm the changes in proteins related with hypoxia-induced retinal cell death and to assess the effects of resveratrol(Res).METHODS: The therapeutic effect of Res was verified using an ischemic/reperfusion(I/R) model in vivo and a hypoxia modelin retinal ganglion cells(RGCs) in *** of RGCs were confirmed by TUNEL *** expression was confirmed by Western blotting and *** addition, flow cytometric analysis was used to confirm the response in the cell unit to obtain more accurate ***: ErbB2 expression and apoptosis in the ganglion cell layer(GCL) increased after I/R *** of Res rescued I/R-induced ganglion cell death, downregulated apoptosis and ErbB2 protein expression in the *** subsequent in vitro models, Res affects apoptosis by regulating the phosphorylation and expression of mouse double minute 2 homolog(MDM2), along with those of *** results suggest that Res reverses GCL-specific apoptosis via downregulation of ErbB2 in ischemic ***: In light of Res favorable properties, it should be evaluated in the treatment of RGC death and related retinal disease characterized by ErbB2 and MDM2 ***, Res is appropriate therapeutic agent for treating ischemic injury-related eye diseases by targeting the expression of ErbB2 and MDM2.

关键词： ischemia/reperfusion injury hypoxia retinal ganglion cell resveratrol ErbB2

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Optimum condition by mechanical characteristic evaluation in friction stir welding for 5083-O Al alloy

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中国有色金属学会会刊：英文版 2009年第B9期19卷 17-22页

作者： Min-Su HAN Seung-Jun LEE Jae-Cheul PARK Seok-Cheol KO yong-Bin WOO seong-Jong KIM Division of Marine Engineering Mokpo Maritime University Chungnam Regional Innovation Agency

The mechanical characteristies for friction stir welding (FSW) of 5083-O Al alloy were evaluated. The results show that in FSW at 800 r/min and 124 mm/min, a weld defect is observed at the start point. However, the button shape at the end point is good and the stir zone has a soft appearance. At 267 mm/min, a void occurs at the button. A slight weld defect and rough stir zone are seen both at the start and end points at 342 mm/min. Moreover, at the bottom, a tunnel-type void is observed from an early stage to the end point, and at 1 800 r/min, a weld defect can be found from an early stage to the end point. These defects are rough with imperfect joining due to excessive rotation speed and high physical force. Weld fractures relative to rotational and travel speeds are observed at the stir zone. The optimum FSW conditions are a welding speed of 124 mm/min and a rotational speed of 800 r/min.

关键词：搅拌摩擦焊接摩擦特性机械性能铝合金焊缝缺陷评估优化氧

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Sol-gel synthesis and characterization of hydroxyapatite nanorods

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Particuology 2009年第6期7卷 466-470页

作者： Sanosh Kunjalukkal Padmanabhan Avinash Balakrishnan Min-Cheol Chu yong Jin Lee Taik Nam Kim seong-Jai Cho Department of Information and Electronic Materials Engineering College of EngineeringPaichai UniversityDaejeon 302-735Republic of Korea Division of Metrology for Emerging Technology Korea Research Institute of Standards and Science1 Doryong-DongYuseong-GuDaejeon 305-340Republic of Korea Division of Advanced Technology Korea Research Institute of Standards and ScienceDaejeon 305-340Republic of Korea

In the present study hydroxyapatite （HA） nano-hexagonal rods with 70-90 nm diameter and 400-500 nm length are synthesized using a simple sol-gel route with calcium nitrate and potassium dihydrogenphosphate as calcium and phosphorus precursors respectively. Deionized water was used as a diluting media for HA sol preparation and ammonia was used to adjust the pH = 9. After aging, the HA gel was dried at 60 ℃ and calcined at different temperatures ranging from 300 to 700 ℃. The dried and calcined powders were characterized for phase composition using X-ray diffractrometry, elemental dispersive X-ray and Fourier transform infrared spectroscopy. Rietveld analysis showed the calcined HA powders of high purity with a hexagonal unit cell structure. Calcination yielded HA nanopowders of increased particle size and crystallinity with increase in temperature. The particle size and morphology was studied using transmission electron microscopy. The aspect ratio （length to diameter ratio） of HA nanorods was measured to be between 6 and 7.

关键词： Hydroxyapatite Nanorods Sol-gel Particle size Morphology

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Voxel-based statistical analysis of regional cerebral glucose metabolism in children with attention-deficit hyperactivity disorder

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Neural Regeneration Research 2011年第36期6卷 2850-2855页

作者： Ji-Hoon Kim Young-In Chung Jung Sub Lee In-Joo Kim yong-Ki Kim seong-Jang Kim Division of Child-Adolescent Psychiatry Department of Psychiatry Pusan National University School of Medicine Yangsan-si Gyeongnam Republic of Korea Medical Research Institute Pusan National University School of Medicine Yangsan-si Gyeongnam Republic of Korea Department of Psychiatry Pusan National University School of Medicine Yangsan-si Gyeongnam Republic of Korea Department of Orthopedic Surgery Pusan National University School of Medicine Yangsan-si Gyeongnam Republic of Korea Department of Nuclear Medicine Pusan National University School of Medicine Yangsan-si Gyeongnam Republic of Korea

The technique of region of interest-based positron emission tomography is limited by its poor reli-ability and relatively few examined brain regions. In the present study, we compared brain metabo-lism assessed using fluorine-18-fluorodeoxyglucose positron emission tomography between 14 at-tention-deficit hyperactivity disorder （ADHD） patients and 15 normal controls with scoliosis at resting state by statistical parametric mapping. Glucose metabolism was decreased in the left parahippo-campal gyrus, left hippocampus, left anterior cingulate gyrus, right anterior and posterior lobes of the cerebellum, left superior temporal gyrus, left insula, left medial and middle frontal gyri, right medial frontal gyrus, and left basal ganglia （putamen, amygdala, and caudate nucleus） in children with ADHD. These data suggest that children with ADHD exhibit hypometabolism in various brain regions compared to controls, indicating that ADHD symptoms are unlikely the result of abnormalities in specific areas.

关键词： attention-deficit hyperactivity disorder positron emission tomography statistical parametric mapping

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Acute myelomonocytic leukemia during pembrolizumab treatment for non-small cell lung cancer: A case report

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World Journal of Clinical Cases 2020年第13期8卷 2833-2840页

作者： Hong-Beum Kim Sang-Gon Park Ran Hong seong-Ho Kang yong Sub Na Department of Premedical Course Chosun University School of MedicineGwangju 61452South Korea Department of Hemato-oncology Chosun University HospitalGwangju 61453South Korea Department of Pathology Chosun University HospitalGwangju 61453South Korea Department of Laboratory Medicine Chosun University HospitalGwangju 61453South Korea Department of Pulmonology and Critical Care Medicine Chosun University HospitalGwangju 61453South Korea

BACKGROUND Pembrolizumab is a highly selective IgG4 kappa isotype monoclonal antibody against the programmed cell death-1(PD-1)*** the treatment of nonsmall cell lung cancer(NSCLC),pembrolizumab has demonstrated significant efficacy,significant survival outcomes,long-lasting responses,and a good safety profile compared with cytotoxic *** SUMMARY A 79-year-old Korean male presented with a left side palpable neck *** ultrasound-guided core-needle biopsy of the largest neck mass was performed,and squamous cell carcinoma was confirmed based on the histological and immunohistochemical *** was diagnosed with squamous cell carcinoma of the lung with multiple lymph nodes and rib metastases(T1N3M1b,Stage IVA)using enhanced chest computed tomography and 18F-fluorodeoxyglucose positron emission/computed *** 4 cycles of gemcitabine and carboplatin,we clinically judged the disease as *** to the high PD-1 expression demonstrated by the patient,pembrolizumab was initiated(200 mg every 3 wk).After 3 cycles of pembrolizumab,a complete response was *** the 4th cycle of pembrolizumab,the white blood cell count was markedly *** blood smear analysis and bone marrow biopsy were *** patient was diagnosed with acute myelomonocytic *** We present the first report of acute myelomonocytic leukemia during pembrolizumab treatment in an NSCLC patient;the mechanism remains unknown.

关键词： Acute myeloid leukemia Immunotherapy Non-small cell lung cancer Adverse events Case report

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Effects of thickness of Al thermal spray coating for STS 304

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中国有色金属学会会刊：英文版 2009年第4期19卷 925-929页

作者： Min-Su HAN yong-Bin WOO Seok-Cheol KO Young-Jae JEONG Seok-Ki JANG seong-Jong KIM Division of Marine Engineering Mokpo Maritime University Chungnam Regional Innovation Agency Jeonnam Techno Park

Thermal spray coating presents a sacrificial-anode cathodic protection method since differences between the potentials of materials are *** a base metal is exposed to seawater,due to defect in the thermal spray coating,the metal is protected by the sacrificial anodic characteristics of the coating layer because micro-cells formed by the base metal and the thermal spray coating act as cathodes and anodes,*** coating thickness has little effect on the surface morphology of the ***,the electrochemical properties with the increasing of coating thickness present good results.

关键词：涂层厚度热喷涂 STS 金属接触电化学性能保护方法牺牲阳极阳极涂层

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Formation behavior of anodic TiO_2 nanotubes in fluoride containing electrolytes

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中国有色金属学会会刊：英文版 2009年第4期19卷 842-845页

作者： Byung-Gwan LEE Jin-Wook CHOI seong-Eun LEE yong-Soo JEONG Han-Jun OH Choong-Soo CHI School of Advanced Materials Engineering Kookmin University Korea Institute of Materials Science Department of Materials Science Han seo University

TiO2 nanotube layers can be formed with titanium in the electrolytes containing fluoride by electrochemical *** role of fluoride ion,the crystallinity of the anodic oxide,and the chemical state were *** results show the anodic film is composed of oxide and a little amount of *** presence of F- ions leads to chemical dissolution of Ti oxide layer and prevents hydroxide ***,chemical dissolution rate increases with increasing the fluoride content in the range of 0-2%(in mass fraction) because F- ions in electrolyte attack the interface and allow the ions of the electrolyte to easily penetrate into the *** as-anodized TiO2 nanotubes exhibit an amorphous *** treated nanotubes are composed of mixtures of the anatase and rutile phases.

关键词： TiO2纳米管阳极氧化处理氟离子电解质行为二氧化钛化学溶解电化学方法

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Purifying behavior of photocatalytic TiO_2 anodized in nitrate ion containing solution

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中国有色金属学会会刊：英文版 2009年第4期19卷 1027-1030页

作者： Jin-Wook CHOI seong-Eun LEE Byung-Gwan LEE yong-Soo JEONG Han-Jun OH Choong-Soo CHI School of Advanced Materials Engineering Kookmin University Korea Institute of Materials Science Department of Materials Science Han seo University

Mesoporous titanium dioxide films were fabricated on titanium plates by micro-arc oxidation *** increase the photocatalytic activity of the films,NH4NO3 was added to the H2SO4 solution,and anodizing was carried out at high voltages using a DC power *** crystal structure,chemical composition,surface morphology and the optical property of the films were investigated by XPS,XRD,UV-VIS spectroscopy and *** photocatalytic activity of the films was evaluated by the decomposition of aniline blue,and the activity of the films for the degradation turned out to be improved by the additives to the electrolyte *** enhanced photocatalytic activity might result from the increased porosity and nitrate ion incorporation into the anodic films by micro arcing,and thereby the TiO2 layer might exhibit an improved absorption property for the visible light.

关键词：二氧化钛硝酸溶液盐离子催化行为氧化钛薄膜光催化活性 H2SO4溶液净化

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Predicting tumor response after preoperative chemoradiation using clinical parameters in rectal cancer

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World Journal of Gastroenterology 2011年第48期17卷 5310-5316页

作者： Chan Ho Park Hee Cheol Kim yong Beom Cho seong Hyeon Yun Woo yong Lee Young Suk Park Doo Ho Choi Ho-Kyung Chun Departmentof Surgery Samsung Medical Center Sungkyunkwan Univer-sity School of Medicine Irwon-dong 50 Gangnam-gu Seoul135-710 South Korea Division of Hematology-Oncology Depart-ment of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Irwon-dong 50 Gangnam-guSeoul 135-710 South Korea Department of Radiation Oncology SamsungMedical Center Sungkyunkwan University School of MedicineIrwon-dong 50 Gangnam-gu Seoul 135-710 South Korea

AIM: To evaluate the clinical parameters and identify a better method of predicting pathological complete response (pCR). METHODS: We enrolled 249 patients from a database of 544 consecutive rectal cancer patients who underwent surgical resection after preoperative chemoradiation therapy (PCRT). A retrospective review of morphological characteristics was then performed to collect data regarding rectal examination findings. A scoring model to predict pCR was then created. To validate the ability of the scoring model to predict complete ***: Seventy patients (12.9%) achieved a pCR. A multivariate analysis found that pre-CRT movability (P = 0.024), post-CRT size (P = 0.018), post-CRT morphology (P = 0.023), and gross change (P = 0.009) were independent predictors of pCR. The accuracy of the scoring model was 76.8% for predicting pCR with the threshold set at 4.5. In the validation set, the accuracy was 86.7%. CONCLUSION: Gross changes and morphological findings are important predictors of pathological response. Accordingly, PCRT response is best predicted by a combination of clinical, laboratory and metabolic information.

关键词： Rectal cancer Preoperative chemoradiotherapy Downstaging Tumor regression Validation

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