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Study of extrudability and standoff distance effect during nanoclay-enabled direct printing

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Bio-Design and Manufacturing 2018年第2期1卷 123-134页

作者： Yifei jin Danyang Zhao yong Huang Department of Mechanical and Aerospace Engineering University of Florida R O. Box 116250 Gainesville FL 32611 USA Department of Mechanical Engineering Dalian University of Technology Dalian 116023 Liaoning China

Nanoclay-enabled self-supporting printing has been emerging as a promising filament-based extrusion fabrication approach for different biomedical and engineering applications including tissue engineering. With the addition of nanoclay powders, liquid build materials may exhibit solid-like behavior upon extrusion and can be directly printed in air into complex three-dimensional structures. The objective of this study is to investigate the effect of nanoclay on the extrudability of N-isopropylacrylamide （NIPAAm） and the effect of standoff distance on the print quality during nanoclay-enabled direct printing. It is found that the addition of nanoclay can significantly improve the NIPAAm extrudability and effectively eliminate die swelling in material extrusion. In addition, with the increase of standoff distance, deposited filaments change from over-deposited to well-defined to stretched to broken, the filament width decreases, and the print fidelity deteriorates. A mathematical model is further proposed to determine the optimal standoff distance to achieve better print fidelity during nanoclay-enabled direct printing. Based on the extrudability and standoff distance knowledge from this study, NIPAAm-Laponite nanoclay and NIPAAm-Laponite nanoclay-graphene oxide nanocomposite hydrogel precursors are successfully printed into a three-layered one-dimensional responsive pattern, demonstrating the good extrudability and print quality during nanoclay-enabled printing under optimal printing conditions.

关键词： Extrudability Print quality Nanoclay Standoff distance Direct printing

Rellich type inequalities related to Grushin type operator and Greiner type operator

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Applied Mathematics(A Journal of Chinese Universities) 2012年第3期27卷 353-362页

作者： SHEN Shou-feng jin yong-yang Department of Applied Mathematics Zhejiang University of TechnologyHangzhou 310032China

We prove some sharp Hardy inequality associated with the gradient △γ=（△x,｜x｜γ [x△y） by a direct and simple approach. Moreover, similar method is applied to ob- tain some weighted sharp Rellich inequality related to the Grushin operator in the setting of L^p. We also get some weighted Hardy and Rellich type inequalities related to a class of Greiner type operators.

关键词： Rellich inequality Hardy inequality Grushin type operator Greiner type operator.

Increased Maleness at Flowering Stage and Femaleness at Fruiting Stage with Size in an Andromonoecious Perennial, Veratrum nigrum

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Journal of Integrative Plant Biology 2008年第8期50卷 1024-1030页

作者： Wan-jin Liao Da-yong Zhang Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering & Institute of Ecology Beijing Normal University Beijing 100875 China

Theory predicts that cosexual plants should adjust their resource investment in male and female functions according to their size if female and male fitness are differentially affected by size. However, few empirical studies have been carried out at both the flowering and fruiting stages to adequately address size-dependent sex allocation in cosexual plants. In this paper, we investigated resource investment between female and male reproduction, and their size-dependence in a perennial andromonoecious herb, Veratrum nigrum L. We sampled 192 flowering plants, estimated their standardized phenotypic gender, and assessed the resource investment in male and female functions in terms of absolute dry biomass. At the flowering stage, male investment increased with plant size more rapidly than female investment, and the standardized phenotypic femaleness （ranging from 0.267 to 0.776） was negatively correlated with plant size. By contrast, female biased allocation was found at the fruiting stage, although both flower biomass and fruit biomass were positively correlated with plant size. We propose that increased maleness with plant size at the flowering stage may represent an adaptive strategy for andromonoecious plants, because male flowers promote both male and female fertility by increasing pollinator attraction without aggravating pollen discounting.

关键词： andromonoecy phenotypic gender size-dependent sex allocation Veratrum nigrum

Group Classification of Differential-difference Equations： Low-dimensional Lie Algebras

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Acta Mathematicae Applicatae Sinica 2017年第2期33卷 345-362页

作者： Shou-feng SHEN yong-yang jin Department of Applied Mathematics Zhejiang University of Technology Hangzhou 310023 China

Differential-difference equations of the form un = Fn（t, un-1,Un,Unn＋1,Un-1,un,Un＋1） are clas- sifted according to their intrinsic Lie point symmetries, equivalence group and some low-dimensional Lie algebras including the Abelian symmetry algebras, nilpotent nonAbelian symmetry algebras, solvable symmetry algebras with nonAbelian nilradicals, solvable symmetry algebras with Abelian nilradicals and nonsolvable symmetry al- gebras. Here Fn is a nonlinear function of its arguments and the dot over u denotes differentiation with respect to t.

关键词： group classification differential-difference equation equivalence group finite-dimensional Lie algebra.

Potential coordination role between O-GIcNAcylation and epigenetics

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Protein & Cell 2017年第10期8卷 713-723页

作者： Donglu Wu yong Cai jingji jin School of Life Sciences Jilin University Changchun 130012 China National Engineering Laboratory for AIDS Vaccine Jilin University Changchun 130012 China Key Laboratory for Molecular Enzymology and Engineering The Ministry of Education Jilin University Changchun 130012 China

Dynamic changes of the post-translational O-GIcNAc modification （O-GIcNAcylation） are controlled by O-linked β-N-acetylglucosamine （O-GIcNAc） transferase （OGT） and the glycoside hydrolase O-GIcNAcase （OGA） in cells. O-GIcNAcylation often occurs on serine （Ser） and threonine （Thr） residues of the specific substrate proteins via the addition of O-GIcNAc group by OGT. It has been known that O-GIcNAcylation is not only involved in many fundamental cellular processes, but also plays an important role in cancer development through various mechanisms. Recently, accumulating data reveal that O-GIcNAcylation at histones or non-histone proteins can lead to the start of the subsequent biological processes, suggesting that O-GIcNAcylation as ＇protein code＇ or ＇histone code＇ may provide recognition platforms or executive instructions for subse- quent recruitment of proteins to carry out the specific functions. In this review, we summarize the interaction of O-GIcNAcylation and epigenetic changes, introduce recent research findings that link crosstalk between O- GIcNAcylation and epigenetic changes, and speculate on the potential coordination role of O-GIcNAcylation with epigenetic changes in intracellular biological processes.

关键词： O-GIcNAcylation post-translationa modification histone modification epigenetics

On F-Almost Split Sequences

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Acta Mathematica Sinica,English Series 2010年第6期26卷 1149-1164页

作者： Xiao jin ZHANG Zhao yong HUANG College of Mathematics & Physics Nanjing University of Information Science & Technology Nanjing 210044 P. R. China Department of Mathematics Nanjing University Nanjing 210093 P. R. China

Let A be an Artinian algebra and F an additive subbifunctor of Ext,（-, -） having enough projectives and injectives. We prove that the dualizing subvarieties of mod A closed under F-extensions have F-almost split sequences. Let T be an F-cotilting module in mod A and S a cotilting module over F = End（T）. Then Horn（-, T） induces a duality between F-almost split sequences in ⊥FT and almost sl31it sequences in ⊥S, where addrS = Hom∧（f（F）, T）. Let A be an F-Gorenstein algebra, T a strong F-cotilting module and 0→A→B→C→0 and F-almost split sequence in ⊥*** the injective dimension of S as a Г-module is equal to d, then C≌（ΩCM^-dΩ^dDTrA^＊）^＊,where（-）^＊=Hom（g,T）.In addition, if the F-injective dimension of A is equal to d, then A≌ΩMF^-dDΩFop^-d TrC≌ΩCMF^-d ≌F^d DTrC.

关键词： F-almost split sequences almost split sequences F-Gorenstein algebras

Meta-analysis of effects of obstructive sleep apnea on the renin-angiotensinaldosterone system

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Journal of Geriatric Cardiology 2016年第4期13卷 333-343页

作者： Ze-Ning jin yong-Xiang WEI Emergency Center Beijing Anzhen Hospital Capital Medical University Beijing China Department of Otolaryngology Beijing Anzhen Hospital Capital Medical University Beijing China

Background Obstructive sleep apnea （OSA） is the most common cause of resistant hypertension, which has been proposed to result from activation of the renin-angiotensin-aldosterone system （RAAS）. We meta-analyzed the effects of OSA on plasma levels of RAAS components. Methods Full-text studies published on MEDL1NE and EMBASE analyzing fasting plasma levels of at least one RAAS component in adults with OSA with or without hypertension. OSA was diagnosed as an apnea-hypopnea index or respiratory disturbance index 〉 5. Study quality was evaluated using the Newcastle-Ottawa Scale, and heterogeneity was assessed using the 12 statistic. Results from individual studies were synthesized using inverse variance and pooled using a random-effects model. Subgroup analysis, sensitivity analysis, and meta-regression were performed, and risk of publication bias was assessed. Results The meta-analysis included 13 studies, of which 10 reported results on renin （n = 470 cases and controls）, 7 on angiotensin II （AnglI, n = 384）, and 9 on aldosterone （n = 439）. AnglI levels were significantly higher in OSA than in controls [mean differences = 3.39 ng/L, 95% CI： 2.00-4.79, P 〈 0.00001], while aldosterone levels were significantly higher in OSA with hypertension than OSA but not with hypertension （mean differences = 1.32 ng/dL, 95% CI： 0.58-2.07, P = 0.0005）. Meta-analysis of all studies suggested no significant differences in aldosterone between OSA and controls, but a significant pooled mean difference of 1.35 ng/mL （95% CI： 0.88-1.82, P 〈 0.00001） emerged after excluding one small-sample study. No significant risk of publication bias was detected among all included studies. Conelusions OSA is associated with higher AnglI and aldosterone levels, espe- cially in hypertensive patients. OSA may cause hypertension, at least in part, by stimulating RAAS activity.

关键词： Hypertension Obstructive sleep apnea Renin-angiotensin-aldosterone system

Physics problems in bio or bioinspired additive manufacturing

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Bio-Design and Manufacturing 2023年第2期6卷 99-102页

作者： Jun Yin jin Qian yong Huang The State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310028China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province School of Mechanical EngineeringZhejiang UniversityHangzhou 310028China Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province Department of Engineering MechanicsZhejiang UniversityHangzhou 310027China Department of Mechanical and Aerospace Engineering University of FloridaGainesvilleFL 32611USA

Additive manufacturing,also known as three-dimensional(3D)printing,has attracted increasing attention due to the innovations in materials science and manufacturing over recent decades[1].Recently,innovations in biocompatible materials and biology have enabled the extension of 3D printing techniques into bioadditive manufacturing,which focuses on the fabrication of 3D engineered native-like tissues/organs[2].Currently,bioadditive manufacturing technologies can be categorized into inkjet-based bioprinting,microextrusion-based bioprinting,digital light processing(DLP)bioprinting,electric field-assisted bioprinting,and fused deposition modeling(FDM),to name a few[3,4](Fig.1).Artificial tissues and organs with delicate structures,such as the heart[5]and liver[6],have been successfully fabricated using various bioadditive manufacturing techniques.

关键词： printing additive organs

Adenoma arising from xanthoma in the transverse colon:a case report

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Gastroenterology Report 2023年第1期11卷 542-544页

作者： Yu jin jung Jun Lee Seong jung Kim Ran Hong Department of Internal Medicine College of MedicineChosun UniversityGwangjuRepublic of Korea Department of Pathology College of MedicineChosun UniversityGwangjuRepublic of Korea

Introduction A xanthoma is a benign lesion consisting of foamy cells characterized by a highly vacuolated *** lesions can develop anywhere in the gastrointestinal tract but most often occur in the stomach,duodenum,or esophagus and very rarely in the colon[1].Gastric xanthoma shows a high incidence in gastric cancer patients and is reportedly an independent predictor of gastric cancer[2].Although adenomas associated with colorectal xanthoma were first reported in 1997,clear evidence supporting an association between xanthoma and colorectal adenoma or cancer is lacking[3].Furthermore,the association between adenoma and lipid deposits is unproven,and although adenoma has been found adjacent to or around xanthoma,this is more likely coincidental.

关键词： colon stomach adenoma