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脑血管病急性期血尿酸/血肌酐比值与脑血管事件复发及死亡的关系:一项前瞻性队列研究

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中国全科医学 2025年第2期28卷 175-182,192页

作者：任小乔王盼吴昊纪勇石志鸿天津医科大学神经内外科及神经康复临床学院天津市300070 天津市环湖医院 300350

背景脑卒中在世界各地有较高的死亡率和复发率。血尿酸(SUA)是嘌呤代谢的产物,已被认为是心脑血管病的危险因素。血尿酸/血肌酐比值(SUA/Scr)是代表肾功能标准化的SUA,目前有关SUA/Scr在急性脑血管病中的作用仍有争议。目的探讨脑血管... 详细信息

背景脑卒中在世界各地有较高的死亡率和复发率。血尿酸(SUA)是嘌呤代谢的产物,已被认为是心脑血管病的危险因素。血尿酸/血肌酐比值(SUA/Scr)是代表肾功能标准化的SUA,目前有关SUA/Scr在急性脑血管病中的作用仍有争议。目的探讨脑血管病急性期SUA/Scr与脑血管事件复发和死亡的关系。方法本研究为前瞻性队列研究,选取2006年9月—2019年9月天津市环湖医院连续收治的首次发生脑血管事件的13313例患者为研究队列,并对患者进行随访,随访截至2020年9月。随访方式为门诊及电话相结合。随访主要终点事件为全因死亡,次要终点事件为脑血管事件复发、心血管事件复发、其他血管事件发生(如下肢动静脉栓塞)。采用Cox比例风险回归模型探究SUA/Scr与脑血管事件复发与死亡的关系。结果根据脑血管病急性期SUA/Scr四分位数,将患者分为Q1组(SUA/Scr≤3.16,n=3520)、Q2组(3.164.92,n=3243)。截至随访结束,774例(5.8%)患者死亡,2064例(15.5%)患者复发脑血管事件。脑血管病急性期SUA/Scr位于Q1~Q4的患者中,男性复发脑血管病的例数依次为302、375、408、337例,女性依次为99、125、169、249例;男性复发脑梗死的例数依次为261、314、345、283例,女性依次为90、101、142、205例;男性复发大动脉粥样硬化型脑梗死的例数依次为154、191、214、183例,女性依次为58、52、45、31例;男性全因死亡的例数依次为165、128、131、88例,女性依次为57、63、62、80例;男性因脑梗死死亡的例数依次为93、72、70、46例,女性依次为31、33、36、44例;男性因大动脉粥样硬化型脑梗死死亡的例数依次为58、52、45、31例,女性依次为17、18、27、24例。调整多项混杂因素后,SUA/Scr位于Q4相较于Q1是男性急性脑梗死复发的影响因素(HR=0.690,95%CI=0.500~0.953,P=0.026);SUA/Scr位于Q4相较于Q1是男性脑梗死亚组患者大动脉粥样硬化型脑梗死复发的影响因素(HR=0.740,95%CI=0.578~0.947,P=0.017)。SUA/Scr位于Q4相较于Q1是男性全因死亡、因脑梗死死亡的影响因素(HR=0.575,95%CI=0.368~0.901,P=0.003;HR=0.610,95%CI=0.353~0.814,P=0.011)。SUA/Scr位于Q3、Q4相较于Q1是男性出院后死亡的影响因素(HR=0.656,95%CI=0.476~0.904,P=0.010;HR=0.582,95%CI=0.409~0.829,P=0.001)。SUA/Scr位于Q4相较于Q1是男性脑梗死亚组患者因大动脉粥样硬化型脑梗死死亡的影响因素(HR=0.580,95%CI=0.386~0.873,P=0.007)。结论一定范围内,脑血管病急性期SUA/Scr升高对男性患者脑血管事件复发及死亡有一定的保护作用,低SUA/Scr与男性大动脉粥样硬化型脑梗死的死亡和复发风险升高有关,但与小动脉闭塞型脑梗死和心源性卒中复发和死亡无关。在女性患者中没有观察到SUA/Scr与脑血管事件复发及死亡的关系。

关键词：脑血管障碍脑卒中血尿酸/血肌酐比值动脉粥样硬化男性复发死亡队列研究前瞻性研究 Cox比例风险回归模型

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Topological r-entropy and Measure Theoretic r-entropy of Flows

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Acta Mathematica Sinica,English Series 2022年第4期38卷 761-769页

作者： yong ji Yun Ping WANG Department of Mathematics Ningbo UniversityNingbo 315211P.R.China School of Science Ningbo University of TechnologyNingbo 315211P.R.China School of Mathematical Sciences and Institute of Mathematics Nanjing Normal UniversityNanjing 210023P.R.China

The topological r-entropy and measure theoretic r-entropy of a flow are *** a flow(X,φ),it is shown that topological(measure theoretic)r-entropy is equal to the topological(measure theoretic)entropy of the time one ... 详细信息

关键词： Topological r-entropy measure theoretic r-entropy flow

Effects of UV intensity and water turbidity on microbial indicator Inactivation

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Journal of Environmental Sciences 2006年第4期18卷 650-653页

作者： LIU Wen-jun ZHANG yong-ji Department of Environmental Science and Engineering Tsinghua University Beijing 100084 China

The effects of UV intensity and turbidity on selected microbial indicator inactivation were investigated. Results showed that UV disinfection was effective in killing all the selected microbial indicators, the resistance order of the microorganisms was as follows： MS-2 coliphage 〉 Bacillus subtilis 〉 E. coil 〉 Staphylococcus aureus and Candida albicans. UV intensity had influence on the inactivation of all the microorganisms, high UV disinfection efficency was obtained with higher UV intensity. Turbidity had impact on the bacteria inactivation rate, but there was no evidence that turbidity had any negative contribution to MS-2 coliphage. Under the same UV dosage, higher UV intensity could overcome the negative influence of turbidity on UV performance, enhanced microorganism inactivation effect in turbidity water.

关键词： UV disinfection intensity exposure time microbial indicator

Graphical interface for motion editing using procedure visualization

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Science China(Information Sciences) 2011年第6期54卷 1227-1237页

作者： KWON ji-yong LEE In-Kwon Department of Computer Science Yonsei University

In this paper, we introduce an interface for motion editing that visualizes editing procedures. For intuitive understanding and construction of motion editing procedures, our system represents an editing element that produces modified motion from a given input motion as a graphical node, and enables user to construct a whole motion editing procedure by connecting the nodes with a few mouse interactions. The system provides both the 3D transform manipulator and the time-line slider for intuitive controlling of the parameters of each node. The user evaluation results show that our system is easy and intuitive to be used by users for editing of motion sequences.

关键词： motion editing procedural visualization graphical development environment animation system character animation

The study of sodium channels involved in pain responses using specific modulators

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生理学报 2008年第5期60卷 628-634页

作者： ji yong-Hua LIU Tong School of Life Sciences Shanghai University Shanghai 200444 China Graduate School of the Chinese Academy of Sciences Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China

Voltage-gated sodium channels(VGSCs) are transmembrane proteins responsible for generation and conduction of action potentials in excitable *** and pharmacological studies have demonstrated that VGSCs play a critical role in chronic pain associated with tissue or nerve *** long-chain peptide toxins(60-76 amino acid residues) purified from the venom of Asian scorpion Buthus martensii Karsch(BmK) are investigated to be sodium channel-specific *** α-like neurotoxins that can bind to receptor site 3 of sodium channels,named as BmK I and BmK abT,could induce nociceptive effects in *** the contrast,the β-like neurotoxins that can bind to receptor site 4 of sodium channels,named as BmK AS,BmK AS-1 and BmK IT2,could produce potent anti-nociceptive effects in animal pain *** I could strongly prolong the fast inactivation of tetrodotoxin(TTX)-sensitive Na+ currents on the rat dorsal root ganglia(DRG) neurons together with the augmentation of peak current ***,BmK IT2 and BmK ASs,potently suppressed both the peak TTX-resistant and TTX-sensitive Na+ currents on rat small DRG ***,BmK ASs could decrease the excitability of small DRG ***,the nociception/anti-nociception induced by scorpion neurotoxins may attribute to their distinct modulation on sodium channels in primary afferent sensory ***,the sodium channel-specific modulators from BmK venom could be used as not only pharmacological tools for better understanding the roles of VGSCs in pain signal conduction,but also lead molecules in the development of ideal analgesics targeting VGSCs.

关键词：疼痛反应钠离子可兴奋细胞临床分析

The Monotone Method for Controllability of the Nonlinear Evolution Systems

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Acta Mathematicae Applicatae Sinica 2011年第4期27卷 721-726页

作者： Yue LU yong LI Ming-ji LIU College of Mathematics Jilin University Changchun 130012 China

In this paper, we study the controllability of the nonlinear evolution systems. We establish the controllability results by using the monotone operator theory. No compactness assumptions are imposed in the main result... 详细信息

关键词： controllability monotone operator nonlinear control systems

Effect of pipe material and low level disinfectants on biofilm development in a simulated drinking water distribution system

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第5期10卷 725-731页

作者： Ling-ling ZHOU yong-ji ZHANG Gui-bai LI School of Municipal Environmental Engineering Harbin Institute of Technology Harbin 150090 China State Key Laboratory of Pollution Control and Resources Reuse Tongji University Shanghai 200092 China

The efficiency of chlorine and chloramines disinfection on biofilm development in a simulated drinking water distribution system was investigated by using heterotrophic bacterial spread plate technique. The experiments were carried out with four annular reactors (ARs) with stainless steel (SS) or copper (Cu) material slides. The results showed that there were fewer bacteria attached to Cu slides without a disinfectant compared with those attached to SS slides. When the water was disinfected with chloramines, the heterotrophic plate counts (HPCs) on the biofilm attached to the Cu slides were significantly lower (by 3.46 log CFU/cm2) than those attached to the SS slides. Likewise, the biofilm HPC numbers on the Cu slides were slightly lower (by 1.19 log CFU/cm2) than those on the SS slides disinfected with chlorine. In a quasi-steady state, the HPC levels on Cu slides can be reduced to 3.0 log CFU/cm2 with chlorine and to about 0.9 log CFU/cm2 with chloramines. The addition of chloramines resulted in a more efficient reduction of biofilm heterotrophic bacteria than did chlorine. We concluded that the chlorine and chloramines levels usually employed in water distribution system were not sufficient to prevent the growth and development of microbial biofilm. The combination of copper pipe slides and chloramines as the disinfectant was the most efficient combination to bring about diminished bacterial levels.

关键词： Copper (Cu) Stainless steel (SS) Biofilm Heterotrophic plate counts (HPCs) Chlorine Chloramines

Applications of transition-metal sulfides in the cathodes of lithium-sulfur batteries

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Tungsten 2020年第2期2卷 134-146页

作者： jing‑Han Zuo yong‑ji Gong School of Materials Science and Engineering Beihang UniversityBeijing 100191China

Lithium-sulfur(Li-S)batteries are considered as one of the most promising candidates for next-generation energy storage systems with high energy density and reliable ***,the commercial applications of lithium-sulfur batteries is hindered by several shortcomings like the poor conductivity of sulfur and its reaction products,and the loss of active materials owing to the diffusion of lithium polysulfides(LiPSs)into the ***,the effective restraining of the LiPSs and the promotion of the sluggish conversion are highly demanded to fulfill the potential of lithium-sulfur ***,we summarize the applications of transition-metal sulfides(TMSs)in the cathodes over recent years and demonstrate the unique advantages they possess to realize reliable long-life lithium-sulfur batteries.

关键词： Lithium–sulfur battery Transition metal sulfides Polysulfide adsorption Electrode conductivity Electrocatalysis

Interventional urethral balloon dilatation before endoscopic visual internal urethrotomy for post-traumatic bulbous urethral stricture:A case report

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World Journal of Clinical Cases 2022年第34期10卷 12787-12792页

作者： ji yong Ha Mu Sook Lee Department of Urology Keimyung University Dongsan HospitalKeimyung University School of MedicineDaegu 42601South Korea Department of Radiology Keimyung University Dongsan HospitalKeimyung University School of MedicineDaegu 42601South Korea

BACKGROUND While several treatment options are available for pediatric urethral strictures,the appropriate treatment must be based on several *** endoscopic visual internal urethrotomy(EVIU)could be a first-line treatment option for short pediatric urethral strictures,it is not feasible if the urethroscope cannot pass through the stricture ***,we present a pediatric case of severe posttraumatic bulbous urethral stricture that was successfully treated by EVIU after securing the urethral route via interventional balloon *** SUMMARY A 12-year-old boy presented at our outpatient clinic with the inability to *** had sustained a straddle injury three months *** post-void residual urine volume was 644 mL,and retrograde urethrography confirmed severe stricture of the bulbous *** was planned;however,the first attempt to treat the stricture failed because the urethroscope could not pass through the stricture *** urethral route was subsequently secured via balloon dilatation of the stricture,which was performed in collaboration with specialists from the department of interventional *** urethroscope was then able to pass,and the repeat EVIU was *** Interventional urethral balloon dilatation before EVIU may help secure the urethral route in the treatment of pediatric urethral strictures.

关键词： Urethral stricture Endoscopic visual internal urethrotomy Urethroplasty Urethral balloon dilatation Interventional radiology Case report