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Inhibition of Proliferation of Prostate Cancer Cell Line DU-145 in vitro and in vivo Using Salvia miltiorrhiza Bunge

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Chinese Journal of Integrative Medicine 2020年第7期26卷 533-538页

作者： Woong Jin Bae Jin Bong Choi Kang Sup Kim U Syn ha Sung Hoo Hong Ji Youl Lee Tae-Kon hwang Sung Yeoun hwang WANG Zhi-ping Sae Woong Kim Department of Urology The Catholic University of KoreaCollege of MedicineSeoul(06591)Republic of Korea Catholic Integrative Medicine Research Institute College of MedicineThe Catholic University of KoreaSeoul(06591)Republic of Korea Korea Bio-Medical Science Institute Seoul(06106)Republic of Korea Department of Urology Second Hospital of Lanzhou UniversityLanzhou(730030)China

Objective:To investigate the antiproliferative activity of Salvia miltiorrhiza Bunge.(SM)on the castration-resistant prostate cancer(CRPC)cell line DU-145 in vitro and in ***:Prostate cancer cell line(DU-145)and normal prostate cell line(RWPE-1)were treated with SM at different concentrations(3.125,12.5,25 and 50μg/mL)to investigate the antiproliferative *** laddering analysis was performed to investigate the apoptosis of DU-145 *** mechanism was investigated by Western blot analysis of p53,Bcl-2,prostate specific antigen(PSA),and androgen receptor(AR).Six-week-old male BALB/c nude mice were randomly divided into normal control group(n=101)and treated group(n=101)which administered 500 mg/kg SM for 2 *** volumes were ***:Treatment with SM resulted in a dose-dependent decrease in cell number of DU-145 cells in comparison with *** laddering analysis indicated the apoptosis of DU-145 *** with SM increased the expression of p53 and reduced the expression of Bcl-2 *** levels of PSA were considerably reduced in SM-treated group compared to the controls,and a decrease in AR expression was observed when cells were treated with SM in the same pattern as a reduction in *** the tumour xenograft study,SM given once a day for 2 weeks significantly inhibited tumour ***:SM might contribute to the anticancer actions such as induction of apoptosis and inhibition of proliferation of prostate cancer cells.

关键词： apoptosis prostate cancer Salvia miltiorrhiza Bunge Chinese medicine

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Preparation and Characterization of Porous PVdF-HFP/clay Nanocomposite Membranes

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Journal of Materials Science & Technology 2010年第7期26卷 633-638页

作者： Mi Jin Koh hae Young hwang Deuk Ju Kim Hyeng Jun Kim Young Taik Hong Sang yong Nam School of Materials Science and Engineering Engineering Research Institutei-Cube CenterGyeongsang National UniversityJinjuKorea Fuel Cell Research Center Korea Institute of Science and TechnologySeoul 136-791Korea Energy Material Research Center Korea Research Institute of Chemical TechnologyDaejeon 305-600Korea

Polyvinylidene fluoride-hexafluoropropylene （PVdF-HFP） / clay nanocomposite membranes were prepared by phase inversion method through controlling retention time to apply for a lithium ion secondary batteries. Increased membrane porosity with macrovoids was observed at increasing retention time. Partially intercalated structures of PVdF-HFP/clay nanocomposite membranes were confirmed by X-ray diffraction （XRD） analysis. PVdF-HFP membranes containing various kind of clay showed the increase of membrane modulus compared to the pristine PVdF-HFP membrane.

关键词： PVdF-HFP Porosity Mechanical properties Clay Separator

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Are human dental papilla-derived stem cell and human brain-derived neural stem cell transplantations suitable for treatment of Parkinson’s disease?

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Neural Regeneration Research 2013年第13期8卷 1190-1200页

作者： Hyung Ho Yoon Joongkee Min Nari Shin yong Hwan Kim Jin-Mo Kim Yu-Shik hwang Jun-Kyo Francis Suh Onyou hwang Sang Ryong Jeon Department of Neurological Surgery Asan Medical Center University of Ulsan College of Medicine Department of Biochemistry and Molecular Biology University of Ulsan College of Medicine Department of Computer Science and Engineering University of Notre Dame Notre Dame Center for Bionics of Korea Institute of Science and Technology Department of Maxillofacial Biomedical Engineering Institute of Oral Biology School of Dentistry Kyung Hee University

Transplantation of neural stem cells has been reported as a possible approach for replacing impaired dopaminergic neurons. In this study, we tested the efficacy of early-stage human dental papilla-derived stem cells and human brain-derived neural stem cells in rat models of 6-hydroxydopamine-induced Parkinson＇s disease. Rats received a unilateral injection of 6-hydroxydopamine into right medial forebrain bundle, followed 3 weeks later by injections of PBS, early-stage human dental papilla-derived stem cells, or human brain-derived neural stem cells into the ipsilateral striatum. All of the rats in the human dental papilla-derived stem cell group died from tumor formation at around 2 weeks following cell transplantation. Postmortem examinations revealed homogeneous malignant tumors in the striatum of the human dental papilla-derived stem cell group. Stepping tests revealed that human brain-derived neural stem cell transplantation did not improve motor dysfunction. In apomorphine-induced rotation tests, neither the human brain-derived neural stem cell group nor the control groups （PBS injection） demonstrated significant changes. Glucose metabolism in the lesioned side of striatum was reduced by human brain-derived neural stem cell transplantation. [18F]-FP-CIT PET scans in the striatum did not demonstrate a significant increase in the human brain-derived neural stem cell group. Tyrosine hydroxylase （dopaminergic neuronal marker） staining and G protein-activated inward rectifier potassium channel 2 （A9 dopaminergic neuronal marker） were positive in the lesioned side of striatum in the human brain-derived neural stem cell group. The use of early-stage human dental papilla-derived stern cells confirmed its tendency to form tumors. Human brain-derived neural stem cells could be partially differentiated into dopaminergic neurons, but they did not secrete dopamine.

关键词： neural regeneration stern cells cell transplantation glucose metabolism human brain-derivedneural stem cells human dental papilla-derived stem cells Parkinson's disease positron emissiontomography grants-supported paper neuroregeneration

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Iatrogenic aortic dissection during right transradial intervention in a patient with aberrant right subclavian artery:A case report

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World Journal of Clinical Cases 2022年第27期10卷 9897-9903页

作者： Kyungeun ha Albert Youngwoo Jang yong Hoon Shin Joonpyo Lee Jeongduk Seo Seok In Lee Woong Chol Kang Soon yong Suh Division of Cardiology Department of Internal MedicineYonsei University College of Medicine50 Yonsei-roSeodaemun-guSeoulSouth Korea Division of Cardiology Department of Internal MedicineGil Medical CenterGachon University College of MedicineIncheonSouth Korea Department of Thoracic and Cardiovascular Surgery Gil Medical CenterGachon University College of MedicineIncheonIncheonSouth Korea

BACKGROUND Aberrant right subclavian artery(ARSA)is the most common congenital anomaly of the aortic *** patients having such anomalies receive transradial intervention(TRI),aortic dissection(AD)may ***,we discuss a case of iatrogenic type B AD occurring during right TRI in an ARSA patient,that was later salvaged by percutaneous *** SUMMARY A 73-year-old man presented to our hospital with intermittent chest *** computed tomography(CT)angiography revealed significant stenosis in the left anterior descending *** coronary angiography was performed via the right radial artery without ***,we were unable to advance the guiding catheter past the ostium of the right subclavian artery to the aortic arch for percutaneous coronary intervention,while the guidewire tended to go down the descending *** patient suddenly complained of chest and back *** CT aortography revealed type B AD propagating to the left renal artery(RA)with preserved renal ***,after 2 d,the patient suddenly complained of right lower limb pain where the femoral pulse was suddenly ***-up CT indicated further progression of dissection to the right external iliac artery(EIA)and left RA with limited *** performed percutaneous angioplasty of the right EIA and left RA without ***-up CT aortography at 8 mo showed optimal *** A caution is required during right TRI in ARSA to avoid *** angioplasty can be a treatment option.

关键词： Aberrant subclavian artery Coronary angiography Aortic dissection Aortography Percutaneous transluminal angioplasty Case report

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Gastric per-oral endoscopic myotomy: Current status and future directions

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World Journal of Gastroenterology 2019年第21期25卷 2581-2590页

作者： Alexander Podboy Joo ha hwang Linda A Nguyen Patricia Garcia Thomas A Zikos Afrin Kamal George Triadafilopoulos John O Clarke Division of Gastroenterology and Hepatology Stanford University School of Medicine

Gastroparesis, or symptomatic delayed gastric emptying in the absence of mechanical obstruction, is a challenging and increasingly identified syndrome. Medical options are limited and the only medication approved by the Food and Drug Administration for treatment of gastroparesis is metoclopramide, although other agents are frequently used off label. With this caveat, first-line treatments for gastroparesis include dietary modifications, antiemetics and promotility agents, although these therapies are limited by suboptimal efficacy and significant medication side effects. Treatment of patients that fail first-line treatments represents a significant therapeutic challenge. Recent advances in endoscopic techniques have led to the development of a promising novel endoscopic therapy for gastroparesis via endoscopic pyloromyotomy, also referred to as gastric per-oral endoscopic myotomy or per-oral endoscopic pyloromyotomy. The aim of this article is to review the technical aspects of the per-oral endoscopic myotomy procedure for the treatment of gastroparesis, provide an overview of the currently published literature, and outline potential next directions for the field.

关键词： Gastroparesis Gastric per-oral endoscopic myotomy Per-oral endoscopic pyloromyotomy Myotomy Endoscopic myotomy Peroral endoscopic myotomy Gastric emptying

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Discovery of highly immunogenic spleen-resident FCGR3^(+)CD103^(+)cDC1s differentiated by IL-33-primed ST2^(+)basophils

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Cellular & Molecular Immunology 2023年第7期20卷 820-834页

作者： Myeong-Ho Kang JungHyub Hong Jinjoo Lee Min-Suk Cha Sangho Lee Hye-Young Kim Sang-Jun ha yong Taik Lim yong-Soo Bae Department of Biological Sciences Sungkyunkwan University2066 Seobu-roJangan-guSuwon-siGyeonggi-do 16419Republic of Korea Center for Immune Research on Non-Lymphoid Organs Sungkyunkwan University2066 Seobu-roJangan-guSuwon-siGyounggi-do 16419Republic of Korea Laboratory of Mucosal Immunology Department of Biomedical SciencesSeoul National University College of Medicine103 Daehak-roJongno-guSeoul 03080Republic of Korea Institute of Allergy and Clinical Immunology Seoul National University Medical Research CenterSeoulRepublic of Korea Department of Biochemistry College of Life Science and BiotechnologyYonsei UniversitySeoul 03722Republic of Korea Department of Nano Engineering and School of Chemical Engineering Sungkyunkwan University2066 Seobu-roJangan-guSuwon-siGyeonggi-do 16419Republic of Korea.

Recombinant interleukin-33(IL-33)inhibits tumor growth,but the detailed immunological mechanism is still ***-33-mediated tumor suppression did not occur in Batf3^(−/−)mice,indicating that conventional type 1 dendritic cells(cDC1s)play a key role in IL-33-mediated antitumor immunity.A population of CD103^(+)cDC1s,which were barely detectable in the spleens of normal mice,increased significantly in the spleens of IL-33-treated *** newly emerged splenic CD103^(+)cDC1s were distinct from conventional splenic cDC1s based on their spleen residency,robust effector T-cell priming ability,and surface expression of *** and DC precursors did not express Suppressor of Tumorigenicity 2(ST2).However,recombinant IL-33 induced spleen-resident FCGR3^(+)CD103^(+)cDC1s,which were found to be differentiated from DC precursors by bystander ST2+immune *** immune cell fractionation and depletion assays,we found that IL-33-primed ST2^(+)basophils play a crucial role in the development of FCGR3^(+)CD103^(+)cDC1s by secreting IL-33-driven extrinsic *** GM-CSF also induced the population of CD103^(+)cDC1s,but the population neither expressed FCGR3 nor induced any discernable antitumor *** population of FCGR3^(+)CD103^(+)cDC1s was also generated in vitro culture of Flt3L-mediated bone marrow-derived DCs(FL-BMDCs)when IL-33 was added in a pre-DC stage of ***-BMDCs generated in the presence of IL-33(FL-33-DCs)offered more potent tumor immunotherapy than control Flt3L-BMDCs(FL-DCs).Human monocyte-derived DCs were also more immunogenic when exposed to IL-33-induced *** findings suggest that recombinant IL-33 or an IL-33-mediated DC vaccine could be an attractive protocol for better tumor immunotherapy.

关键词： Recombinant interleukin-33(IL-33) Highly immunogenic Spleen residency FCGR3^(+)CD103^(+)cDC1s ST2^(+)basophils Antitumor immunity

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Choroidal and skin metastases from colorectal cancer

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World Journal of Gastroenterology 2016年第43期22卷 9650-9653页

作者： Joo Young ha Edward Hynseung Oh Moon Ki Jung Song Ee Park Ji Tak Kim In Gyu hwang Department of Internal Medicine Chung-Ang University College of Medicine Department of Internal Medicine Division of Hemato-oncology Chung-Ang University College of Medicine Department of Ophthalmology Chung-Ang University College of Medicine

Choroidal and skin metastasis of colon cancer is rare. In women, the frequency of cutaneous metastasis from colon cancer as the primary lesion in is 9% and skin metastasis occurs in 0.81% of all colorectal cancers. We report a patient with colonic adenocarcinoma who presented with visual disorder in her right eye and scalp pain as her initial symptoms. Contrast-enhance orbital magnetic resonance imaging with fat suppression revealed an infrabulbar mass, and skin biopsy of the posterior parietal scalp confirmed adenocarcinoma. These symptoms were diagnosed as being caused by choroidal and skin metastases of colonic adenocarcinoma. We started palliative chemotherapy with oral capecitabine(1000 mg/m2, twice a day, on days 1-14) every 3 wk, which was effective at shrinking the brain masses and improving the visual disorder. This is the first report that capecitabine is effective at reducing a choroidal and cutaneous metastatic lesion from rightsided colorectal cancer.

关键词： Colon cancer Choroid cancer Skin cancer Capecitabine

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Long-term outcome of stem cell transplantation with and without anti-tumor necrotic factor therapy in perianal fistula with Crohn’s disease

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World Journal of Stem Cells 2024年第3期16卷 257-266页

作者： Min Young Park yong Sik Yoon Jae ha Park Jong Lyul Lee Chang Sik Yu Division of Colon and Rectal Surgery Department of SurgeryYonsei University College of MedicineSeoul 03722South Korea Division of Colon and Rectal Surgery Department of SurgeryUniversity of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea

BACKGROUND Stem cell transplantation is a promising therapeutic option for curing perianal fistula in Crohn’s disease(CD).Anti-tumor necrotic factor(TNF)therapy combined with drainage procedure is effective as ***,previous studies are limited to proving whether the combination treatment of biologics and stem cell transplantation improves the effect of fistula *** This study aimed to evaluate the long-term outcomes of stem cell transplantation and compare Crohn’s perianal fistula(CPF)closure rates after stem cell transplantation with and without anti-TNF therapy,and to identify the factors affecting CPF closure and *** The patients with CD who underwent stem cell transplantation for treating perianal fistula in our institution between Jun 2014 and December 2022 were *** data were compared according to anti-TNF therapy and CPF *** A total of 65 patients were *** median age of females was 26 years(range:21-31)and that of males was 29(44.6%).The mean follow-up duration was 65.88±32.65 months,and complete closure was observed in 50(76.9%)*** closure rates were similar after stem cell transplantation with and without anti-TNF therapy(66.7%vs 81.6%at 3 year,P=0.098).The patients with fistula closure had short fistulous tract and infrequent proctitis and anorectal stricture(P=0.027,0.002,and 0.008,respectively).Clinical factors such as complexity,number of fistulas,presence of concurrent abscess,and medication were not significant for *** cumulative 1-,2-,and 3-year closure rates were 66.2%,73.8%,and 75.4%,*** Anti-TNF therapy does not increase CPF closure rates in patients with stem cell ***,both refractory and non-refractory CPF have similar closure rates after additional anti-TNF *** tract length,proctitis,and anal stricture are risk factors for non-closure in patients with CPF after stem cell transplantation.

关键词： Crohn’s disease Anus Fistula Stem cell transplantation Tumor necrosis factor-alpha inhibitors Infliximab

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An easily misdiagnosed and rare cause of traumatic back pain: bilateral renal infarction caused by traumatic bilateral renal artery dissection

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World Journal of Emergency Medicine 2023年第2期14卷 155-157页

作者： Woo Sung Choi Sung Youl Hyun Jae-Hyug Woo Jung han hwang yong Su Lim Department of Emergency and Critical Care Medicine Gachon University Gil Medical CenterGachon University College of MedicineIncheon 21565Republic of Korea Department of Traumatology Gachon University Gil Medical CenterGachon University College of MedicineIncheon 21565Republic of Korea Department of Interventional Radiology Gachon University Gil Medical CenterGachon University College of MedicineIncheon 21565Republic of Korea

Dear editor,The incidence of renal infarction in patients admitted to the emergency department(ED) is approximately 0.004%.[1]Among patients with renal infarction, bilateral renal involvement has been reported in 28.6... 详细信息

关键词： traumatic infarction admitted

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Associations of lifestyle and diet with the risk of nasopharyngeal carcinoma in Singapore:a case–control study

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Chinese Journal of Cancer 2017年第2期36卷 63-70页

作者： Sook Kwin yong Tam Cam ha Ming Chert Richard Yeo Valerie Gaborieau James D.McKay Joseph Wee Division of Clinical Trials and Epidemiological Sciences National Cancer Centre Singapore11 Hospital DriveSingapore 169610Singapore Medical Education Research&Evaluation Department(MERE)Duke-NUS Medical School8 College RoadSingapore 169857Singapore Division of Radiation Oncology National Cancer Centre Singapore11 Hospital DriveSinga-pore 169610Singapore Genetic Cancer Susceptibility Group International Agency for Research on CancerWorld Health Organization150 Cours Albert Thomas69372 Lyon Cedex 08France

Background: Nasopharyngeal carcinoma(NPC) is a commonly diagnosed cancer in Southeast Asia. Many studies have examined the risk factors for NPC, yet the roles of some risk factors remain inconclusive. The purpose of this study was to examine associations between modifiable lifestyle factors and the risk of NPC in the Singaporean ***: We conducted a case–control study in Singapore with 300 patients and 310 controls who were recruited between 2008 and 2012. Each control was selected and individually matched to each patient based on sex, ethnicity, and age(±5 years). A total of 290 pairs of cases and controls were matched successfully. We examined lifestyle factors such as tobacco smoking, alcohol drinking, various salted and preserved food consumption, and weaning ***: After adjusting for covariates, multivariate analysis showed that those participants who were current smokers and had ever smoked tobacco had a higher risk of NPC than participants who had never smoked, with odds ratios(ORs) of 4.50(95% confidence interval [CI] 2.58–7.86; P han those who never or rarely consumed salted vegetables, with an OR of 4.18(95% CI 1.69–10.38; P = 0.002).Conclusion: Smoking(currently and ever-smoked) and consuming salted vegetables once a week or more were lifestyle risk factors for NPC, and changes of these factors for the better may reduce the risk of NPC.

关键词： Nasopharyngeal carcinoma Diet Smoking Alcohol drinking Case–control study Preserved food

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