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Potential therapy strategy: targeting mitochondrial dysfunction in sepsis

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Military Medical Research 2019年第3期6卷 230-241页

作者： Hui Zhang yong-Wen Feng yong-Ming yao Trauma Research Center First Hospital Affiliated to the Chinese PLA General HospitalFucheng Road 51Haidian DistrictBeijing 100048China Department of Critical Care Medicine the Second People’s Hospital of ShenzhenShenzhen 518035China.

Recently, the definition of sepsis was concluded to be a life-threatening organ dysfunction caused by a dysregulated host response to infection. Severe patients always present with uncorrectable hypotension or hyperlactacidemia, which is defined as septic shock. The new definition emphasizes dysregulation of the host response and multiple organ dysfunction, which is partially attributed to metabolic disorders induced by energy crisis and oxidative stress. Mitochondria are a cellular organelle that are well known as the center of energy production, and mitochondrial damage or dysfunction is commonly induced in septic settings and is a predominant factor leading to a worse prognosis. In the present review, we determine the major mitochondrial disorders from morphology to functions in sepsis. In the following, several clinical or pre-clinical assays for monitoring mitochondrial function are demonstrated according to accumulated evidence, which is the first step of specific therapy targeting to modulate mitochondrial function. Accordingly, various reagents used for regulating mitochondrial enzyme activities and promoting biogenesis have been documented, among which mitochondriatargeted cation, TPP-conjugated antioxidants are the most valuable for future trials and clinical treatment to improve mitochondrial function as they may take advantage of the prognosis associated with septic complications.

关键词： Sepsis Mitochondria Electron transfer chain Monitor Therapy strategy

Projectively flat arctangent Finsler metric

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第12期7卷 2097-2103页

作者： YU yao-yong Department of Mathematics Zhejiang University Hangzhou 310028 China

In this work, we study a class of special Finsler metrics F called arctangent Finsler metric, which is a special （α, β）-metric, where a is a Riemannian metric and β is a 1-form, We obtain a sufficient and necessary condition that F is locally projectively fiat if and only if α and β satisfy two special equations. Furthermore we give the non-trivial solutions for F to be locally projectively fiat. Moreover, we prove that such projectively fiat Finsler metrics with constant flag curvature must be locally Minkowskian.

关键词： Arctangent Finsler metric Projectively flat (α,β)-metric Flag curvature

Creating animal models, why not use the Chinese tree shrew ( Tupaia belangeri chinensis)？

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Zoological Research 2017年第3期38卷 118-126页

作者： yong-Gang yao Key Laboratory of Animal Models and Human Disease Mechanisms Kunming Institute of Zoology Chinese Academy of SciencesKunming Yunnan 650223 China Kunming Primate Research Center of the Chinese Academy of Sciences Kunming Institute of Zoology Chinese Academy of SciencesKunming Yunnan 650223 China

The Chinese tree shrew （Tupaia belangeri chinensis） a squirrel-like and rat-sized mammal, has a wide distribution in Southeast Asia, South and Southwest China and has many unique characteristics that make it suitable for use as an experimental animal. There have been many studies using the tree shrew （Tupaia belangeri） aimed at increasing our understanding of fundamental biological mechanisms and for the modeling of human diseases and therapeutic responses. The recent release of a publicly available annotated genome sequence of the Chinese tree shrew and its genome database （***） has offered a solid base from which it is possible to elucidate the basic biological properties and create animal models using this species. The extensive characterization of key factors and signaling pathways in the immune and nervous systems has shown that tree shrews possess both conserved and unique features relative to primates. Hitherto, the tree shrew has been successfully used to create animal models for myopia, depression, breast cancer, alcohol-induced or non-alcoholic fatty liver diseases, herpes simplex virus type 1 （HSV-1） and hepatitis C virus （HCV） infections, to name a few. The recent successful genetic manipulation of the tree shrew has opened a new avenue for the wider usage of this animal in biomedical research. In this opinion paper, I attempt to summarize the recent research advances that have used the Chinese tree shrew, with a focus on the new knowledge obtained by using the biological properties identified using the tree shrew genome, a proposal for the genome-based approach for creating animal models, and the genetic manipulation of the tree shrew. With more studies using this species and the application of cutting-edge gene editing techniques, the tree shrew will continue to be under the spot light as a viable animal model for investigating the basis of many different human diseases.

关键词： Chinese tree shrew Genome biology Animal model Gene editing Innate immunity

The 3rd Symposium on Animal Models of Primates——The Application of Non-Human Primates to Basic Research and Translational Medicine

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Journal of Genetics and Genomics 2015年第6期42卷 339-341页

作者： yong-Gang yao yong-Bin Chen Bin Liang Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province and Kunming Primate Research CenterKunming Institute of ZoologyChinese Academy of Sciences

In order to understand the fundamental questions of the biology of life and to duplicate the pathogenesis of human diseases, animal models using different experimental animals, such as rodents, Drosophila, Caenorhabditis elegans, and zebrafish, have been established and used widely for many decades. The controllability of environmental conditions, the high reproducibility, the ease of scale and the comparability of results, as well as the ability to use different standards for ethical protocols, all make an animal model the ideal tool for carrying out studies on human diseases and the development of novel pharmaceuticals and new therapies （Xue et al., 2014）. An ideal animal model should reflect the complete spectra of a specific human disease, with similar features on the following key issues：（1） genetic basis; （2） anatomy and physiology; （3） pathological response（s） and underlying mechanism（s）; （4） phenotypic endpoints as clinical studies; （5） responsiveness to known drugs with clinical efficacy; and （6） prediction of clinical efficacy （McGonigle and Ruggeri, 2014）.

关键词： The 3rd Symposium on Animal Models of Primates The Application of Non-Human Primates to Basic Research and Translational Medicine

ZR and ZRDC embrace a new era

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Zoological Research 2023年第1期44卷 1-2页

作者： yong-Gang yao yong-Tang Zheng Kunming Institute of Zoology Chinese Academy of SciencesKunmingYunnan 650223China

Since its establishment in 1980, Zoological Research(ZR) has continued to strive forward with the enthusiastic and generous support of every author and reader. ZR has been a loyal companion to many generations of researchers and scholars,who have not only witnessed the evolution of ZR, but also devoted themselves to helping ZR grow(yao & Jiang, 2021).Here, at the beginning of a fresh year, we are honored to have the opportunity to express our deepest appreciation to you all.

关键词： devoted continued evolution

A dynamic signal coordination control method for urban arterial roads and its application

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Frontiers of Information Technology & Electronic Engineering 2016年第9期17卷 907-918页

作者： Guo-jiang SHEN yong-yao YANG College of Computer Science and Technology Zhejiang University of Technology Zhejiang Zheda Supcon Information Technique Co. Ltd.

We propose a novel dynamic traffic signal coordination method that takes account of the special traffic flow characteristics of urban arterial roads. The core of this method includes a control area division module and a signal coordination control module. Firstly, we analyze and model the influences of segment distance, traffic flow density, and signal cycle time on the correlation degree between two neighboring intersections. Then, we propose a fuzzy computing method to estimate the correlation degree based on a hierarchical structure and a method to divide the control area of urban arterial roads into subareas based on correlation degrees. Subarea coordination control arithmetic is used to calculate the public cycle time of the control subarea, up-run offset and down-run offset of the section, and the split of each intersection. An application of the method in Shaoxing City, Zhejiang Province, China shows that the method can reduce the average travel time and the average stop rate effectively.

关键词： Urban arterial Control subarea Coordination control Correlation degree Fuzzy logic Intelligent transportation

Projectively flat Asanov Finsler metric

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第6期8卷 963-968页

作者： HAN Jing-wei YU yao-yong Department of Mathematics Zhejiang University Hangzhou 310027 China School of Science Hangzhou Dianzi University Hangzhou 310028 China

In this work, we study the Asanov Finsler metric F=α（β^2/α^2＋gβ/α＋1）^1/2exp{（G/2）arctan[β/（hα）＋G/2]}, where α=（αijy^iy^i）^1/2 is a Riemannian metric and β=by^i is a 1-fom, g∈（-2,2）, h=（1-g^2/4）^1/2, G=g/h. We give the necessary and sufficient condition for Asanov metric to be locally projectively flat, i.e., α is projectively flat and ,Sis parallel with respect to α. Moreover, we proved that the Douglas tensor of Asanov Finsler metric vanishes if and only if β is parallel with respect to α.

关键词： Exponential Finsler metric Projectively flat (α β)-metrics Douglas tensor

Projectively flat exponential Finsler metric

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第6期7卷 1068-1076页

作者： YU yao-yong YOU Ying Department of Mathematics Zhejiang University Hangzhou 310028 China

In this paper, we study a class of Finsler metric in the form F=αexp(β/α)+εβ, where α is a Riemannian metric and β is a 1-form, ε is a constant. We call F exponential Finsler metric. We proved that exponential Finsler metric F is locally projectively flat if and only if α is projectively flat and β is parallel with respect to α. Moreover, we proved that the Douglas tensor of expo-nential Finsler metric F vanishes if and only if β is parallel with respect to α. And from this fact, we get that if exponential Finsler metric F is the Douglas metric, then F is not only a Berwald metric, but also a Landsberg metric.

关键词： Exponential Finsler metric Projectively flat (α β)-metric Douglas tensor

An “impact” in publishing

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Zoological Research 2019年第4期40卷 239-240页

作者： yong-Gang yao Yun Zhang yong-Tang Zheng Kunming Institute of Zoology Chinese Academy of Sciences

On 20 June 2019, Clarivate Analytics (2019) announced its Journal Citation Reports of 2018. From this, Zoological Research (ZR) received its first impact factor based on citations in 2018 for indexed papers published ... 详细信息

关键词： publishing Clarivate Analytics Zoological Research (ZR)