检索结果-南通市图书馆

Neuroscience Bulletin 2024年第2期40卷 182-200页

作者： Yang Zhu Hao Huang Zhi Chen yong tao Ling-Yi Liao Shi-Hao Gao Yan-Jiang Wang Chang-Yue Gao Department of Rehabilitation Medicine Daping HospitalArmy Medical UniversityChongqing 400042China Department of Neurology and Center for Clinical Neuroscience Daping HospitalArmy Medical UniversityChongqing 400042China Department of Special Medicine Daping HospitalArmy Medical UniversityChongqing 400042China

Intermittent theta burst stimulation(iTBS),a time-saving and cost-effective repetitive transcranial magnetic stimulation regime,has been shown to improve cognition in patients with Alzheimer’s disease(AD).However,the specific mechanism underlying iTBS-induced cognitive enhancement remains unknown.Previous studies suggested that mitochondrial functions are modulated by magnetic stimulation.Here,we showed that iTBS upregulates the expression of iron-sulfur cluster assembly 1(ISCA1,an essential regulatory factor for mitochondrial respiration)in the brain of APP/PS1 mice.In vivo and in vitro studies revealed that iTBS modulates mitochondrial iron-sulfur cluster assembly to facilitate mitochondrial respiration and function,which is required for ISCA1.Moreover,iTBS rescues cognitive decline and attenuates AD-type pathologies in APP/PS1 mice.The present study uncovers a novel mechanism by which iTBS modulates mitochondrial respiration and function via ISCA1-mediated iron-sulfur cluster assembly to alleviate cognitive impairments and pathologies in AD.We provide the mechanistic target of iTBS that warrants its therapeutic potential for AD patients.

关键词： Intermittent theta burst stimulation Alzheimer’s disease Iron-sulfur cluster assembly 1 Mitochondrial dysfunction Neurodegeneration

Neuroprotective effects of repetitive transcranial magnetic stimulation on Alzheimer's disease: Undetermined therapeutic protocols and mechanisms

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroprotection 2024年第1期2卷 16-32页

作者： Yang Zhu Lingyi Liao Shihao Gao yong tao Hao Huang Xiangqin Fang Changyan Yuan Changyue Gao Department of Rehabilitation Medicine Daping HospitalArmy Medical UniversityChongqingChina Department of Rehabilitation Medicine General Hospitalof SouthernTheatre Command of PLAGuangzhouChina

Alzheimer's disease(AD)is a prevalent neurodegenerative disorder characterized by gradual deterioration of cognitive functions,for which an effective treatment is currently unavailable.Repetitive transcranial magnetic stimulation(rTMS),a well-established noninvasive brain stimulation method,is utilized in clinical settings to address various neuropsychiatric conditions,such as depression,neuropathic pain,and poststroke dys-function.Increasing evidence suggests that rTMs may enhance cognitive abilities in individuals with AD.However,its optimal therapeutic protocols and precise mechanisms are currently unknown,impeding its clinical implementation.In the present review,we aimed to summarize and discuss the efficacy-related parameters in rTMs treatment,encompassing stimulus frequency,stimulus pattern,stimulus intensity,and the configuration of the stimulus coil.Furthermore,we reviewed promising rTMS therapeutic protocols involving various combinations of these factors,that were examined in clinical studies.Based on our analysis,we propose that a multisite high-frequency rTMS(HF-rTMS)regimen has value in AD therapy,and that promising single-site protocols,such as HF-rTMS,applied over the left dorsolateral prefrontal cortex,precuneus,or cerebellum are required to be validated in larger clinical studies.Lastly,we provide a comprehensive review of the potential mechanisms underlying the neuroprotective effects of rTMS on cognition in AD in terms of brain network modulation as well as cellular and molecular reactions.In conclusion,the interaction of diverse mechanisms may be responsible for the total therapeutic effect of rTMS on AD.This review provides theoretical and practical evidence for the future clinical application and scientific research of rTMS in AD.

关键词： Alzheimer's disease cognitive improvement molecular mechanism neuroprotection repetitive transcranial magnetic stimulation synaptic plasticity

B cell development and antibody responses in human immune system mice:current status and future perspective

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第4期67卷 645-652页

作者： tao Zhang Wentao Liu yong-Guang Yang Key Laboratory of Organ Regeneration&Transplantation of the Ministry of Education The First Hospital of Jilin UniversityChangchun 130061China National-Local Joint Engineering Laboratory of Animal Models for Human Diseases Jilin UniversityChangchun 130061China International Center of Future Science Jilin UniversityChangchun 130061China

Humanized immune system(HIS)mice have been developed and used as a small surrogate model to study human immune function under normal or disease conditions.Although variations are found between models,most HIS mice show robust human T cell responses.However,there has been unsuccessful in constructing HIS mice that produce high-affinity human antibodies,primarily due to defects in terminal B cell differentiation,antibody affinity maturation,and development of primary follicles and germinal centers.In this review,we elaborate on the current knowledge about and previous attempts to improve human B cell development in HIS mice,and propose a potential strategy for constructing HIS mice with improved humoral immunity by transplantation of human follicular dendritic cells(FDCs)to facilitate the development of secondary follicles.

关键词： humanized immune system mouse humoral immunity germinal center B cell follicular dendritic cell

Operando investigation of particle re-entrainment mechanism in electrostatic capture process on the lab-on-a-chip

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第2期136卷 337-347页

作者： yong Zhu Yikun Zhang Xiaoyong Yang Shanlong tao Mingxia Chen Wenfeng Shangguan Research Center for Combustion and Environmental Technology School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Inhalable particle is a harmful air pollutant that causes a significant threat to people's health and ecological environments,which should be removed to purify air,but there exists limited removal efficiency due to particle re-entrainment.Here,Operando observation system based on microscopic visualization method is developed to make in situ test of particle migration,deposition and re-entrainment characteristics on a lab-on-a-chip to achieve the investigation in micro-level scale.The deposition evolution of charged particles is recorded in electric field region intuitively,which confirms the fracture of particle chain occurs during the growth process of deposited particles.It captures the instantaneous process that a larger particle with micron size due to the coagulation of submicron particles fractures from main body of the particle chain for the first time.The analysis of migration behavior of a single submicron particle near electrode surface demonstrates the direct influence of drag force on the fracture of particle chain.This work is the first-time visualization of dynamic process and mechanism elucidation of particle re-entrainment at the micron level,and the findings will provide the theory support for the particle re-entrainment mechanism and bring inspires of enhancing capture efficiency of inhalable particle.

关键词： Inhalable particle Re-entrainment mechanism Operando observation Lab-on-a-chip Capture efficiency

Sparse-Grid Implementation of Fixed-Point Fast Sweeping WENO Schemes for Eikonal Equations

在线全文

学校读者我要写书评

暂无评论

Communications on Applied Mathematics and Computation 2024年第1期6卷 3-29页

作者： Zachary M.Miksis yong-tao Zhang Department of Applied and Computational Mathematics and Statistics University of Notre DameNotre DameIN46556USA

Fixed-point fast sweeping methods are a class of explicit iterative methods developed in the literature to efficiently solve steady-state solutions of hyperbolic partial differential equations(PDEs).As other types of fast sweeping schemes,fixed-point fast sweeping methods use the Gauss-Seidel iterations and alternating sweeping strategy to cover characteristics of hyperbolic PDEs in a certain direction simultaneously in each sweeping order.The resulting iterative schemes have a fast convergence rate to steady-state solutions.Moreover,an advantage of fixed-point fast sweeping methods over other types of fast sweeping methods is that they are explicit and do not involve the inverse operation of any nonlinear local system.Hence,they are robust and flexible,and have been combined with high-order accurate weighted essentially non-oscillatory(WENO)schemes to solve various hyperbolic PDEs in the literature.For multidimensional nonlinear problems,high-order fixed-point fast sweeping WENO methods still require quite a large amount of computational costs.In this technical note,we apply sparse-grid techniques,an effective approximation tool for multidimensional problems,to fixed-point fast sweeping WENO methods for reducing their computational costs.Here,we focus on fixed-point fast sweeping WENO schemes with third-order accuracy(Zhang et al.2006[41]),for solving Eikonal equations,an important class of static Hamilton-Jacobi(H-J)equations.Numerical experiments on solving multidimensional Eikonal equations and a more general static H-J equation are performed to show that the sparse-grid computations of the fixed-point fast sweeping WENO schemes achieve large savings of CPU times on refined meshes,and at the same time maintain comparable accuracy and resolution with those on corresponding regular single grids.

关键词： Fixed-point fast sweeping methods Weighted essentially non-oscillatory(WENO)schemes Sparse grids Static Hamilton-Jacobi(H-J)equations Eikonal equations

Endocrine aberrations of human nonobstructive azoospermia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2022年第3期24卷 274-286页

作者： yong tao Ottawa Fertility Center 955 Green Valley CrescentOttawaON K2C 3V4Canada

Nonobstructive azoospermia(NOA)refers to the failure of spermatogenesis,which affects approximately 1%of the male population and contributes to 10%of male infertility.NOA has an underlying basis of endocrine imbalances since proper human spermatogenesis relies on complex regulation and cooperation of multiple hormones.A better understanding of subtle hormonal disturbances in NOA would help design and improve hormone therapies with reduced risk in human fertility clinics.The purpose of this review is to summarize the research on the endocrinological aspects of NOA,especially the hormones involved in hypothalamic–pituitary–testis axis(HPTA),including gonadotropin-releasing hormone,follicle-stimulating hormone,luteinizing hormone,prolactin,testosterone,estradiol,sex hormone binding globulin,inhibin B,anti-Müllerian hormone,and leptin.For the NOA men associated with primary testicular failure,the quality of currently available evidence has not been sufficient enough to recommend any general hormone optimization therapy.Some other NOA patients,especially those with hypogonadotropic hypogonadism,could be treated with hormonal replacement.Although these approaches have succeeded in resuming the fertility in many NOA patients,the prudent strategies should be applied in individuals according to specific NOA etiology by balancing fertility benefits and potential risks.This review also discusses how NOA can be induced by immunization against hormones.

关键词： endocrine follicle-stimulating hormone gonadotropin-releasing hormone inhibin B nonobstructive azoospermia prolactin sperm retrieval testosterone

Mirizzi syndrome:Problems and strategies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 234-240页

作者： Jun Wu Shuang-yong Cai Xu-Liang Chen Zhi-tao Chen Shao-Hua Shi Department of Hepatobiliary and Pancreatic Surgery People’s Hospital of Jiulongpo DistrictChongqing 400050China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan International Medical CollegeHangzhou 310003China

Mirizzi syndrome is a serious complication of gallstone disease.It is caused by the impacted stones in the gallbladder neck or cystic duct.One of the features of Mirizzi syndrome is severe inflammation or dense fibrosis at the Calot’s triangle.In our clinical practice,bile duct,branches of right hepatic artery and right portal vein clinging to gallbladder infundibulum are often observed due to gallbladder infundibulum adhered to right hepatic hilum.The intraoperative damage of branches of right hepatic artery occurs more easily than that of bile duct,all of which are hidden pitfalls for surgeons.Magnetic resonance cholangiopancreatography(MRCP)and endoscopic retrograde cholangiopancreatography(ERCP)are the preferable tools for the diagnosis of Mirizzi syndrome.Anterograde cholecystectomy in Mirizzi syndrome is easy to damage branches of right hepatic artery and bile duct due to gallbladder infundibulum adhered to right hepatic hilum.Subtotal cholecystectomy is an easy,safe and definitive approach to Mirizzi syndrome.When combined with the application of ERCP,a laparoscopic management of Mirizzi syndrome by well-trained surgeons is feasible and safe.The objective of this review was to highlight its existing problems:(1)low preoperative diagnostic rate,(2)easy to damage bile duct and branches of right hepatic artery,and(3)high concomitant gallbladder carcinoma.Meanwhile,the review aimed to discuss the possible therapeutic strategies:(1)to enhance its preoperative recognition by imaging findings,and(2)to avoid potential pitfalls during surgery.

关键词： Mirizzi syndrome Bile duct injury Artery injury Surgical treatment Subtotal cholecystectomy

Development and validation of a nomogram model for predicting the risk of gallstone recurrence after gallbladder-preserving surgery

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 288-292页

作者： Peng Liu yong-Wei Chen Che Liu Yin-tao Wu Wen-Chao Zhao Jian-yong Zhu Yang An Nian-Xin Xia Faculty of Hepato-Pancreato-Biliary Surgery the First Medical CenterChinese PLA General HospitalBeijing 100853China Institute of Hepatobiliary Surgery of Chinese PLA Beijing 100853China Key Laboratory of Digital Hepetobiliary Surgery of Chinese PLA Beijing 100853China

Background:The high incidence of gallstone recurrence was a major concern for laparoscopic gallbladderpreserving surgery.This study aimed to investigate the risk factors for gallstone recurrence after gallbladder-preserving surgery and to establish an individualized nomogram model to predict the risk of gallstone recurrence.Methods:The clinicopathological and follow-up data of 183 patients who were initially diagnosed with gallstones and treated with gallbladder-preserving surgery at our hospital from January 2012 to January 2019 were retrospectively collected.The independent predictive factors for gallstone recurrence following gallbladder-preserving surgery were identified by multivariate logistic regression analysis.A nomogram model for the prediction of gallstone recurrence was constructed based on the selected variables.The C-index,receiver operating characteristic(ROC)curve and calibration curve were used to evaluate the predictive power of the nomogram model for gallstone recurrence.Results:During the follow-up period,a total of 65 patients experienced gallstone recurrence,and the recurrence rate was 35.5%.Multivariate logistic regression analysis revealed that the course of gallstones>2 years[odds ratio(OR)=2.567,95%confidence interval(CI):1.270-5.187,P=0.009],symptomatic gallstones(OR=2.589,95%CI:1.059-6.329,P=0.037),multiple gallstones(OR=2.436,95%CI:1.133-5.237,P=0.023),history of acute cholecystitis(OR=2.778,95%CI:1.178-6.549,P=0.020)and a greasy diet(OR=2.319,95%CI:1.186-4.535,P=0.014)were independent risk factors for gallstone recurrence after gallbladder-preserving surgery.A nomogram model for predicting the recurrence of gallstones was established based on the above five variables.The results showed that the C-index of the nomogram model was 0.692,suggesting it was valuable to predict gallstone recurrence.Moreover,the calibration curve showed good consistency between the predicted probability and actual probability.Conclusions:The nomogram model for the prediction of gallstone recurrence might hel

关键词： Gallstone Gallbladder-preserving surgery Recurrence Risk factors Nomogram

Experimental and first-principles calculation of TiN growth mechanism on CeAlO_(3) surface in steel

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research(International) 2024年第2期31卷 452-463页

作者： Fei-hu He Jun Peng Fang Zhang yong-bin Wang Hong-tao Chang School of Materials and Metallurgy Inner Mongolia University of Science and TechnologyBaotou014010Inner MongoliaChina

Regular TiN is harmful to the toughness of steel,and its shape and size need to be controlled.Understanding the behavior of TiN precipitation on CeAlO_(3) surfaces is critical for controlling the morphology and formation process of CeAlO_(3)–TiN composite inclusions in the steel.Experimental results showed that TiN had a square morphology on the CeAlO3 surface,and electron backscatter diffraction phase identification results revealed the orientation relationship between CeAlO_(3) and TiN as follows:(001)_(CeAlO_(3))//(110)_(TiN),(100)_(CeAlO_(3))/(001)_(TiN),and[010]_(CeAlO_(3))/[110]_(TiN).The CeAlO3 crystal structure was studied using the first-principles calculation method,and the adsorption and growth process of TiN on the CeAlO_(3) surface were investigated from the atomic scale.The calculation results indicate that there is no metallic bonding present in the CeAlO_(3) system.Among the low-index crystal planes of CeAlO_(3),the(110)planes terminated with O and CeAlO have the highest and lowest surface energies,respectively,with values of 0.373 and 0.051 eV/Å^(2).On the high surface energy plane of CeAlO_(3),the TiN atomic permutation structure is consistent with the arrangement of Ti and N atoms in TiN(100)or(110).For the low surface energy plane of CeAlO_(3),the Ti and N atoms are arranged in a ring-like structure.

关键词： CeAlO_(3)-TiN inclusion Orientation relationship Crystal structure First principle Surface energy

Engineering g-C_(3)N_(4)based materials for advanced photocatalysis:Recent advances

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Green Energy & Environment 2024年第2期9卷 166-197页

作者： Xin-Lian Song Lei Chen Li-Jiao Gao Jin-tao Ren Zhong-yong Yuan National Institute for Advanced Materials School of Materials Science and EngineeringSmart Sensing Interdisciplinary Science CenterNankai UniversityTianjin300350China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai UniversityTianjin300071China

Photocatalysis driven by abundant yet intermittent solar energy has considerable potential in renewable energy generation and environmental remediation.The outstanding electronic structure and physicochemical properties of graphitic carbon nitride(g-C_(3)N_(4)),together with unique metal-free characteristic,make them ideal candidates for advanced photocatalysts construction.This review summarizes the up-to-date advances on g-C_(3)N_(4)based photocatalysts from ingenious-design strategies and diversified photocatalytic applications.Notably,the advantages,fabrication methods and limitations of each design strategy are systemically analyzed.In order to deeply comprehend the inner connection of theory–structure–performance upon g-C_(3)N_(4)based photocatalysts,structure/composition designs,corresponding photocatalytic activities and reaction mechanisms are jointly discussed,associated with introducing their photocatalytic applications toward water splitting,carbon dioxide/nitrogen reduction and pollutants degradation,etc.Finally,the current challenges and future perspectives for g-C_(3)N_(4)based materials for photocatalysis are briefly proposed.These design strategies and limitations are also instructive for constructing g-C_(3)N_(4) based materials in other energy and environment-related applications.

关键词： Graphitic carbon nitride g-C_(3)N_(4) Design strategies Photocatalysis Photocatalysts Reaction mechanism