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A new triterpenoid from Kadsura coccinea

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Chinese Chemical Letters 2010年第11期21卷 1352-1354页

作者： Yan Song Qing Jie Zhao yong sheng jin Chuan Wei Feng Hai sheng Chen Department of Phytochemistry School of Pharmacy Second Military Medical University Shanghai 200433 China Department of Organic Chemistry School of Pharmacy Second Military Medical University Shanghai 200433 China

A new triterpenoid,possessing a lanost-9（11）-3-one skeleton,was isolated from the roots of Kadsura coccinea,based on the spectral analysis,its structure was elucidated as 3-hydroxy-12-acetoxycoccinic acid.

关键词： Kadsura coccinea Triterpene Coccinic acid

A comprehensive overview on antiviral effects of baicalein and its glucuronide derivative baicalin

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Journal of Integrative Medicine 2024年第6期22卷 621-636页

作者： Xin-yang Liu Wei Xie He-yang Zhou Hui-qing Zhang yong-sheng jin School of Basic Medicine Naval Medical University Faculty of Traditional Chinese Medicine Naval Medical University School of Pharmacy Naval Medical University

Natural product-based antiviral candidates have received significant ***,there is a lack of sufficient research in the field of antivirals to effectively combat patterns of drug *** and its glucuronide derivative baicalin are two main components extracted from Scutellaria baicalensis *** have proven to be effective against a broad range of viruses by directly killing virus particles,protecting infected cells,and targeting viral antigens on their surface,among other *** natural products,they both possess the advantage of lower toxicity,enhanced therapeutic efficacy,and even antagonistic effects against drug-resistant viral *** and baicalin exhibit promising potential as potent pharmacophore scaffolds,demonstrating their antiviral ***,to date,no review on the antiviral effects of baicalein and baicalin has been *** review summarizes the recent research progress on antiviral effects of baicalein and baicalin against various types of viruses both in vitro and in vivo with a focus on the dosages and underlying *** aim is to provide a basis for the rational development and utilization of baicalein and baicalin,as well as to promote antiviral drug research.

关键词： Baicalin Baicalein Antiviral effects Influenza virus Flavivirus Hepatitis B virus Mechanism

Investigating the Mechanism of Qu Du Qiang Fei 1 Hao Fang Formula against Coronavirus Disease 2019 Based on Network Pharmacology Method

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 93-103页

作者： Yuan-Hua Wang He-Yang Zhou jin-Yun Ma Gui-Qing Ding Hua Yu yong-sheng jin Xiao-Dong Cheng Institute of Clinical Immunology Yue-Yang Hospital of Integrative MedicineShanghai University of Traditional Chinese MedicineShanghaiChina School of Pharmacy Naval Medical UniversityShanghaiChina

Objective:Qu Du Qiang Fei 1 Hao Fang(QDQF1)is a novel Chinese herbal medicine formula used to treat coronavirus disease 2019(COVID-19).However,the pharmacological mechanisms of action of QDQF1 remain *** objective of this study was to identify the effective ingredients and biological targets of QDQF1 for COVID-19 *** and Methods:The effective ingredients and mechanisms of action of QDQF1 were analyzed by using network pharmacology methods,which included an analysis of the effective ingredients and corresponding targets,COVID-19-related target acquisition,compound-target network analyses,protein-protein interaction network analysis,Kyoto Encyclopedia of Genes and Genomes(KEGG)and Gene Ontology(GO)enrichment analyses,and molecular docking ***:In total,288 effective QDQF1 ingredients were *** identified 51 core targets from the 148 targets through an overlap between putative QDQF1 targets and COVID-19-related *** key components,including formononetin,kaempferol,luteolin,naringenin,quercetin,and wogonin were identified through component-target network *** functional enrichment analysis of the core targets revealed 1296 items,while KEGG pathway enrichment analysis identified 148 signaling *** central targets(CCL2,CXCL8,IL1B,IL6,MAPK1,MAPK3,MAPK8,STAT3,and TNF)related to the COVID-19 pathway were identified in the KEGG pathway enrichment ***,molecular docking analysis suggested that the docking scores of the six key components to the nine central targets were better than those to ***:QDQF1 may regulate multiple immune-and inflammation-related targets to inhibit the progression of severe acute respiratory syndrome coronavirus 2,and thus,may be suitable for the treatment of COVID-19.

关键词： Coronavirus disease 2019 molecular docking molecular mechanism network pharmacology Qu Du Qiang Fei 1 Hao Fang formula

A STUDY ON THE WATER—SOLUBLE PEPTIDES IN RAPE POLLEN:EXTRACTION,PURIFICATION,SEQUENCE DETERMINATION AND MEASUREMENT OF IMMUNOPROMOTIVE ACTIVITY

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Chinese Chemical Letters 1990年第1期1卷 85-86页

作者： yong Liang ZHANG sheng jin Department of Chemistry Peking University Beijing 100871

Four peptide components RP1,RP2,RP3Ⅰ and RP3Ⅱ were purified from the water—ex- tract of rape(Brassica campestris L.)*** primary sequence of RP3I,with 12 amino acid residues,has been determined by Edman degradation—N—terminal *** immunopro- motive activities of the initially separated sample and RP3I have been also observed in vitro.

关键词： SOLUBLE PEPTIDES IN RAPE POLLEN A STUDY ON THE WATER Pro

串联亲和纯化(TAP)技术在蛋白质组学中的应用

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生物化学与生物物理进展 2004年第4期31卷 379-383页

作者：程永升刘进元清华大学生物科学与技术系分子生物学实验室北京100084

蛋白质是各种生命活动的主要执行者 ,因此构建蛋白质相互作用的网络图对于准确理解蛋白质功能、揭开各种细胞活动的奥秘十分重要 .串联亲和纯化 (TAP) ,是近年来发展出来的一种能够快速研究在生理条件下蛋白质相互作用 ,揭示蛋白质复合... 详细信息

蛋白质是各种生命活动的主要执行者 ,因此构建蛋白质相互作用的网络图对于准确理解蛋白质功能、揭开各种细胞活动的奥秘十分重要 .串联亲和纯化 (TAP) ,是近年来发展出来的一种能够快速研究在生理条件下蛋白质相互作用 ,揭示蛋白质复合体相互作用网络的新技术 ,已成为研究蛋白质组学的一个重要工具 .随着该技术的不断完善 ,TAP技术在认识蛋白质相互作用的过程中必将发挥越来越重要的作用 .

关键词：串联亲和纯化 TAP 蛋白质组学网络图免疫共沉淀纯化

Vector meson's spin alignments in high energy reactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 5-20页

作者： jin-Hui Chen Zuo-Tang Liang Yu-Gang Ma Xin-Li sheng Qun Wang Key Laboratory of Nuclear Physics and Ion-beam Application (MoE) Institute of Modern PhysicsFudan University Institute of Frontier and Interdisciplinary Science Key Laboratory of Particle Physics and Particle Irradiation (MOE)Shandong University INFN-Firenze Department of Modern Physics University of Science and Technology of China School of Mechanics and Physics Anhui University of Science and Technology

The global spin alignment of vector mesons has been observed by the STAR collaboration at the Relativistic Heavy Ion Collider （RHIC） at Brookhaven National Laboratory （BNL）.It provides a unique opportunity to probe the correlation between the polarized quark and antiquark in the strongly coupled quark-gluon plasma （sQGP） produced in relativistic heavy ion collisions,opening a new window to explore the properties of s *** addition,spin alignments of vector mesons have also been observed in other high-energy particle collisions such as e+e-annihilations at high energies where hadron production is dominated by quark fragmentation *** results obtained are quite different from those obtained in heavy ion collisions where quark coalescence/combination mechanism dominates suggesting strong dependence on hadronization *** comprehensive studies in different hadronization processes are *** this article,we present a brief review of theoretical and experimental advances in the study of vector meson’s spin alignments in a variety of high-energy particle collisions,with emphasis on hadronization mechanisms.

关键词： vector meson spin alignment global polarization relativistic heavy ion collisions fragmentation

经济外交与“经济全球化”——机遇与挑战、竞争与合作

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外交学院学报 2003年第4期 58-64页

作者：周永生刘锦明外交学院北京100037 国家发展和改革委员会对外经济研究所北京100038

经济全球化是指市场经济在世界各地普及的过程,也是市场经济在新的历史时期获得空前发展的过程。经济全球化所带来的不仅仅有发展机遇,也有严峻的挑战。国际社会成员通过激烈的竞争和密切的合作,彼此的联系也将更加密切。经济外交在经... 详细信息

经济全球化是指市场经济在世界各地普及的过程,也是市场经济在新的历史时期获得空前发展的过程。经济全球化所带来的不仅仅有发展机遇,也有严峻的挑战。国际社会成员通过激烈的竞争和密切的合作,彼此的联系也将更加密切。经济外交在经济全球化中具有不可替代的作用,为使经济全球化不被少数国家和少数垄断资本控制,有必要通过经济外交,建立新的经济外交机制,促进经济全球化向着既注重效益又兼顾公平的方向发展。这是21世纪各国对外政策和外交活动所面临的崭新课题。

关键词：经济外交经济全球化经济竞争经济合作跨国公司

Single-cell transcriptomic profiling reveals ZEB1-mediated regulation in microglial subtypes and the impact of exercise on neuroinflammatory responses

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Traditional Medicine Research 2025年第2期10卷 55-64页

作者： jin-Fang Wu Yi-sheng Chen Yu-Chun Xie Department of Rehabilitation Medicine Jiangsu Province Geriatric HospitalNanjing 210024China Fujian Key Laboratory of Toxicant and Drug Toxicology Medical CollegeNingde Normal UniversityNingde 352100China Central Laboratory Jiangsu Province Geriatric HospitalNanjing 210024China

Background:This study aims to identify distinct cellular subtypes within brain tissue using single-cell transcriptomic analysis,focusing on specific biomarkers that differentiate cell types and the effects of traditional and exercise ***:Four samples were analyzed:older control(OC),older exercise(OE),younger control(YC),and younger exercise(YE).Single-cell RNA sequencing was used to distinguish cellular subtypes through their biomarker *** visualization included violin and t-SNE plots to illustrate biomarker expression across cell clusters such as oligodendrocytes,microglia,and ***,BV2 cells were exposed to amyloid-beta fragments to simulate Alzheimer’s disease,assessing the impact of exercise-induced cellular ***:Distinct cellular subtypes were identified:oligodendrocytes(MBP,St18),microglia(Dock8),and astrocytes(Aqp4,Gpc5).Sample OE was predominantly oligodendrocytes,while YE had more astrocytes,inhibitory neurons,and Canal-Retzius *** showed a significant presence of Olfm3+ganglion ***1 gene knockout revealed changes in SMAD family gene expression,which regulate *** stress levels were also ***:This profiling enhances our understanding of brain cellular functions and interactions,potentially informing targeted therapies in neurological *** may influence brain cell immune responses and cell death pathways by regulating specific gene expressions,offering new insights for treating neuroinflammation and degeneration.

关键词： single-cell transcriptomics brain tissue cellular subtypes biomarker expression neuronal diversity

Enhancing m^(6)A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1749-1763页

作者： Tian Qin Yuxin jin Yiming Qin Feifei Yuan Hongbin Lu Jianzhong Hu yong Cao Chengjun Li Department of Spine Surgery and Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Sports Medicine Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Spinal cord injury typically causes corticospinal tract disruption. Although the disrupted corticospinal tract can self-regenerate to a certain degree, the underlying mechanism of this process is still unclear. N6-methyladenosine(m^(6)A) modifications are the most common form of epigenetic regulation at the RNA level and play an essential role in biological processes. However, whether m^(6)A modifications participate in corticospinal tract regeneration after spinal cord injury remains unknown. We found that expression of methyltransferase 14 protein(METTL14) in the locomotor cortex was high after spinal cord injury and accompanied by elevated m^(6)A levels. Knockdown of Mettl14 in the locomotor cortex was not favorable for corticospinal tract regeneration and neurological recovery after spinal cord injury. Through bioinformatics analysis and methylated RNA immunoprecipitation-quantitative polymerase chain reaction, we found that METTL14 regulated Trib2 expression in an m^(6)A-regulated manner, thereby activating the mitogen-activated protein kinase pathway and promoting corticospinal tract regeneration. Finally, we administered syringin, a stabilizer of METTL14, using molecular docking. Results confirmed that syringin can promote corticospinal tract regeneration and facilitate neurological recovery by stabilizing METTL14. Findings from this study reveal that m^(6)A modification is involved in the regulation of corticospinal tract regeneration after spinal cord injury.

关键词： corticospinal tract remodeling epigenetic regulations locomotor cortex m^(6)A modification methyltransferase 14 protein(METTL14) mitogen-activated protein kinase neural regeneration spinal cord injury syringin TRIB2