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Vein transplantation using human umbilical cord blood stem cells in the treatment of stroke sequela

Neural Regeneration Research 2006年第7期1卷 618-621页

作者： yong man1, jianbin li2, bo yang3, ji ma1 1department of cerebral surgery, the second people’s hospital of zhengzhou, zhengzhou 450000, henan province, china 2Red Cross Blood Center of henan province, zhengzhou 450000, henan province, china 3department of Neurosurgery, the First Affiliated hospital of zhengzhou University, zhengzhou 450000, henan province, china department of cerebral surgery The Second People's Hospital of Zhengzhou Zhengzhou 450000 Henan Province China Red Cross Blood Center of henan province Zhengzhou 450000 Henan Province China department of Neurosurgery Hospital of Zhengzhou University Zhengzhou 450000 Henan Province China

BACKGROUND: Transplanted mononuclear cell (MNC) of umbilical blood can survive in central nervous system (CNs) of host through blood brain barrier, differentiate into nerve cells, migrate to damaged site and integrate morphological structure and function with nerve cells of host so as to improve deficiencies of sensatory function, motor function and cognitive function and influence on stroke sequela. OBJECTIVE: To observe the vein transplantation of human umbilical cord blood stem cells (HUCBsC) for improving neurological function, limb function and activity of daily living of patients with stroke and evaluate the reliability. DEsIGN: self-controlled study. sETTING: department of Neurosurgery, the second people's hospital of zhengzhou City; Red-crossed Blood Center of henan province; department of Neurosurgery, the Fist Affiliated hospital of zhengzhou University. PARTICIPANTs: A total of 10 patients with stroke sequela were selected from department of cerebral surgery, the second people's hospital of zhengzhou City from April to December 2005. There were 9 males and 1 female aged from 35 to 75 years with the mean age of 56 years. All of them were diagnosed with CT and MRI examination and coincidence with diagnostic criteria of stroke established by the Fourth National Academic Meeting for Cerebrovascular Disease. All patients provided informed consent. METHODs: 80-140 mL umbilical blood of term birth of newborn was selected hermetically and maintained in sterile plastic bag. And then, the blood was centrifugated at the speed of 1 500 r/min for 30 minutes at 22 ℃ in order to separate MNC, i.e., HUCBsC. In addition, after final diagnosis during hospitalization, stroke patients were perfused with HUCBsC through superficial vein of back of the hand. Each patient was averagely perfused with 6 portions of HUCBsC (cellular numbers ≥ 1×108/portion) and the interval between each portion was 1-7 days with the mean interval of 4 days. maIN OUTCOME MEAsUREs: ① Neurological fun

关键词： cell stem Vein transplantation using human umbilical cord blood stem cells in the treatment of stroke sequela

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