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Long-term outcomes of staged recanalization for concurrent chronic total occlusion in patients with ST-segment elevation myocardial infarction after primary percutaneous coronary intervention

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Journal of Geriatric Cardiology 2020年第1期17卷 16-25,I0002-I0007页

作者： kong-yong CUI Fei YUAN Hong LIU Feng XU Min ZHANG Wei WANG Ming-Duo ZHANG Yun-Lu WANG Dong-Feng ZHANG Xiao ZHANG Jin-Fan TIAN Shu-Zheng LYU Department of Cardiology Beijing Anzhen HospitalCapital Medical University and Beijing Institute of HeartLung and Blood Vessel DiseasesBeijingChina Department of Anesthesiology Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina Department of VIP Clinic Beijing Anzhen HospitalCapital Medical UniversityBeijingChina

Background In patients with acute ST-segment elevation myocardial infarction(STEMI)who undergo primary percutaneous coronary intervention(PCI),approximately 10%are concomitant with a chronic total occlusion(CTO)in a non-culprit ***,the impact of staged CTO recanalization on prognosis in this cohort remains *** study aimed to compare the long-term outcomes of staged CTO recanalization versus medical therapy in patients with STEMI after primary *** Between January 2005 and December 2016,a total of 287 patients were treated with staged CTO-PCI(n=91)or medical therapy(n=196)after primary PCI in our *** primary endpoint was major adverse cardiovascular and cerebrovascular event(MACCE),defined as a composite of all-cause death,nonfatal myocardial infarction(MI),stroke or unplanned *** propensity-score matching,77 pairs of well-balanced patients were *** The mean follow-up period was 6.06 ***,the incidence of the primary endpoint of MACCE was significantly lower in staged CTO-PCI group than that in medical therapy group in both overall population(22.0%vs.46.9%;hazard ratio(HR)=0.48,95%CI:0.29-0.77)and propensity-matched cohorts(22.1%vs.42.9%;HR:0.48,95%CI:0.27-0.86).In addition,staged CTO-PCI was also associated with reduced risk of the composite of cardiac death,nonfatal MI or stroke compared with medical therapy in both overall population(9.9%vs.26.5%;hazard ratio(HR)=0.39,95%CI:0.19-0.79)and propensity-matched cohorts(9.1%vs.22.1%;HR:0.40,95%CI:0.16-0.96).After correction of the possible confounders,staged CTO-PCI was independently associated with reduced risks of MACCE(adjusted HR:0.46,95%CI:0.28-0.75),the composite of cardiac death,nonfatal MI or stroke(adjusted HR:0.45,95%CI:0.22-0.94)and all-cause mortality(adjusted HR:0.32,95%CI:0.13-0.83).Moreover,the results of sensitivity analysis were almost concordant with the overall *** In patients with STEMI and a concurrent

关键词： Concurrent chronic total occlusion Long-term outcome Staged recanalization ST-segment elevation myocardial infarction

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Multi-dimensionality in plant root traits:progress and challenges

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Journal of Plant Ecology 2024年第4期17卷 1-8页

作者： Jiabao Zhao Binglin Guo Yueshuang Hou Qingpei Yang Zhipei Feng yong Zhao Xitian Yang Guoqiang Fan Deliang kong College of Forestry Henan Agricultural UniversityZhengzhouChina

Plant roots,the major agent for water and nutrient acquisition,are fundamental for plant growth,evolution and ecosystem services that human beings depend on(Bardgett et al.2014;Weigelt et al.2023).Nutrient acquisition can be depicted by a wealth of traits of absorptive roots,the few terminal root branch orders with primarily developed tissues(Guo et al.2008;McCormack et al.2015).

关键词： traits plant roots

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Improvement of Photoluminescence of Perovskite CH_(3)NH_(3)PbI_(3) by Adding Additional CH3NH3I during Grinding

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Chinese Physics Letters 2021年第8期38卷 131-135页

作者： Dou-Dou Qian Lei Liu Zhi-Xue Xing Rui Dong Li Wu Hong-Kun Cai yong-Fa kong Yi Zhang Jing-Jun Xu Key Laboratory of Weak-Light Nonlinear Photonics(Ministry of Education) School of PhysicsNankai UniversityTianjin 300071China College of Electronic Information and Optical Engineering and Tianjin Key Laboratory of Photo-electronic Thin Film Devices and Technology Nankai UniversityTianjin 300071China

The organic-inorganic hybrid perovskite CH_(3)NH_(3)PbI_(3) has been a good candidate for many optoelectronic applications such as light-emitting diodes due to its unique *** the optical properties of the CH_(3)NH_(3)PbI_(3) material to improve the device performance is a hot ***,a new strategy is proposed to enhance the light emission of CH_(3)NH_(3)PbI_(3) phosphor *** adding the reactant CH_(3)NH_(3)I powder in an appropriate proportion and simply grinding,the emission intensity of CH_(3)NH_(3)PbI_(3) is greatly *** advantages of the proposed method are swiftness,simplicity and reproducibility,and no requirement for a complex organic *** mechanism of this phenomenon is revealed by x-ray diffraction,scanning electron microscopy,energy dispersive spectroscopy,photoluminescence,and temperature-dependent *** study offers a unique insight for optimizing the optical properties of halide perovskite materials.

关键词： properties materials perovskite

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水杨醛席夫碱配体在聚合反应中的研究进展

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科学技术与工程 2020年第30期20卷 12279-12289页

作者：孔勇中国石化石油工程技术研究院北京100101

近年来,由于茂金属催化体系过于活泼且需加入大量昂贵的助催化剂,导致工业生产成本偏高,非茂催化体系研究成为聚合研究热点。水杨醛席夫碱配体由于特殊的骨架结构已被广泛应用于制备多种聚合物催化剂,成为金属有机化学研究领域的明星配... 详细信息

近年来,由于茂金属催化体系过于活泼且需加入大量昂贵的助催化剂,导致工业生产成本偏高,非茂催化体系研究成为聚合研究热点。水杨醛席夫碱配体由于特殊的骨架结构已被广泛应用于制备多种聚合物催化剂,成为金属有机化学研究领域的明星配体,并在多种聚合反应表现出优异的催化性能。结合水杨醛席夫碱的相关研究报道,首先简要介绍水杨醛席夫碱的种类,随后重点介绍水杨醛席夫碱配体金属化,及其金属配合物在烯烃配位聚合、CO2聚合和内酯开环聚合等聚合反应的应用。在此基础上,指出了今后水杨醛席夫碱配体在聚合反应研究的发展方向。

关键词：水杨醛席夫碱烯烃配位聚合 CO2聚合催化

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N-杂环卡宾配体在聚合反应中的研究进展

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化学通报 2020年第9期83卷 792-798页

作者：孔勇中国石化石油工程技术研究院北京100101

N-杂环卡宾(NHC)配体的优异催化性能引起了人们的广泛关注,已成功应用于多种烯烃聚合反应。本文主要介绍NHC及其在开环易位聚合、烯烃配位聚合和原子转移自由基聚合等反应中的应用。在此基础上,指出了今后NHC配体在聚合反应研究的发展... 详细信息

N-杂环卡宾(NHC)配体的优异催化性能引起了人们的广泛关注,已成功应用于多种烯烃聚合反应。本文主要介绍NHC及其在开环易位聚合、烯烃配位聚合和原子转移自由基聚合等反应中的应用。在此基础上,指出了今后NHC配体在聚合反应研究的发展方向。

关键词： N-杂环卡宾金属配合物催化剂聚合反应

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“谱身”兼“谱道”:清代衍圣公宗族意识的表达和实践

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齐鲁学刊 2020年第1期 32-51页

作者：孔勇山东大学历史文化学院山东济南250100

“谱身”与“谱道”是清代衍圣公纂作族谱时经常使用的两个概念,折射出是安于“圣裔”身份抑或争入“道统”谱系的纠结状态。结合孔府档案所藏孔氏族谱、衍圣公和时人论述,可以看到:清代以前孔氏族谱重在“考世系,叙尊卑”,以此来表先... 详细信息

“谱身”与“谱道”是清代衍圣公纂作族谱时经常使用的两个概念,折射出是安于“圣裔”身份抑或争入“道统”谱系的纠结状态。结合孔府档案所藏孔氏族谱、衍圣公和时人论述,可以看到:清代以前孔氏族谱重在“考世系,叙尊卑”,以此来表先德而合全族;至清代则变为“锄非种,辨窜冒”,强化内外孔之别和真伪孔之分。同时,在清代衍圣公的深层意识之中,还暗存着某种以道统自居及以传道自任的使命感,每当政治控制稍显宽松或儒学发展受困时,此一暗流就会浮于面前,故“谱身”只是表面功用,“谱道”才是终极指向。

关键词：衍圣公谱身谱道道统世统

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阴离子N-杂环卡宾研究进展

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科学技术与工程 2020年第34期20卷 13959-13970页

作者：孔勇中国石化石油工程技术研究院北京100101

N-杂环卡宾的优异催化性能引起了人们的广泛关注,但简单N-杂环卡宾金属配合物容易发生原位还原消除,导致催化反应终止或效率降低。针对这一难题,通过在N-杂环卡宾边臂引入多种阴离子官能团,以提高N-杂环卡宾金属配合物的稳定性。阴离子N... 详细信息

N-杂环卡宾的优异催化性能引起了人们的广泛关注,但简单N-杂环卡宾金属配合物容易发生原位还原消除,导致催化反应终止或效率降低。针对这一难题,通过在N-杂环卡宾边臂引入多种阴离子官能团,以提高N-杂环卡宾金属配合物的稳定性。阴离子N-杂环卡宾金属配合物合成和催化研究已成为当前N-杂环卡宾研究的热点。结合阴离子N-杂环卡宾的相关研究报道,对C、N、O和S等阴离子N-杂环卡宾及其金属配合物的合成研究和应用情况进行评述。在此基础上,指出了今后阴离子N-杂环卡宾研究的发展方向。

关键词： N-杂环卡宾催化烯烃聚合阴离子

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Long term outcomes of drug-eluting stent versus coronary artery bypass grafting for left main coronary artery disease： a meta-analysis

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Journal of Geriatric Cardiology 2018年第2期15卷 162-172页

作者： kong-yong CUI Shu-Zheng LYU Xian-Tao SONG Fei YUAN Feng XU Min ZHANG Ming-Duo ZHANG Wei WANG Dong-Feng ZHANG Jing DAI Jin-Fan TIAN Yun-Lu WANG Department of Cardiology Beijing Anzhen Hospital Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing China Department of Anesthesiology Beijing Chaoyang Hospital Capital Medical University Beijing China

Background It is still controversial whether percutaneous coronary intervention with drug-eluting stent （DES） is safe and effective compared to coronary artery bypass graft surgery （CABG） for unprotected left main coronary artery （ULMCA） disease at long-term follow up （≥3 years）. Methods Eligible studies were selected by searching PubMed, EMBASE, and Cochrane Library up to December 6, 2016. The primary endpoint was a composite of death, myocardial infarction （MI） or stroke during the longest follow-up. Death, cardiac death, MI, stroke and repeat revascularization were the secondary outcomes. Results Four randomized controlled trials and twelve adjusted observational studies involving 14,130 patients were included. DES was comparable to CABG regarding the occurrence of the primary endpoint （FIR = 0.94, 95% CI： 0.86-1.03）. Besides, DES was significantly associated with higher incidence of MI （HR = 1.56, 95% CI： 1.09-2.22） and repeat revascularization （HR = 3.09, 95% CI： 2.33-4.10） compared with CABG, while no difference was found between the two strategies regard as the rate of death, cardiac death and stroke. Furthermore, DES can reduce the risk of the composite endpoint of death, MI or stroke （HR = 0.80, 95% CI： 0.67-0.95） for ULMCA lesions with SYNTAX score ≤32. Conclusions Although with higher risk of repeat revascularization, PCI with DES appears to be as safe as CABG for ULMCA disease at long-term follow up. In addition, treatment with DES could be an alternative interventional strategy to CABG for ULMCA lesions with low to intermediate anatomic complexity.

关键词： Coronary artery bypass graft Dmg-eluting stent Long term Unprotected left main coronary disease

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Revealing the Structure-Property Difference of Natural Rubber Prepared by Different Methods: Protein and Gel Content are Key Factors

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Chinese Journal of Polymer Science 2024年第4期42卷 457-467页

作者： Shao-Qi Huang Jun-Qi Zhang yong Zhu Ling-Min kong Lu-Sheng Liao Fu-Quan Zhang Zheng-Tian Xie Jin-Rong Wu State Key Laboratory of Polymer Materials Engineering College of Polymer Science and EngineeringSichuan UniversityChengdu610065China Hainan Provincial Key Laboratory of Natural Rubber Processing Agricultural Products Processing Research Institute of Chinese Academy of Tropical Agricultural SciencesZhanjiang524001China

Natural rubber (NR) is widely used in various fields including aerospace, military industry and transportation due to its superior elasticity and comprehensive mechanical properties. Nonetheless, the commercial NR prepared by different methods usually exhibits different mechanical properties, primarily due to variations in processing conditions during the conversion from latex to bulk rubber material. Consequently, this poses challenges in scientific research and industrial production of NR. In order to assess the properties of various commercially available NR and identify key structural and compositional components, this study systematically compares and analyzes four representative NR raw materials: air dried sheet (ADS), ribbed smoked sheets (RSS), constant viscidity NR (CV), and whole field latex rubber (WF). The investigation focuses on evaluating their static mechanical behavior, SIC behavior, wear resistance, and fatigue resistance. The findings indicate that protein and gel content exhibit a crucial influence on the NR properties. These constituents contribute to the formation of a high-crosslinking density region, generating a heterogeneous network structure within the rubber. This structure amplifies strains during deformation, leading to earlier and stronger strain-induced crystallization (SIC). Among the four commercial NR brands, RSS demonstrates superior overall mechanical and dynamic properties owing to its high protein and gel content. This study serves as a valuable reference for comprehending the differences in properties among various commercial NR, thereby offering guidance for the actual processing and selection of NR.

关键词： Natural rubber Processingmethod Protein Gel content Property

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Epigenetic regulation of SARS-Cov-2 spike protein modulates cellular viability and nascent RNA transcription in neuronal cells

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Genes & Diseases 2024年第2期11卷 535-538页

作者： Xi kong Peng Lu Jinyue Zhang Zheng Bao Chenghao Kuang Bingqing Xie Jianhua Peng Ning Ma yong Jiang Shigang Yin Laboratory of Neurological Diseases and Brain Function The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan 646000China Institute of Epigenetics and Brain Science Southwest Medical UniversityLuzhouSichuan 646000China Department of Neurosurgery The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan 646000China Inflammation and Allergic Diseases Research Unit The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan 646000China

SARS-CoV-2 has been demonstrated to be highly susceptible to neuron-and glial-like cells,1 but there is no consensus regarding how the virus affects neurons following *** is therefore unknown if and how SARS-CoV-2 maintains the homeostasis of neuronal ***,we revealed that the receptor-binding domain(RBD)of the SARS-CoV-2 spike protein acted as an extracellular remodeling component to undermine epigenetic regulation,perturbnascentRNA(nsRNA)transcription,promote mitochondrial biogenesis,and increase cellular viability in SH-SY5Y cells.

关键词： invasion homeostasis maintain

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