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Changing trends and characteristics of peptic ulcer disease:A multicenter study from 2010 to 2019 in Korea

World Journal of Gastroenterology 2023年第44期29卷 5882-5893页

作者： Yoon Jin Choi Tae Jun Kim Chang Seok Bang yong kang lee Moon Won lee Su Youn Nam Woon Geon Shin Seung In Seo Department of Internal Medicine National Cancer CenterGoyang-si 13620South Korea Department of Internal Medicine Samsung Medical CenterSeoul 06351South Korea Department of Internal Medicine Chuncheon Sacred Heart HospitalChuncheon 24253South Korea Department of Internal Medicine National Health Insurance Service Ilsan HospitalGoyang-si 10444South Korea Department of Internal Medicine Pusan National University School of MedicineBusan 50463South Korea Division of Gastroenterology and Hepatology Department of Internal MedicineKyungpook National University Chilgok HospitalDaegu 41404South Korea Department of Internal Medicine Kangdong Sacred Heart HospitalHallym University College of MedicineSeoul 05355South Korea Institute for Liver and Digestive Diseases Hallym UniversityChuncheon 24253South Korea Division of Gastroenterology Department of Internal MedicineKangdong Sacred Heart HospitalSeoul 05355South Korea

BACKGROUND The clinical trend and characteristics of peptic ulcer disease(PUD)have not fully been investigated in the past *** To evaluate the changing trends and characteristics of PUD according to age and METHODS We analyzed seven hospital databases converted into the Observational Medical Outcomes Partnership-Common Data Model between 2010 and *** classified patients with PUD who underwent rapid urease tests or Helicobacter pylori(***)serology into three groups:***-related,drug[nonsteroidal anti-inflammatory drugs(NSAIDs)or aspirin]-related,and idiopathic(***/NSAID/aspirin-negative)PUD and compared the yearly trends and characteristics among the three *** We included 26785 patients in 7 databases,and the proportion of old age(≥65 years)was 38.8%.The overall number of PUD exhibited no decrease,whereas PUD in old age revealed an increasing trend(P=0.01 for trend).Of the 19601 patients,41.8%had ***-related,36.1%had drug-related,and 22.1%had idiopathic *** PUD exhibited a decreasing trend after 2014(P=0.01),drug-related PUD demonstrated an increasing trend(P=0.04),and idiopathic PUD showed an increasing trend in the old-age group(P=0.01)during 10 *** with drug-related PUD had significantly more comorbidities and concomitant ulcerogenic *** idiopathic PUD group had a significantly higher number of patients with chronic liver *** With the aging population increase,the effects of concomitant ulcerogenic drugs and preventive strategies should be investigated in drug-induced *** studies are required to clarify the relationship between idiopathic PUD and chronic liver disease.

关键词： Peptic ulcer disease Drug Idiopathic Trend Characteristics

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Ionizing terahertz waves with 260 MV/cm from scalable optical rectification

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Light(Science & Applications) 2024年第6期13卷 1075-1087页

作者： Hyeongmun Kim Chul kang Dogeun Jang Yulan Roh Sang Hwa lee Joong Wook lee Jae Hee Sung Seong Ku lee Ki-yong Kim Advanced Photonics Research Institute GISTGwangju61005Korea Department of Physics and Optoelectronics Convergence Research Center Chonnam National UniversityGwangju61186Korea Pohang Accelerator Laboratory POSTECHPohang37673Korea Center for Relativistic Laser Science Institute for Basic ScienceGwangju61005Korea Institute for Research in Electronics and Applied Physics Department of PhysicsUniversity of MarylandCollege ParkMaryland20742USA

Terahertz(THz)waves,known as non-ionizing radiation owing to their low photon energies,can actually ionize atoms and molecules when a sufficiently large number of THz photons are concentrated in time and ***,we demonstrate the generation of ionizing,multicycle,15-THz waves emitted from large-area lithium niobate crystals via phase-matched optical rectification of 150-terawatt laser pulses.A complete characterization of the generated THz waves in energy,pulse duration,and focal spot size shows that the field strength can reach up to 260 megavolts per *** particular,a single-shot THz interferometer is employed to measure the THz pulse duration and spectrum with complementary numerical *** intense THz pulses are irradiated onto various solid targets to demonstrate THz-induced tunneling ionization and plasma *** study also discusses the potential of nonperturbative THz-driven ionization in gases,which will open up new opportunities,including nonlinear and relativistic THz physics in plasma.

关键词： optical interferometer matched

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STRESS INTENSITY FACTOR OF AN ANTI-PLANE CRACK PARALLEL TO THE WEAK/MICRO-DISCONTINUOUS INTERFACE IN A BI-FGM COMPOSITE

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Acta Mechanica Solida Sinica 2008年第1期21卷 34-43页

作者： yong-Dong Li Wei Tan kang yong lee Department of Mechanical Engineering Academy of Armored Force Engineering No.21 Du Jia Kan Chang Xin Dian Beijing 100072 China School of Mechanical Engineering Yonsei University Seoul 120-749 South Korea

The problem considered is a mode Ⅲ crack lying parallel to the interface of an exponential-type functional graded material （FGM） strip bonded to a linear-type FGM substrate with infinite thickness. By applying the Fourier integral transform, the problem was reduced as a Cauchy singular integral equation with an unknown dislocation density function. The collocation method based on Chebyshev polynomials proposed by Erdogan and Gupta was used to solve the singular integral equation numerically. With the numerical solution, the effects of the geometrical and physical parameters on the stress intensity factor （SIF） were analyzed and the following conclusions were drawn：（a） The region affected by the interface or free surface varies with the material rigidity, and higher material rigidity will lead to bigger affected region. （b） The SIF of the crack in the affected region and parallel to the micro-discontinuous interface is lower than those of the weak discontinuous cases. Reducing the weak-discontinuity of the interface will be beneficial to decrease the SIF of the interface-parallel crack in the region affected by the interface. （c） The effect of the free surface on SIF is more remarkable than that of the interface, and the latter is still more notable than that of the material rigidity. When the effects of the interface and free surface are fixed, increase of the material rigidity will enhance the value of SIF.

关键词： bi-FGM composite mode Ⅲ crack stress intensity factor weak/mico discontinuity,the Cauchy singular integral equation

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Thermodynamic model for deoxidation of liquid steel considering strong metal-oxygen interaction in the quasichemical model framework

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International Journal of Minerals,Metallurgy and Materials 2024年第5期31卷 988-1002页

作者： yong-Min Cho Youn-Bae kang Graduate Institute of Ferrous and Eco Materials Technology Pohang University of Science and TechnologyPohangKyungbuk37673Rep.of Korea N.EX.T Hub POSCO HoldingsPohangKyungbuk37673Rep.of Korea Department of Materials Science and Engineering Pohang University of Science and TechnologyPohangKyungbuk37673Rep.of Korea

Herein,a thermodynamic model aimed at describing deoxidation equilibria in liquid steel was *** model provides explicit forms of the activity coefficient of solutes in liquid steel,eliminating the need for the minimization of internal Gibbs energy preliminarily when solving deoxidation *** elimination of internal Gibbs energy minimization is particularly advantageous during the coupling of deoxidation equilibrium calculations with computationally intensive approaches,such as computational fluid *** model enables efficient calculations through direct embedment of the explicit forms of activity coefficient in the computing *** proposed thermodynamic model was developed using a quasichemical approach with two key approximations:random mixing of metallic elements(Fe and oxidizing metal) and strong nonrandom pairing of metal and oxygen as nearest *** these approximations,the quasichemical approach yielded the activity coefficients of solutes as explicit functions of composition and temperature without requiring the minimization of internal Gibbs energy or the coupling of separate *** model was successfully applied in the calculation of deoxidation equilibria of various elements(Al,B,C,Ca,Ce,Cr,La,Mg,Mn,Nb,Si,Ti,V,and Zr).The limitations of the model arising from these assumptions were also discussed.

关键词： deoxidation equilibria thermodynamics quasichemical approach computational fluid dynamics

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Clean-DM1, a Korean Polyherbal Formula, Improves High Fat Diet-Induced Diabetic Symptoms in Mice by Regulating IRS/PI3K/AKT and AMPK Expressionsin Pancreas and Liver Tissues

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Chinese Journal of Integrative Medicine 2024年第2期30卷 125-134页

作者： Piao Wang Yi Liu Seok yong kang Chenzi Lyu Xiang Han Tianjun Ho Kyung Jae lee Xianglong Meng yong-Ki Park Hyo Won Jung Department of Herbology College of Korean MedicineDongguk UniversityGyeongju 38066Korea College of Pharmacy&Graduate School of Pharmaceutical Sciences Ewha Womans UniversitySeoul 03760Korea Korean Medicine R&D Center Dongguk UniversityGyeongju 38066Korea Shanxi Key Laboratory of Traditional Herbal Medicines Processing Shanxi University of Chinese MedicineJinzhong(030619)ShanxiProvinceChina

Objective:To investigate the effects of Clean-DM1(C-DM1),a polyherbal formulation of Radix Scrophulariae,Radix Astragali,Rhizoma Atractylodis,and Radix Salviae Miltiorrhizae,on high-fat diet(HFD)-induced diabetes ***:The information about active components of C-DM1 extract and molecular mechanism was obtained from network pharmacology *** compounds of C-DM1 extract by high performance liquid chromatography-mass spectrometry(HPLC-MS)analysis were conducted for quality *** in vivo study,mice were induced diabetes by HFD for 12 *** mice in the normal group(Nor)were maintained with a regular diet and treated with saline by *** HFD model mice were randomly divided into 3 groups,including a HFD diabetic model group,a C-DM1 extract-administered group(C-DM1,500 mg/kg),and metformin-administered groups(Met,500 mg/kg),8 mice in each *** intake,body weight(BW),and fasting blood glucose(FBG)levels were recorded weekly for 4 *** 4 weeks of treatment,alanine aminotransferase(ALT),aspartate aminotransferase(AST),blood glucose,low-density lipoprotein cholesterol(LDL-C)were determined using an automated clinical chemistry analyzer,and homeostatic model for assessing insulin resistance(HOMA-IR)levels and oral glucose tolerance test(OGTT)were *** histopathological changes of liver and pancreatic tissues were observed by hematoxylin-eosin *** receptor substrate(IRS)/phosphatidylinositol 3 kinase(PI3K)/protein kinase B(AKT)and adenosine 5'-monophosphate-activated protein kinase(AMPK)expressions in liver and pancreas tissues were detected by Western blot ***:HPLC-MS identified dihydroisotanshinone,dihydroisotanshinone I,cryptotanshinone,harpagoside,and atractyloside A in C-DM1 *** administration of C-DM1 extract significantly decreased body weight,calorie intake,and the levels of blood glucose and insulin in the diabetic mice(P<0.05 or P<0.01).The C-DM1 extract administration improved the im

关键词： high-fat diet type 2 diabetes mellitus herbal formulation insulin receptor substrate/phosphatidylinositol 3 kinase/protein kinase B adenosine 5'-monophosphate-activated protein kinase network pharmacology high performance liquid chromatography-mass spectrometry analysis

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Pylorus-preserving gastrectomy for early gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 653-658页

作者： Ke-kang Sun yong-You Wu Department of Gastrointestinal Surgery The Affiliated Kunshan Hospital to Jiangsu UniversitySuzhou 215300Jiangsu ProvinceChina Department of Gastrointestinal Surgery The Second Affiliated Hospital of Soochow UniversitySuzhou 215008Jiangsu ProvinceChina

Pylorus-preserving gastrectomy(PPG)has been widely accepted as a function-preserving gastrectomy for middle-third early gastric cancer(EGC)with a distal tumor border at least 4 cm proximal to the *** procedure essentially preserves the function of the pyloric sphincter,which requires to preserve the upper third of the stomach and a pyloric cuff at least 2.5 *** suprapyloric and infrapyloric vessels are usually preserved,as are the hepatic and pyloric branches of the vagus *** with distal gastrectomy,PPG has significant advantages in preventing dumping syndrome,body weight loss and bile reflux *** postoperative complications after PPG have reached an acceptable *** can be considered a safe,effective,and superior choice in EGC,and is expected to be extensively performed in the future.

关键词： Gastric cancer Pylorus-preserving gastrectomy Oncological safety Gastric stasis

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Emission wavelength selection via anomalous polarized fluorescence in ZnO-C nanowires

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Nano Research 2024年第5期17卷 4489-4497页

作者： Joon Kiat kang Kim yong Lim Chorng Haur Sow Department of Physics National University of SingaporeSingapore 117542Singapore

Defect fluorescence from high aspect ratio semiconductor nanowires typically displays a weak polarization parallel to the nanowire’s long axis due to dielectric mismatch in high aspect ratio ***,anomalous 2.2 eV defect fluorescence distinctly polarized perpendicular to the nanowire is observed and measured from carbon-incorporated zinc oxide *** observations are significant because polarized defect emissions with consistent polarization on a mesoscopic scale are *** a systematic study and comparison of experimental results with density functional theory calculations,an oriented defect complex comprising carbon substituting on an oxygen site and an oxygen vacancy(CO-VO)is deduced to be responsible for the anomalous yellow fluorescence,demonstrating a method for relating atomic-scale defect geometry to mesoscopic *** anomalous emission can appear in both green-and red-fluorescing nanowires grown with different carbon concentrations,verifying the independence and uniqueness of the 2.2 eV *** allows for polarization-dependent emission wavelength selection from a single nanowire.

关键词： anomalous polarization defects fluorescence zinc oxide carbon

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Numerical modeling of fracture propagation of supercritical CO_(2)compound fracturing

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2607-2628页

作者： Hao Chen yong kang Wanchun Jin Changhai Li Can Cai School of Mechanical Engineering Southwest Petroleum UniversityChengdu610500China Laboratory of High-pressure Jet Theory and Application Technology Southwest Petroleum UniversityChengdu610500China Hubei Key Laboratory of Waterjet Theory and New Technology Wuhan UniversityWuhan430072China Sinopec International Petroleum Exploration and Production Corporation Beijing 100029China

The exploitation of shale gas is promising due to depletion of the conventional energy and intensification of the greenhouse *** this paper,we proposed a heat-fluid-solid coupling damage model of supercritical CO_(2)(SC-CO_(2))compound fracturing which is expected to be an efficient and environmentally friendly way to develop shale *** coupling model is solved by the finite element method,and the results are in good agreement with the analytical solutions and fracturing *** on this model,the fracture propagation characteristics at the two stages of compound fracturing are studied and the influence of pressurization rate,in situ stress,bedding angle,and other factors are *** results show that at the SC-CO_(2)fracturing stage,a lower pressurization rate is conducive to formation of the branches around main fractures,while a higher pressurization rate inhibits formation of the branches around main fractures and promotes formation of the main *** bedding and in situ stress play a dominant role in the fracture *** the in situ stress ratio(sx/sy)is 1,the presence of bedding can reduce the initiation pressure and failure ***,it will cause the fracture to propagate along the bedding direction,reducing the fracture *** rocks without bedding,hydraulic fracturing has the lengthening and widening effects for SC-CO_(2)induced *** shale,fractures induced at the hydraulic fracturing stage are more likely to be dominated by in situ stresses and have a shorter reorientation ***,fracture branches propagating along the maximum principal stress direction may be generated around the main fractures induced by SC-CO_(2)at the hydraulic fracturing *** the branches converge with the main fractures,fracture zones are easily formed,and thus the fracture complexity and damage area can be significantly *** results are instructive for the design and application of SC-CO_(2

关键词： Compound fracturing Fracture propagation Finite element method Damage evolution

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The Weighted Basis for PHT-Splines

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工程与科学中的计算机建模(英文) 2024年第1期138卷 739-760页

作者： Zhiguo yong Hongmei kang Falai Chen School of Mathematical Sciences Soochow UniversitySuzhou215006China School of Mathematical Sciences University of Science and Technology of ChinaHefei230026China

PHT-splines are defined as polynomial splines over hierarchical T-meshes with very efficient local refinement *** original PHT-spline basis functions constructed by the truncation mechanism have a decay phenomenon,resulting in numerical *** non-decay basis functions are constructed as the B-splines that are defined on the 2×2 tensor product meshes associated with basis vertices in kang et al.,but at the cost of losing the partition of *** the field of finite element analysis and topology optimization,forming the partition of unity is the default ingredient for constructing basis functions of approximate *** this paper,we will show that the non-decay PHT-spline basis functions proposed by kang et *** be appropriately modified to form a partition of *** non-decay basis function is multiplied by a positive weight to form the weighted *** weights are solved such that the sum of weighted bases is equal to 1 on the *** provide two methods for calculatingweights,based on geometric information of basis functions and the subdivision of *** are given in the form of explicit formulas and can be efficiently *** also prove that the weights on the admissible hierarchical T-meshes are positive.

关键词： PHT-splines partition of unity weighted bases PHT-splines subdivision

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High mechanical strength Si anode synthesis with interlayer bonded expanded graphite structure for lithium-ion batteries

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Journal of Energy Chemistry 2024年第6期93卷 253-263,I0007页

作者： Wenhui Lai Jong Hak lee Lu Shi Yuqing Liu Yanhui Pu yong kang Ong Carlos Limpo Ting Xiong Yifan Rao Chorng Haur Sow Barbaros Ozyilmaz Department of Material Science&Engineering National University of SingaporeSingapore 117575Singapore Center for Advanced 2D Materials National University of SingaporeSingapore 117546Singapore Department of Physics National University of SingaporeSingapore 117551Singapore Institute forFunctional Intelligent Materials National University of SingaporeSingapore 117544Singapore

Despite advancements in silicon-based anodes for high-capacity lithium-ion batteries,their widespread commercial adoption is still hindered by significant volume expansion during cycling,especially at high active mass loadings crucial for practical *** root of these challenges lies in the mechanical instability of the material,which subsequently leads to the structural failure of the ***,we present a novel synthesis of a composite combining expanded graphite and silicon *** composite features a unique interlayer-bonded graphite structure,achieved through the application of a modified spark plasma sintering ***,this innovative structure not only facilitates efficient ion and electron transport but also provides exceptional mechanical strength(Vickers hardness:up to658 MPa,Young's modulus:11.6 GPa).This strength effectively accommodates silicon expansion,resulting in an impressive areal capacity of 2.9 mA h cm^(-2)(736 mA h g^(-1)) and a steady cycle life(93% after 100cycles).Such outsta nding performance is paired with features appropriate for large-scale industrial production of silicon batteries,such as active mass loading of at least 3.9 mg cm^(-2),a high-tap density electrode material of 1.68 g cm^(-3)(secondary clusters:1.12 g cm^(-3)),and a production yield of up to 1 kg per day.

关键词： Lithium-ion battery Silicon anode Spark plasma sintering Interlayer bonding Mechanical strength Tap density

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