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Quantitative Trait Loci for Grain Chalkiness and Endosperm Transparency Detected in Three Recombinant Inbred Line Populations of Indica Rice

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Journal of Integrative Agriculture 2013年第1期12卷 1-11页

作者： MEI De-yong ZHU yu-jun yu yong-hong FAN Ye-yang HUANG De-run ZHUANG jie-yun China National Rice Research Institute

Quantitative trait loci（QTL） for percentage of chalky grain,degree of chalkiness,and endosperm transparency were detected using 3 recombinant inbred line populations derived from crosses between parental lines of commercial three-line hybrids of indica *** of the populations showed great variations on heading date,and the other had a short range of heading date variation.A total of 40 QTLs were detected and fell into 15 regions of 10 chromosomes,of which 5 regions were detected for 1 or more same traits over different populations,2 were detected for different traits in different populations,3 were detected for 2 or all the 3 traits in a single population,and 5 were detected for a single trait in a single *** of these QTLs have been reported previously,but a region located on the long arm of chromosome 10 showing significant effects in all the 3 populations has not been reported *** was shown that a number of gene cloned,including the Wx and Alk for the physiochemical property of rice grain,and GW2,GS3 and GW5 for grain weight and grain size,could have played important roles for the genetic control of grain chalkiness in rice,but there are many more QTLs exerting stable effects for rice chalkiness over different genetic *** is worth paying more attentions to these regions which harbor QTL such as the qPCG5.2/qDC5.2/qET5.2 and qPCG10/qDC10/qET10 detected in our *** results also showed that the use of segregating populations having high-uniform heading date could greatly increase the efficiency of the identification of QTL responsible for traits that are subjected to great environmental influence.

关键词： percentage of chalky grain degree of chalkiness endosperm transparency quantitative trait locus headingdate variation indica rice(Oryza sativa L.subsp.indica)

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Power Analysis and Sample Size Determination for Crossover Trials with Application to Bioequivalence Assessment of Topical Ophthalmic Drugs Using Serial Sampling Pharmacokinetic Data

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Biomedical and Environmental Sciences 2019年第8期32卷 614-623页

作者： yu yong Pei YAN Xiao Yan YAO Chen XIA jie Lai College o f Military Preventive Medicine the Fourth Military Medical UniversityXi'an 710032ShaanxiChina Peking University Clinical Research Institute Peking University Health Science CenterBeijing 100191China

Objective To develop methods for determining a suitable sample size for bioequivalence assessment of generic topical ophthalmic drugs using crossover design with serial sampling *** The power functions of the Fieller-type confidence interval and the asymptotic confidence interval in crossover designs with serial-sampling data are here *** studies were conducted to evaluate the derived power *** Simulation studies show that two power functions can provide precise power estimates when normality assumptions are satisfied and yield conservative estimates of power in cases when data are log-normally *** intra-correlation showed a positive correlation with the power of the bioequivalence *** the expected ratio of the AUCs was less than or equal to 1, the power of the Fieller-type confidence interval was larger than the asymptotic confidence *** the expected ratio of the AUCs was larger than 1, the asymptotic confidence interval had greater *** size can be calculated through numerical iteration with the derived power *** The Fieller-type power function and the asymptotic power function can be used to determine sample sizes of crossover trials for bioequivalence assessment of topical ophthalmic drugs.

关键词： Serial-sampling data Crossover design Topical ophthalmic drug Bioequivalence Sample size

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Research of novel complex optical network routing architecture

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The Journal of China Universities of Posts and Telecommunications 2010年第5期17卷 93-99页

作者： HAN Da-hai ZHANG jie ZHAO yong-li ZHAO Shi-yu Key Laboratory of Information Photonics and Optical Communications Ministry of Education Beijing University of Posts & Telecommtmications Beijing 100876 China

This article puts forward a novel routing architecture for complex optical network,which core component is path calculation element （PCE）.As is well known,the PCE-based distributed path computation structure is making the routing control and computation loosely coupled from traditional control *** the study,the resource allocation and routing algorithm are the critical part of PCE *** compare the performance of new architecture and the traditional one,the user uses the flooding suppression,routing delay,resource utilization and traffic blocking probability as performance simulation parameters and taking the verification simulation on objective modular network testbed （OMNeT） platform against to source-node routing *** numerical analysis,computer simulation and experiment work indicate that the operation of PCE-based routing architecture can reduce the flooding information of path calculation request as well as the routing hops significantly and improve the quality of service （QoS） by decreasing the blocking probability when failure happened.

关键词： complex optical network PCE routing architecture

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TIME-DOMAIN RESPONSES OF IMMERSING TUNNEL ELEMENT UNDER WAVE ACTIONS

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Journal of Hydrodynamics 2009年第6期21卷 739-749页

作者： CHEN Zhi-jie WANG yong-xue WANG Guo-yu HOU yong State Key Laboratory of Coastal and Offshore Engineering Dalian University of Technology Dalian 116024 China CCCC-FHDI Engineering Co. Ltd Guangzhou 510230 China

The time domain responses of the tunnel element under wave actions during its immersion are investigated based on the linear wave diffraction theory. The integral equation is derived by using the time-domain Green function that satisfies the free water surface condition in the finite water depth, and is solved by the boundary element method. The motion equations of the tunnel element are solved by the fourth order Runge-Kutta method. A comparison between the computed and measured results reveals that the numerical model can effectively simulate the motion responses of the tunnel element and the cable tensions when the motions of the tunnel element are within some limit. Taking the tunnel element of 100 m in length, 15 m in width and 10 m in height as an example, the computational results of the motion responses of the tunnel element and the cable tensions in different immersing depths are obtained under different incident wave conditions.

关键词： Immersed tunnel time-domain response cable tension boundary element method

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Online upgrading of organic vapors from the fast pyrolysis of biomass

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燃料化学学报 2008年第6期36卷 666-671页

作者： LI Hong-yu YAN yong-jie REN Zheng-wei Research Center for Biomass Energy State Key Laboratory of Bioreactor Engineering East China University of Scince and Technology Shanghai 200237

The online upgrading process that combined the fast pyrolysis of biomass and catalytic cracking of bio-oil was developed to produce a high quality liquid product from the *** installation consisted of a fluidized bed reactor for pyrolysis and a packed bed reactor for *** proper pyrolysis processing conditions with a temperature of 500℃ and a flow rate of 4m3·h-1 were determined in *** such conditions,the effects of temperature and weight hourly space velocity(WHSV) on both the liquid yields and the oil qualities of the online catalytic cracking process were *** results showed that such a combined process had the superiority of increasing the liquid yield and improving the product quality over the separate ***,when the temperature was 500℃,with a WHSV of 3h-1,the liquid yield reached the maximum and the oxygenic compounds also decreased obviously.

关键词：有机水蒸气高温分解反应生物量化学分析

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PVC胶起泡原因分析及改善措施

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现代涂料与涂装 2016年第10期19卷 64-66页

作者：潘晓铭商智勇李玉杰原伟伟北京奔驰汽车有限公司北京100176

根据实际生产过程中,车身的四门、机盖和后盖出现PVC胶起泡的情况,从PVC胶材料、输胶系统、人员操作和装焊板材等几个方面来查找问题原因,重点对起泡处板材进行了拆解分析和截面分析,结果表明,板材包边不紧实或折边胶填充不够是影响PVC... 详细信息

根据实际生产过程中,车身的四门、机盖和后盖出现PVC胶起泡的情况,从PVC胶材料、输胶系统、人员操作和装焊板材等几个方面来查找问题原因,重点对起泡处板材进行了拆解分析和截面分析,结果表明,板材包边不紧实或折边胶填充不够是影响PVC胶起泡的主要原因,通过临时措施和永久措施可以改善PVC胶起泡处质量和解决起泡问题。

关键词： PVC胶起泡原因分析措施

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Experimental investigation of regular wave propagation over an idealized reef model

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Journal of Hydrodynamics 2020年第4期32卷 717-726页

作者： Gan-cheng Zhu Bing Ren Hong-jie Wen Guo-yu Wang yong-xue Wang State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China

The wave transformation over the deep-sea coral reefs is an essential issue in the analysis of the reef ecosystem and the design of large reef-top *** wave flume experiments are conducted to investigate the wave transformation processes over an idealized reef *** measurements of the wave height,the wave set-up and the wave-generated flow on the reef-top are made with and without the reef-top structure at various submerged depths and under different wave *** is found that the reef-top structure has a significant influence on the wave breaking,the wave set-up and the wave-generated *** wave set-up increases with the increasing wave height and the decreasing submergence ***,the relationship between the wave set-up and the wave period is complex,influenced by the reef-top structure.

关键词： Coral reef wave set-up reef-top structure wave breaking wave-generated flow

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Deep learning-based drug screening for the discovery of potential therapeutic agents for Alzheimer's disease

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Journal of Pharmaceutical Analysis 2024年第10期14卷 1514-1526页

作者： Tong Wu Ruimei Lin Pengdi Cui jie yong Heshui yu Zheng Li College of Pharmaceutical Engineering of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin301617China State Key Laboratory of Component-Based Chinese Medicine Tianjin301617China Haihe Laboratory of Modern Chinese Medicine Tianjin301617China National Key Laboratory of Chinese Medicine Modernization Tianjin301617China

Alzheimer's disease(AD)is gradually increasing in prevalence and the complexity of its pathogenesis has led to a lengthy process of developing therapeutic drugs with limited *** with this challenge,we proposed using a state-of-the-art drug screening algorithm to identify potential therapeutic compounds for AD from traditional Chinese medicine formulas with strong empirical *** developed four deep neural network(DNN)models for AD drugs screening at the disease and target *** AD model was trained with compounds labeled for AD activity to predict active compounds at the disease level,while the acetylcholinesterase(AChE),monoamine oxidase-A(MAO-A),and 5-hydroxytryptamine 6(5-HT6)models were trained for specific AD *** four models performed excellently and were used to identify potential AD agents in the Kaixinsan(KXS)***-scoring compounds underwent experimental validation at the enzyme,cellular,and animal *** like 2,4-di-tert-butylphenol and elemicin showed significant binding and inhibitory effects on AChE and ***,13 compounds,includingα-asarone,penetrated the blood-brain barrier(BBB),indicating potential brain target binding,and eight compounds enhanced microglialβ-amyloid phagocytosis,aiding in clearing AD pathological *** results demonstrate the effectiveness of deep learning models in developing AD therapies and provide a strong platform for AD drug discovery.

关键词： Alzheimer'sdisease Deep learning modelsl Drug screeningl Kaixinsan formulal Acetylcholinesterasel Monoamine oxidase-A

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Novel treatment for post-orgasmic illness syndrome:a case report and literature review

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Asian Journal of Andrology 2022年第3期24卷 332-334页

作者： Tian-Bao Huang Jun-jie yu yong-Jun Du Zhi-yong Liu Department of Urology Northern Jiangsu People’s HospitalYangzhou UniversityYangzhou 225001China Department of Urology College of Clinical MedicineYangzhou UniversityYangzhou 225001China Department of Urology Shanghai Changhai HospitalSecond Military Medical UniversityShanghai 200433China

Dear Editor,Post-orgasmic illness syndrome(POIS)is a rare disorder affecting men,and is characterized by flu-like symptoms that appear immediately or within hours after *** 2002,Waldinger and Schweitzer1 reported the first two cases of POIS and subsequently proposed five preliminary diagnostic criteria for POIS.1,2 The symptoms were categorized into seven *** avoid these symptoms,patients with POIS tend to minimize the frequency of ejaculation and avoid sexual ***,POIS poses a severe mental and psychosocial burden on patients and negatively affects their quality of life by affecting schedules,dampening romantic prospects,and creating internal struggles to avoid eroticism.3 Previously,the main treatment strategies were focused on drug and hyposensitization therapies.

关键词： treatment illness affecting

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Hot deformation behaviors of a 9Cr oxide dispersion-strengthened steel and its microstructure characterization

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International Journal of Minerals,Metallurgy and Materials 2019年第5期26卷 597-610页

作者： yu Shao Li-ming yu yong-chang Liu Zong-qing Ma Hui-jun Li jie-feng Wu State Key Lab of Hydraulic Engineering Simulation and Safety Tianjin Key Lab of Composite and Functional Materials Tianjin University Institute of Plasma Physics Chinese Academy of Sciences

The hot deformation behaviors of a 9 Cr oxide dispersion-strengthened(9 Cr-ODS) steel fabricated by mechanical alloying and hot isostatic pressing(HIP) were investigated. Hot compression deformation experiments were conducted on a Gleeble 3500 simulator in a temperature range of 950–1100°C and strain rate range of 0.001–1 s^(-1). The constitutive equation that can accurately describe the relationship between the rheological stress and the strain rate of the 9 Cr-ODS steel was established, and the deformation activation energy was calculated as 780.817 kJ/mol according to the data obtained. The processing maps of 9 Cr-ODS in the strain range of 0.1–0.6 were also developed. The results show that the region with high power dissipation efficiency corresponds to a completely recrystallized structure. The optimal processing conditions were determined as a temperature range of 1000–1050°C with strain rate between 0.003 and 0.01 s^(-1).

关键词： hot deformation constitutive equations processing maps microstructural evolution

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