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Chinese Chemical Letters 2010年第12期21卷 1482-1486页

作者： Hai Yan Fu Hai Long Wu Jin Fang Nie yong jie yu Hong Yan Zou Ru Qin yu State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering Hunan University Changsha 410082 China

A rapid,green and highly sensitive excitation-emission matrix（EEM） fluorescence method was proposed for analysis of irinotecan（CPT-11） in biological fluids including human plasma and urine samples of uncalibrated interferences with the aid of second-order *** to the serious spectral overlapping from biological matrices,the parallel factor analysis（PARAFAC） and the alternating normalization-weighted error（ANWE） have been recommended to perform directly calibration and overcome the problem which makes the traditional fluorospectrophotometer in *** results can be ***, performance of the proposed method was evaluated based on figures of merit and some statistical *** accuracy of both algorithms was validated by the elliptical joint confidence region（EJCR） *** precision and repeatability were also investigated by the relative standard deviations（RSDs） of intra-day and inter-day.

关键词： Irinotecan Biological fluids Excitation-emission matrix fluorescence PARAFAC ANWE

Multiple Episodes of Zircon Growth during Anatectic Metamorphism of Metasedimentary Rocks in Collisional Orogens:Constraints from Felsic Granulites in the Bohemian Massif

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Journal of Earth Science 2023年第3期34卷 609-639页

作者： Guang Yang Ren-Xu Chen yong-Fei Zheng Qiong-Xia Xia yong-jie yu Kun Li Zhaochu Hu Bing Gong Xiang-Ping Zha CAS Key Laboratory of Crust-Mantle Materials and Environments School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China Center of Excellence for Comparative Planetology Chinese Academy of Sciences(CAS)Hefei 230026China Frontiers Science Center for Planetary Exploration and Emerging Technologies University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Geological Processes and Mineral Resources Faculty of Materials Science and ChemistryChina University of GeosciencesWuhan 430078China

Zircon is a key accessary mineral for metamorphic geochronology and geochemical tracing,but it has been a challenge to interpret its complex chemical zoning and age record acquired during multiple episodes of anatectic metamorphism in collisional *** is illustrated by a combined study of petrography,phase equilibrium modeling and metamorphic P-T-t determination for granulites from the Bohemian Massif in the Variscan *** rocks record multiple episodes of zircon growth during anatectic *** started from the compressional heating for prograde metamorphism to high-pressure(HP)to ultrahigh-pressure(UHP)eclogite facies with low degrees of partial ***,they underwent a decompressional stage from UHP eclogite facies to HP granulite facies for dehydration *** were followed by a further decompressional stage either to kyanite granulite facies or to sillimanite granulite facies at ultrahigh-temperature(UHT)*** of zircon growth are linked to specific metamorphic conditions for peritectic reactions on the basis of zoning patterns,trace element signatures,index mineral inclusions in dated domains and textural relationships to coexisting *** results indicate that relict zircon domains are preserved even at UHT granulite facies conditions.A few zircon domains in the kyanite granulite grew during the prograde to peak UHP metamorphism,possibly corresponding to consumption of biotite and plagioclase but growth of *** the decompressional exhumation to the HP granulite-facies,relict or prograde zircon domains were mostly dissolved into anatectic melts produced by muscovite *** zircon grains grew during this transition to the HP granulite-facies in the kyanite granulite and are chemically related to continuous growth of garnet,whereas abundant zircon grains grew subsequently at the UHT granulite facies in the sillimanite granulite and are chemically related to garnet breakdown reactions.A

关键词： ultrahigh-pressure metamorphism ultrahigh-temperature metamorphism felsic granulite zircon continental collision crustal anataxis

Simultaneous determination of metronidazole and tinidazole in plasma by using HPLC-DAD coupled with second-order calibration

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Chinese Chemical Letters 2010年第10期21卷 1223-1226页

作者： Li Qun Ouyang Hai Long Wu Ya Juan Liu Jian yue Wang yong jie yu Hong Yan Zou Ru Qin yu State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering Hunan University Changsha 410082 China Zhoushan Municipal Center for Disease Control & Prevention Zhoushan 310062 China

A method using HPLC-DAD coupled with second-order calibration was developed to simultaneously determine metronidazole and tinidazole in plasma samples in this paper. The second-order calibration method based on APTLD （alternating penalty trilinear decomposition） algorithm was proposed to analyze the three-way HPLC-DAD data from both standard and prediction samples, which makes it possible that calibration can be performed even in the presence of unknown interferences with a simple and green chromatographic condition and short analysis time. The results showed that good recoveries were obtained although the chromatographic and spectral profiles of the analytes of interest as well as background were partially overlapped with each other in plasma samples.

关键词： HPLC-DAD Second-order calibration Alternating penalty trilinear decomposition (APTLD) Metronidazole Tinidazole Plasma

An integrated GPS /DR navigation system for AUV

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Journal of Marine Science and Application 2006年第4期5卷 8-13页

作者： PANG yong-jie SUN yu-shan GAN yong WAN Lei College of Shipbuilding Engineering Harbin Engineering University Harbin 150001 China

GPS/Dead-reckoning navigation system for autonomous underwater vehicle (AUV) is introduced, which includes navigation overall architecture, hardware and software structure. Dead-reckoning theory is presented in details. And the strong tracking Kalman filter and Singer model are applied to handle the imprecise navigation mode, which can improve the navigation system’s precision and reliability. Finally, the sea experiments which include autonomous search mission in an unknown area and long distance motion are conducted to demonstrate the reliability and feasibility of the navigation system.

关键词： AUV GPS dead-reckoning strong tracking Kalman filter (STKF)

Multiple Episodes of Zircon Growth during Anatectic Metamorphism of Metasedimentary Rocks in Collisional Orogens: Constraints from Felsic Granulites in the Bohemian Massif

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Journal of Earth Science 2021年

作者： Guang Yang Ren-Xu Chen yong-Fei Zheng Qiong-Xia Xia yong-jie yu Kun Li Zhaochu Hu Bing Gong Xiang-Ping Zha CAS Key Laboratory of Crust-Mantle Materials and Environments， School of Earth and Space Sciences， University of Science and Technology of China Center of Excellence for Comparative Planetology， Chinese Academy of Sciences (CAS) Frontiers Science Center for Planetary Exploration and Emerging Technologies， University of Science and Technology of China State Key Laboratory of Geological Processes and Mineral Resources， Faculty of Earth Sciences， China University of Geosciences

Zircon is a key accessary mineral for metamorphic geochronology and geochemical tracing， but it has been a challenge to interpret its complex chemical zoning and age record acquired during multiple episodes of anatectic metamorphism in collisional orogens. This is illustrated by a combined study of petrography， phase equilibrium modeling and metamorphic P-T-t determination for granulites from the Bohemian massif in the Variscan orogen. These rocks record multiple episodes of zircon growth during anatectic metamorphism. They started from the compressional heating for prograde metamorphism to high-pressure （HP） to ultrahigh-pressure （UHP） eclogite facies with low degrees of partial melting. Afterwards， they underwent a decompressional stage from UHP eclogite facies to HP granulite facies for dehydration melting. These were followed by a further decompressional stage either to kyanite granulite facies or to sillimanite granulite facies at ultrahigh-temperature （UHT） conditions. Episodes of zircon growth are linked to specific metamorphic conditions for peritectic reactions on the basis of zoning patterns， trace element signatures， index mineral inclusions in dated domains and textural relationships to coexisting minerals. The results indicate that relict zircon domains are preserved even at UHT granulite facies conditions. A few zircon domains in the kyanite granulite grew during the prograde to peak UHP metamorphism， possibly corresponding to consumption of biotite and plagioclase but growth of garnet. During the decompressional exhumation to the HP granulite-facies， relict or prograde zircon domains were mostly dissolved into anatectic melts produced by muscovite breakdown. Most zircon grains grew during this transition to the HP granulite-facies in the kyanite granulite and are chemically related to continuous growth of garnet， whereas abundant zircon grains grew subsequently at the UHT granulite facies in the sillimanite granulite and are chemically related to garn

关键词：

Multiple Episodes of Zircon Growth during Anatectic Metamorphism of Metasedimentary Rocks in Collisional Orogens: Constraints from Felsic Granulites in the Bohemian Massif

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Journal of Earth Science 2021年

Zircon is a key accessary mineral for metamorphic geochronology and geochemical tracing， but it has been a challenge to interpret its complex chemical zoning and age record acquired during multiple episodes of anatectic metamorphism in collisional orogens. This is illustrated by a combined study of petrography， phase equilibrium modeling and metamorphic P-T-t determination for granulites from the Bohemian massif in the Variscan orogen. These rocks record multiple episodes of zircon growth during anatectic metamorphism. They started from the compressional heating for prograde metamorphism to high-pressure (HP) to ultrahigh-pressure (UHP) eclogite facies with low degrees of partial melting. Afterwards， they underwent a decompressional stage from UHP eclogite facies to HP granulite facies for dehydration melting. These were followed by a further decompressional stage either to kyanite granulite facies or to sillimanite granulite facies at ultrahigh-temperature (UHT) conditions. Episodes of zircon growth are linked to specific metamorphic conditions for peritectic reactions on the basis of zoning patterns， trace element signatures， index mineral inclusions in dated domains and textural relationships to coexisting minerals. The results indicate that relict zircon domains are preserved even at UHT granulite facies conditions. A few zircon domains in the kyanite granulite grew during the prograde to peak UHP metamorphism， possibly corresponding to consumption of biotite and plagioclase but growth of garnet. During the decompressional exhumation to the HP granulite-facies， relict or prograde zircon domains were mostly dissolved into anatectic melts produced by muscovite breakdown. Most zircon grains grew during this transition to the HP granulite-facies in the kyanite granulite and are chemically related to continuous growth of garnet， whereas abundant zircon grains grew subsequently at the UHT granulite facies in the sillimanite granulite and are chemically related to garn

关键词： ultrahigh-pressure metamorphism ultrahigh-temperature metamorphism felsic granulite continental collision crustal anataxis

Viscosity and structure relationship with equimolar substitution of CaO with MgO in the CaO–MgO–Al_(2)O_(3)–SiO_(2)slag melts

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 70-79页

作者： yong Hou Shuo Zhang jie Dang Jia Guo Hanghang Zhou Xuewei Lü College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Chongqing Key Laboratory of Vanadium-Titanium Metallurgy and New Materials Chongqing UniversityChongqing 400044China

Currently,the Al_(2)O_(3)content in the high-alumina slag systems within blast furnaces is generally limited to 16wt%–18.5wt%,making it challenging to overcome this *** most studies that concentrated on managing the MgO/Al_(2)O_(3)ratio or basicity,this paper explored the effect of equimolar substitution of MgO for CaO on the viscosity and structure of a high-alumina CaO-MgO-Al_(2)O_(3)-SiO_(2)slag system,providing theoretical guidance and data to facilitate the application of high-alumina *** results revealed that the viscosity first decreased and then increased with higher MgO substitution,reaching a minimum at 15mol%MgO *** transform infrared spectroscopy(FTIR)results found that the depths of the troughs representing[SiO_(4)]tetrahedra,[AlO_(4)]tetrahedra,and Si-O-Al bending became progressively deeper with increased MgO *** of the Raman spectra showed that the average number of bridging oxygens per Si atom and the X_(Q^(3))/X_(Q^(2))(X_(Q^(i))is the molar fraction of Q^(i) unit,and i is the number of bridging oxygens in a[SiO_(4)]tetrahedral unit)ratio increased from 2.30 and 1.02 to 2.52 and 2.14,respectively,indicating a progressive polymerization of the silicate structure.X-ray photoelectron spectroscopy(XPS)results highlighted that non-bridging oxygen content decreased from 77.97mol% to 63.41mol% with increasing MgO concentration,whereas bridging oxygen and free oxygen contents *** analysis demonstrated a gradual increase in the polymerization degree of the tetrahedral structure with the increase in MgO ***,bond strength is another important factor affecting the slag *** occurrence of a viscosity minimum can be attributed to the complex evolution of bond strengths of non-bridging oxygens generated during depolymerization of the[SiO_(4)]and[AlO_(4)]tetrahedral structures by CaO and MgO.

关键词： aluminosilicate viscosity structure spectroscopy

Ideal Bi‑Based Hybrid Anode Material for Ultrafast Charging of Sodium‑Ion Batteries at Extremely Low Temperatures

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Nano-Micro Letters 2025年第3期17卷 152-167页

作者： jie Bai Jian Hui Jia yu Wang Chun Cheng Yang Qing Jiang Key Laboratory of Automobile Materials(Jilin University) Ministry of EducationSchool of Materials Science and EngineeringJilin UniversityChangchun 130022People’s Republic of China

Sodium-ion batteries have emerged as competitive substitutes for low-temperature applications due to severe capacity loss and safety concerns of lithium-ion batteries at−20°C or ***,the key capability of ultrafast charging at ultralow temperature for SIBs is rarely ***,a hybrid of Bi nanoparticles embedded in carbon nanorods is demonstrated as an ideal material to address this issue,which is synthesized via a high temperature shock *** a hybrid shows an unprecedented rate performance(237.9 mAh g^(−1)at 2 A g^(−1))at−60℃,outperforming all reported SIB anode *** with a Na_(3)V_(2)(PO_(4))_(3)cathode,the energy density of the full cell can reach to 181.9 Wh kg^(−1)at−40°*** on this work,a novel strategy of high-rate activation is proposed to enhance performances of Bi-based materials in cryogenic conditions by creating new active sites for interfacial reaction under large current.

关键词： Bi nanoparticles High temperature shock High-rate activation Ultrafast charging Low-temperature sodium-ion batteries

Low-frequency Broadband Janus-Helmholtz Underwater Acoustic Transducer

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Low-frequency Broadband Janus-Helmholtz Underwater Acoustic ...

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

2011年全国压电和声波理论及器件应用研讨会

作者： SANG yong-jie~*,LAN yu Science and Technology on Underwater Acoustic Laboratory,Harbin Engineering University.150001 Harbin

＜正＞In this paper,using the finite element software ANSYS,the structural parameters of Janus-Helmholtz transducer were optimized to obtain excellent acoustic radiation properties in range of *** on optimization results produced a Janus-Helmholtz transducer test prototype,test results show that the simulation results and experimental

关键词： Janus-Helmholtz transducer Finite element Transmitting voltage response

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin Yin Yalan Xu jie Mu yu Leng Lei Ma yu Zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions