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Some New Fossil Localities in the Eastern Tsinling

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地质学报 1938年第Z1期 227-239页

作者： YUEH-YEN lee Geological Survey of China

Ⅰ.INTRODUCTION The Tsinling range is situated in the central part of China and trendsin an east-west *** to the present time,its extensions andboundaries have not yet been definitely defined and the term"EasternTsinl... 详细信息

关键词： Some New Fossil Localities in the Eastern Tsinling

Improving the conduct of meta-analyses of observational studies

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World Journal of Meta-Analysis 2018年第3期6卷 21-28页

作者： Peter N lee P.N. lee Statistics and Computing Ltd.

The author, who has published numerous meta-analyses of epidemiological studies, particularly on tobacco, comments on various aspects of their content. While such meta-analyses, even when well conducted, are more difficult to draw inferences from than are meta-analyses of clinical trials, they allow greater insight into an association than do simple qualitative reviews. This editorial starts with a discussion of some problems relating to hypothesis definition. These include the definition of the outcome, the exposure and the population to be considered, as well as the study inclusion and exclusion criteria. Under literature searching, the author argues against restriction to studies published in peer-reviewed journals, emphasising the fact that relevant data may be available from other sources. Problems of identifying studies and double counting are discussed, as are various issues in regard to data entry. The need to check published effect estimates is emphasised, and techniques to calculate estimates from material provided in the source publication are described. Once the data have been collected and an overall effect estimate obtained, tests for heterogeneity should be conducted in relation to different study characteristics. Though some meta-analysts recommend classifying studies by an overall index of study quality, the author prefers to separately investigate heterogeneity by those factors which contribute to the assessment of quality. Reasons why an association may not actually reflect a true causal relationship are also discussed, with the editorial describing techniques for investigating the relevance of confounding, and referring to problems resulting from misclassification of key variables. Misclassification of disease, exposure and confounding variables can all produce a spurious association, as can misclassification of the variable used to determine whether an individual can enter the study, and the author points to techniques to adjust for this. Issues

关键词： Hypothesis definition Literature searching Heterogeneity Publication bias Misclassification Confounding Meta-analysis

A two-stage algorithm of adaptive model-based parameter estimation and its application in the fast calculation of Green’s function in multi-layer soils

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Progress in Natural Science:Materials International 2004年第10期 87-93页

作者： lee Jae-bok Changwon641-600 Korea Electrotechnology Research Institute

A two-stage algorithm is presented to determine an analytical model-based rational function by adaptively selecting sam-pling *** the first stage,the rational interpolation function is created by using Stoer-Bulirsch algorithm and comparing the fitted model with the different *** the second stage,the fitted model is validated by comparing with the first-principle model at a set of checking *** checking points will be added to the sampling series determined in the first stage to improve the fitted *** new proposed algorithm is more accurate and effective than that using Stoer-Bulirsch interpolation only due to the fact that it appends the validation *** a highly oscillating curve is approximated,the validation ensures the fitting *** the two-stage MBPE algorithm,some time-consuming electromagnetic computations can be replaced by the interpolation from the fitting functions,which can increase the computational efficiency *** method is used to calculate the samplings of the Green’s functions in a multi-layer horizontal soil to demonstrate its *** number of samples used to accurately model such Green’s functions is less than20for the typical soil *** computational time can be reduced by more than two orders of magnitude compared with that using the conventional uniform sampling technology.

关键词： model-based parameter estimation adaptive sampling multi-layer soil Green’s functions

Topological conformational changes of human papillomavirus(HPV)DNA bound to an insoluble aluminum salt—A study by low temperature PCR

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Advances in Biological Chemistry 2013年第1期3卷 76-85页

作者： Sin Hang lee Milford Hospital and Milford Molecular Laboratory MilfordConnecticutUSA

A low temperature (LoTemp?) polymerase chain reaction (PCR), conducted at cycling temperatures not to exceed 85℃and catalyzed by a novel highly processive HiFi? DNA polymerase with proofreading function, was used to study the topological conformational changes of the human papillomavirus (HPV) L1 gene DNA fragments bound to the insoluble amorphous aluminum hydroxyphosphate sulfate (AAHS) adjuvant in the quadrivalent HPV vaccine, Gardasil?. L1 gene DNA fragments of HPV-11, HPV-18 and HPV-16 were detected in the AAHS particles by nested PCR, but all were lacking a region that was amplifiable by an MY09 degenerate primer. In addition, a pair of degenerate consensus GP6/MY11 primers was able to amplify a target segment of the HPV-11 L1 gene DNA and the HPV-18 L1 gene DNA bound to the AAHS particles as expected for any HPV DNA in the B-conformation. However, there was no co-amplification of the HPV-16 L1 gene DNA known to coexist in the same samples. The lack of co-amplification was verified by direct DNA sequencing of the PCR amplicons. The companion HPV-16 L1 gene DNA in the same sample required repeated PCRs with a pair of modified non-degenerate GP6/ MY11 primers for detection. This melting profile of the HPV-16 L1 gene DNA was similar to that of the HPV-16 L1 gene DNA recently discovered in the postmortem blood of a young woman who suffered a sudden unexpected death 6 months after Gardasil? vaccination. The findings suggest that the topological conformational changes in the HPV L1 gene DNA residues bound to the AAHS adjuvant may be genotype-related. The special non-B-conformation may prevent the HPV-16 L1 gene DNA from being degraded in the body of the vaccine recipients after in- tramuscular injection.

关键词： Low Temperature PCR HPV DNA Conformation Gardasil^■ Postmortem AAHS Adjuvant Aluminum

The Eafly Tediary Deposits of the Yuanchü Basin on the Honan-Shansi Border

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地质学报 1938年第Z1期 241-257+441-442页

作者： YUEH-YEN lee Geological Survey of China

Ⅰ.INTRODUCTION The early Tertiary deposits of Yuanchü,Shansi and of Mienchih,Honan were discovered in 1916 and restudied in 1921 by ***;.

关键词： De Basin on the Honan-Shansi Border The Eafly Tediary Deposits of the Yuanch

nhalation of Sevoflurane and Desflurane Can Not Affect QT Interval, Corrected QT, Tp-Te/QT or Tp-Te/JT in Children

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Chinese Medical Journal 2018年第6期131卷 739-740页

作者： Ji-Hyun lee Eun-Hee Kim Young-Eun Jang Jin-Tae Kim Hee-Soo Kim Department of Anesthesiology and Pain Medicine Seoul National University Hospital Seoul 03080 Korea

To the Editor： Sevoflurane and desflurane are tile most common general anesthetics used in children. Previous study has shown that these agents can affect the electrocardiogram （ECG） markers,i^i leading to fatal ventricular arrhythmia. The followings were identified as useful indices for predicting and estimating the occurrence of a fatal arrhythmia： the interval between the peak and the end of T wave （Tp-Te） the ratio of the Tp-Te interval to the QT interval （[Tp-Te/QT]）, and the JY interval （JT）, which is measured from the end of the QRS complex to Te.

关键词： QT 孩子心电图代理人 QRS 建筑群心律学习

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Analyzing the H19-and T65-epitopes in 38 kd phosphory-lated protein of Marek's disease viruses and comparing chicken immunological reactions to viruses point-mutated in the epitopes

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Science China(Life Sciences) 2004年第1期47卷 82-91页

作者： lee Lucy F Avian Disease and Oncology Laboratory East Lansing Ml 48823 USA

DNA sequencing analysis in 38 kd phosphorylated protein (pp38) ORF of Marek's disease viruses (MDV) indicated that all tested 10 virulent strains with different pathotypes had 'A' at base #320 and glutamine at aa#107 while reacted with monoclonal antibody (Mab) H19 in indirect fluorescence antibody test (IFA). However, vaccine strain CVI988 had 'G' at base#320 and arginine at aa#107 instead, when it was negative in IFA with Mab H19. Some strains were also reactive with Mab T65 in IFA while there was 'G' at base #326 and glycine at aa#109, but the other strains, which had 'A' at base #326 and glutamic acid at aa#109, did not react with Mab T65. By comparison of CVI988 to its point mutants CVI/rpp38(AG) and CVI/rpp38(AA) with 1 or 2 base(s) changes at bases #320 and /or #326 of pp38 gene for their reactivity with Mab H19 and T65, it was confirmed that the glutamine at aa#107 and glycine at aa#109 were critical to epitopes H19 and T65 respectively. Immuno-reactions to MDV were compared in SPF chickens inoculated with cloned CVI988 and its mutant CVI/rpp38(AG). It was found that antibody responses to MDV in chickens inoculated with CVI/rpp38(AG) were delayed and significantly lower than that in chickens inoculated with the native CVI988. By differential comparison of antibody titers to different antigens, a third epitope specific to CVI988 and dependent on arginine at aa#107 was suggested to be responsible for the big difference in antibody responses induced by native CVI988 and its mutant.

关键词： Marek's disease virus, pp38 gene, point mutant, epitopes, antibody responses.

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Undifferentiated pleomorphic sarcoma of the liver presenting as a unilocular cyst

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Hepatobiliary & Pancreatic Diseases International 2009年第5期8卷 541-543页

作者： Hyun-Soo Kim Gou Young Kim Sung-Jig Lim Sang Mok lee Youn Wha Kim Departments of Pathology School of MedicineKyung Hee University1 Hoegi-dongDongdaemun-gu130-702 SeoulSouth Korea Departments of Surgery School of MedicineKyung Hee University1 Hoegi-dongDongdaemun-gu130-702 SeoulSouth Korea

BACKGROUND:A malignant fibrous histiocytoma,recently referred to as an undifferentiated pleomorphic sarcoma (UPS),is very rare in the liver,and only 34 cases of primary hepatic malignant fibrous histiocytoma have been reported in the English literature. METHODS:We report a rare case of a hepatic UPS presenting as a unilocular cystic lesion with respect to histopathologic features,the newly revised diagnostic criteria,and the differential diagnosis. RESULTS:A 60-year-old man presented for evaluation of epigastric pain of 7 months *** computed tomography revealed a hypodense,unilocular cystic mass in the right lobe of the liver,measuring 14.0×11.1 cm.A right lobectomy was ***,the cut surface showed a single,well-circumscribed unilocular cystic tumor mass containing dark red-brown necrotic debris and blood clots, which occupied most of the ***,the tumor consisted of haphazardly arranged mononuclear pleomorphic tumor cells,admixed with abundant osteoclast- like multinucleated giant ***,the tumor cells expressed vimentin *** histopathologic and immunohistochemical findings were compatible with a *** patient is alive and well 41 months after surgery without recurrence. CONCLUSIONS:Clinically,most of the hepatic UPSs are solid *** two cases have presented as multilocular cystic masses.A primary hepatic UPS presenting as a unilocular cyst has never been reported.A UPS should be included in the differential diagnosis of unilocular cystic lesions in the liver.

关键词： undifferentiated pleomorphic sarcoma malignant fibrous histiocytoma liver unilocular cyst

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Remaining Vigilant Can even a one-sided collapse crash China’s economy?

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Beijing Review 2014年第28期57卷 36-37页

作者： Ann lee New York University

The topic of shadow banking has now become the topic du jour of what will crash the Chinese economy. Before that, it was the real estate bubble, and before that, the rising cost of cheap labor. Of course, many wrong predictions later, the bears of China continue to prognosticate that China will crash because they have a vested inter- est in seeing China crash. I am not going to say that China will never hit a speed bump. In fact, I think that scenario is likely, but not for the reasons that the China bears often use. But first, the shadow banking issue.

关键词：中国经济房地产泡沫劳动力成本 EST 减速带银行影子