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干粉吸入剂辅料的研究进展

海峡药学 2024年第2期36卷 6-8页

作者：叶永浩于希肖颖陈永奇珠海瑞思普利医药科技有限公司广东珠海519000 澳门科技大学医学院中国澳门999078 澳门科技大学中药质量研究国家重点实验室中国澳门999078

干粉吸入剂(DPI)是一种通过肺部给药的制剂,具有生物利用度高、起效快、无首过效应以及无污染等众多优点,在国内外已有多款产品上市销售。干粉吸入剂是吸入制剂的其中一种,属于化学高端制剂,有着巨大的市场潜力。同时其技术壁垒高,开发... 详细信息

干粉吸入剂(DPI)是一种通过肺部给药的制剂,具有生物利用度高、起效快、无首过效应以及无污染等众多优点,在国内外已有多款产品上市销售。干粉吸入剂是吸入制剂的其中一种,属于化学高端制剂,有着巨大的市场潜力。同时其技术壁垒高,开发难度较大,已成为医药行业研究的热点和难点。本文就对干粉吸入剂的辅料研究进展进行归纳和总结,期望为干粉吸入制剂处方开发中辅料的选择提供参考。

关键词：干粉吸入剂辅料乳糖亮氨酸甘露醇硬脂酸镁

SUBSTRUCTURE PRECONDITIONERS FOR NONCONFORMING PLATE ELEMENTS

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Journal of Computational Mathematics 1998年第4期16卷 289-304页

作者： Shi, ZC Xie, zh Chinese Acad Sci ICMSEC State Key Lab Sci & Engn Comp Beijing 100080 Peoples R China Chinese Acad Sci Inst Atmospher Phys LASG Beijing 100080 Peoples R China

In this paper, we consider the problem of solving finite element equations of biharmonic Dirichlet problems. We divide the given domain into non-overlapping subdomains, construct a preconditioner for Morley element by substructuring on the basis of a function decomposition for discrete biharmonic functions. The function decomposition is introduced by partitioning these finite element functions into the low and high frequency components through the intergrid transfer operators between coarse mesh and fine mesh, and the conforming interpolation operators. The method leads to a preconditioned system with the condition number bounded by C(1 + log(2) H/h) in the case with interior cross points, and by C in the case without interior cross points, where H is the subdomain size and h is the mesh size. These techniques are applicable to other nonconforming elements and are well suited to a parallel computation.

关键词： substructure preconditioner biharmonic equation nonconforming plate element

MULTIGRID METHODS FOR MORLEY ELEMENT ON NONNESTED MESHES

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Journal of Computational Mathematics 1998年第5期16卷 385-394页

作者： Shi, ZC Xie, zh Chinese Acad Sci ICMSEC State Key Lab Sci & Engn Comp Beijing 100080 Peoples R China Chinese Acad Sci Inst Atmospher Phys LASG Beijing 100080 Peoples R China

In this paper, we consider some multigrid algorithms for the biharmonic problem discretized by Morley element on nonnested meshes. Through taking the averages of the nodal variables we construct an intergrid transfer operator that satisfies a certain stable approximation property. The so-called regularity-approximation assumption is then established. Optimal convergence properties of the W-cycle and a uniform condition number estimate for the variable V-cycle preconditioner are presented. This technique is applicable to other nonconforming plate elements.

关键词： multigrid method Morley element nonnested meshes

Laser and Fluorescence Properties of Organic Dye DCM Doped Sol-Gel-Derived Solid-State Materials

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Journal of Materials Science & Technology 1999年第6期15卷 563-566页

作者： zh.ng, QY Jiang, zh Tongji Univ Pohl Inst Solid State Phys Shanghai 200092 Peoples R China Chinese Acad Sci Shanghai Inst Opt & Fine Mech Shanghai 201800 Peoples R China

Two kinds of new Ormosil xerogels derived from GPTMS (3-glycidyl propyl trimethoxisilane) and TEOS (tetraethoxysilane) or GPTMS and Ti(OBu)4 (tetrabutoxytitanate) were synthesized viathe sol-gel method as dye laser host. Their optical properties, microstructure characteristics and sudece laser damage thresholds have been reported. The effects of dye matrix combination on the fluorescence emission, slope efficiency, photostability and tunable bandwidth were *** oscillation was easily achieved near 620 nm with a slope efficiency of 29% from DCM dopedSiO2-Ormosil pumped by a frequency-doubled radiation from a Q-switched Nd:YAG laser. The laser wavelength was tunable over 59 nm, and the laser output energy had only a 10% reduction after 2.5× 104 pulses at a pump repetition rate of 1Hz and a pump intensity of 1

关键词： GPTMS DCM EtOH

Magneto-rheological elastomer (MRE) based composite structures for micro-vibration control

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Earthquake Engineering and Engineering Vibration 2010年第3期9卷 345-356页

作者： YQ Ni ZG Ying zh.Chen Department of Civil and Structural Engineering The Hong Kong Polytechnic University Hung Horn Kowloon Hong Kong China Department of Mechanics Zhejiang University Hangzhou 310027 China

Magneto-rheological elastomers （MILEs） are used to construct composite structures for micro-vibration control of equipment under stochastic support-motion excitations. The dynamic behavior of MREs as a smart viscoelastic material is characterized by a complex modulus dependent on vibration frequency and controllable by external magnetic fields. Frequency-domain solution methods for stochastic micro-vibration response analysis of the MRE-based structural systems are developed to derive the system frequency-response function matrices and the expressions of the velocity response spectrum. With these equations, the root-mean-square （RMS） velocity responses in terms of the one-third octave frequency band spectrum can be calculated. Further, the optimization problem of the complex moduli of the MRE cores is defined by minimizing the velocity response spectra and the RMS velocity responses through altering the applied magnetic fields. Simulation results illustrate the influences of MRE parameters on the RMS velocity responses and the high response reduction capacities of the MRE-based structures. In addition, the developed frequency-domain analysis methods are applicable to sandwich beam structures with arbitrary cores characterized by complex shear moduli under stochastic excitations described by power spectral density functions, and are valid for a wide frequency range.

关键词： magneto-rheological elastomer (MRE) micro-vibration control equipment composite structure sandwich beam stochastic excitation

Investigation of the Surface Properties of Vinyl Ethers – Sodium 2-Acrylamido-2-Methylpropanesulfonate Copolymers

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Advances in Materials Physics and Chemistry 2012年第4期2卷 177-180页

作者： S. Kh. Khussain E. M. Shaikhutdinov N. zh. Seitkaliyeva A. zh. zh.nisova Department of applied chemistry Kazakh National Technical University named after Kanysh Satpaev Almaty Kazakhstan

The surface properties of water soluble copolymers vinyl ethers of monoethanolamine and ethylene glycol with sodium 2-acrylamido-2-methyl-propanesulfonate were investigated by studying adsorption at the aqueous solution – air interface. It is found that copolymers have considerably higher surface activity in comparison with poly- sodium 2-acrylamido-2-methyl-propanesulfonate.

关键词： Surface Active Copolymers Adsorption Interface Standard Free Energy of Adsorption

感恩拓延-建构理论干预在抑郁症患者延续性护理中的价值

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中国医药导报 2024年第9期21卷 161-165页

作者：王俞帆徐涌陈叶浙江省绍兴市第七人民医院焦虑障碍科浙江绍兴312000 浙江省绍兴市第七人民医院老年精神科浙江绍兴312000

目的探讨感恩拓延-建构理论干预在抑郁症患者延续性护理中的价值。方法选取2021年5月至2022年5月浙江省绍兴市第七人民医院收治的抑郁症患者600例,按照随机数字表法将其分为对照组和研究组,各300例。对照组采用常规延续性护理,研究组... 详细信息

目的探讨感恩拓延-建构理论干预在抑郁症患者延续性护理中的价值。方法选取2021年5月至2022年5月浙江省绍兴市第七人民医院收治的抑郁症患者600例,按照随机数字表法将其分为对照组和研究组,各300例。对照组采用常规延续性护理,研究组采用感恩拓延-建构理论指导的延续性护理。比较两组干预前后抑郁改善情况[抑郁症状群量表(PHQ-9)、汉密尔顿抑郁量表(HAMD)]、功能失调情况[功能失调态度量表(DAS)]、幸福感[总体幸福感量表(GWB)]、医学应对方式[医学应对方式问卷(MCMQ)]、生活质量(世界卫生组织生活质量-100量表)。结果干预后,两组PHQ-9、HAMD评分均低于干预前,且研究组低于对照组(P<0.05);干预后,两组DAS评分低于干预前、GWB评分高于干预前,且研究组DAS评分低于对照组、GWB评分高于对照组(P<0.05);干预后,两组屈服应对、回避应对得分低于干预前,面对应对得分高于干预前;且研究组屈服应对、回避应对得分低于对照组,面对应对得分高于对照组(P<0.05);干预后,两组心理、独立性、社会关系及总分高于干预前,且研究组高于对照组(P<0.05)。结论在抑郁症患者中应用感恩拓延-建构理论指导的延续性护理能够改善抑郁症状及生活质量,优化患者医学应对方式,干预效果显著,值得临床推广应用。

关键词：抑郁症延续性护理感恩拓延-建构理论生活质量

Solid liquid Mixed Casting of Al-Si Alloy

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Journal of Central South University 2000年第3期12卷 133-135页

作者： Chen, zh.Kang, ZT Cent S Univ Technol Dept Mat Sci & Engn Changsha 410083 Peoples R China

The paper presents a novel material preparation technology—Solid liquid mixed casting technology. In the technology, large amounts of homogeneous alloy powder or heterogenous powder with perfect wettability are added into the superheated melt. After strong agitation, the mixed melt can be cast or hot processed. Applying solid liquid mixed casting, three kinds of Al Si alloys were investigated. The results show that, when the mass of powder accession to alloy melt is about 1, the mean size of primary Si in hyper eutectic alloy can be controlled at less than 5 μm; and the mean grain size of α phase in hypo eutectic alloy is less than 10 μm. This technology has the advantage of preparing material with very fine microstructure by fairly simple casting process, and may be a new practicable and valuable metal preparation technology.

关键词： solid liquid mixed casting powder melt Document code:A

A Simple and Novel Ipso-Bromination of 1-Bromomethyl-4-t-butyl-2,6-dimethylbenzene

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Chinese Chemical Letters 1997年第4期8卷 271-274页

作者： zh.ng, WC Yu, zh CHINESE ACAD SCI INST CHEMBEIJING 100080PEOPLES R CHINA

A novel ipso electrophlic substitution of 1-bromomethyl-4-t-butyl-2,6-dimethylbenzene 1 with nitric acid in alcohol, which gives ipso-bromination product of 1-bromo-4-t-butyl-2,6-dimethylbenzene 2, is described and a ... 详细信息

关键词： NITRATION