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Characteristics of proppant transport and placement within rough hydraulic fractures

Petroleum Exploration and Development 2024年第2期51卷 453-463页

作者： HUANG Hai zheng yong WANG Yi WANG Haizhu NI Jun WANG Bin YANG Bing ZHANG Wentong School of Petroleum Engineering Xi’an Shiyou UniversityXi’an 710065China Shaanxi Key Laboratory of Carbon Dioxide Sequestration and Enhanced Oil Recovery Xi’an 710075China Shaanxi Provincial Key Laboratory of Oil and Gas Well and Reservoir Seepage and Rock Mechanics Xi’an 710065China Oil&Gas Field Production Construction Division PetroChina Tarim Oilfield CompanyKorla 841000China National Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing 102249China Shaanxi Yanchang Petroleum(Group)Co. Ltd.Xi’an 710075China

A three-dimensional reconstruction of rough fracture surfaces of hydraulically fractured rock outcrops is carried out by casting process,a large-scale experimental setup for visualizing rough fractures is built to perform proppant transport *** typical characteristics of proppant transport and placement in rough fractures and its intrinsic mechanisms are investigated,and the influences of fracture inclination,fracture width and fracturing fluid viscosity on proppant transport and placement in rough fractures are *** results show that the rough fractures cause variations in the shape of the flow channel and the fluid flow pattern,resulting in the bridging buildup during proppant transport to form unfilled zone,the emergence of multiple complex flow patterns such as channeling,reverse flow and bypassing of sand-carrying fluid,and the influence on the stability of the sand *** proppant has a higher placement rate in inclined rough fractures,with a maximum increase of 22.16 percentage points in the experiments compared to vertical fractures,but exhibits poor stability of the sand *** fracture width aggravates the bridging of proppant and induces higher pumping *** the viscosity of the fracturing fluid can weaken the proppant bridging phenomenon caused by the rough fractures.

关键词： reservoir fracturing rough fracture proppant transport and placement characteristics bridging buildup

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Clinical efficacy and mechanism study of mid-frequency anti-snoring device in treating moderate obstructive sleep apnea-hypopnea syndrome

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World Journal of Clinical Cases 2024年第5期12卷 942-950页

作者： Bao Qian Zhan-Jun Chen yong-Sheng Wang Xiao-Yan Hu Xiao-Biao Hu yong-Hua zheng Pulmonary Medicine Shanghai Jinshan Tinglin HospitalShanghai 201505China Radiology Medicine Shanghai Jinshan Tinglin HospitalShanghai 201505China

BACKGROUND Obstructive sleep apnea-hypopnea syndrome(OSAHS)is primarily caused by airway obstruction due to narrowing and blockage in the nasal and nasopha-ryngeal,oropharyngeal,soft palate,and tongue base *** mid-frequency anti-snoring device is a new technology based on sublingual nerve *** principle is to improve the degree of oropharyngeal airway stenosis in OSAHS patients under mid-frequency wave ***,there is a lack of clinical application and imaging *** We selected 50 patients diagnosed with moderate OSAHS in our hospital between July 2022 and August *** underwent a 4-wk treatment regimen involving the mid-frequency anti-snoring device during nighttime *** the treatment,we monitored and assessed the sleep apnea quality of life index and Epworth Sleepiness Scale ***,we performed computed tomo-graphy scans of the oropharynx in the awake state,during snoring,and while using the mid-frequency anti-snoring ***-sectional area measurements in different states were taken at the narrowest airway point in the soft palate posterior and retrolingual *** Compared to pretreatment measurements,patients exhibited a significant reduction in the apnea-hypopnea index,the percentage of time with oxygen saturation below 90%,snoring frequency,and the duration of the most prolonged apnea *** lowest oxygen saturation showed a notable increase,and both sleep apnea quality of life index and Epworth Sleepiness Scale scores *** computed tomography scans revealed that in OSAHS patients cross-sectional areas of the oropharyngeal airway in the soft palate posterior area and retrolingual area decreased during snoring compared to the awake ***,during mid-frequency anti-snoring device treatment,these areas increased compared to *** The mid-frequency anti-snoring device demonstrates the potential to enhance various sleep parameters in pat

关键词： Mid-frequency anti-snoring device Obstructive sleep apnea-hypopnea syndrome Sleep monitoring Oropharyngeal computed tomography Curative effect

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Proppant transport in rough fracture networks using supercritical CO_(2)

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Petroleum Science 2024年第3期21卷 1852-1864页

作者： yong zheng Meng-Meng Zhou Ergun Kuru Bin Wang Jun Ni Bing Yang Ke Hu Hai Huang Hai-Zhu Wang School of Petroleum Engineering Xi'an Shiyou UniversityXian710065ShaanxiChina Shaanxi Key Laboratory of Carbon Dioxide Sequestration and Enhanced Oil Recovery Xi'an710075ShaanxiChina State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing2249China School of Mining and Petroleum Engineering University of AlbertaEdmontonTG2W2AlbertaCanad Shaanxi Yanchang Petroleum(Group)Co. Ltd.Xi'an710075ShaanxiChina

Proppant transport within fractures is one of the most critical tasks in oil,gas and geothermal reservoir stimulation,as it largely determines the ultimate performance of the operating *** transport in rough fracture networks is still a relatively new area of research and the associated transport mechanisms are still *** this study,representative parameters of rough fracture surfaces formed by supercritical CO_(2) fracturing were used to generate a rough fracture network model based on a spectral synthesis *** fluid dynamics(CFD)coupled with the discrete element method(DEM)was used to study proppant transport in this rough fracture *** reveal the turning transport mechanism of proppants into branching fractures at the intersections of rough fracture networks,a comparison was made with the behavior within smooth fracture networks,and the effect of key pumping parameters on the proppant placement in a secondary fracture was *** results show that the transport behavior of proppant in rough fracture networks is very different from that of the one in the smooth fracture *** turning transport mechanisms of proppant into secondary fractures in rough fracture networks are gravity-driven sliding,high velocity fluid suspension,and fracture structure *** the same injection conditions,supercritical CO_(2)with high flow Reynolds number still has a weaker ability to transport proppant into secondary fractures than *** of the supercritical CO_(2)needs to be increased beyond a certain value to have a significant effect on proppant carrying,and under the temperature and pressure conditions of this paper,it needs to be increased more than 20 times(about 0.94 m Pa s).Increasing the injection velocity and decreasing the proppant concentration facilitates the entry of proppant into the branching fractures,which in turn results in a larger stimulated reservoir *** results help to understand the pro

关键词： Reservoir stimulation CCUS Rough fracture network Supercritical CO_(2) Proppanttransport

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Semisynthesis of homogeneous spike RBD glycoforms from SARS-CoV-2 for profiling the correlations between glycan composition and function

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National Science Review 2024年第2期11卷 145-154页

作者： Farong Ye Cheng Li Feng-Liang Liu Xinliang Liu Peng Xu Rong-Hua Luo Wenping Song yong-Tang zheng Tianlei Ying Biao Yu Ping Wang Center for Chemical Glycobiology Frontiers Science Center for Transformative Molecules Zhangjiang Institute for Advanced Study School of Chemistry and Chemical Engineering Shanghai Jiao Tong University MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection Shanghai Institute of Infectious Disease and BiosecurityShanghai Engineering Research Center for Synthetic ImmunologySchool of Basic Medical Sciences Shanghai Medical College Fudan University Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province Center for Biosafety Mega-Science Kunming Institute of ZoologyChinese Academy of Sciences State Key Laboratory of Bioorganic and Natural Products Chemistry Center for Excellence in Molecular Synthesis Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shenzhen Research Institute of Shanghai Jiao Tong University

Vaccines have been the primary remedy in the global fight against coronavirus disease 2019（COVID-19）.The receptor-binding domain（RBD） of the spike protein, a critical viral immunogen, is affected by the heterogeneity of its glycan structures and relatively low immunogenicity. Here, we describe a scalable synthetic platform that enables the precise synthesis of homogeneously glycosylated RBD, facilitating the elucidation of carbohydrate structure–function relationships. Five homogeneously glycosylated RBDs bearing biantennary glycans were prepared, three of which were conjugated to T-helper epitope(Tpep) from tetanus toxoid to improve their weak immune response. Relative to natural HEK293-derived RBD, synthetic RBDs with biantennary N-glycan elicited a higher level of neutralising antibodies against SARS-CoV-2 in mice. Furthermore, RBDs containing Tpepelicited significant immune responses in transgenic mice expressing human angiotensin-converting enzyme 2. Our collective data suggest that trimming the N-glycans and Tpepconjugation of RBD could potentially serve as an effective strategy for developing subunit vaccines providing efficient protection.

关键词： peptide ligation glycosylation glycoprotein

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Construction of metal-organic frameworks with unsaturated Cu sites for efficient and fast reduction of nitroaromatics:A combined experimental and theoretical study

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Chinese Chemical Letters 2024年第8期35卷 514-519页

作者： Longlong Geng Huiling Liu Wenfeng Zhou yong-zheng Zhang Hongliang Huang Da-Shuai Zhang Hui Hu Chao Lv Xiuling Zhang Suijun Liu Shandong Provincial Key Laboratory of Monocrystalline Silicon Semiconductor Materials and Technology College of Chemistry and Chemical EngineeringDezhou UniversityDezhou 253023China School of Chemistry and Chemical Engineering Shandong University of TechnologyZibo 255000China State Key Laboratory of Separation Membranes and Membrane Processes School of Chemical Engineering and TechnologyTiangong UniversityTianjin 300387China School of Chemistry and Chemical Engineering Jiangxi Provincial Key Laboratory of Functional Molecular Materials ChemistryJiangxi University of Science and TechnologyGanzhou 341000China

Metal-organic frameworks(MOFs)functionalized with open metal sites(OMSs)have received widespread attention in various applications due to their fascinating electronic properties and unique interactions with guest ***,rational tailoring of the coordination environment of metal nodes dur-ing the synthesis of MOFs remains a great challenge due to their tendency of saturated coordination with ***,we reported the construction of three new MOFs featuring unsaturated Cu(Ⅱ)sites,namely[Cu(HCOO)(pzta)]_(n)(HL-1),{[Cu(PTA)0.5(pzta)(H_(2)O)]·2H_(2)O}_(n)(HL-2)and[Cu(NA)0.5(pzta)]_(n)(HL-3)(Hpzta=3-pyrazinyl-1,2,4-triazole;PTA=terephthalic acid;NA=1,4-naphthalene dicarboxylic acid),based on the mixed-linker strategy via specific selection of versatile Hpzta ligand and carboxylate ***-markably,the obtained MOFs exhibited excellent activity and good recyclability for the catalytic reduction of nitroaromatics under mild conditions(25℃and 1 atm).In particular,the complete conversion of 4-nitrophenol(4-NP)took only 30 s on HL-2,reaching a record-high TOF value compared with previously reported metal *** combined experimental and theoretical studies on HL-2 revealed that the open Cu site with positive-charged nature could improve the adsorption and subsequent electron trans-port between the substrates,and was responsible for the outstanding *** work shined lights on the further enhancement of performance for MOFs through rational OMSs construction.

关键词： Metal-organic frameworks Open metal sites Catalysis Copper node 4-Nitrophenol

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Ingredients-based Methodology and Fuzzy Logic Combined Short-Duration Heavy Rainfall Short-Range Forecasting:An Improved Scheme

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Journal of Tropical Meteorology 2024年第3期30卷 241-256页

作者： TIAN Fu-you XIA Kun SUN Jian-hua zheng yong-guang HUA Shan National Meteorological Center Beijing100081 China State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics(LASG) Institute of Atmospheric PhysicsChinese Academy of Sciences(IAP/CAS)Beijing 100029 China Key Laboratory of Cloud-Precipitation Physics and Severe Storms(LACS) Institute of Atmospheric PhysicsChinese Academy of Sciences(IAP/CAS)Beijing 100029 China

Short-duration heavy rainfall(SHR),as delineated by the National Meteorological Center of the China Me-teorological Administration,is characterized by hourly rainfall amounts no less than 20.0 *** is one of the most common convective weather phenomena that can cause severe ***-range forecasting of SHR is an important part of operational severe weather *** the present study,an improved objective SHR forecasting scheme was developed by adopting the ingredients-based methodology and using the fuzzy logic *** 1.0°×1.0°National Centers for Environmental Prediction(NCEP)final analysis data and the ordinary rainfall(0.1-19.9 mm h-1)and SHR observational data from 411 stations were used in the improved *** best lifted index,the total precipitable water,the 925 hPa specific humidity(Q 925),and the 925 hPa divergence(DIV 925)were selected as predictors based on objective *** distributed membership functions of predictors were obtained based on relative frequency *** weights of predictors were also objectively *** with a typhoon SHR case and a spring SHR case show that the main possible areas could be captured by the improved *** of SHR forecasts within 96 hours with NCEP global forecasts 1.0°×1.0°data initiated at 08:00 Beijing Time during the warm seasons in 2015 show the results were improved from both deterministic and probabilistic *** study provides an objectively feasible choice for short-range guidance forecasts of *** scheme can be applied to other convective phenomena.

关键词： ingredients-based methodology fuzzy logic approach probability of short-duration heavy rainfall(SHR) improved forecasting scheme objectively obtained membership functions

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Invisible and semi-invisible decays of bottom baryons

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Chinese Physics C 2024年第8期48卷 127-139页

作者： yong zheng Jian-Nan Ding Dong-Hao Li Lei-Yi Li Cai-Dian Lü Fu-Sheng Yu MOE Frontiers Science Center for Rare Isotopes Lanzhou UniversityLanzhou 730000China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China Center for High Energy Physics Peking UniversityBeijing 100871China Institute of High Energy Physics CASBeijing 100049China School of Physical Sciences University of Chinese Academy of SciencesBeijing 101408China

The similar densities of dark matter and baryons in the universe imply that they may arise from the same ultraviolet model.B-Mesogenesis,which assumes dark matter is charged under the baryon number,attempts to simultaneously explain the origin of baryon asymmetry and dark matter in the *** particular,B-Mesogenesis may induce bottom-baryon decays into invisible or semi-invisible final states,which provide a distinctive signal for probing this *** this work,we systematically study the invisible decays of bottom baryons into dark matter and the semi-invisible decays of bottom baryons into a meson or a photon together with a dark matter *** particular,the fully invisible decay can reveal the stable particles in *** QCD-based frameworks are used to calculate the hadronic matrix elements under the B-Mesogenesis *** estimate the constraints on the Wilson coefficients or the product of some new physics couplings with the Wilson coefficients according to the semi-invisible and invisible decays of bottom baryons detectable at future colliders.

关键词： baryon asymmetry dark matter B-Mesogenesis invisible and semi-invisible decay bottom baryons

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Cronkhite-Canada syndrome complicated with pulmonary embolism:A case report

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World Journal of Clinical Cases 2024年第21期12卷 4820-4826页

作者： Mao-Lang He yong zheng Shu-Xin Tian College of Medicine Shihezi UniversityShihezi 832099Xinjiang Uygur Autonomous RegionChina Department of Gastroenterology The First Affiliated Hospital of Shihezi UniversityShihezi 832008Xinjiang Uygur Autonomous RegionChina

BACKGROUND Cronkhite-Canada syndrome(CCS)is a rare disease,that causes gastrointestinal polyps,ectodermal abnormalities,and gastrointestinal *** is prone to thromboembolism,but clinical workers have not yet established a clinical consciousness of preventing *** present case illustrates pulmonary embolism(PE)complicated by *** SUMMARY A 46-year-old male patient presented with mucus,purulent,and bloody *** changes included skin pigmentation,alopecia,and nail *** revealed the presence of multiple *** a comprehensive evaluation,the patient was diagnosed with *** the disease,he was also diagnosed with pulmonary embolism,Riehl's melanosis,and intestinal flora *** symptomatic treatment with omeprazole,mesalazine,rivaroxaban,nutritional support,and regulation of intestinal flora,the patient’s symptoms were significantly *** CCS complicated with PE was reported for the first time in China in this *** the fact that CCS is extremely rare,patients with CCS should be classified as a high-risk venous thromboembolism(VTE)population,and emphasis should be placed on venous thromboembolism risk assessment and stratification,deep venous thromboembolism screening,prevention of VTE,and careful long-term follow-up.

关键词： Cronkhite-Canada syndrome Pulmonary embolism Hip arthroplasty Venous thromboembolism Case report

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Mast cell degranulation-triggered by SARS-CoV-2 induces tracheal-bronchial epithelial inflammation and injury

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Virologica Sinica 2024年第2期39卷 309-318页

作者： Jian-Bo Cao Shu-Tong Zhu Xiao-Shan Huang Xing-Yuan Wang Meng-Li Wu Xin Li Feng-Liang Liu Ling Chen yong-Tang zheng Jian-Hua Wang Guangzhou Institutes of Biomedicine and Health Chinese Academy of SciencesGuangzhou 510530China School of Life Sciences and Medicine University of Science and Technology of ChinaHefei 230026China Key Laboratory of Bioactive Peptides of Yunnan Province Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of SciencesKIZCUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesCenter for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academy of SciencesKunming 650223China University of Chinese Academy of Sciences Beijing 101408China

SARS-CoV-2 infection-induced hyper-inflammation is a key pathogenic factor of *** research,along with others',has demonstrated that mast cells(MCs)play a vital role in the initiation of hyper-inflammation caused by *** previous study,we observed that SARS-CoV-2 infection induced the accumulation of MCs in the peri-bronchus and bronchioalveolar-duct junction in humanized ***,we found that MC degranulation triggered by the spike protein resulted in inflammation in alveolar epithelial cells and capillary endothelial cells,leading to subsequent lung *** trachea and bronchus are the routes for SARS-CoV-2 transmission after virus inhalation,and inflammation in these regions could promote viral *** are widely distributed throughout the respiratory ***,in this study,we investigated the role of MCs and their degranulation in the development of inflammation in tracheal-bronchial *** analyses showed the accumulation and degranulation of MCs in the peri-trachea of humanized mice infected with *** degranulation caused lesions in trachea,and the formation of papillary hyperplasia was *** transcriptome analysis in bronchial epithelial cells,we found that MC degranulation significantly altered multiple cellular signaling,particularly,leading to upregulated immune responses and *** administration of ebastine or loratadine effectively suppressed the induction of inflammatory factors in bronchial epithelial cells and alleviated tracheal injury in *** together,our findings confirm the essential role of MC degranulation in SARS-CoV-2-induced hyper-inflammation and the subsequent tissue ***,our results support the use of ebastine or loratadine to inhibit SARS-CoV-2-triggered degranulation,thereby preventing tissue damage caused by hyper-inflammation.

关键词： SARS-CoV-2 Mast cell(MC) Bronchial epithelial cell Inflammation Tracheal injury

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Calculation of the energy dependence of fission fragments yields and kinetic energy distributions for neutron-induced ^(235)U fission

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Chinese Physics C 2024年第8期48卷 159-169页

作者： Ya-Ning Han zheng Wei Yi-Xuan Wang Dong-Ying Huo Peng-Qi Zhang Ming Li Jun Ma Kang Wu yong-Guang zheng Yuan He Zhi-yong Deng Tian-Zhi Jiang Xiang-Lin Zhuo Jin Li Yun Zhang Yu Zhang Jun-Run Wang Xiao-Dong Su Ze-En Yao School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China Engineering Research Center for Neutron Application Technology Ministry of EducationLanzhou UniversityLanzhou 730000China MOE Frontiers Science Center for Rare Isotopes Lanzhou UniversityLanzhou 730000China School of Mathematics and Statistics Lanzhou UniversityLanzhou 730000China Nuclear Power Institute of China Chengdu 610000China

Fission fragments yields and average total kinetic energy are fundamental nuclear data for nuclear energy applications and the study of nuclear *** fission products,such as ^(95)Zr,^(99)Mo,^(140)Ba,^(144)Ce,and ^(147)Nd,serve as burnup monitors,assessing the number of fissions induced by neutrons on ^(235)***,current experimental data for these fission products worldwide are inconsistent,introducing significant uncertainty into related scientific *** this study,we employed the Potential-driving Model to calculate the independent yields of ^(235)U and evaluate its advantages in such ***,we investigated the energy dependence of independent yields to select important ***,we calculated the cumulative yields of ^(95)Zr,^(99)Mo,^(140)Ba,^(144)Ce,and ^(147)Nd,and compared them with existing literature data to explore the energy dependence of fission products for ^(235)*** the lack of fission product yield data above 14.8 MeV,we extended our calculated incident neutron energy to 20 MeV,aiming to support future scientific *** Geant4 physical model does not consider the influence of incident neutron energy on the average total kinetic energy of fission fragments;thus,we introduced the excitation function of the total kinetic energy of fission fragments recommended by Madland et al.,which effectively describes the experimental data of the average total kinetic energy of fragments formed in ^(235)U *** this paper,we comprehensively discuss the energy dependence of fission product yields and average total kinetic energy.

关键词： ^(235)U(n f) potential-driving model fission yields kinetic energies energy dependence

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