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Stereoselective Synthesis of (+)-△~5-Dehydrosugiyl Methyl Ether

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Chinese Chemical Letters 2001年第2期12卷 111-112页

作者： An Pai LI Xiao Shui PENG yong hong gan Xin Fu PAN Department of Chemistry National Laboratory of Applied Organic ChemistryLanzhou UniversityLanzhou 730000

A stereoselective synthetic route to △~5-dehydrosugiyl methyl ether was developed from (S)-(-)-α-cyclocitral, DDQ as a better oxidant for enone was used.

关键词： synthesis diterpenoids geranic (+)-△~5-dehydrosugiyl methyl ether.

Total Synthesis of 16-Acetoxy-6,7-didehydroferruginyl Methyl Ether

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Chinese Chemical Letters 2000年第6期11卷 513-514页

作者： yong hong gan An Pai LI Ping Yan BIE Xin Fu PAN (Department of Chemistry, National Laboratory of Applied Organic Chemistry, Lanzhou University.Lanzhou. 730000 ) Department of Chemistry Natl. Lab. of Appl. Organ. Chemistry Lanzhou University Lanzhou 730000 China

An efficient synthetic route have been developed to 16-acetoxy-6,7-didehydroferruginyl methyl ether.

关键词： total synthesis 16-hydroxy-6,7-didehydroferruginol 16-acetoxy-6,7-didehydroferruginyl methyl ether

3D Printing of Tough Hydrogel Scaffolds with Functional Surface Structures for Tissue Regeneration

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Nano-Micro Letters 2025年第2期17卷 18-45页

作者： Ke Yao Gaoying hong Ximin Yuan Weicheng Kong Pengcheng Xia Yuanrong Li Yuewei Chen Nian Liu Jing He Jue Shi Zihe Hu Yanyan Zhou Zhijian Xie yong He State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Liangzhu Laboratory Zhejiang UniversityHangzhou 310027People’s Republic of China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province College of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Stomatology Hospital School of StomatologyZhejiang University School of MedicineHangzhou 310027People’s Republic of China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001People’s Republic of China Institute of Digital Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006People’s Republic of China

Hydrogel scaffolds have numerous potential applications in the tissue engineering ***,tough hydrogel scaffolds implanted in vivo are seldom reported because it is difficult to balance biocompatibility and high mechanical *** by Chinese ramen,we propose a universal fabricating method(printing-P,training-T,cross-linking-C,PTC&PCT)for tough hydrogel scaffolds to fill this ***,3D printing fabricates a hydrogel scaffold with desired structures(P).Then,the scaffold could have extraordinarily high mechanical properties and functional surface structure by cycle mechanical training with salting-out assistance(T).Finally,the training results are fixed by photo-cross-linking processing(C).The tough gelatin hydrogel scaffolds exhibit excellent tensile strength of 6.66 MPa(622-fold untreated)and have excellent ***,this scaffold possesses functional surface structures from nanometer to micron to millimeter,which can efficiently induce directional cell ***,this strategy can produce bionic human tissue with mechanical properties of 10 kPa-10 MPa by changing the type of salt,and many hydrogels,such as gelatin and silk,could be improved with PTC or PCT *** experiments show that this scaffold can effectively promote the new generation of muscle fibers,blood vessels,and nerves within 4 weeks,prompting the rapid regeneration of large-volume muscle loss injuries.

关键词： 3D printing Tough hydrogel scaffold Functional surface structure Tissue regeneration Biomaterials

Unraveling the mechanism of action of Shangxia Liangji formula for treating insomnia:a metabolomics and network pharmacology approach

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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： Xia-Jie Quan Hao Liang yong-hong Tang Li Jiang Xiong-Ying Ji Feng-Ying Zhang Ping Zhang Bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia Liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

Proactive eviction of flow entry for SDN based on hidden Markov model

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Frontiers of Computer Science 2020年第4期14卷 107-116页

作者： gan HUANG Hee yong YOUN College of Software Sungkyunkwan UniversitySuwon440746Korea

With the fast development of software defined network(SDN),numerous researches have been conducted for maximizing the performance of ***,flow tables are utilized in OpenFlows witch for *** to the space limitation of flow table and switch capacity,various issues exist in dealing with the *** existing schemes typically employ reactive approach such that the selection of evicted entries occurs when timeout or table miss *** this paper a proactive approach is proposed based on the prediction of the probability of matching of the *** eviction occurs proactively when the utilization of flow table exceeds a threshold,and the flow entry of the lowest matching probability is *** matching probability is estimated using hidden Markov model(HMM).Computersimulation reveals that it significantly enhances the prediction accuracy and decreases the number of table misses compared to the standard Hard timeout scheme and Flow master scheme.

关键词： SDN OpenFlow flow entry eviction HMM matching probability

Chemical Constituents of Schisandra rubriflora Rehd. et Wils.

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Journal of Integrative Plant Biology 2005年第3期47卷 362-367页

作者： gan-PengLI Jing-FengZHAO yong-QiangTU Xiao-DongYANG hong-BinZHANG LiangLI SchoolofPharmacy YunnanUniversityKunming650091China／／SchoolofChemistryandBiotechnologyYunnanNationalitiesUniversityKunming650031China SchoolofPharmacy YunnanUniversityKunming650091China DepartmentofChemistry NationalLaboratoryofAppliedOrganicChemistryLanzhouUniversityLanzhou730000China

Abstract: Schisandra rubriflora Rehd. et Wils. is a traditional Chinese medicine. To search for new and bioactive components from traditional Chinese medicines and provide scientific evidence for taxonomy, the chemical constituents of the plant were investigated by various column chromatography methods (silica gel, Sephadex LH-20, and RP-18). From the aerial parts of S. rubriflora, three new megastigmane glycosides, namely (3S, 5R, 6S, 9R)-megastigmane-3, 9-diol 3-O-[α-L-arabionfuranosyl-(1→6)-β-D-glucopyranoside] (1), 7-megastigmene-3-ol-9-one 3-O-[α-L-arabionfuranosyl-(1→6)-β-D-glucopyranoside] (2), and megastigmane-3α, 4β, 9σ-triol 3-O-β-D-glucopyranoside (3), along with 14 known compounds, were isolated. The structures of the new compounds were elucidated by a combination of spectroscopic and chemical methods.

关键词： alangionoside megastigmane glycosides Schisandra rubriflora Rehd. et Wils Schisandraceae

Experimental investigation of regular wave propagation over an idealized reef model

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Journal of Hydrodynamics 2020年第4期32卷 717-726页

作者： gan-cheng Zhu Bing Ren hong-jie Wen Guo-yu Wang yong-xue Wang State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China

The wave transformation over the deep-sea coral reefs is an essential issue in the analysis of the reef ecosystem and the design of large reef-top *** wave flume experiments are conducted to investigate the wave transformation processes over an idealized reef *** measurements of the wave height,the wave set-up and the wave-generated flow on the reef-top are made with and without the reef-top structure at various submerged depths and under different wave *** is found that the reef-top structure has a significant influence on the wave breaking,the wave set-up and the wave-generated *** wave set-up increases with the increasing wave height and the decreasing submergence ***,the relationship between the wave set-up and the wave period is complex,influenced by the reef-top structure.

关键词： Coral reef wave set-up reef-top structure wave breaking wave-generated flow

Recent development of thermoelectric nanofibers and their composites

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Journal of Materiomics 2023年第1期9卷 99-130页

作者： yong X.gan Department of Mechanical Engineering California State Polytechnic University Pomona3801 W Temple AvenuePomonaCA 91768USA

This review deals with the recent development of thermoelectric(TE)nanofibers and their composite *** processing and manufacturing technologies for preparing nanofibers are ***,electrospinning,electrochemical oxidation,and liquid phase chemical deposition approaches are *** kinds of TE nanofibers are introduced *** important inorganic and organic nanofibers including carbon-based nanofibers,conducting polymer-based nanofibers,and transition metal oxide-based nanofibers with significant thermoelectric responses are *** properties of some important nanofibers are *** applications of TE nanofibers for energy conversion,thermal imaging and temperature sensing are *** and concluding remarks are presented.

关键词： Thermoelectricity Nanofibers and composites Processing and manufacturing Energy conversion Thermal imaging Temperature sensing

Carbon-based materials for electrochemical dechlorination

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Nano Research 2023年第11期16卷 12543-12557页

作者： Guoqiang gan Guo hong Wenjun Zhang Center of Super-Diamond and Advanced Films(COSDAF) Department of Materials Science and EngineeringCity University of Hong KongHong Kong 999077China School of Materials Science and Engineering Dalian University of TechnologyDalian 116024China

Electrochemical dechlorination reaction(EDR)is a promising,environmentally friendly,and economically profitable technology for treating chlorinated organic *** efficient environmental protection,electrocatalysts with high stability and low cost are of extremely significance to the development of EDR ***-based materials have aroused broad interest as electrocatalysts for many electrochemical reactions due to their characteristics including large specific surface area,controllable structure,good conductivity,and chemical *** EDR,the carbon-based materials also show many unique superiorities,like strong adsorption capacity to chlorinated organic compounds(COCs),excellent catalytic activity and stability,and environmental *** review starts with a detailed summary on the mechanisms of electrochemical dechlorination(direct and indirect electron transfer pathway)and factors affecting the effectiveness of *** the paper comprehensively overviews the current progresses of carbon-based materials for EDR of COCs,following their two major application scenarios,i.e.,directly as electrocatalysts and as advanced supports for other ***,the formation of different active sites in carbon-based electrocatalysts and their EDR activities are ***,the current challenges and perspectives in this field are *** review will provide an in-depth understanding for the design of advanced carbon-based materials and promote the development of EDR technology.

关键词： carbon-based electrocatalysts carbon supports electrochemical dechlorination chlorinated organic compounds mechanism active sites