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Guided Mode Resonance Transmission Filters Working at the Intersection Region of the First and Second Leaky Modes

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Chinese Physics Letters 2012年第2期29卷 214-216页

作者： MA Jian-yong fan yong-Tao Shanghai Institute of Fine Mechanics and Optics Chinese Academy of SciencesShanghai 201800

Based on the guided mode resonance effect,single-layer transmission filters are *** is found that there is an intersection region in which the strong modulation waveguide modes TE_(0) and TE_(2) can be simultaneously excited by the second and first diffraction orders,respectively.A very high transmission peak emerges when the leaky modes interact with each *** on the normalized eigen-function of a single-layer waveguide grating,the high resonance transmission filters can be designed at any central *** order to demonstrate this concept,we design narrow line-shaped band pass filters with a central wavelength at 0.8,1.06 and 10.6μm.

关键词： waveguide filters narrow

Evaluation and optimization of blasting approaches to reducing oversize boulders and toes in open-pit mine

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International Journal of Mining Science and Technology 2020年第3期30卷 373-380页

作者： Zhendong Leng yong fan Qidong Gao Yingguo Hu College of Hydraulic and Environmental Engineering China Three Gorges UniversityYichang 443002China China Gezhouba Group Explosive Co. Ltd.Chongqing 401121China School of Highway Chang’an UniversityXi’an 710064China Yangtze River Scientific Research Institute Wuhan 430010China

A new blasting approach of combined blastholes with different diameters is proposed to solve the problems of oversize boulders and rock toes in open-pit mine. A non-ideal detonation model and a statistical damage constitutive model are implemented in dynamic finite element analysis to investigate the formation mechanism of oversize boulders and toes. The damage distribution and evolution process of rock blasting fragmentation is simulated, and the scheme is further optimized. Numerical analysis results showed that pocket charges and satellite blastholes can only improve bench top fragmentation, but they cannot reduce the oversize in the middle and bottom of bench as well as the toe problem. The new blasting approach of combined blastholes with different diameters can effectively reduce the oversize boulders and toes as well as the production costs.

关键词： Rock blasting Blasthole diameter Oversize boulders Rock toes Damage distribution

W-Band High-Efficiency Waveguide Slot Array Antenna with Low Sidelobe Levels Based on Silicon Micromachining Technology

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Chinese Journal of Electronics 2022年第4期31卷 665-673页

作者： YAO Shisen CHENG Yujian BAI Hang fan yong University of Electronic Science and Technology of China

A high-efficiency waveguide slot array antenna with low sidelobe level(SLL) is investigated for W-band applications. The silicon micromachining technology is utilized to realize multilayer antenna architecture by three key steps of selective etching, gold plating and Au-Au bonding. The radiating slot based on this technique becomes thick with a minimum thickness of 0.2 mm and accompanies with the decrease of slot's radiation ability. To overcome this weakness, a stepped radiation cavity is loaded on the slot. The characteristic of cavityloaded slot is investigated to synthesize the low-SLL array antenna. The unequal hybrid corporate feeding network is constructed to achieve sidelobe suppression in the E-plane. A pair of 16 × 8 low-SLL and high-effciency slot arrays is fashioned and confirmed experimentally. The bandwidth with the radiation effciency higher than 80% is92.3–96.3 GHz. The SLLs in both E-and H-planes are below-19 d B.

关键词： W-band Micromachined waveguide Silicon micromachining Stepped radiation cavity High effciency Sidelobe level (SLL)

Advances on immune-related adverse events associated with immune checkpoint inhibitors

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Frontiers of Medicine 2021年第1期15卷 33-42页

作者： yong fan Yan Geng Lin Shen Zhuoli Zhang Department of Rheumatology and Clinical Immunology Peking University First HospitalBeijing 100034China Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer Hospital&InstituteBeijing 100142China

Immunotherapy has recently led to a paradigm shift in cancer therapy,in which immune checkpoint inhibitors(ICIs)are the most successful agents approved for multiple advanced ***,given the nature of the non-specific activation of effector T cells,ICIs are remarkably associated with a substantial risk of immune-related adverse events(irAEs)in almost all organs or *** to 90%of patients who received ICIs combination therapy experienced irAEs,of which majority were low-grade *** lymphocyte antigen-4 and programmed cell death protein-1/programmed cell death ligand 1 inhibitors usually display distinct features of *** this review,the mechanisms of action of ICIs and how they may cause irAEs are *** unsolved challenges,however really engrossing issues,such as the association between irAEs and cancer treatment response,tumor response to irAEs therapy,and ICIs in challenging populations,are comprehensively summarized.

关键词： cancer immunotherapy immune checkpoint inhibitors immune-related adverse events review

Replacing what’s lost: a new era of stem cell therapy for Parkinson’s disease

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Translational Neurodegeneration 2020年第1期9卷 10-19页

作者： yong fan Winanto Shi-Yan Ng The Third Affiliated Hospital of Guangzhou Medical University Guangzhou 510150China Institute of Molecular and Cell Biology A^*STAR Research EntitiesSingapore 138673Singapore yong Loo Lin School of Medicine(Physiology) National University of SingaporeSingapore 117456Singapore National Neuroscience Institute Singapore 308433Singapore

Background Stem cells hold tremendous promise for regenerative medicine because they can be expanded infinitely,giving rise to large numbers of differentiated cells required for *** cells can be derived from fetal sources,embryonic origins(embryonic stem cells or ESCs)or reprogrammed from adult cell types(induced pluripotent stem cells or iPSCs).One unique property of stem cells is their ability to be directed towards specific cell types of clinical interest,and can mature into functional cell types in *** transplantations of fetal or ESC-derived tissues are known to illicit a host immunogenic response,autologous transplantations using cell types derived from one’s own iPSCs eliminate risks of tissue rejection and reduce the need for ***,even with these benefits,cell therapy comes with significant hurdles that researchers are starting to *** this review,we will discuss the various steps to ensure safety,efficacy and clinical practicality of cell replacement therapy in neurodegenerative diseases,in particular,Parkinson’s *** body Parkinson’s disease(PD)results from a loss of dopaminergic neurons from the substantia nigra and is an ideal target for cell replacement *** trials using fetal midbrain material in the late 1980s have resulted in long term benefit for some patients,but there were multiple shortcomings including the non-standardization and quality control of the transplanted fetal material,and graft-induced dyskinesia that some patients experience as a *** the other hand,pluripotent stem cells such as ESCs and iPSCs serve as an attractive source of cells because they can be indefinitely cultured and is an unlimited source of *** cell technologies and our understanding of the developmental potential of ESCs and iPSCs have deepened in recent years and a clinical trial for iPSC-derived dopaminergic cells is currently undergoing for PD patients in *** this focused review,w

关键词： Parkinson’s disease Induced pluripotent stem cells Cell therapy Regenerative medicine

Performance Analysis of Wireless Network Coding via Percolation

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Chinese Journal of Electronics 2014年第1期23卷 179-185页

作者： SHANG Tao fan yong WANG Chao LIU Jianwei College of Electronic and Information Engineering Beihang University

In order to investigate the effect of network connectivity on the performance of wireless network coding, we introduce percolation theory to construct the system model of multi-hop wireless network for asymptotic connectivity. Concretely, we proposed a normalization algorithm for random network to layer the nodes of the largest connected component in multi-hop wireless network, and derived the theoretical conditions of percolation occurrence for the normalized hierarchical network of the largest connected component. Furthermore, according to the critical threshold of percolation phenomenon,we derived the performance of wireless network coding for the largest connected component. The mean delay and throughput were quantified in terms of network coding parameters such as coding window size, transmission radius, and node density. These conclusions clarify the effective performance of wireless network coding for random network, and will contribute to the evaluation of optimal performance of wireless network coding.

关键词： Network coding Percolation theory Random network Connectivity Node density

Simultaneous Thermoluminescence and Thermally Stimulated Current in Polyamide

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Journal of Materials Science & Technology 1998年第4期14卷 357-360页

作者： fan, yong Wang, Xuan Zhang, Xiaohong Lin, Jiaqi Lei, Qingquan Harbin Univ Sci & Technol Dept Elect Mat Engn Harbin 150040 Peoples R China

The simultaneous thermoluminescence (TL) and thermally stimulated current (TSC) spectra were obtained in two types of polyamide film, such as nylons 6 and 11 under study of electron detrapping and recombination. There are three main relaxation peaks or regions, designated gamma , beta and alpha in order of increasing temperature in the TSC spectra, in contrast, a high temperature relaxation peak in TL spectra disappears. The centers of peaks of these relaxation regions are located at near 180, 230 and 310 K, respectively, deviating plus or minus 10 K. However, two anomalous phenomena were observed: firstly, a very large, short-circuited, thermally stimulated discharge current (TSDC) is up to 10** minus **8A, but reversible in direction for non-polarized nylons 6 and 11, even after several times repeatedly; secondly, there is no TL signal except for non-polarized nylon 6 film. (Edited author abstract) 11 Refs.

关键词： Polyamides

Adsorption and Reaction of CN +O→OCN on Cu(100) Surface: A Density Functional Theory Study

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Chinese Journal of Structural Chemistry 2005年第8期24卷 865-874页

作者： LI Yi HU Jian-Ming ZHANG yong-fan LI Jun-Qiana Department of Chemistry Fuzhou University ChinaFuzhou 350002 Scientific and Technical Section Command Academy of FuzhouThe Chinese People''s Armed Police Force ChinaFuzhou 350002 State Key Laboratory of Structural Chemistry ChinaFuzhou 350002

The adsorption and reaction of O ＋ CN → OCN on Cu（100） are studied by using density functional theory and cluster model. Cu14 cluster model is used to simulate the surface. The calculated results show that the OCN species with the molecule perpendicular to the surface via N atom （N-down） is more favorable than other adsorption models, and the N-down at the bridge site is the most favorable. For N-down, calculated OCN symmetric and asymmetric stretching frequencies are all blue-shifted compared with the calculated values of free and in good agreement with the experiments. The charge transfer from the surface to the OCN species leads to that the bonding of OCN to the metal surface is largely ionic. The present studies also show that CN with the molecule perpendicular to the surface via C atom （NC-down） at the top site is the most stable. Except NC-down at the top site, the calculated CN stretching frequencies are all red-shifted. With O coadsorbed at the hollow site, the adsorption of NC-down at the next nearest bridge or top site is energetically more favorable than that at the adjacent hollow site. The reaction of O ＋ CN → OCN on Cu（100） has no energy barrier via both Eley-Rideal and Langmuir-Hinshelwood processes.

关键词： density functional theory adsorption and reaction cyanate,cyanide Cu(100) surface

Demethylation of miR-34a upregulates expression of membrane palmitoylated proteins and promotes the apoptosis of liver cancer cells

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World Journal of Gastroenterology 2021年第6期27卷 470-486页

作者： Fu-yong Li Ting-yong fan Hao Zhang Yu-Min Sun Department of Interventional Radiology Jinan City People's HospitalJinan 271100Shandong ProvinceChina Department of Radiation Oncology Shandong Cancer Hospital affiliated to Shandong UniversityJinan 250117Shandong ProvinceChina Department of Endoscopy Shandong Cancer Hospital affiliated to Shandong UniversityJinan 250117Shandong ProvinceChina Department of Cardiology Jinan City People's HospitalJinan 271100Shandong ProvinceChina

BACKGROUND Liver cancer is a common cancer and the main cause of cancer-related deaths *** cancer is the sixth most common cancer in the *** miR-34a and palmitoyl membrane palmitoylated protein(MPP2)are reportedly involved in various cell processes,their precise roles in liver cancer are still *** To investigate the expression of micro RNA 34a(miR-34a),methylation of the miR-34a promoter and the expression of MPP2 in liver cancer cells and their related *** Together,78 cases of liver cancer tissues and 78 cases of adjacent tissues were *** methylation degree of miR-34a promoter in liver cancer/paracancerous tissue and liver cancer cells/normal liver cells,and the expression levels of miR-34a and MPP2 in the above samples were *** of liver cancer cells or transfection of liver cancer cells with miR-34a mimetic was *** MPP2 overexpression vector was used to transfect liver cancer cells,and the changes in proliferation,invasion,apoptosis,migration,and other biological functions of liver cancer cells after the above interventions were *** luciferase reporter genes were used to detect the targeting relationship between miR-34a and *** Clinical samples showed that the expression levels of miR-34a and MPP2 in liver cancer tissues were lower than those in the normal *** methylation degree of miR-34a promoter region in liver cancer cells was higher than that in normal liver *** miR-34a demethylation/mimetic transfection/MPP2 overexpression,the apoptosis of liver cancer cells was increased;the proliferation,invasion and migration capabilities were decreased;the expression levels of caspase 3,caspase 9,E-cadherin,and B-cell lymphoma 2(Bcl-2)-associated X protein were increased;and the expression levels of Bcl-2,N-cadherin,andβ-catenin were *** luciferase reporter genes confirmed that MPP2 is targeted by *** experiments showed that sm

关键词： Liver cancer miR-34a Membrane palmitoylated proteins Methylation Cell apoptosis Caspase 3