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Enhancing m^(6)A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1749-1763页

作者： Tian Qin Yuxin Jin Yiming Qin Feifei Yuan Hongbin Lu Jianzhong Hu yong cao Chengjun Li Department of Spine Surgery and Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Sports Medicine Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Spinal cord injury typically causes corticospinal tract disruption. Although the disrupted corticospinal tract can self-regenerate to a certain degree, the underlying mechanism of this process is still unclear. N6-methyladenosine(m^(6)A) modifications are the most common form of epigenetic regulation at the RNA level and play an essential role in biological processes. However, whether m^(6)A modifications participate in corticospinal tract regeneration after spinal cord injury remains unknown. We found that expression of methyltransferase 14 protein(METTL14) in the locomotor cortex was high after spinal cord injury and accompanied by elevated m^(6)A levels. Knockdown of Mettl14 in the locomotor cortex was not favorable for corticospinal tract regeneration and neurological recovery after spinal cord injury. Through bioinformatics analysis and methylated RNA immunoprecipitation-quantitative polymerase chain reaction, we found that METTL14 regulated Trib2 expression in an m^(6)A-regulated manner, thereby activating the mitogen-activated protein kinase pathway and promoting corticospinal tract regeneration. Finally, we administered syringin, a stabilizer of METTL14, using molecular docking. Results confirmed that syringin can promote corticospinal tract regeneration and facilitate neurological recovery by stabilizing METTL14. Findings from this study reveal that m^(6)A modification is involved in the regulation of corticospinal tract regeneration after spinal cord injury.

关键词： corticospinal tract remodeling epigenetic regulations locomotor cortex m^(6)A modification methyltransferase 14 protein(METTL14) mitogen-activated protein kinase neural regeneration spinal cord injury syringin TRIB2

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Guest-assisted assembly strategy:boosting solvent-processed organic solar cells toward commercialization

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Science China Chemistry 2022年第4期65卷 645-646页

作者： yong cao State Key Laboratory of Luminescent Materials and Devices Institute of Polymer Optoelectronic Materials and DevicesInstitute of Optoelectronic Materials and DevicesSouth China University of TechnologyGuangzhou 510640China

In recent years, due to the increasing demand for green energy, organic/polymer heterojunction solar cells have aroused great interest in the academic and industrial ***/polymer solar cells (OSCs) have a series of advantages over their counterparts. The morphology of the active layer and the energy band structure of the device can be adjusted easily by changing the molecular ***-area low-cost modules can be prepared by roll-to-roll solution printing at room temperature.

关键词： temperature structure polymer

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Modeling effects of alloying elements and heat treatment parameters on mechanical properties of hot die steel with back-propagation artificial neural network

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Journal of Iron and Steel Research International 2017年第12期24卷 1254-1260页

作者： yong Liu Jing-chuan Zhu yong cao School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001HeilongjiangChina National Key Laboratory for Metal Precision Hot Processing of Metals Harbin 150001HeilongjiangChina

Materials data deep-excavation is very important in materials genome *** order to carry out materials data deep-excavation in hot die steels and obtain the relationships among alloying elements,heat treatment parameters and materials properties,a 11×12×12×4 back-propagation（BP）artificial neural network（ANN）was set *** element contents,quenching and tempering temperatures were selected as input;hardness,tensile and yield strength were set as output *** ANN shows a high fitting *** effects of alloying elements and heat treatment parameters on the properties of hot die steel were studied using this *** results indicate that high temperature hardness increases with increasing alloying element content of C,Si,Mo,W,Ni,V and Cr to a maximum value and decreases with further increase in alloying element *** ANN also predicts that the high temperature hardness will decrease with increasing quenching temperature,and possess an optimal value with increasing tempering *** model provides a new tool for novel hot die steel design.

关键词： Back-propagation artificial neural network Hot die steel Alloying element Heat treatment

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Special issue on recent progress in organic electronics and photonics

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Science China Chemistry 2017年第4期60卷 431-432页

作者： Fei Huang yong cao Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and Devices South China University of Technology Guangzhou 510641 China

Organic electronic and photonic devices have received tre- mendous attention from both academia and industry be- cause of their great promise for practical use as organic light-emitting diodes （OLEDs）, organic solar cells （OSCs）, organic field-effect transistors （OFETs）, and chemical and biological sensors. During the past decade, remarkable pro- gress has been achieved in this cutting-edge research field, which has opened numerous opportunities for the fabrica- tion of advanced organic electronic devices. For instance, solution-processable OSCs with a power conversion effi- ciency （PCE） exceeding 12% have been achieved, which meets the basic requirements for commercialization. Re- cently, active-matrix OLEDs that can be used in smart phones, televisions, and as flexible displays for portable devices have been commercialized.

关键词：电子学有机发光二极管光子学有机太阳能电池场效应晶体管有机电子器件功率转换效率生物传感器

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A Brief Introduction to Organic Electrodeposition and a Review of the Fabrication of OLEDs based on Electrodeposition Technology

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Chinese Journal of Polymer Science 2023年第5期41卷 621-639,I0005页

作者： Bo-Han Wang Yu-Guang Ma yong cao Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and DevicesSouth China University of TechnologyGuangzhou 510640China

Electrodeposition is an old and effective method for the fabrication of organic *** electrodeposited organic films have been widely used in various applications,highly luminescent films have been a great challenge because the electrochemically doped state may strongly quench the *** the first part of this review,the organic electrodeposition techniques,along with general electropolymerization and other special electrodepositions are *** the second part of the review,we describe how to electrochemically fabricate luminescent films for organic light-emitting diodes(OLEDs).With the rational molecular design and well-controlled electrodeposition process,we have not only demonstrated high-performance OLEDs,but also paved a promising way to practice active-matrix OLEDs(AMOLEDs)and super-resolution *** particular,RGB 3×3 array OLEDs based on active-matrix substrates,RGB passive-matrix OLEDs(PMOLEDs)with a resolution of 210 ppi,and monochromatic OLEDs with a super-resolution of 2822 ppi have been successfully *** is highly anticipated that the organic electrodeposition technology is of comparable or perhaps even higher contenders in manufacturing and downscaling OLEDs and AMOLEDs with low-cost and high-resolution for the human-computer interaction fields such as augmented reality(AR),virtual reality(VR),etc.

关键词： Electrochemistry Organic electrodeposition Electropolymerization Luminescent films OLEDs

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The Physical Significance of the Synthetic Running Correlation Coefficient and Its Applications in Oceanic and Atmospheric Studies

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Journal of Ocean University of China 2018年第3期17卷 451-460页

作者： ZHAO Jinping cao yong WANG Xin College of Oceanic and Atmospheric Sciences Ocean University of China Physical Oceanography Laboratory Ministry of Education

In order to study the temporal variations of correlations between two time series,a running correlation coefficient(RCC)could be *** RCC is calculated for a given time window,and the window is then moved sequentially through *** current calculation method for RCCs is based on the general definition of the Pearson product-moment correlation coefficient,calculated with the data within the time window,which we call the local running correlation coefficient(LRCC).The LRCC is calculated via the two anomalies corresponding to the two local means,meanwhile,the local means also *** is cleared up that the LRCC reflects only the correlation between the two anomalies within the time window but fails to exhibit the contributions of the two varying *** address this problem,two unchanged means obtained from all available data are adopted to calculate an RCC,which is called the synthetic running correlation coefficient(SRCC).When the anomaly variations are dominant,the two RCCs are ***,when the variations of the means are dominant,the difference between the two RCCs becomes *** SRCC reflects the correlations of both the anomaly variations and the variations of the ***,the SRCCs from different time points are intercomparable.A criterion for the superiority of the RCC algorithm is that the average value of the RCC should be close to the global correlation coefficient calculated using all *** SRCC always meets this criterion,while the LRCC sometimes ***,the SRCC is better than the LRCC for running *** suggest using the SRCC to calculate the RCCs.

关键词： running correlation coefficient time window anomaly varying mean synthetic running correlation coefficient

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Bioinspired Closed-loop CPG-based Control of a Robotic Manta for Autonomous Swimming

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Journal of Bionic Engineering 2024年第1期21卷 177-191页

作者： Yiwei Hao yonghui cao Yingzhuo cao Xiong Mo Qiaogao Huang Lei Gong Guang Pan yong cao School of Marine Science and Technology Northwestern Polytechnical UniversityXi'an 710072China Unmanned Vehicle Innovation Center Ningbo Institute of NPUNingbo 315103China Key Laboratory of Unmanned Underwater Vehicle Technology of Ministry of Industry and Information Technology Xi'an 710072China

Fish in nature exhibit a variety of swimming modes such as forward swimming,backward swimming,turning,pitching,etc.,enabling them to swim in complex scenes such as coral *** is still difficult for a robotic fish to swim autonomously in a confined area as a real ***,we develop an untethered robotic manta as an experimental platform,which consists of two flexible pectoral fins and a tail fin,with three infrared sensors installed on the front,left,and right sides of the head to sense the surrounding *** generate multiple swimming modes of the robotic manta and online switching of different modes,we design a closed-loop Central Pattern Generator(CPG)controller based on distance information and use a combination of phase difference and amplitude of the CPG model to achieve stable and rapid adjustment of yaw *** verify the autonomous swimming ability of the robotic manta in complex scenes,we design an experimental scenario with a concave *** experimental results show that the robotic manta can achieve forward swimming,backward swimming,in situ turning within the concave obstacle,and finally exit from the area safely while relying on the perception of external obstacles,which can provide insight into the autonomous exploration of complex scenes by the biomimetic robotic ***,the swimming ability of the robotic manta is verified by field tests.

关键词： Biomimetic robotic manta Central Pattern Generator Closed-loop control Backward swimming

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Towards a bright future： polymer solar cells with power conversion efficiencies over 10%

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Science China Chemistry 2017年第5期60卷 571-582页

作者： Zhicheng Hu Lei Ying Fei Huang yong cao State Key Laboratory of Luminescent Materials and Devices Institute of Polymer Optoelectronic Materials and DevicesSouth China University of Technology

Remarkable progress in high-performance polymer solar cells demonstrates their great potential for practical applications in the near future. Indeed, the power conversion efficiencies over 10% have been reported by many research groups, which are achieved through rational optimization of light-harvesting materials, interfaces and device processing technologies. In this mini review, we summarized the recent progress of highly efficient polymer solar cells, with specifically concern on successful strategies of rational molecular design of electron-donating and electron-accepting materials, elaborative interfacial engineering, and reasonable device architectures.

关键词： polymer solar cells donor/acceptor design interface engineering device engineering

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Investigation on Transmission Properties of Terahertz Wave Through Semiconductor Aperture

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Communications in Theoretical Physics 2008年第2期49卷 485-488页

作者： HE Xiao-yong cao Jun-Cheng State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information Technology the Chinese Academy of Sciences Shanghai 200050 China

The transmission properties of terahertz （THz） wave passing through semiconductor aperture have been investigated. The dispersion relationship for surface plasmon polariton （SPP） at different temperatures has been numerically calculated. The results show that the dispersion relationship increases with the increasing of frequency and the decreasing of temperature, the thickness of slab has to be taken into consideration because of the large skin depth for semiconductor slab. In addition, the propagation constant increases with the increasing of frequency and the decreasing of temperature.

关键词： terahertz surface plasmon propagation constant

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Asymmetric reversible structural switching of a diene coordination polymer promoted by UV-visible light

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Science China Chemistry 2024年第2期67卷 536-541页

作者： yong Wang Qiaoqiao Zhang yong-yong cao Qi Liu Brendan F.Abrahams Jian-Ping Lang College of Chemistry Chemical Engineering and MaterialsSoochow UniversitySuzhou215123China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai200032China College of Biological Chemical Science and EngineeringJiaxing UniversityJiaxing314001China School of Chemistry University of MelbourneVictoria3010Australia

In natural and artificial systems,reversible reactions are commonly asymmetric with respect to the time scale and nature of the stimuli which drive the forward and backward *** applications for which switching behavior is required,it is desirable that the reversible reaction goes as close to symmetric as possible;however,such systems are ***,we report an example of ultraviolet(UV)-visible light-regulated asymmetric reversible structural switching involving a diene-based coordination polymer,CP1 and its monocyclobutane product,*** is possible to cycle at least ten times through a forward [2+2] photocycloaddition reaction and the reverse,photocleavage reaction.A single cycle can be completed within a few *** transformation is accompanied by fast and distinct fluorescence changes,arising from optimisation of the reaction *** functional theory calculations allow rationalisation of the asymmetric reversible transformation between CP1 and CP1a rather than between CP1 and its dicyclobutane product *** work provides a clear illustration of reversible structural switching which approaches symmetric behaviour with respect to reaction rate and *** insights gained from this work also assist in the design of fast,reversible switching materials.

关键词： asymmetrical reversible structural switching coordination polymer photocycloaddition UV-visible light-controlled fluorescence switching

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