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Prevalence and Influencing Factor Analysis of Typhoid/Paratyphoid Fever—China,2011-2020

China CDC weekly 2024年第21期6卷 493-498页

作者： Shumei Huang Meiying yan.Biao kan School of Public Health Shandong UniversityJinan CityShandong ProvinceChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina

Introduction:Over the last 12 years,there has been a consistent decline in the cases of typhoid/paratyphoid fever in *** the epidemiological patterns of these diseases in various provincial-level administrative divisions(PLADs)and examining potential influencing factors can provide crucial information for implementing successful control ***:In this study,we analyzed the cases and incidence rates of typhoid/paratyphoid fever reported in various PLADs of China from 2011 to 2022,along with exploring potential influencing *** initially studied spatial shifts in the incidence rates through centroid shift *** variations in typhoid/paratyphoid fever onset were examined using *** autocorrelation analysis was utilized to understand the spatial correlations among different *** assess potential factors,we utilized a generalized estimating equations model that integrated spatial lag effects and sequence comparison ***:The study identified significant geographical clustering of typhoid/paratyphoid fever cases in southwestern China.A decrease in incidence rates in the west resulted in a movement of the disease center towards the *** incidence occurred during warmer seasons,highlighting the seasonal pattern of the *** such as meteorological conditions and socioeconomic status were probable influencers of typhoid/paratyphoid ***:The geographical and temporal spread of typhoid/paratyphoid fever can be impacted by meteorological and socioeconomic *** economic conditions,particularly in regions with high disease prevalence,could aid in the prevention and management of these fevers.

关键词： prevention utilized meteorological

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Aerodynamic Analysis and Optimization of Pantograph Streamline Fairing for High-Speed Trains

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Fluid Dynamics & Materials Processing 2024年第5期20卷 1075-1091页

作者： Xiang kan yan.Li Tian Li Jiye Zhang State Key Laboratory of Rail Transit Vehicle System Southwest Jiaotong UniversityChengdu610031China Technical Center Southwest Jiaotong University Chengdu Design Institute Co.Ltd.Chengdu610031China

A pantograph serves as a vital device for the collection of electricity in ***,its aerodynamic resistance can limit the train’s running *** installing fairings around the pantograph is known to effectively reduce the resistance,in this study,different fairing lengths are considered and the related aerodynamic performances of pantograph are *** particular,this is accomplished through numerical simulations based on the k-ωShear Stress Transport(SST)two-equation turbulence *** results indicate that the fairing diminishes the direct impact of high-speed airflow on the pantograph,thereby reducing its aerodynamic ***,it also induces interferences in the flow field around the train,leading to variations in the aerodynamic resistance and lift of train *** is shown that a maximum reduction of 56.52%in pantograph aerodynamic resistance and a peak decrease of 3.38%in total train aerodynamic resistance can be achieved.

关键词： Pantograph fairing train aerodynamic numerical simulation

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Manure substitution improves maize yield by promoting soil fertility and mediating the microbial community in lime concretion black soil

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Journal of Integrative Agriculture 2024年第2期23卷 698-710页

作者： Minghui Cao yan.Duan Minghao Li Caiguo Tang Wenjie kan Jiangye Li Huilan Zhang Wenling Zhong Lifang Wu The Center for Ion Beam Bioengineering&Green Agriculture Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China University of Science and Technology of China Hefei 230026China Zhongke Taihe Experimental Station Taihe 236626China Institute of Resources and Environment Jiangsu Academy of Agricultural SciencesNanjing 210014China

Synthetic nitrogen(N)fertilizer has made a great contribution to the improvement of soil fertility and productivity,but excessive application of synthetic N fertilizer may cause agroecosystem risks,such as soil acidification,groundwater contamination and biodiversity ***,organic substitution has received increasing attention for its ecologically and environmentally friendly and productivity ***,the linkages between manure substitution,crop yield and the underlying microbial mechanisms remain *** bridge this gap,a three-year field experiment was conducted with five fertilization regimes:i)Control,non-fertilization;CF,conventional synthetic fertilizer application;CF_(1/2)M_(1/2),1/2 N input via synthetic fertilizer and 1/2 N input via manure;CF_(1/4)M_(3/4),1/4 N input synthetic fertilizer and 3/4 N input via manure;M,manure *** fertilization treatments were designed to have equal N *** results showed that all manure substituted treatments achieved high soil fertility indexes(SFI)and productivities by increasing the soil organic carbon(SOC),total N(TN)and available phosphorus(AP)concentrations,and by altering the bacterial community diversity and composition compared with ***,AP,and the soil C:N ratio were mainly responsible for microbial community *** co-occurrence network revealed that SOC and AP had strong positive associations with Rhodospirillales and Burkholderiales,while TN and C:N ratio had positive and negative associations with Micromonosporaceae,*** specific taxa are implicated in soil macroelement *** Forest analysis predicted that both biotic(bacterial composition and Micromonosporaceae)and abiotic(AP,SOC,SFI,and TN)factors had significant effects on crop *** present work strengthens our understanding of the effects of manure substitution on crop yield and provides theoretical support for optimizing fertilization strategies.

关键词： fertilization manure substitution soil fertility maize yield bacterial community

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Mitophagy in neurodegenerative disease pathogenesis

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Neural Regeneration Research 2024年第5期19卷 998-1005页

作者： kan yan. Yuqing yan.Anni Yu Ru Zhang Yuefang Zhang Zilong Qiu Zhengyi Li Qianlong Zhang Shihao Wu Fei Li Department of Developmental and Behavioural Pediatric&Child Primary Care Brain and Behavioural Research Unit of Shanghai Institute for Pediatric Research and MOE-Shanghai Key Laboratory for Children’s Environmental HealthXinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Center for Excellence in Brain Science and Intelligence Technology Institute of NeuroscienceState Key Laboratory of NeuroscienceCAS Key Laboratory of Primate NeurobiologyChinese Academy of SciencesShanghaiChina College of Materials and Chemical Engineering Hunan Institute of EngineeringXiangtanHunan ProvinceChina School of Medicine Yunnan UniversityKunmingYunnan ProvinceChina Songjiang Research Institute Shanghai Jiao Tong University School of MedicineShanghaiChina Neurosurgery Department Kunming Yenan HospitalKunmingYunnan ProvinceChina

Mitochondria are critical cellular energy resources and are central to the life of the *** selectively clears damaged or dysfunctional mitochondria through autophagic machinery to maintain mitochondrial quality control and *** neurons are postmitotic and consume substantial energy,thus require highly efficient mitophagy pathways to turn over damaged or dysfunctional *** evidence indicates that mitophagy is pivotal to the pathogenesis of neurological ***,more work is needed to study mitophagy pathway components as potential therapeutic *** this review,we briefly discuss the characteristics of nonselective autophagy and selective autophagy,including ERphagy,aggrephagy,and *** then introduce the mechanisms of Parkin-dependent and Parkin-independent mitophagy pathways under physiological ***,we summarize the diverse repertoire of mitochondrial membrane receptors and phospholipids that mediate ***,we review the critical role of mitophagy in the pathogenesis of neurodegenerative diseases including Alzheimer’s disease,Parkinson’s disease,and amyotrophic lateral ***,we discuss recent studies considering mitophagy as a potential therapeutic target for treating neurodegenerative ***,our review may provide novel views to better understand the roles of mitophagy in neurodegenerative disease pathogenesis.

关键词： Alzheimer’s disease amyotrophic lateral sclerosis autophagy mitochondria mitophagy mitophagy receptor Parkin Parkinson’s disease PINK1

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Gut microbiota dysbiosis contributes toα-synuclein-related pathology associated with C/EBPβ/AEP signaling activation in a mouse model of Parkinson’s disease

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Neural Regeneration Research 2024年第9期19卷 2081-2088页

作者： Xiaoli Fang Sha Liu Bilal Muhammad Mingxuan Zheng Xing Ge yan.Xu Shu kan yan. Zhang Yinghua Yu Kuiyan. Zheng Deqin Geng Chun-Feng Liu Department of Neurology and Clinical Research Center of Neurological Disease The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Jiangsu Key Laboratory of Immunity and Metabolism Department of Pathogen Biology and ImmunologyXuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Neurology Xuzhou Central HospitalXuzhouJiangsu ProvinceChina Jiangsu Key Laboratory of Neuropsychiatric Disease and Institute of Neuroscience Soochow UniversitySuzhouJiangsu ProvinceChina

Parkinson’s disease is a neurodegenerative disease characterized by motor and gastrointestinal *** dysfunction can precede the onset of motor symptoms by several *** microbiota dysbiosis is involved in the pathogenesis of Parkinson’s disease,whether it plays a causal role in motor dysfunction,and the mechanism underlying this potential effect,remain ***/enhancer binding proteinβ/asparagine endopeptidase(C/EBPβ/AEP)signaling,activated by bacterial endotoxin,can promoteα-synuclein transcription,thereby contributing to Parkinson’s disease *** this study,we aimed to investigate the role of the gut microbiota in C/EBPβ/AEP signaling,α-synuclein-related pathology,and motor symptoms using a rotenone-induced mouse model of Parkinson’s disease combined with antibiotic-induced microbiome depletion and fecal microbiota *** found that rotenone administration resulted in gut microbiota dysbiosis and perturbation of the intestinal barrier,as well as activation of the C/EBP/AEP pathway,α-synuclein aggregation,and tyrosine hydroxylase-positive neuron loss in the substantia nigra in mice with motor ***,treatment with rotenone did not have any of these adverse effects in mice whose gut microbiota was depleted by pretreatment with ***,we found that transplanting gut microbiota derived from mice treated with rotenone induced motor deficits,intestinal inflammation,and *** of fecal microbiota from healthy control mice alleviated rotenone-induced motor deficits,intestinal inflammation,endotoxemia,and intestinal barrier *** results highlight the vital role that gut microbiota dysbiosis plays in inducing motor deficits,C/EBPβ/AEP signaling activation,andα-synuclein-related pathology in a rotenone-induced mouse model of Parkinson’s ***,our findings suggest that supplementing with healthy microbiota may be a safe and effective treatment that c

关键词： C/EBP/AEP signaling pathway endotoxemia fecal microbiota transplantation intestinal barrier intestinal inflammation microbiota-gut-brain axis Parkinson’s disease

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Serum activin A as a prognostic biomarker for community acquired pneumonia

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World Journal of Clinical Cases 2024年第22期12卷 5016-5023页

作者： Yu-Ting Wang yan.Liu Guang-Hui Zhou kan Liu yan.Fen Hui Ding Pulmonary and Critical Care Medicine Yixing People’s Hospital of Jiangsu UniversityYixing 214200Jiangsu ProvinceChina

BACKGROUND It is essential to develop new biomarker with effective prognostic roles because of the unclear clinical use of the current community-acquired pneumonia(CAP)*** To evaluate the association between serum activin A levels and prognosis in CAP *** A total of 168 CAP individuals grouped according to the severity and prognosis of illness condition,and 48 healthy individuals as the control group were enrolled in this *** concentrations of activin A were measured using enzymelinked *** interaction between activin A levels and etiologies of CAP was *** on the severity of CAP,110 patients(65.48%)were categorized into group-I,42(25%)cases were grouped into group-II,and 16(9.52%)cases were categorized into *** Serum activin A levels were higher in patients with CAP than controls,but independent of ***,the scores of Pneumonia Severity Index(PSI)and CURB-65 positively correlated with the increasing levels of serum activin A,and were at their highest peak in individuals in group-III(P<0.001).Combining activin A with CURB-65 or PSI was more effective in improving predictive property(P<0.01).According to Cox proportional regression analysis,after adjusting clinical parameters,we confirmed that activin A showed a powerful predictive property for hospital mortality in CAP patients(P<0.001).CONCLUSION Higher level of serum activin A was associated with poor prognosis of *** A can be used as a more valuable biomarker of prognosis in CAP patients.

关键词： Community-acquired pneumonia Activin A Etiology Prognosis Etiology

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Review of the potential value of serum interleukin levels as prognostic biomarkers of liver failure

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World Journal of Clinical Cases 2024年第27期12卷 6045-6056页

作者： yong Lin Geng-Jie yan.Mei-yan.Liu Yin Cao kan Zhang Na Wang Fu-Li Long De-Wen Mao Graduate School Guangxi University of Chinese MedicineNanning 530200Guangxi Zhuang Autonomous RegionChina Guangxi School of Chinese Medicine Guangxi University of Traditional Chinese MedicineNanning 530022Guangxi Zhuang Autonomous RegionChina Department of Hepatology The First Affiliated Hospital of Guangxi University of Chinese MedicineNanning 530023Guangxi Zhuang Autonomous RegionChina Department of Administration The First Affiliated Hospital of Guangxi University of Chinese MedicineNanning 530023Guangxi Zhuang Autonomous RegionChina

Liver failure(LF)is prevalent in China and is characterized by complex path-ogenesis,challenging clinical management,poor prognosis,and rising incidence and mortality *** immune status is an important factor affecting LF ***(Ils)are a type of cytokine that act and interact with multiple cells,including immune *** signaling molecules play important roles in intercellular information transmission,including the regulation of immune cells;mediation of the activation,proliferation,and differentiation of T and B cells;and orchestration of the inflammatory *** date,many studies have explored the correlation between IL expression and liver disease prognosis,but few studies have evaluated Ils as the prognostic biomarkers of *** article reviews the potential use of Ils as the prognostic biomarkers of ***,it evaluates the predictive values of IL-21,IL-22,and IL-31,the three often overlooked yet promising prognostic biomarkers,in predicting suscept-ibility to *** biomarkers for early prognostic insights can facilitate tailored treatment strategies and enhance patient ***,this article focuses on the identification of IL-21,IL-22,and IL-33 as biomarkers in preclinical and clinical studies on LF and reviews their role as biomarkers in the pathogenesis and diagnosis of LF.

关键词： Interleukin-21 Interleukin-22 Interleukin-31 Liver failure Biological markers Potential value

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双弯曲旋转超声椭圆振动加工系统设计

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北京航空航天大学学报 2024年第9期50卷 2912-2918页

作者：邵壮壮郑侃董松孙振文孙连军严嘉文南京理工大学机械工程学院南京210094

由于旋转超声单一振动模式加工效率提升有限,因此采用超声振动激励源耦合法设计了一种双弯曲旋转超声椭圆振动加工系统。推导弯曲波动方程,计算的弯曲超声振动系统参数与仿真结果的理论分析误差仅为5%。耦合双弯曲旋转超声椭圆振动加工... 详细信息

由于旋转超声单一振动模式加工效率提升有限,因此采用超声振动激励源耦合法设计了一种双弯曲旋转超声椭圆振动加工系统。推导弯曲波动方程,计算的弯曲超声振动系统参数与仿真结果的理论分析误差仅为5%。耦合双弯曲旋转超声椭圆振动加工系统2个不同方向的振动,控制弯振频率偏差低于1%。对超声刀柄的法兰位置与形状进行有限元分析发现,开设减振槽有利于增大弯振振幅,并确定了法兰的最佳位置。对双弯曲旋转超声椭圆振动加工系统的振动频率和振幅进行测试,结果表明:所设计系统在工作频率和2个方向的振幅均满足设计预期。

关键词：双弯曲超声椭圆振动激励源耦合超声刀柄弯振频率弯振振幅

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肿瘤医院护士对女性癌症患者生育力保护的知信行现状及影响因素分析

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中华护理杂志 2024年第12期59卷 1490-1496页

作者：陈小岑阚中帆谷晨晨付雅鑫严玄月阎玲国家恶性肿瘤临床医学研究中心/天津市“肿瘤防治”重点实验室/天津市恶性肿瘤临床医学研究中心/天津医科大学肿瘤医院放射治疗科天津市300060 国家恶性肿瘤临床医学研究中心/天津市“肿瘤防治”重点实验室/天津市恶性肿瘤临床医学研究中心/天津医科大学肿瘤医院护理部天津市300060 天津中医药大学研究生院

目的调查肿瘤医院护士对女性癌症患者生育力保护的知信行现状并分析其影响因素,为临床开展相关护理服务工作提供依据。方法于2022年10月,通过便利抽样法,采用一般资料调查表、肿瘤医院护士对女性癌症患者生育力保护知信行问卷对天津市... 详细信息

目的调查肿瘤医院护士对女性癌症患者生育力保护的知信行现状并分析其影响因素,为临床开展相关护理服务工作提供依据。方法于2022年10月,通过便利抽样法,采用一般资料调查表、肿瘤医院护士对女性癌症患者生育力保护知信行问卷对天津市某三级甲等肿瘤医院的336名护士进行问卷调查,采用单因素分析及多元线性回归分析肿瘤医院护士对女性癌症患者生育力保护知信行水平的影响因素。结果最终纳入291名肿瘤医院护士,其对女性癌症患者生育力保护知信行问卷的总分为(88.08±12.78)分,知识、态度、行为维度得分分别为(46.13±8.66)、[31.00(29.00,33.00)]、[12.00(8.00,14.00)]分。多元线性回归分析结果显示,文化程度、职务、科室类别和是否学习过女性癌症患者生育力保护相关知识是肿瘤医院护士对女性癌症患者生育保护知信行水平的影响因素。结论肿瘤医院护士对女性癌症患者生育力保护的态度较为积极,但知识掌握不足,行为有待加强。护理管理者应重视提高肿瘤医院护士对女性癌症患者生育力保护的知识水平和实践能力,从而推动肿瘤生殖护理的发展。

关键词：生育力保护肿瘤护士知识态度行为影响因素分析护理管理研究

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抽蓄系统抽水快转发电过渡过程的水力不稳定性

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南水北调与水利科技（中英文） 2024年第4期22卷 821-832页

作者：汤国和闫晓彤何腾张志兵郑源阚阚华电福新周宁抽水蓄能有限公司福建宁德355400 河海大学水利水电学院南京210098 河海大学电气与动力工程学院南京211100

为满足电力系统动态服务需求,要求抽蓄系统快速完成工况转换,抽水快转发电过渡过程是抽蓄系统在工况转换过程中最为复杂和危险的工况之一,但目前相关研究较少。为明确该过程的水力不稳定性,建立抽蓄电站全过流系统三维模型,开展抽蓄系... 详细信息

为满足电力系统动态服务需求,要求抽蓄系统快速完成工况转换,抽水快转发电过渡过程是抽蓄系统在工况转换过程中最为复杂和危险的工况之一,但目前相关研究较少。为明确该过程的水力不稳定性,建立抽蓄电站全过流系统三维模型,开展抽蓄系统抽水快转发电过渡过程的数值模拟计算,探究水泵水轮机组的外特性参数变化、压力脉动特性和内部流态演变。研究表明:抽蓄机组抽水快转发电过程中,流量、力矩及受力的变化皆随着活动导叶动作呈现出阶梯式变化;水泵制动运行工况及转轮转速发生转向期间为机组易产生较大摆动、力矩易发生剧烈波动的时段,且尤以无叶区的压力波动最为剧烈;导叶开度的快速变化以及流量和转速的变向成为机组内部危险流动的主要来源。研究结果可为提高抽水快转发电过渡过程中的稳定性和优化控制策略提供理论支撑。

关键词：抽蓄全过流系统水泵水轮机抽水快转发电过渡过程水力不稳定性

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