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engineering nanomedicines for immunogenic eradication of cancer cells:Recent trends and synergistic approaches

Acta Pharmaceutica Sinica B 2024年第6期14卷 2475-2504页

作者： Ahmed O.elzoghby Omar Samir Hagar e.emam Ahmed Soliman Riham m.Abdelgalil yomna m.e.morshe.y Kadria A.elkhodairy mahmoud L.Nasr Division of engineering in medicine and Division of Renal medicine Department of MedicineBrigham and Women's HospitalHarvard Medical SchoolBoston 02115MAUSA Cancer Nanotechnology Research Laboratory(CNRL) Faculty of PharmacyAlexandria UniversityAlexandria 21521Egypt

Resistance to cancer immunotherapy is mainly attributed to poor tumor immunogenicity as well as the immunosuppressive tumor microenvironment(Tme)leading to failure of immune *** therapeutic strategies including chemotherapy,radiotherapy,photodynamic,photothermal,magnetic,chemodynamic,sonodynamic and oncolytic therapy,have been developed to induce immunogenic cell death(ICD)of cancer cells and thereby elicit immunogenicity and boost the antitumor immune ***,many challenges hamper the clinical application of ICD inducers resulting in modest immunogenic ***,we outline the current state of using nanomedicines for boosting ICD of cancer ***,synergistic approaches used in combination with ICD inducing nanomedicines for remodeling the Tme via targeting immune checkpoints,phagocytosis,macrophage polarization,tumor hypoxia,autophagy and stromal modulation to enhance immunogenicity of dying cancer cells were *** further highlight the emerging trends of using nanomaterials for triggering amplified ICD-mediated antitumor immune *** reticulum localized ICD,focused ultrasound hyperthermia,cell membrane camouflaged nanomedicines,amplified reactive oxygen species(ROS)generation,metallo-immunotherapy,ion modulators and engineered bacteria are among the most innovative *** challenges,merits and demerits of ICD inducer nanomedicines were also discussed with shedding light on the future role of this technology in improving the outcomes of cancer immunotherapy.

关键词： Immunogenic cell death Immunogenic eradication Nanomedicines Drug delivery Cancer immunotherapy Antitumor immunity T cells Tumor associated antigens Synergistic immune response

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Bone marrow microRNA-34a is a good indicator for response to treatment in acute myeloid leukemia

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Oncology Research 2024年第3期32卷 577-584页

作者： mONA SA BDeLLATeIF NAGLAA mHASSAN mAHmOUD mKAmeL yomna meL-meLIGUI Department of Cancer Biology Medical Biochemistry and Molecular BiologyNational Cancer InstituteCairo UniversityCairo11976Egypt Department of Cinical Pathology National Cancer InstituteCairo UniversityCairo11976Egypt

Background:microRNA 34a(miR 34a)had been reported to have a diagnostic role in acute myeloid leukemia(AmL).However,its value in the bone marrow(Bm)of AmL patients,in addition to its role in response to therapy is still *** current study was designed to assess the diagnostic,prognostic,and predictive significance of miR 34a in the Bm of AmL ***:The miR.34a was assed in Bm aspirate of 82 AmL patients in relation to 12 normal control subjects using *** data were assessed for correlation with the relevant dinical critenia,response to therapy,disease-free survival(DFS),and overall survival(OS)***:miR.34a was significantly downregulated in AmL patients[0.005(3.3×10^(-6)-1.32)],compared to the control subjects[0.108(3.2× 10^(-4)-1.64),p=0.021].*** relative quantification(RQ)of miR-34a was 0.106(range;0-32.12).The specifaity,sensitivity,and area under the curve(AUC)for the diagnosis of AmL were(58.3%,69.5%,0.707,respectively,p=0.021).patients with upregulated miR-34a showed decreased platelets counteved early complete remission(CR,p=0.031,p=0.044,respectively).Similarly,patients who were refractory to therapy showed decreased miR 34a levels in comparison to those who achieved CR[0.002(0-0.01)and 0.12(0-32.12),respectively,p=0.002].Therefore,miR 34a could significantly identify patients with CR with a specificity of 75%and sensitivity of 100%at a cut-off of 0.014(AUC=0.927,p=0.005).There was no considerable association between miR-34a expression and survival rates of the induded AmL ***:miR-34a could be a beneficial diagnostic biomarker for AmL *** addition,it serves as a good indicator for response to therapy,which could possibly identify patients who are refractory to treatment with 100%sensitivity and 75%specificity.

关键词： AmL miR 34a microRNA Leukemia

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A holistic approach to improving safety for battery energy storage systems

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Journal of energy Chemistry 2024年第5期92卷 422-439页

作者： James Close Jonathan e.Barnard y.m.John Chew Semali Perera Department of Chemical engineering Centre for DigitalManufacturing&DesignUniversity of BathBath BA27AYUK iomosaic International Limited 16-18 Queen SquareBath BA12HNUK

The integration of battery energy storage systems(BeSS)throughout our energy chain poses concerns regarding safety,especially since batteries have high energy density and numerous BeSS failure events have *** spread adoption will only increase the prevalence of these failure events unless there is a step change in the management and design of *** understand the causes of failure,the main challenges of BeSS safety are *** consequences and failure events are discussed,including specific focus on the chain of events causing thermal runaway,and a case study of a BeSS explosion in Surprise Arizona is *** on the technology and past events,a paradigm shift is required to improve BeSS *** this review,a holistic approach is *** combines currently adopted approaches including battery cell testing,lumped cell mathematical modelling,and calorimetry,alongside additional measures taken to ensure BeSS safety including the requirement for computational fluid dynamics and kinetic modelling,assessment of installation level testing of the full BeSS system and not simply a single cell battery test,hazard and layers of protection analysis,gas chromatography,and composition *** holistic approach proposed in this study aims to address challenges of BeSS safety and form the basis of a paradigm shift in the safety management and design of these systems.

关键词： energy storagesystems Process safety Battery safety Thermal safety

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On B(5,20)2-Groups

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Algebra Colloquium 2024年第3期31卷 429-440页

作者： e.A.Alhassan y.L.Tan y.Li School of mathematical Sciences Jiangsu UniversityZhenjiangJiangsu 212013China Department of mathematics Brock UniversitySt.CatharinesOntario L2S 3A1Canada

A finite group G is said to be a B(n,k)group if for any n-element subset[a_(1),…,a_(n)]of G,|{a_(i)a_(j)|1≤i,j≤n}|≤*** is of interest to characterize the structure of B(n,k)groups for n(n+1)/2≤k≤n^(2)-*** B(5,k)groups for 15≤k≤19 have been investigated by several *** this paper,we give a complete characterization of B(5,20)2-groups by showing there are five classes of such groups which are nontrivial and nonabelian.

关键词： B(n,k)groups small squaring property central extension GAP

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Growth of RB Population in the Conversion Phase of Chlamydia Life Cycle

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Communications on Applied mathematics and Computation 2024年第1期6卷 90-112页

作者： Frederic y.m.Wan Department of mathematics University of CaliforniaIrvineCA92697-3875USA

Upon infecting a host cell,the reticulate body(RB)form of the Chlamydia bacteria simply proliferates by binary fission for an extended *** data show only RB units in the infected cells 20 hours post infection(hpi),spanning nearly half way through the development *** data collected every 4 hpi,conversion to the elementary body(eB)form begins abruptly at a rapid rate sometime around 24 *** modeling proliferation and conversion as simple birth and death processes,it has been shown that the optimal strategy for maximizing the total(mean)eB population at host cell lysis time is a bang-bang control qualitatively replicating the observed conversion ***,the simple birth and death model for the RB proliferation and conversion to eB deviates in a significant way from the available data on the evolution of the RB population after the onset of RB-to-eB *** working with a more refined model that takes into account a small size threshold eligibility requirement for conversion noted in the available data,we succeed in removing the deficiency of the previous models on the evolution of the RB population without affecting the optimal bang-bang conversion strategy.

关键词： Chlamydia Life cycle Optimal control maximal infectious spread Specie competitive survival

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A Collocation Technique via Pell-Lucas Polynomials to Solve Fractional Differential equationmodel for HIV/AIDS with Treatment Compartment

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Computer modeling in engineering & Sciences 2024年第10期141卷 281-310页

作者： Gamze yıldırım Suayip yüzbası Department of mathematics Faculty of ScienceAkdeniz UniversityAntalya07058Turkey Department of mathematics Faculty of Basic ScienceGebze Technical UniversityKocaeli41400Turkey Department of mathematics Faculty of ScienceBartın UniversityBartın74100Turkey

In this study,a numerical method based on the Pell-Lucas polynomials(PLPs)is developed to solve the fractional order HIV/AIDS epidemic model with a treatment *** HIV/AIDS mathematical model with a treatment compartment is divided into five classes,namely,susceptible patients(S),HIV-positive individuals(I),individuals with full-blown AIDS but not receiving ARV treatment(A),individuals being treated(T),and individuals who have changed their sexual habits sufficiently(R).According to the method,by utilizing the PLPs and the collocation points,we convert the fractional order HIV/AIDS epidemic model with a treatment compartment into a nonlinear system of the algebraic ***,the error analysis is presented for the Pell-Lucas approximation *** aim of this study is to observe the behavior of five populations after 200 days when drug treatment is applied to HIV-infectious and full-blown AIDS *** demonstrate the usefulness of this method,the applications are made on the numerical example with the help of *** addition,four cases of the fractional order derivative(p=1,p=0.95,p=0.9,p=0.85)are examined in the range[0,200].Owing to applications,we figured out that the outcomes have quite decent ***,we understand that the errors decrease when the value of N *** figures in this study are created in *** outcomes indicate that the presented method is reasonably sufficient and correct.

关键词： Collocation method fractional differential equations HIV/AIDS epidemic model Pell-Lucas polynomials

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Quantum correlations and entanglement in coupled optomechanical resonators with photon hopping via Gaussian interferometric power analysis

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Chinese Physics B 2024年第5期33卷 204-211页

作者： y.Lahlou B.maroufi m.Daoud LPHe-mS Department of PhysicsFaculty of SciencesMohammed V UniversityRabatMorocco LPmS Department of PhysicsFaculty of SciencesIbn Tofail UniversityKénitraMorocco

Quantum correlations that surpass entanglement are of great importance in the realms of quantum information processing and quantum ***,for quantum systems prepared in pure states,it is difficult to differentiate between quantum entanglement and quantum ***,this indistinguishability is no longer holds for mixed *** contribute to a better understanding of this differentiation,we have explored a simple model for both generating and measuring these quantum *** study concerns two macroscopic mechanical resonators placed in separate Fabry–Pérot cavities,coupled through the photon hopping *** system offers a comprehensively way to investigate and quantify quantum correlations beyond entanglement between these mechanical *** key ingredient in analyzing quantum correlation in this system is the global covariance *** forms the basis for computing two essential metrics:the logarithmic negativity(e_(N)^(m))and the Gaussian interferometric power(P_(G)^(m)).These metrics provide the tools to measure the degree of quantum entanglement and quantum correlations,*** study reveals that the Gaussian interferometric power(P_(G)^(m))proves to be a more suitable metric for characterizing quantum correlations among the mechanical modes in an optomechanical quantum system,particularly in scenarios featuring resilient photon hopping.

关键词： quantum correlations entanglement Gaussian interferometric power logarithmic negativity optomechanics photon hopping

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Supposition of graphene stacks to estimate the contact resistance and conductivity of nanocomposites

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Applied mathematics and mechanics(english edition) 2024年第4期45卷 663-676页

作者： y.ZARe m.T.mUNIR G.J.WeNG K.y.RHee Biomaterials and Tissue engineering Research Group Department of Interdisciplinary TechnologiesBreast Cancer Research CenterMotamed Cancer InstituteTehran ***Iran College of engineering and Technology American University of the Middle EastEgaila 54200Kuwait Department of mechanical and Aerospace engineering Rutgers UniversityNew BrunswickNJ 08903U.S.A. Department of mechanical engineering(BK21 Four) College of EngineeringKyung Hee UniversityYongin 446701Republic of Korea

In this study,the effects of stacked nanosheets and the surrounding interphase zone on the resistance of the contact region between nanosheets and the tunneling conductivity of samples are evaluated with developed equations superior to those previously *** contact resistance and nanocomposite conductivity are modeled by several influencing factors,including stack properties,interphase depth,tunneling size,and contact *** developed model's accuracy is verified through numerous experimental *** further validate the models and establish correlations between parameters,the effects of all the variables on contact resistance and nanocomposite conductivity are ***,the contact resistance is primarily dependent on the polymer tunnel resistivity,contact area,and tunneling *** dimensions of the graphene nanosheets significantly influence the conductivity,which ranges from 0 S/m to90 S/*** increased number of nanosheets in stacks and a larger gap between them enhance the nanocomposite's ***,the thicker interphase and smaller tunneling size can lead to higher sample conductivity due to their optimistic effects on the percolation threshold and network efficacy.

关键词： graphene polymer composite stacked nanosheet tunneling conductivity contact resistance interphase

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Impact of device resistances in the performance of graphene‑based terahertz photodetectors

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Frontiers of Optoelectronics 2024年第2期17卷 87-97页

作者： O.Castelló Sofía m.López Baptista K.Watanabe T.Taniguchi e.Diez J.e.Velázquez-Pérez y.m.meziani J.m.Caridad J.A.Delgado-Notario Department of Applied Physics University of Salamanca37008 SalamancaSpain Unidad de excelencia en Luz y materia estructurada(LUmeS) University of Salamanca37008 SalamancaSpain Research Center for electronic and Optical materials National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan Research Center for materials Nanoarchitectonics National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan Nanotechnology Group USAL-NanolabUniversity of Salamanca37008 SalamancaSpain

In recent years,graphene field-effect-transistors(GFeTs)have demonstrated an outstanding potential for terahertz(THz)photodetection due to their fast response and *** features are essential to enable emerging THz applications,including 6G wireless communications,quantum information,bioimaging and ***,the overall performance of these photodetectors may be utterly compromised by the impact of internal resistances presented in the device,so-called access or parasitic *** this work,we provide a detailed study of the influence of internal device resistances in the photoresponse of high-mobility dual-gate GFeT *** dual-gate architectures allow us to fine tune(decrease)the internal resistance of the device by an order of magnitude and consequently demonstrate an improved responsivity and noise-equivalent-power values of the photodetector,*** results can be well understood by a series resistance model,as shown by the excellent agreement found between the experimental data and theoretical *** findings are therefore relevant to understand and improve the overall performance of existing high-mobility graphene photodetectors.

关键词： Graphene THz Photodetector Field-effect transistor Plasmonic

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Optimal Coordination of Transportable Power Sources and Repair Crews for Service Restoration of Distribution Networks Considering Uncertainty of Traffic Congestion

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Journal of modern Power Systems and Clean energy 2024年第1期12卷 189-201页

作者： Zhao Shi yan Xu Dunjian Xie Shiwei Xie Amer m.y.m.Ghias Nanyang Technological University Singapore the School of electrical engineering and Automation Fuzhou UniversityFuzhou 350108China

This paper proposes a new method for service restoration of distribution network with the support of transportable power sources(TPSs)and repair crews(RCs).Firstly,a coupling model of distribution networks and vehicle routing of TPSs and RCs is proposed,where the TPSs serve as emergency power supply sources,and the RCs are used to repair the faulted *** the uncertainty of traffic congestion,the probability distribution of the travel time spent on each road is derived based on the Nesterov user equilibrium model,and a two-stage stochastic program is formulated to determine the optimal routings of TPSs and *** efficiently solve the proposed stochastic mixed-integer linear program(mILP),a two-phase scenario reduction method is then developed to scale down the problem size,and an adaptive progressive hedging algorithm is used for an efficient *** effectiveness of the proposed methods and algorithms has been illustrated in a modified Ieee 33-bus system.

关键词： Service restoration distribution network traffic uncertainty transportable power source repair crew stochastic program

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