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The Iberian Roma Population Variant Server(IRPVS)

Journal of Genetics and Genomics 2024年第7期51卷 769-773页

作者： Fabiola Mavillard Javier Perez-Florido Francisco M.Ortuño Amador Valladares Miren L.Álvarez-Villegas Gema Roldán Rosario Carmona Manuel Soriano Santiago Susarte Pilar Fuentes Daniel López-López Ana María Nuñez-Negrillo Alejandra Carvajal yolanda Morgado Daniel Arteaga Rosa Ufano Pablo Mir Juan F.Gamella Joaquín Dopazo Carmen Paradas Macarena Cabrera-Serrano Instituto de Biomedicina de Sevilla(IBiS) Hospital Universitario Virgen del Rocío/CSIC/Universidad de SevillaSevillaSpain Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas(CIBERNED) Instituto de Salud CarlosⅢSevillaSpain Plataforma Andaluza de Medicina Computacional Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevillaSpain Grupo de medicina computacional de sistemas Instituto de Biomedicina de Sevilla(IBiS)Hospital Virgen del RocíoSevillaSpain Nodo de Genómica Funcional (INB-ELIXIR-es)Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevilla 41013Spain Bioinformática en Enfermedades raras(BiER) Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER)Instituto de salud CarlosⅢSevillaSpain Departamento de Ingeniería de Computadores Automática y RobóticaUniversidad de GranadaGranadaSpain Servicio de Urgencias de Atención Primaria Distrito SevillaSevillaSpain Centro de Servicios Sociales Negociado de Servicios EspecializadosAyuntamiento de SevillaSevillaSpain Departamento de Enfermería Facultad de Ciencias de la SaludUniversidad de GranadaGranadaSpain Departamento de Neurología Hospital Virgen de las NievesGranadaSpain Departamento de Neurología Hospital Virgen de ValmeSevillaSpain Centro de Salud Utrera Sur SevillaSpain Centro de Salud Polígono Sur SevillaSpain Unidad de Trastornos del Movimiento Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain Departamento de Medicina Facultad de MedicinaUniversidad de SevillaSevilleSpain Departamento de Antropología Social Universidad de GranadaSpain Unidad Enfermedades Neuromusculares Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain

In recent years,the number of known disease genes has exponentially grown due to the widespread adoption of cost-effective massive parallel *** identify new disease variants,especially in monogenic disorders,a frequen... 详细信息

关键词： Server filtering massive

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A review of landscape ecology experiments to understand ecological processes

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Ecological Processes 2022年第1期11卷 802-811页

作者： yolanda F.Wiersma Department of Biology Memorial UniversitySt.John’sNL A1C 5S7Canada

Background:One way in which we make inferences about ecological processes is via *** ecological processes happen at landscape extents and it is at this extent that experimentation is more *** review explores the intersection between experimentation,ecological processes and landscape ***,this review seeks to discover how scientists design experiments to understand ecological processes at landscape ***:I found 87 papers where these three concepts intersected,and reviewed them in more depth to assess characteristics of scale(treatment and study area extent),replication,research question and experiment ***:The findings suggest that experimental approaches for understanding ecological processes are well established,and beginning to more readily accommodate spatial ***,there is room to integrate more spatially explicit,landscape-scale experiments into studies of ecological processes.

关键词： Inference Landscape ecology Manipulative experiment Observational experiment Scale

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Performance of aerogel as a thermal insulation material towards a sustainable design of residential buildings for tropical climates in Nigeria

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Energy and Built Environment 2022年第3期3卷 291-315页

作者： Aminu Wali Bashir Brenda chaves Coelho Leite Departamento de Engenharia de Construção Civil Escola Politécnica da Universidade de São PauloSão Paulo 05508-010Brasil

The building sector accounts for nearly 40%of global energy *** Nigeria,more than two-thirds of the consumption comes from residential *** efficiency measures through the adoption of insulation materials are tools that could crash the peak demand of energy in buildings while improving its thermal comfort and aerogel is considered as the most effective material for insulation,owing to its unique thermal *** this paper,we present the performance of aerogel as a thermal insulation material towards a sustainable design of residential buildings for tropical climates in ***,a typical residential building in the tropical region was modeled with conventional materials utilized in the region and was later modified through the application of aerogel material on various surfaces of the model.A whole building energy simulation was then carried out in each variation and the outcome was compared to effectively conclude on the significance of aerogel in terms of thermal comfort improvement and energy consumption *** show that aerogel had the highest influence when inserted in the attic and floor slabs of the designed model.A reduction of more than 6%was attained in the recorded indoor mean air and operative temperatures while still maintaining an acceptable humidity *** energy consumption,a reduction of more than 15%was ***,the high price of aerogel may hinder its application on the studied building but could be a good investment where climate change and sustainability are of high importance and less concern is given to *** demonstrated significant potential with respect to both thermal comfort improvement and energy consumption reduction on the designed *** outcome of the study is hoped to serve as a base reference for the insulation of residential buildings with similar climate and characteristics to the adopted case building.

关键词： Aerogels Building energy consumption Energy efficiency Thermal insulation materials Thermal comfort Building energy simulation

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Soil organic carbon stocks in native forest of Argentina:a useful surrogate for mitigation and conservation planning under climate variability

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Ecological Processes 2024年第1期13卷 3-24页

作者： Pablo L.Peri Juan Gaitán Matías Mastrangelo Marcelo Nosetto Pablo E.Villagra Ezequiel Balducci Martín Pinazo Roxana P.Eclesia Alejandra Von Wallis Sebastián Villarino Francisco Alaggia Marina González Polo Silvina Manrique Pablo A.Meglioli Julián Rodríguez-Souilla Martín Mónaco Jimena E.chaves Ariel Medina Ignacio Gasparri Eugenio Alvarez Arnesi María Paula Barral Axel von Müller Norberto M.Pahr Josefina Uribe Echevarria Pedro Fernández Marina Morsucci Dardo López Juan Manuel Cellini Leandro Alvarez Ignacio Barberis Hernán Colomb Ludmila La Manna Sebastián Barbaro Cecilia Blundo Ximena Sirimarco Laura Cavallero Gualberto Zalazar Guillermo Martínez Pastur Instituto Nacional de Tecnología Agropecuaria (INTA) Universidad Nacional de la Patagonia Austral (UNPA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Universidad Nacional de Luján Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Grupo de Estudio de Agroecosistemas y Paisajes Rurales (GEAP) Universidad Nacional de Mar del Plata Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET ) CCT San Luis Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Instituto Argentino de Nivología Glaciología y Ciencias Ambientales (IANIGLA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Universidad Nacional de Cuyo Instituto de Investigaciones en Biodiversidad y Medioambiente (INIBIOMA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Instituto de Investigaciones en Energía No Convencional CCT Salta-JujuyConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Laboratorio de Recursos Agroforestales Centro Austral de Investigaciones Científicas (CADIC) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Dirección Nacional de Bosques Ministerio de Ambiente y Desarrollo Sostenible de la Nación Instituto de Ecología Regional Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET )Universidad Nacional de Tucumán Universidad Nacional de Rosario Instituto de Investigaciones en Ciencias Agrarias de Rosario Centro Científico Tecnológico CONICET Grupo de Estudio de Agroecosistemas y Paisajes Rurales (GEAP) Universidad Nacional de Mar del Plata Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Laboratorio de Investigaciones en Maderas (LIMAD) Universidad Nacional de La Plata (UNLP) Administración de Parques Nacionales (APN) Parque Nacional Los Alerces Centro de Estudios Ambientales Integrados (CEAI) Universidad Nacional de la Patagonia San Juan Bosco (UNPASJB) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET )

Background The nationally determined contribution（NDC） presented by Argentina within the framework of the Paris Agreement is aligned with the decisions made in the context of the United Nations Framework Conven-tion on Climate Change（UNFCCC） on the reduction of emissions derived from deforestation and forest degradation, as well as forest carbon conservation（REDD+）. In addition, climate change constitutes one of the greatest threats to forest biodiversity and ecosystem services. However, the soil organic carbon（SOC） stocks of native forests have not been incorporated into the Forest Reference Emission Levels calculations and for conservation planning under cli-mate variability due to a lack of information. The objectives of this study were:（i） to model SOC stocks to 30 cm of native forests at a national scale using climatic, topographic and vegetation as predictor variables, and（ii） to relate SOC stocks with spatial–temporal remotely sensed indices to determine biodiversity conservation concerns due to threats from high inter-annual climate *** We used 1040 forest soil samples（0–30 cm） to generate spatially explicit estimates of SOC native forests in Argentina at a spatial resolution of approximately 200 m. We selected 52 potential predictive environmental covari-ates, which represent key factors for the spatial distribution of SOC. All covariate maps were uploaded to the Google Earth Engine cloud-based computing platform for subsequent modelling. To determine the biodiversity threats from high inter-annual climate variability, we employed the spatial–temporal satellite-derived indices based on Enhanced Vegetation Index（EVI） and land surface temperature（LST） images from Landsat *** SOC model（0–30 cm depth） prediction accounted for 69% of the variation of this soil property across the whole native forest coverage in Argentina. Total mean SOC stock reached 2.81 Pg C（2.71–2.84 Pg C with a probability of 90%） for a total area of 460,790 km2,

关键词： Soil organic carbon Biodiversity Native forest Climate change mitigation Modelling Resilience

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化学与微生物实验室

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现代装饰 2024年第3期 62-69页

作者： Jose Luis Esteban Penelas(设计) yolanda Hernandez Lorente(设计) Maria Esteban Casanas(设计) Antonio Guijarro(设计) Marina Rodriguez Sotoca(设计) Kevin Roman Cruz(设计) Yakaterina Savina(设计) Imagen Subliminal(摄影) 舒禹(编译) 不详 Miguel de Guzman+Rocio Romero

建筑呈现明显的后工业美学特征,内设有一个微生物和化学分析实验室,功能设施极为复杂,使用中需要极高的功能效率与超先进的图像兼容。设计重新激活地区周围的强大工业景观,通过穿孔立面,过滤环境并生成独特的室内景观。

关键词：微生物实验室工业景观室内景观功能设施美学特征

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Automatic Detection of Nephrops Norvegicus Burrows from Underwater Imagery Using Deep Learning

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Computers, Materials & Continua 2022年第3期70卷 5321-5344页

作者： Atif Naseer Enrique Nava Baro Sultan Daud Khan yolanda Vila Jennifer Doyle ETSI Telecomunicación Universidad deMálagaMálaga29071Spain Department of Computer Science National University of TechnologyIslamabad44000Pakistan Instituto Espanol de Oceanografía Centro Oceanográfico de CádizCádiz39004Spain Marine Institute Rinville OranmoreIreland

The Norway lobster,Nephrops norvegicus,is one of the main commercial crustacean fisheries in *** abundance of Nephrops norvegicus stocks is assessed based on identifying and counting the burrows where they live from underwater videos collected by camera systems mounted on *** Spanish Oceanographic Institute(IEO)andMarine Institute Ireland(MIIreland)conducts annual underwater television surveys(UWTV)to estimate the total abundance of Nephrops within the specified area,with a coefficient of variation(CV)or relative standard error of less than 20%.Currently,the identification and counting of the Nephrops burrows are carried out manually by the marine *** is quite a time-consuming *** a solution,we propose an automated system based on deep neural networks that automatically detects and counts the Nephrops burrows in video footage with high *** proposed system introduces a deep-learning-based automated way to identify and classify the Nephrops *** research work uses the current state-of-the-art Faster RCNN models Inceptionv2 and MobileNetv2 for object detection and *** conduct experiments on two data sets,namely,the Smalls Nephrops survey(FU 22)and Cadiz Nephrops survey(FU 30),collected by Marine Institute Ireland and Spanish Oceanographic Institute,*** the results,we observe that the Inception model achieved a higher precision and recall rate than *** best mean Average Precision(mAP)recorded by the Inception model is 81.61%compared to MobileNet,which achieves the best mAP of 75.12%.

关键词： Faster RCNN computer vision nephrops norvegicus nephrops norvegicus stock assessment underwater videos classification

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The effects of industrial policymaking on the economics of low-emission technologies: the TRANSid model

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Energy Storage and Saving 2023年第3期2卷 513-521页

作者： Timo Gerres José Pablo chaves Pedro Linares Institute for Research in Technology(IIT) ICAI School of EngineeringComillas Pontifical UniversityMadrid28015Spain

Basic materials such as steel,cement,aluminium,and(petro)chemicals are the building blocks of industrialised ***,their production is extremely energy and emission intensive,and these industries need to decarbonise their emissions over the next decades to keep global warming at least below 2°***-emission industrial-scale production processes are not commercially available for any of these basic materials and require policy support to ensure their large-scale diffusion over the upcoming *** novel transition to industry decarbonisation(TRANSid)model analyses the framework conditions that enable large-scale investment decisions in climate-friendly basic material *** present a simplified case study of the cement sector to demonstrate the process by which the model optimises investment and operational costs in carbon capture technology by ***,we demonstrate that extending the model to other sectors allows for the analysis of industry-and sector-specific policy options.

关键词： Deep decarbonisation Industrial policy Basic material sector Industry transition Emission pricing Carbon capture

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Ventilator-associated events: From surveillance to optimizing management

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Journal of Intensive Medicine 2023年第3期3卷 204-211页

作者： Sergio Ramirez-Estrada yolanda Peña-Lopez Tarsila Vieceli Jordi Rello Intensive Care Department Hospital Sanitas CIMABarcelona 08034Spain Paediatric Critical Care Department Hospital Universitari Vall d’HebronBarcelona 08035Spain Clinical Research/Epidemiology in Pneumonia and Sepsis(CRIPS) Vall d’Hebron Research InstituteBarcelona 08035Spain Infectious Diseases Department Hospital de Clínicas de Porto AlegrePorto Alegre RS 90035-007Brazil Universitat Internacional de Catalunya Barcelona 08195Spain

Mechanical ventilation(MV)is a life-support therapy that may predispose to morbid and lethal complications,with ventilator-associated pneumonia(VAP)being the most *** 2013,the Center for Disease Control(CDC)defined criteria for ventilator-associated events(VAE).Ten years later,a growing number of studies assessing or validating its clinical applicability and the potential benefits of its inclusion have been *** with VAE criteria is retrospective and the focus is often on a subset of patients with higher thanlower *** date,it is estimated that around 30%of ventilated patients in the intensive care unit(ICU)develop *** surveillance enhances the detection of infectious and non-infectious MV-related complicationsthat are severe enough to impact the patient’s outcomes,there are still many gaps in its classification and *** this review,we provide an update by discussing VAE etiologies,epidemiology,and *** strategies on optimizing ventilation,sedative and neuromuscular blockade therapy,and restrictivefluid management are *** ideal VAE bundle is likely to minimize the period of *** believethat it is time to progress from just surveillance to clinical ***,with this review,we have aimed toprovide a roadmap for future research on the subject.

关键词： Intensive care Mechanical ventilation Infection control Ventilator-associated pneumonia

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Proteomic analysis of F_(1)hybrids and intermediate variants in a Littorina saxatilis hybrid zone

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Current Zoology 2022年第3期68卷 351-359页

作者： Angel P.diz Mónica R.ROMERO Juan GALINDO María SAURA David O.F.SKIBINSKI Emilio ROLÁN-ALVAREZ Centro de Investigación Mariña(CIM-UVIGO) Universidade de VigoVigo 36310Spain Departamento de Mejora Genética Animal INIAMadrid 28040Spain Institute of Life Science Swansea University Medical SchoolSwansea SA28PPUK

Proteomic analysis was carried out on the Crab(upper-shore)and Wave(lower-shore)ecotypes of Littorina saxatilis from a hybrid zone at Silleiro Cape,*** profiles of individual snails were *** expression in F_(1)hybrid snails bred in the laboratory and snails with intermediate shell phenotypes collected from the mid-shore were compared with Crab and Wave ecotypes using analytical approaches used to study *** analysis over many protein spots showed that the F_(1)snails are distinct from both ecotypes but closer to the Wave *** intermediate snails are highly variable,some closer to the Crab and others to the Wave *** on a protein by protein basis,some proteins are significantly closer in expression to the Crab and others to the Wave ecotype for both F_(1)and intermediate ***,a significant majority of proteins were closer in expression to the Wave ecotype for the F_(1),consistent with the multivariate *** such significant majority toward either the Crab or Wave ecotype was observed for the intermediate *** closer similarity of F_(1)and Wave ecotype expression patterns could be the result of similar selective pressures in the similar mid-shore and low-shore *** a significantly larger number of proteins,intermediate snails were closer in expression to the ecotype having the lower expression,for both Crab and Wave *** is somewhat unexpected as lower expression might be expected to be an indication of impairment of function and lower *** analysis could be important for the identification of candidate proteins useful for gaining improved understanding of adaptation and barriers to gene flow in hybrid zones.

关键词： F_(1)hybrids gene expression marine invertebrates molecular phenotype reproductive isolation speciation

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Spatial cluster mapping and environmental modeling in pediatric inflammatory bowel disease

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World Journal of Gastroenterology 2023年第23期29卷 3688-3702页

作者： Mielle Michaux Justin M Chan Luke Bergmann Luis F chaves Brian Klinkenberg Kevan Jacobson Department of Pediatrics Division of GastroenterologyHepatology and NutritionFaculty of MedicineBritish Columbia Children’s HospitalUniversity of British ColumbiaVancouver V6H 3V4British ColumbiaCanada British Columbia Children’s Hospital Research Institute British Columbia Children’s HospitalVancouver V5Z 4H4British ColumbiaCanada Department of Geography University of British ColumbiaVancouver V6T 1Z2British ColumbiaCanada Department of Environmental and Occupational Health School of Public HealthIndiana UniversityBloomingtonIN 47405United States Department of Cellular and Physiological Sciences University of British ColumbiaVancouver V6T 1Z3British ColumbiaCanada

BACKGROUND Geographical(geospatial)clusters have been observed in inflammatory bowel disease(IBD)incidence and linked to environmental determinants of disease,but pediatric spatial patterns in North America are *** hypothesized that we would identify geospatial clusters in the pediatric IBD(PIBD)population of British Columbia(BC),Canada and associate incidence with ethnicity and environmental *** To identify PIBD clusters and model how spatial patterns are associated with population ethnicity and environmental *** One thousand one hundred eighty-three patients were included from a BC Children’s Hospital clinical registry who met the criteria of diagnosis with IBD≤age 16.9 from 2001–2016 with a valid postal code on file.A spatial cluster detection routine was used to identify areas with similar *** ecological analysis employed Poisson rate models of IBD,Crohn’s disease(CD),and ulcerative colitis(UC)cases as functions of areal population ethnicity,rurality,average family size and income,average population exposure to green space,air pollution,and vitamin-D weighted ultraviolet light from the Canadian Environmental Health Research Consortium,and pesticide *** Hot spots(high incidence)were identified in Metro Vancouver(IBD,CD,UC),southern Okanagan regions(IBD,CD),and Vancouver Island(CD).Cold spots(low incidence)were identified in Southeastern BC(IBD,CD,UC),Northern BC(IBD,CD),and on BC’s coast(UC).No high incidence hot spots were detected in the densest urban *** results were represented as incidence rate ratios(IRR)with 95%*** risk factors for PIBD included fine particulate matter(PM2.5)pollution(IRR=1.294,CI=1.113-1.507,P<0.001)and agricultural application of petroleum oil to orchards and grapes(IRR=1.135,CI=1.007-1.270,P=0.033).South Asian population(IRR=1.020,CI=1.011-1.028,P<0.001)was a risk factor and Indigenous population(IRR=0.956,CI=0.941-0.971,P<0.001),family size(IRR=0.467,CI=0.268-0.81

关键词： Inflammatory bowel diseases Crohn disease Ulcerative colitis Pesticides Air pollution South Asian people

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