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Emerging contaminants:A One Health perspective

The Innovation 2024年第4期5卷 140-170,139页

作者： Fang Wang Leilei Xiang Kelvin Sze-Yin Leung Martin Elsner Ying Zhang Yuming Guo Bo Pan Hongwen Sun Taicheng An Guangguo Ying Bryan WBrooks Deyi Hou Damian EHelbling Jianqiang Sun Hao Qiu Timothy MVogel Wei Zhang Yanzheng Gao Myrna JSimpson Yi Luo Scott XChang Guanyong Su Bryan MWong Tzung-May Fu Dong Zhu Karl JJobst Chengjun Ge Frederic Coulon Jean Damascene Harindintwali Xiankui Zeng Haijun Wang Yuhao Fu Zhong Wei Rainer Lohmann Changer Chen Yang Song Concepcion Sanchez-Cid Yu Wang Ali El-Naggar Yiming Yao Yanran Huang Japhet Cheuk-Fung Law Chenggang Gu Huizhong Shen Yanpeng Gao Chao Qin Hao Li Tong Zhang Natàlia Corcoll Min Liu Daniel SAlessi Hui Li Kristian KBrandt yolanda pico Cheng Gu Jianhua Guo Jianqiang Su Philippe Corvini Mao Ye Teresa Rocha-Santos Huan He Yi Yang Meiping Tong Weina Zhang Fidèle Suanon Ferdi Brahushi Zhenyu Wang Syed AHashsham Marko Virta Qingbin Yuan Gaofei Jiang Louis A.Tremblay Qingwei Bu Jichun Wu Willie Peijnenburg Edward Topp Xinde Cao Xin Jiang Minghui Zheng Taolin Zhang Yongming Luo Lizhong Zhu Xiangdong Li DamiàBarceló Jianmin Chen Baoshan Xing Wulf Amelung Zongwei Cai Ravi Naidu Qirong Shen Janusz Pawliszyn Yong-guan Zhu Andreas Schaeffer Matthias C.Rillig Fengchang Wu Gang Yu James M.Tiedje State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Beijing 100049China Department of Chemistry Hong Kong Baptist UniversityHong KongChina HKBU Institute of Research and Continuing Education Shenzhen Virtual University ParkShenzhenChina Technical University of Munich TUM School of Natural SciencesInstitute of Hydrochemistry85748 GarchingGermany School of Resources&Environment Northeast Agricultural UniversityHarbin 150030China Climate Air Quality Research UnitSchool of Public Health and Preventive MedicineMonash UniversityMelbourneVICAustralia Faculty of Environmental Science&Engineering Kunming University of Science&TechnologyKunming 650500China Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria College of Environmental Science and EngineeringNankai UniversityTianjin 300350China Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control School of Environmental Science and EngineeringInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China Ministry of Education Key Laboratory of Environmental Theoretical Chemistry South China Normal UniversityGuangzhouGuangdong 510006China Department of Environmental Science Baylor UniversityWacoTXUSA Center for Reservoir and Aquatic Systems Research(CRASR) Baylor UniversityWacoTXUSA School of Environment Tsinghua UniversityBeijing 100084China School of Civil and Environmental Engineering Cornell UniversityIthacaNY 14853USA Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province Zhejiang University of TechnologyHangzhou 310014China School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Laboratoire d’Ecologie Microbienne Universite Claude Bernard Lyon 1UMR CNRS 5557UMR INRAE 1418VetAgro Sup69622 VilleurbanneFrance Department of Pla

Environmental pollution is escalating due to rapid global development that often prioritizes human needs over planetary *** global efforts to mitigate legacy pollutants,the continuous introduction of new substances remains a major threat to both people and the *** response,global initiatives are focusing on risk assessment and regulation of emerging contaminants,as demonstrated by the ongoing efforts to establish the UN’s Intergovernmental Science-Policy Panel on Chemicals,Waste,and Pollution *** review identifies the sources and impacts of emerging contaminants on planetary health,emphasizing the importance of adopting a One Health *** for monitoring and addressing these pollutants are discussed,underscoring the need for robust and socially equitable environmental policies at both regional and international *** actions are needed to transition toward sustainable pollution management practices to safeguard our planet for future generations.

关键词： pollution planet contaminants

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Epigenetic regulation of N-hydroxypipecolic acid biosynthesis by the AIPP3-PHD2-CPL2 complex

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Journal of Integrative Plant Biology 2023年第12期65卷 2660-2671页

作者： Jiameng Lan Siyu Chen Joana pico Kevin Ao Shitou Xia Shucai Wang Xin Li Simone D.Castellarin Yuelin Zhang Department of Botany University of British ColumbiaVancouverV6T 1Z4 Canada Laboratory of Plant Molecular Genetics&Crop Gene Editing School of Life SciencesLinyi UniversityLinyi276005 China Wine Research Centre Faculty of Land and Food SystemsUniversity of British ColumbiaVancouver V6T 1Z4Canada Michael Smith Laboratories University of BritishColumbiaVancouverV6T1Z4Canada Hunan Provincial Key Laboratory of Phytohormones Hunan Agricultural UniversityChangsha 410125China College of Life Science Sichuan UniversityChengdu 610064China

N-Hydroxypipecolic acid(NHP)is a signaling molecule crucial for systemic acquired resistance(SAR),a systemic immune response in plants that provides long-lasting and broad-spectrum protection against secondary pathogen *** identify negative regulators of NHP biosynthesis,we performed a forward genetic screen to search for mutants with elevated expression of the NHP biosynthesis gene FLAVIN-DEPENDENT MONOOXYGENASE 1(FMO1).Analysis of two constitutive expression of FMO1(cef)and one induced expression of FMO1(ief)mutants revealed that the AIPP3–PHD2–CPL2 protein complex,which is involved in the recognition of the histone modification H3K27me3 and transcriptional repression,contributes to the negative regulation of FMO1 expression and NHP *** study suggests that epigenetic regulation plays a crucial role in controlling FMO1 expression and NHP levels in plants.

关键词： plant immunity SAR epigenetic regulation NHP FMO1 H3K27me3 transcriptional repression AIPP3 PHD2 CPL2

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The Eloquent Sounds of Silence

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英语学习 1994年第7期 67-70页

作者： pico Iyer 简墨

Every one of us knows the sensation of going up, on retreat, toa high place and feeling ourselves so lifted up that we canhardly imagine the circumstances of our usual lives, or all thethings that make us fret. In such a place, in such a state, we startto recite the standard litany: that silence is sunshine where corn-pany is clouds; that silence is rapture, where company is doubt;that silence is golden, where company is brass.

关键词： The Eloquent Sounds of Silence 梅尔维尔《白鲸》

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Histologic patterns of liver injury induced by anti-PD-1 therapy

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Gastroenterology Report 2020年第1期8卷 50-55,I0002页

作者： Dongwei Zhang John Hart Xianzhong Ding Xuchen Zhang Michael Feely Lindsay Yassan Lindsay Alpert Consuelo Soldevila-pico Xuefeng Zhang Xiuli Liu Jinping Lai Department of Pathology Immunology and Laboratory of MedicineUniversity of Florida College of MedicineGainesvilleFLUSA Department of Pathology and Laboratory Medicine University of Rochester Medical CenterRochesterNYUSA Department of Pathology University of Chicago Pritzker School of MedicineChicagoILUSA Department of Pathology and Laboratory of Medicine Loyola University Medical CenterMaywoodILUSA Department of Pathology Yale School of MedicineNew HavenCTUSA Department of Medicine University of Florida College of MedicineGainesvilleFLUSA Department of Pathology Duke University Medical CenterDurhamNCUSA Department of Pathology Kaiser Permanente Sacramento Medical CenterSacramentoCAUSA

Background:Nivolumab and pembrolizumab—two monoclonal antibodies that block human programmed cell death-1(PD-1)—have been successfully used to treat patients with multiple advanced *** histologic patterns of hepatic toxicity induced by anti-PD-1 treatment have not been well studied and the aim of this study was to explore ***:Eight patients with advanced malignancies who were treated with either nivolumab or pembrolizumab were identified from five *** patients had no history of underlying liver disease and a viral hepatitis panel was negative in all ***:Seven of eight patients exhibited mild to moderate gastrointestinal symptoms such as abdominal pain,fatigue,nausea,vomiting,and jaundice after anti-PD-1 *** elevations in liver-chemistry tests were detected in all *** cases(6/8)demonstrated an acute lobular hepatitis pattern of histologic *** remaining two cases showed different histologic patterns of injury:steatohepatitis with mild cholestasis(1/8)and pure acute cholestatic injury(1/8).No case showed typical features of autoimmune *** liver function recovered in all eight cases after cessation of anti-PD-1 agents and with immunosuppressive ***:Our study suggests that screening patients for abnormal liver-function tests prior to anti-PD-1 therapy as well as periodic monitoring of liver-function tests are necessary to prevent severe liver *** than causing classical autoimmune hepatitis,PD-1 inhibitors appear to produce an immune-mediated nonspecific acute *** cessation,without steroid therapy,may therefore be sufficient in some patients.

关键词： nivolumab pembrolizumab anti-PD-1 liver injury histology hepatitis

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马路勇士抒情曲——旅行不为人知的乐趣

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商业周刊（中文版） 2012年第B6期 84-87页

作者： pico lyer

去年秋天，我从加州圣巴巴拉飞到印度海得拉巴，航程S6个小时。一落地，我已料到问讯处不会有人、马路上不会有标志、的士停靠站当然不会有的士。只有一个人不会对这样闪电式的商务旅行望而却步，那就是我。理由很简单：我已经走过很多... 详细信息

去年秋天，我从加州圣巴巴拉飞到印度海得拉巴，航程S6个小时。一落地，我已料到问讯处不会有人、马路上不会有标志、的士停靠站当然不会有的士。只有一个人不会对这样闪电式的商务旅行望而却步，那就是我。理由很简单：我已经走过很多这样的路了。我把它看做一种礼遇——当我独自迷失在世界里，切断一切通讯，让陌生人宠一宠自己，然后在探险的气氛中过上几天。

关键词：商务旅行乐趣抒情陌生人

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日本会沉没吗？

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商业周刊（中文版） 2012年第1期 88-89页

作者： pico lyer

在日本北部城市仙台一带，震后的灾难场景至今仍触目惊心。一座座两层楼房的外面，挂着洗过的衣服。一楼完全是一片狼藉，早就没有人住了；二楼则没有什么太大改变。一把椅子孤独地站在废墟之中，而这片废墟在几个月前一定是一个客厅。... 详细信息

在日本北部城市仙台一带，震后的灾难场景至今仍触目惊心。一座座两层楼房的外面，挂着洗过的衣服。一楼完全是一片狼藉，早就没有人住了；二楼则没有什么太大改变。一把椅子孤独地站在废墟之中，而这片废墟在几个月前一定是一个客厅。狭窄的河流上到处都能看到漂浮的汽车，电线杆东倒西歪，倾斜成各种危险的角度。1月份的日本高速公路，一向以干净漂亮著称，如今巨大的长方形废金属碎片散落其间。

关键词：日本沉没高速公路电线杆废金属长方形废墟城市

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上海马路让心情由阴转晴

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航空港 2013年第1期 30-31页

作者： Freddy pico

很多人说,优雅精致的申城总有一种从骨子里散发出来的小资情怀。任时光流逝,上海一直在展现着它的魅力,并保存着它的精髓,就像上海总有几条马路,总可以让你的心情由阴转晴。

关键词：上海美术电影制片厂罗马式

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匹莫苯(Pimobendan)治疗充血性心力衰竭(PICA)

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岭南心血管病杂志 1999年第2期5卷 156-157页

作者： pico研究组

研究疾病:充血性心力衰竭.目的:评估正性肌力药物Pimobendan对心力衰竭患者运动耐受性的影响.设计:随机、双盲、安慰剂对照的多中心研究.病人资料:共317名病情稳定的慢性心力衰竭患者,年龄≥18岁,心功能分级为Ⅱ～Ⅲ级,左室射血分数≤0.... 详细信息

研究疾病:充血性心力衰竭.目的:评估正性肌力药物Pimobendan对心力衰竭患者运动耐受性的影响.设计:随机、双盲、安慰剂对照的多中心研究.病人资料:共317名病情稳定的慢性心力衰竭患者,年龄≥18岁,心功能分级为Ⅱ～Ⅲ级,左室射血分数≤0.45,以下情况的患者被排除在研究之外:狭窄性、阻塞性和感染性心脏病患者,因心绞痛而使运动耐力受限患者,已排期候补行心脏移植术患者,急性心肌梗死患者,冠脉再通患者,三月内有晕厥或心脏停搏史者,AICD安装者,伴有其他严重疾病者.

关键词：充血性心力衰竭 Pimobendan 匹莫苯安慰剂运动耐受性置信区间危险系数正性肌力药物急性心肌梗死心力衰竭患者

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