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Glucagon-like peptide 1 receptor activation:anti-inflammatory effects in the brain

Neural Regeneration Research 2024年第8期19卷 1671-1677页

作者： yolanda diz-chaves.zainab maas.or Carlos Spuch José Antonio Lamas Lucas C.González-Matías Federico Mallo Biomedical Research Centre(CINBIO) Laboratory of EndocrinologyUniversity of VigoGalicia Sur Health Research InstituteVigoSpain Translational Neuroscience Research Group Galicia Sur Health Research InstituteCIBERSAMHospitalÁlvaro CunqueiroSala InvestigaciónEstrada Clara CampoamorVigoSpain Biomedical Research Centre(CINBIO) Laboratory of NeuroscienceUniversity of VigoGalicia Sur Health Research InstituteVigoSpain

The glucagon-like peptide 1 is a pleiotropic hormone that has potent insulinotropic effects and is key in treating metabolic diseases such as diabetes and ***-like peptide 1 exerts its effects by activating a membrane receptor identified in many tissues,including diffe rent brain ***-like peptide 1 activates several signaling pathways related to neuroprotection,like the support of cell growth/survival,enhancement promotion of synapse formation,autophagy,and inhibition of the secretion of proinflammatory cytokines,microglial activation,and apoptosis during neural *** glial cells,including astrocytes and microglia,maintain metabolic homeostasis and defe nse against pathogens in the central nervous *** brain insult,microglia are the first cells to respond,followed by reactive *** activated cells produce proinflammato ry mediators like cytokines or chemokines to react to the ***,under these circumstances,mic roglia can become chro nically inflammatory by losing their homeostatic molecular signature and,consequently,their functions during many *** processes promote the development of neurological disorders and influence their pathological evolution:like the formation of protein aggregates,the accumulation of abnormally modified cellular constituents,the formation and release by injured neurons or synapses of molecules that can dampen neural function,and,of critical impo rtance,the dysregulation of inflammato ry control *** glucagonlike peptide 1 receptor agonist emerges as a critical tool in treating brain-related inflammatory pathologies,restoring brain cell homeostasis under inflammatory conditions,modulating mic roglia activity,and decreasing the inflammato ry *** review summarizes recent advances linked to the anti-inflammato ry prope rties of glucagon-like peptide 1 receptor activation in the brain related to multiple sclerosis,Alzheimer’s disease,Parkins

关键词： astrocytes brain glucagon-like peptide 1 receptor inflammation microglia

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Perception beyond sight:Investigating the cognitive maps of congenitally blind individuals in urban environments

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Frontiers of Architectural Research 2024年第4期13卷 809-821页

作者： Anwar Ibrahim Hikmat HAli zainab Mahmoud College of Architecture and Design Jordan University of Science and TechnologyIrbidJordan College of Engineering and Architecture Al Yamamah UniversityRiyadhKSA

This study explores the challenges faced by congenitally blind individuals in navigating urban ***,this research investigates the factors that contribute to the construction of city mental mapping for individuals who are born ***-one congenitally blind individuals from the University of Jordan were asked to define and describe specific elements of the city based on their personal experiences and ***,participants were guided through two urban paths:familiar and *** participants were asked to complete a survey regarding their experiences during the *** collected data was analyzed by using thematic *** results revealed that congenitally blind individuals construct their mental image of the city by using their three senses of touching,hearing,and smelling,as well as their safety and *** mental image consists of five key elements:links,reference points,areas,separators,and *** the small size of the study sample and the specificity of the context,the results of this study will tremendously help planners in designing highly inclusive urban *** characteristics that can be recognized by the blinds will enhance their accessibility of urban spaces,encourage independent mobility,increase the quality of life and social inclusion for them.

关键词： Mental map City image Congenital blind Cognitive mapping Environmental perception

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Pediatric and adult liver transplantation in Bahrain: The experiences in a country with no available liver transplant facilities

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World Journal of Transplantation 2024年第1期14卷 96-111页

作者： Hasan M Isa Fatema A Alkharsi Jawad K Khamis Sawsan A Hasan zainab A Naser zainab N Mohamed Afaf M Mohamed Shaikha A Altamimi Department of Pediatrics Salmaniya Medical ComplexManama 26671Bahrain Department of Pediatrics Arabian Gulf UniversityManama 26671Bahrain Department of Medicine Salmaniya Medical ComplexManama 26671Bahrain Public Health Directorate Ministry of HealthManama 26671Bahrain The Overseas Office Supreme Committee for Treatment AbroadMinistry of HealthManama 26671Bahrain

BACKGROUND Liver transplantation(LT)is a life-saving procedure for patients with end-stage liver disease and has become the standard and most effective treatment method for these *** are many indications for LT that vary between countries and *** outcome of LT depends on the available facilities and surgical expertise,as well as the types of liver graft donors *** To assess the clinical characteristics of patients from Bahrain who underwent LT overseas,and analyze factors affecting their *** In this retrospective cohort study,we reviewed the medical records and overseas committee registry information of all pediatric and adult patients who were sent overseas to undergo LT by the Pediatric and Medical Departments of Salmaniya Medical Complex and Bahrain Defence Force Hospital via the Overseas Treatment Office,Ministry of Health,Kingdom of Bahrain,between 1997 and *** data,LT indication,donor-recipient relationship,overseas LT center,graft type,post-LT medications,and LT complications,were *** measured included the overall and 5-year LT survival ***’s exact,Pearsonχ2,and Mann-Whitney U tests were used to compare the pediatric and the adults’group in terms of clinical characteristics,donor-recipient relationship,medication,complications,and *** analysis was estimated via the Kaplan-Meier’s *** and multivariate analyses were used to detect predictors of *** Of the 208 eligible patients,170(81.7%)were sent overseas to undergo LT while 38(18.3%)remained on the waiting *** the 170 patients,167(80.3%)underwent LT and were included in the *** majority of the patients were Bahraini(91.0%),and most were males(57.5%).One-hundred-and-twenty(71.8%)were adults and 47(28.3%)were *** median age at transplant was 50.0[interquartile range(IQR):14.9–58.4]*** main indication for pediatric LT was biliary atresia(31.9%),while that of adult LT was

关键词： Overseas liver transplantation End-stage liver disease Liver transplant facilities Liver donor Biliary atresia Hepatitis C

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Predictive modelling of volumetric and Marshall properties of asphalt mixtures modified with waste tire-derived char:A statistical neural network approach

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Journal of Road Engineering 2024年第3期4卷 318-333页

作者： Nura Shehu Aliyu Yaro Muslich Hartadi Sutanto Noor zainab Habib Aliyu Usman Abiola Adebanjo Surajo Abubakar Wada Ahmad Hussaini Jagaba Department of Civil and Environmental Engineering Universiti Teknologi PETRONASSeri Iskandar 32610Malaysia Department of Civil Engineering Ahmadu Bello UniversityZaria 810107Nigeria Institute of Infrastructure and Environment Heriot-Watt UniversityDubai 294345United Arab Emirates School of Civil Engineering Central South UniversityChangsha 410075China Interdisciplinary Research Centre for Membranes and Water Security King Fahd University of Petroleum and MineralsDhahran 31261Saudi Arabia

The goals of this study are to assess the viability of waste tire-derived char(WTDC)as a sustainable,low-cost fine aggregate surrogate material for asphalt mixtures and to develop the statistically coupled neural network(SCNN)model for predicting volumetric and Marshall properties of asphalt mixtures modified with *** study is based on experimental data acquired from laboratory volumetric and Marshall properties testing on WTDCmodified asphalt mixtures(WTDC-MAM).The input variables comprised waste tire char content and asphalt binder *** output variables comprised mixture unit weight,total voids,voids filled with asphalt,Marshall stability,and *** coupled neural networks were utilized to predict the volumetric and Marshall properties of asphalt *** predictive modeling,the SCNN model is employed,incorporating a three-layer neural network and preprocessing techniques to enhance accuracy and *** optimal network architecture,using the collected dataset,was a 2:6:5 structure,and the neural network was trained with 60%of the data,whereas the other 20%was used for cross-validation and testing *** network employed a hyperbolic tangent(tanh)activation function and a feed-forward *** to the results,the network model could accurately predict the volumetric and Marshall *** predicted accuracy of SCNN was found to be as high value>98%and low prediction errors for both volumetric and Marshall *** study demonstrates WTDC's potential as a low-cost,sustainable aggregate *** SCNN-based predictive model proves its efficiency and versatility and promotes sustainable practices.

关键词： Waste tire Neural network Sustainable practices Asphalt mixtures Predictive model

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Exploring the impact of tacrolimus on kidney transplant recipients:insights into immunological outcomes

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Journal of Chinese Pharmaceutical Sciences 2024年第8期33卷 737-750页

作者： zainab A Abbood Ahmed Hamza AL-Shammari Eman M.Jasim Amjad I.Oraibi Department of Pharmacy Kut University CollegeAlkutWasitIraq52001 AL-Manara College For Medical Science/Department of Pharmacy MisanIraq62001

To minimize graft rejection,it is crucial to reduce *** the present study,we investigated immunological markers in the blood of transplant patients who did not receive *** also assessed alloreactive CD4+CD25+FoxP3+ Tregs both before transplantation and after tacrolimus *** comparative analysis included 50 individuals experiencing early rejection after tacrolimus discontinuation and 100 *** reducing tacrolimus,rejectors exhibited elevated levels of memory CD8+T cells compared to Tregs,while non-rejectors displayed a lower ratio of memory CD4+T cells to *** tacrolimus removal,rejectors showed an increase in naïve T cells and a decrease in effector T *** transplantation,CD4+Treg levels declined,but their anti-donor regulatory function remained consistent in both rejectors and *** correlation revealed an association between acute rejection after tacrolimus discontinuation and the pre-reduction ratio of memory T cells to regulatory T *** indicators identified individuals whose immunosuppression could be safely reduced.

关键词： Tacrolimus Kidney Transplant Immune system Rejection

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Postpartum Quality of Life in Primiparous Women after Normal Vaginal Delivery versus Caesarean Section

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Open Journal of Obstetrics and Gynecology 2024年第7期14卷 1027-1045页

作者： Bayan Ahmed Basma Alsayegh Fatema Ahmed zainab Aljufari Department of Obstetrics and Gynecology Salmaniya Medical Complex Manama Kingdom of Bahrain

Background: Studies on either postnatal quality of life in general or studies that compare quality of life in new mothers after different mode of delivery are limited. An investigation on health related quality of life measures in women after different type of delivery showed that women who had vaginal delivery had better health related quality of life compared to those who had caesarean section. However, the best method of delivery, vaginal or caesarean for postpartum quality of life is a difficult question as it is a matter of controversy both from professional’s perspectives and from women’s experience during childbirth. Objective: To compare postpartum quality of life in primiparous women after vaginal delivery versus caesarean section. Methods: Prospective cross-sectional study was conducted at the department of Obstetrics and Gynecology, Salmaniya medical complex in Kingdom of Bahrain. 500 primiparous women who gave birth either vaginally or by cesarean section answered a questionnaire designed to include general information, questions from short form health survey questionnaire (SF-36) and specific questions regarding postnatal related symptoms. Results: Body pain, fatigue, wound pain, headache and backache were significantly higher in cesarean section group as compared to vaginal delivery group (p-value Conclusion: Cesarean delivery has negatively affected the quality of life (QOL) of primiparous women. More studies with larger sample sizes should be conducted to examine the effects of cesarean delivery on QOL in both primiparous and multiparas within a shorter period after delivery. .

关键词： Quality of Life Primiparous Vaginal Delivery Caesarean Section

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Subconjunctival hemorrhage after wet cupping therapy: a case report

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Clinical Research Communications 2024年第2期7卷 27-29页

作者： zainab AlMusleh Ahmad Alrawashdeh Tamer Aboushanab Department of Academic Tabibi Poly ClinicDoha 212100Qatar Hearing&Balance Disorders Hamad Medical CorporationDoha 3050Qatar Department of Therapeutic Ministry of Health and PopulationCairo 11467Egypt.

Introduction:Cupping therapy is an integrative and complementary medicine therapy that practiced worldwide by several civilizations for thousands of *** therapy is reported to be a relatively safe practice especially if performed by qualified *** hemorrhage(SCH)is a common cause of eye redness and can be classified into traumatic and *** presentation:This case report discussed an adverse event related to wet cupping *** patient developed SCH one day after performing cupping *** was completely recovered after 2 *** case report should increase the knowledge of cupping therapists regarding increasing safety of patient when performing wet cupping therapy on specific body parts especially,head,neck and cervical ***,it highlighted the importance of conducting research regarding the mechanical and physiological effects of cupping ***:Adverse events related to cupping therapy should be reported with every *** therapists should be aware of this possible mild adverse *** the best of our knowledge,this is the first published adult case of SCH related to wet cupping therapy *** studies are critically needed for evaluation of cupping therapy effects and adverse events especially when performed on head and neck.

关键词： cupping therapy wet cupping Hijama subconjunctival hemorrhage adverse event

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中巴经济走廊洪扎段潜在滑坡SBAS-InSAR早期识别及发育特征分析

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遥感学报 2024年第4期28卷 885-899页

作者：苏晓军张毅孟兴民 Rehman Mohib Ur Khalid zainab 赵富萌岳东霞郭富赟周自强兰州大学资源环境学院兰州730000 兰州大学地质科学与矿产资源学院兰州730000 甘肃省环境地质与灾害防治技术创新中心兰州730000 兰州大学西部环境教育部重点实验室兰州730000 甘肃省地质环境监测院兰州730050 甘肃省科学院地质自然灾害防治研究所兰州730000

中巴经济走廊巴基斯坦境内洪扎河谷(Hunza Valley)段地形高差巨大、地质环境复杂,滑坡灾害多发,对河谷内村镇威胁极大,也严重制约中巴经济走廊安全建设与运行。为了加深对Hunza河谷滑坡灾害的认识,亟待进行滑坡识别编目和发育特征研究... 详细信息

中巴经济走廊巴基斯坦境内洪扎河谷(Hunza Valley)段地形高差巨大、地质环境复杂,滑坡灾害多发,对河谷内村镇威胁极大,也严重制约中巴经济走廊安全建设与运行。为了加深对Hunza河谷滑坡灾害的认识,亟待进行滑坡识别编目和发育特征研究。本研究基于升、降轨获取的87景哨兵一号(Sentinel-1)数据,利用SBAS-InSAR技术获取了洪扎河谷地表形变,计算了地表斜坡向形变速率。并综合利用光学遥感影像解译和野外实地调查验证,成功识别了洪扎河谷53处潜在滑坡,并讨论了滑坡识别效果,对Ghulmet和Humarri两个典型大型滑坡监测形变、影像解译和验证特征进行了分析。在此基础上,选取11个地形地质环境因素作为影响滑坡发育的因子,分析了滑坡分布发育特征。结果表明,升轨和降轨数据监测到研究区内斜坡向最大形变速率分别为−311 mm/a和−490 mm/a,洪扎河谷区不稳定形变阈值为−20 mm/a。大型滑坡受河流侵蚀作用,形变剧烈,次级滑坡发育。识别的潜在滑坡主要集中在河流两岸、公路上下边坡;潜在滑坡主要分布在风化堆积层以及千枚岩、板岩等变质岩区;高差200—1000 m、坡度30°—40°和坡向南、南西向为滑坡发育的优势地形条件;斜坡地表裸露、植被稀疏地段(NDVI<0.2)物源充足,滑坡较为发育。研究结果可用于巴基斯坦洪扎河谷防灾减灾工作,保障中巴经济走廊畅通运营,为具有毁路与堵江风险的滑坡重点监测和评价研究提供科学参考和数据支持。

关键词：中巴经济走廊洪扎河谷滑坡 SBAS-InSAR 地表形变早期识别发育特征

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Acute Transverse Myelitis in Pregnancy—A Case Report and a Literature Review

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Open Journal of Obstetrics and Gynecology 2024年第9期14卷 1512-1521页

作者： Huda Abbas Ali Isa Fatema Hasan zainab Mohd Al Aswad Naeema Ahmed Abdulkareem Salmaniya Medical Complex Manama Bahrain Ob Gyn Faculty Arabian Gulf University Manama Bahrain

Purpose: This case report highlights a rare instance of a 26-week pregnant woman presenting with limb numbness, diagnosed with acute transverse myelitis (ATM) following COVID-19 vaccination. Notably, she tested positive for neuromyelitis optica (NMO) but did not exhibit the typical symptoms of blurred vision. Methods: Data were collected from I Seha in governmental hospitals in Bahrain, providing a comprehensive overview of the patient’s clinical journey. Results: The patient was treated with carbamazepine, steroids, and clexane, leading to the successful delivery of a healthy baby at 34 weeks. However, two years postpartum, she reported new episodes of blurred vision and numbness. Subsequent treatment with Rituximab resulted in significant improvement, with a diagnosis of Devic’s disease established. Conclusion: Acute transverse myelitis is a rare condition, particularly during pregnancy, and in this case, symptoms of Devic’s disease were masked by the absence of blurred vision. This condition predominantly affects females in their 20s during childbearing years and can lead to complications such as premature delivery. Effective management includes steroids and antiepileptic drugs, with clexane playing a crucial role in preventing embolisms. A delivery mode may vary based on obstetric factors, and MRI remains the gold standard for diagnosis. Close follow-up is essential for optimal patient outcomes.

关键词： Acute Transverse Myelitis (ATM) COVID-19 Devic’s Syndrome Neuromyelitis Optica (NMO) Obstetric Management of ATM

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Factors Promoting Retention of Nurses in Three Private Hospitals of Lahore: A Cross Sectional Descriptive Survey

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Open Journal of Nursing 2024年第7期14卷 344-367页

作者： zainab Suleman Najma Balquees Anwar Sadaf Younis Alya Bilquees Anwar Naeema Khan Syed Saemul Hassan College of Nursing University of Health Sciences Lahore Lahore Pakistan

Introduction: Pakistan has a large number of professional nurses but a higher rate of turnover contributes towards the shortage of nurses which is intensified by nurses’ immigration, lack of recruitment of new nurses and retirement of senior nurses. Aim: The study aimed at examining the factors that increase retention of nurses. Research Method: The study is descriptive cross sectional with a sample of 150 nurses including both the genders, from 3 private hospitals located in Pakistan. A convenient sampling technique was used. The data collection was done through close ended questionnaires based on 20 questions. Data collection was done quantitatively and then data was entered in SPSS. Correlation and regression tests were performed. Findings: The analysis revealed that 91.3% nurses are loyal to their hospitals but, 8.7%nurses can switch the hospital for different reasons. It was also found that the idea of leaving the job based on the intention of moving to abroad and public sector was higher than the retirement and other causes. Resultantly, enhancements in nurses’ work environments have the ability to decrease nurses’ job burnout and turnover and increase patients’ satisfaction. Recommendations: Hospital leaders should implement effective strategies to encourage nurses to continue their job by motivation, strengthening management skills within the hospital and improving a positive work environment by promoting teamwork, continuous learning, trust, respect and flexible arrangements which can lead towards achieving better ***, further studies quantitatively and qualitatively can explore more factors related to dissatisfaction of nurses. Health systems policy makers should lead by developing related strategies for the retention of nurses.

关键词： Retention of Nurses Shortage of Nurses Turnover Workforce

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