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Methylation changes at the GNAS imprinted locus in pancreatic cystic neoplasms are important for the diagnosis of malignant cysts

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World Journal of Gastrointestinal Oncology 2020年第9期12卷 1056-1064页

作者： Sandra Faias Marlene Duarte Luísa Pereira Paula chaves Marília Cravo Antonio Dias Pereira Cristina Albuquerque Department of Gastroenterology Instituto Português de Oncologia de Lisboa Francisco GentilEPELisboa 1099-023Portugal Faculty of Health Sciences University of Beira InteriorCovilhã6200-506Portugal Unidade de Investigação em Patobiologia Molecular(UIPM) Instituto Português de Oncologia de Lisboa Francisco GentilEPELisboa 1099-023Portugal Centro de Matemática e Aplicações(CMA-UBI) Universidade da Beira InteriorCovilhã6200-506Portugal Department of Pathology Instituto Português de Oncologia de Lisboa Francisco GentilEPELisboa 1099-023Portugal Department of Gastroenterology Hospital BeatrizÂngeloLoures 2674-514Portugal

BACKGROUND Guanine nucleotide-binding protein,alpha stimulating(GNAS)mutations are characteristic of intraductal papillary mucinous neoplasms(IPMNs).Pancreatic ductal adenocarcinomas(PDACs)harboring GNAS mutations originate in *** is a complex imprinted locus that produces five transcripts regulated by differential methylated regions,NESP55,GNASAS,GNASXL,GNAS1A,and *** To evaluate if methylation changes in the differential methylated regions of GNAS locus contributed to malignant progression of pancreatic *** GNAS locus methylation was analyzed in archival pancreatic cyst fluid(PCF)obtained by endoscopic ultrasound with fine-needle aspiration by methylation specific–multiplex ligation dependent probe *** were normalized and analyzed using *** *** Fifty-two PCF samples obtained by endoscopic ultrasound with fine-needle aspiration and previously characterized for KRAS and GNAS mutations were *** final diagnoses were surgical(11)and clinicopathological(41),including 30 benign cysts,14 pre-malignant cyst,and eight malignant *** changes at NESP55,GNASAS,GNAS1A,and especially GNASXL were more frequent in malignant cysts,and NESP55 and GNASAS were useful for diagnosis.A combined variable defined as“GNAS locus methylation changes”was significantly associated with malignancy(6/8 malignant cysts and only 2/20 benign cysts)and improved *** in both maternally(NESP55)and paternally(GNASXL)derived promoters was found in 3/3 *** This is the first study to identify methylation changes in the GNAS locus,improving the diagnosis of malignant pancreatic cysts and suggesting a role in progression to PDAC.

关键词： Intraductal papillary mucinous neoplasms Pancreas cyst Methylation Biomarker GNAS locus Pancreatic neoplasm

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Effects of inclusion of purple prairie clover (Dalea purpurea Vent.)with native coolseason grasses on in vitro fermentation and in situ digestibility of mixed forages

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Journal of Animal Science and Biotechnology 2020年第2期11卷 563-576页

作者： Kai Peng Gemma L.Gresham Tim A.McAllister Zhongjun Xu Alan Iwaasa Mike Schellenberg Alex V.chaves Yuxi Wang Key Laboratory of Animal Nutrition and Feed Science(South China)of Ministry of Agriculture Guangdong Key Laboratory of Animal Breeding and NutritionInstitute of Animal ScienceGuangdong Academy of Agricultural ScienceGuangzhou 510640People’s Republic of China Agriculture and Agri-Food Canada Lethbridge Research and Development CentreLethbridgeAB T1J 4B1Canada School of Life and Environmental Sciences The University of SydneySydneyNSW 2006Australia Agriculture and Agri-Food Canada Swift Current Research and Development CentreSwift CurrentSK S9H 3X2Canada

Background:Incorporation of legume species into native North American pastures is considered an effective method to increase native pasture productivity and improve the nutritive value of *** study evaluated the effects of inclusion of purple prairie clover(PPC,Dalea purpurea Vent.),a native legume forage,with native coolseason grasses on the in vitro fermentation and in situ digestibility of mixed ***:Whole plant PPC and mixtures of cool-season grasses were harvested when the PPC reached the vegetative(VEG),full flower(FL)and seedpod(SP)stages,and were combined in ratios(DM basis)of 0:100,25:75,50:50,75:25 and 100:0 at each *** vitro ruminal incubations using these mixtures were conducted for 48 h to determine gas production(GP),in vitro DM disappearance(IVDMD),total volatile fatty acids(VFA)and ammonia-N *** of forages harvested when the PPC reached the FL stage and 50:50 mixture of forages harvested at VEG,FL and SP stages were incubated in the rumen of three heifers for 0,2,6,12,24,48,72 and 96 h to determine in situ degradabilities of DM,neutral detergent fibre(aNDF)and crude protein(CP).Results:Contents of aNDF and ADF increased(PVEG>SP(P<0.05).Regardless of PPC proportions in the mixture,GP decreased(P<0.05)with increasing PPC *** PPC proportions linearly increased(P<0.001)GP,IVDMD and total VFA at VEG,but linearly decreased(P<0.001)them at *** of PPC maturity,ammonia-N production linearly increased(P<0.01)with increasing proportions of PPC and the concentration was higher(P<0.05)at VEG than at FL and SP *** proportion of PPC at either maturity linearly increased(P<0.001)molar percentage of acetate(A)and branched-chain VFA,but linearly decreased(P<0.001)molar percentage of propionate(P),resulting in a linearly increase(P<0.001)in the A:P *** FL PP

关键词： Condensed tannins Cool-season grass In vitro fermentation In situ digestibility Purple prairie clover

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Asymptotic Inefficiency of Incomplete Asset Markets and Symmetric Event Trees

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Chinese Business Review 2016年第6期15卷 296-304页

作者： Ricardo Luis chaves Feijo University of Sao Paulo Ribeirao Preto Brazil

Demonstrating theoretically the possibility that the financial market, albeit incomplete, has equilibrium and that this equilibrium is efficient and has been an important topic at the frontier of the research on general equilibrium for financial markets. The paper examines the asymptotic properties of incomplete financial markets taking into accounting the asset structure. The paper deals with a case in which a structure of securities relates to the asymptotic inefficiency.

关键词： asymptotic inefficiency incomplete market general equilibrium with financial assets event tree

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The issue of the cost of robotic distal pancreatectomies

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Hepatobiliary Surgery and Nutrition 2019年第6期8卷 655-658页

作者： Benedetto Ielpo Javier Nunez-Alfonsel Maria Victoria Diago Alvaro Hidalgo yolanda Quijano Emilio Vicente Department of General Surgery Division of HBP SurgeryLeon University HospitalLeonSpain Instituto de Validación de la Eficiencia Clínica Fundación de Investigación HM HospitalesMadridSpain Department of General Surgery Sanchinarro University Hospital HMMadridSpain Department of Economics and Finance Universidad de Castilla la ManchaToledoSpain

Robotic approach is already a new technological system in surgery and its potential advantages such as ergonomics,reduced tremor,3D view and improved instruments movements have been well described(1,2).Concerning the current literature,the studies addressing the robotic benefits on left pancreatectomies are ***,it has been showed that robotic distal pancreatectomy is both feasible and safe as well as the laparoscopic and the standard open ***,there is a lack of high-level economic studies comparing these techniques(3-6).

关键词： robotic cost feasible

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Early-onset colorectal cancer:A separate subset of colorectal cancer

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World Journal of Gastroenterology 2014年第46期20卷 17288-17296页

作者： Irene Osorio Silla Daniel Rueda yolanda Rodríguez Juan Luis García Felipe de la Cruz Vigo José Perea Department of Surgery 12 de Octubre University HospitalMadrid 28041Spain Molecular Biology Laboratory 12 de Octubre University HospitalMadrid 28041Spain Department of Pathology 12 de Octubre University HospitalMadrid 28041Spain Centre for Cancer Research Medical University of SalamancaSalamanca 37008Spain

Colorectal cancer(CRC)has a great impact on the world *** increasing frequency,CRC is described according to the presenting phenotype,based on its molecular *** of CRC tumors according to their genetic and/or epigenetic alterations is not only important for establishing the molecular bases of the disease,but also for predicting patient outcomes and developing more individualized ***-onset CRC is a heterogeneous disease,with a strong familial component,although the disease is sporadic in an important proportion of *** molecular alterations appear to contribute to the apparent heterogeneity of the early-onset population and subgroups can be distinguished with distinct histopathologic and familial ***,compared with late-onset CRC,there are characteristicsthat suggest that early-onset CRC may have a different molecular *** purpose of this review was to analyze the current state of knowledge about earlyonset CRC with respect to clinicopathologic,familial and molecular ***,these features make it increasingly clear that this subset of CRC may be a separate disease,although it has much in common with late-onset CRC.

关键词： Chromosomal instability CpG island methylator phenotype Early-onset colorectal cancer Lynch syndrome Microsatellite instability

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Porphyrins,phthalocyanines,and related covalent-organic frameworks in the photochemical and electrochemical water splitting:A review

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Particuology 2024年第7期90卷 236-265页

作者： Oxana V.Kharissova yolanda Peña Méndez Boris I.Kharisov Aleksandr LNikolaev Edith Luévano-Hipólito Lucy T.González Universidad Autónoma de Nuevo León Ave.Universidad s/nSan Nicolás de los GarzaNuevo León66455Mexico Department of Chemistry Moscow State UniversityVorobievy HillsMoscowRussia CONACYT-Universidad Autónoma de Nuevo León Facultad de Ingeniería Civil-Departamento de Ecomateriales y EnergíaCd.UniversitariaC.P.66455San Nicolás de los GarzaNLMexico Tecnologico de Monterrey Escuela de Ingeniería y CienciasMonterreyNuevo León 64890Mexico Tecnologico de Monterrey Centro del AguaMonterreyNuevo León 64890Mexico

In this review,the possibilities of photochemical and electrochemical water splitting(WS)using porphyrins,phthalocyanines,related macrocycles,and their metal complexes are *** efforts are being carried out in order to develop novel and cheap methods for water decomposition to generate inexhaustible greener energy sources(molecular hydrogen)instead of oil and *** processes of WS in heterogeneous and homogeneous media require novel photo-and electrocatalysts,in particular those on macrocycle basis.A high WS efficiency has been observed for porphyrins and phthalocyanines,showing their suitability both for HER and OER processes are available using these relative compounds for WS *** can be used in photocatalytic and electrocatalytic WS processes both in their free forms or as metal porphyrins/porphyrinates,mainly loaded on various inorganic materials,such as Au NPs,C_(3)N_(4),GaP,KTaO_(3),GaP,and so on,as part of porphyrin-containing polymers or on electrode surface as modifying coatings,being sometimes better than commercial catalysts,such as Pt/*** H2 evolution can be considerably depended on the shape of porphyrin particles;in particular,porphyrin nanowires can yield up to 20 times more H2 than its *** certain cases,both HER and OER can be driven in the same electrolyte using metal *** capacity of metal porphyrins to generate ROS(in particular,singlet oxygen 1O_(2))under ultrasonic treatment is known and can be successfully used for H_(2)O_(2) and O_(2) *** can be used in similar processes in free form or as composites with inorganic or organic counterparts,being immobilized on nanocarbons,metal oxides and salts,or simply dissolved in water acting in a homogeneous *** additional use of ultrasound can lead to better results due to the synergistic effect of the sonochemical treatment and ***-organic frameworks are also applied for WS purposes and are mainly based

关键词： Porphyrins Phthalocyanines COFs Water splitting Photocatalysis Electrocatalysis

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Quality evaluation of Nothofagus pumilio seeds linked to forest management and climatic events

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Ecological Processes 2024年第1期13卷 98-107页

作者： Julian Rodríguez-Souilla Jimena E.chaves María Vanessa Lencinas Juan Manuel Cellini Fidel A.Roig Pablo L.Peri Guillermo Martinez Pastur Laboratorio de Recursos Agroforestales Centro Austral de Investigaciones Científicas (CADIC) Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET ) Laboratorio de Investigaciones en Maderas (LIMAD) Universidad Nacional de la Plata (UNLP) Instituto Argentino de Nivología Glaciología y Ciencias Ambientales (IAN-IGLA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Instituto Nacional de Tecnología Agropecuaria (INTA) Universidad Nacional de la Patagonia Austral (UNPA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET )

Background Forest ecosystems undergo significant transformations due to harvesting and climate fluctuations, emphasizing the critical role of seeding in natural regeneration and long-term structural preservation. Climate change further amplifies these dynamics, affecting phenology across species and regions. In Tierra del Fuego(Argentina), Nothofagus pumilio(lenga) forests represent the most important timber resource, and it is managed through different silvicultural strategies. This species demonstrates notable post-disturbance regeneration, yet seed fall exhibits signifi-cant variability, leading to variations in seed quality(e.g., viability). This study aims to assess fluctuations in N. pumilio seed quality, determine how it varies concerning forest management strategies, annual productivity, and the co-occurrence of climatic phenomena including El Ni?o-Southern Oscillation(ENSO) and the Southern Annular Mode(SAM).Results Viable seeds represented 18.4% of the total, notably higher in unharvested than in managed areas. Con-versely, empty seeds were more prevalent in harvested areas(> 75%). Seed quality exhibited significant differences across silvicultural treatments, except for insect-predated seeds, which had similar proportions across all areas, though dispersed retention showed higher predation. When considering years with varying production levels, high-production years favoured full and viable seeds, particularly in unharvested forests and aggregated retention, while low-production years saw reduced viability across all treatments. Quadratic models revealed that viability increased with seed production, where unharvested forests achieved the highest values. Climate variability influenced seed proportions, where ENSO+/SAM+ promoting more full and viable seeds, while ENSO–/SAM+ favoured non-predated seeds, especially in unharvested *** Seed quality varies among treatments and years with different levels of seeding. Variations in seed qual-ity, l

关键词： Forest management Seeding Climate change Extreme event Patagonia

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FAIR Computational Workflows

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Data Intelligence 2020年第1期2卷 108-121,307,308,309页

作者： Carole Goble Sarah Cohen-Boulakia Stian Soiland-Reyes Daniel Garijo yolanda Gil Michael R.Crusoe Kristian Peters Daniel Schober Department of Computer Science The University of ManchesterOxford RoadManchester M139PLUK Laboratoire de Recherche en Informatique CNRSUniversitéParis-SaclayBatiment 650UniversitéParis-Sud91405 ORSAY CedexFrance Information Sciences Institute University of Southern CaliforniaMarina Del Rey CA 90292USA Common Workflow Language project Software Freedom ConservancyInc.137 Montague St STE 380NY 11201-3548USA Leibniz Institute of Plant Biochemistry(IPB Halle) Department of Biochemistry of Plant InteractionsWeinberg 306120 Halle(Saale)Germany

Computational workflows describe the complex multi-step methods that are used for data collection,data preparation,analytics,predictive modelling,and simulation that lead to new data *** can inherently contribute to the FAIR data principles:by processing data according to established metadata;by creating metadata themselves during the processing of data;and by tracking and recording data *** properties aid data quality assessment and contribute to secondary data ***,workflows are digital objects in their own *** paper argues that FAIR principles for workflows need to address their specific nature in terms of their composition of executable software steps,their provenance,and their development.

关键词： Computational workflow Reproducibility Software FAIR data Provenance

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Countenbeit Chic

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中国服装（北京） 2008年第1期 64-65页

作者： yolanda Wu（编译） Susun Scafidi

时尚没有统一的标准，美是一种主观的判断。虽然已有中国服装界的人士在呼吁中国的时尚话语权，但国外时尚对世界潮流的引领仍是不争的事实。我们仍要保持追赶的姿态。于是，请国外设计师、代理国外服装品牌、参加国外展会…我们想更近... 详细信息

时尚没有统一的标准，美是一种主观的判断。虽然已有中国服装界的人士在呼吁中国的时尚话语权，但国外时尚对世界潮流的引领仍是不争的事实。我们仍要保持追赶的姿态。于是，请国外设计师、代理国外服装品牌、参加国外展会…我们想更近距离地触摸国外时尚产业。但显然，因为各种因素。不是所有的人都有机会，不是所有的层面都能看到。源于此，我们特别推出了几位国外知名人士的时尚博客。他们有的是记者，有的专业是法律，还有的长年游走于全球的时尚舞台。他们与时尚的距离，能让我们对国外时尚看得更清楚。

关键词：中国时尚服装业博客

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Effects of the allelopathic plant Artemisia herba-alba Asso on the soil seed bank of a semi-arid plant community

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Journal of Plant Ecology 2017年第6期10卷 927-936页

作者： Antonio I.Arroyo yolanda Pueyo Ramón Reiné Maria Luz Giner Concepción L.Alados Instituto Pirenaico de Ecología(CSIC) Av.Montañana 1005P.O.Box 13.034Zaragoza 50080Spain Escuela Politécnica Superior(Universidad de Zaragoza) Ctra.Cuarte s/nHuesca 22071Spain

Aims Seed bank strongly influences composition and structure of above-ground *** attention has been paid to the role of allel-opathy driving soil seed bank dynamics,even though allelochemicals released by allelopathic plants might determine whether a species can or cannot germinate from the soil seed bank and,therefore,to co-exist in the neighborhood of the allelopathic ***,the effects of allelopathic plants on community organization through the effects of allelochemicals on soil seed bank remain largely *** this study,we assessed spatial heterogeneities in soil seed bank caused by the presence of allelopathic plants,and evaluated allelo-pathic effects on seed bank germination and seedling *** We examined the effects of the allelopathic shrub Artemisia herba-alba Asso on the spatial structure(in terms of species richness and seed density)of the soil seed bank of a semi-arid ecosystem in NE ***,we evaluated seed bank richness and density at three microsites:under the canopy of ***-alba individuals,under the canopy of Salsola vermiculata L.(a non-allelopathic shrub)individuals,and in bare *** addition,we assessed the effects of aqueous extract of ***-alba on soil seed bank germination(seed-ling emergence and emergence timing)and seedling *** Findings We found that seed bank richness and density were higher under shrub canopy than they were in bare ***-alba and *** microsites had similar seed bank ***,seed bank density was higher under ***-alba because of the high abundance of ***-alba *** extract reduced seedling emergence from the seed bank by 50%,and affected mortality of some emerged *** the other hand,aqueous extract did not influence the emergence timing of *** conclude that,although the presence of allelo-pathic plants does not cause relevant changes in seed bank struc-ture relative to similar non-allelopathi

关键词： allelopathic shrub aqueous extract Middle Ebro Valley seed bank inhibition seed bank density seedling emergence

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