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Science China Earth Sciences 2005年第10期48卷 1718-1727页

作者： yokoyama kazumi Department of Geology National Science Museum Tokyo Japan

The Late Cenozoic strata are 313 m thick, revealed by the drilling core PD-99 in the south Changjiang delta. Monazite chemical dating shows that 350-500-Ma monazites predominate in the Pliocene and 100-275-Ma monazites in the Quaternary, indicating a great change of their provenance. The first presence horizon of monazites younger than 25 Ma is just above the Matruyama/Gauss boundary (~2.58 Ma), whch is exactly when uplift of the Tibetan Plateau began to influence deposition in the East China Sea. Variations in contents of monazites younger than 25 Ma can be divided into two sections. The Early-Middle Pleistocene with less <25 Ma monazites corresponds with rapid uplift of the Tibetan Plateau, and the Late Pleistocene with more <25 Ma monazites parallels the peak uplift of the Tibetan Plateau. This study demonstrates that chemical dating of monazites in the river-mouth strata is a useful method to explore changes of river drainage basins, and deconvolute multistage tectonic and magmatic activity histories in the provenance areas.

关键词： delta, monazite, electron microprobe, chemical dating, formation of the Changjiang, uplift of the Tibetan Plateau.

河口地层独居石Th(U)-Pb年龄对长江贯通时限的约束

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海洋地质动态 2006年第7期22卷 11-15页

作者：范代读李从先 yokoyama kazumi 同济大学海洋地质国家重点实验室上海200092 Department of Geology National Science Museum Tokyo Japan

新生代长江水系调整、东西贯通时限是国内外学者共同关注的问题。长江发展演化的复杂性在近一个世纪的河流沉积地貌学研究中得到充分的认识,但在贯通时限问题上难以形成共识。河口地层中碎屑独居石的电子探针Th(U)-Pb年龄较好地限定长... 详细信息

新生代长江水系调整、东西贯通时限是国内外学者共同关注的问题。长江发展演化的复杂性在近一个世纪的河流沉积地貌学研究中得到充分的认识,但在贯通时限问题上难以形成共识。河口地层中碎屑独居石的电子探针Th(U)-Pb年龄较好地限定长江东西贯通的时间在2.58MaBP前后。随着碎屑矿物微区分析技术的发展,锆石、独居石年代学和微区特征将成为研究流域演化、构造运动的主要手段。

关键词：河流沉积地貌学碎屑独居石 Th(U)-Pb年龄长江贯通时限

PD-99孔记录的长江三角洲晚新生代地层特征及长江贯通的时间

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PD-99孔记录的长江三角洲晚新生代地层特征及长江贯通的时间

Real-world efficacy and safety of tofacitinib treatment in Asian patients with ulcerative colitis

第三届全国沉积学大会

作者：范代读李从先周保春王强 kazumi yokoyama 李保华杨守业邓兵吴国暄同济大学海洋地质教育部重点实验室同济大学海洋地质教育部重点实验室上海市自然博物馆天津地质矿产研究所 Department of Geology National Science MuseumTokyoJapan 同济大学海洋地质教育部重点实验室同济大学海洋地质教育部重点实验室同济大学海洋地质教育部重点实验室同济大学海洋地质教育部重点实验室

＜正＞ PD-99孔位于上海浦东大众汽车厂院内,是上海市地震局的基岩标孔之一。孔深318.73m,芯长258.6m,取芯率平均达到81.1%,部分层段高达90%。该孔313.0m 打到基岩,为古近系紫红色石英砂岩,之上为松散的新近系和第四系。第四系与新近系...

＜正＞ PD-99孔位于上海浦东大众汽车厂院内,是上海市地震局的基岩标孔之一。孔深318.73m,芯长258.6m,取芯率平均达到81.1%,部分层段高达90%。该孔313.0m 打到基岩,为古近系紫红色石英砂岩,之上为松散的新近系和第四系。第四系与新近系的界线在松山-高斯极性转变事件（M/Ga）附近。根据岩石地层、磁化率利有机元素曲线,将此界线最后确定在240m 处。界线之下为上新世沉积层,为一套河湖相的砂质、粘土质沉积,沉积层

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World Journal of Gastroenterology 2024年第13期30卷 1871-1886页

作者： Kentaro Kojima Kenji Watanabe Mikio Kawai Soichi Yagi Koji Kaku Maiko Ikenouchi Toshiyuki Sato Koji Kamikozuru Yoko yokoyama Tetsuya Takagawa Masahito Shimizu Shinichiro Shinzaki Department of Gastroenterology Hyogo Medical UniversityNishinomiya 663-8501Japan Department of Gastroenterology Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Internal Medicine for Inflammatory Bowel Disease The University of ToyamaToyama 930-0194Japan Center for Clinical Research and Education Hyogo Medical UniversityNishinomiya 663-8501Japan

BACKGROUND Real-world data on tofacitinib(TOF)covering a period of more than 1 year for a sufficient number of Asian patients with ulcerative colitis(UC)are *** To investigate the long-term efficacy and safety of TOF treatment for UC,including clinical *** We performed a retrospective single-center observational analysis of 111 UC patients administered TOF at Hyogo Medical University as a tertiary inflammatory bowel disease *** consecutive UC patients who received TOF between May 2018 and February 2020 were *** were followed up until August *** primary outcome was the clinical response rate at week *** outcomes included clinical remission at week 8,cumulative persistence rate of TOF administration,colectomy-free survival,relapse after tapering of TOF and predictors of clinical response at week 8 and week *** The clinical response and remission rates were 66.3%and 50.5%at week 8,and 47.1%and 43.5%at week 48,*** overall cumulative clinical remission rate was 61.7%at week 48 and history of anti-tumor necrosis factor-alpha(TNF-α)agents use had no influence(P=0.25).The cumulative TOF persistence rate at week 48 was significantly lower in patients without clinical remission than in those with remission at week 8(30.9%vs 88.1%;P<0.001).Baseline partial Mayo Score was significantly lower in responders vs non-responders at week 8(odds ratio:0.61,95%confidence interval:0.45-0.82,P=0.001).Relapse occurred in 45.7%of patients after TOF tapering,and 85.7%of patients responded within 4 wk after *** 6 patients with herpes zoster(HZ)developed the infection after achieving remission by *** TOF was more effective in UC patients with mild activity at baseline and its efficacy was not affected by previous treatment with anti-TNF-α*** relapsed patients responded again after re-increase of TOF and nearly half relapsed after tapering off *** attention is needed for tapering and H

关键词： Ulcerative colitis Tofacitinib Janus kinase inhibitor Real-world Biologics

Transformed gastric mucosa-associated lymphoid tissue lymphoma originating in the colon and developing metachronously after Helicobacter pylori eradication:A case report

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4281-4288页

作者： Makoto Saito Zen-Ichi Tanei Masumi Tsuda Toma Suzuki Emi yokoyama Minoru Kanaya Koh Izumiyama Akio Mori Masanobu Morioka Takeshi Kondo Blood Disorders Center Aiiku HospitalSapporo 064-0804HokkaidoJapan Department of Cancer Pathology Faculty of MedicineHokkaido UniversitySapporo 060-8638HokkaidoJapan

BACKGROUND Helicobacter pylori(***)eradication treatment for primary gastric mucosaassociated lymphoid tissue(MALT)lymphoma has already been ***,t(11;18)(q21;q21)/API2-MALT1 translocation-positive lesions are a type of primary gastric MALT lymphoma in which a response to eradication treatment is difficult to *** addition,trisomy 18 may be associated with diffuse large B-cell lymphoma(DLBCL)transformation of gastric MALT *** SUMMARY A 66-year-old man was diagnosed with MALT lymphoma in the ascending colon by colonoscopy and *** years later,esophagogastroduodenoscopy revealed chronic atrophic gastritis that was positive for ***,and eradication treatment was *** years and nine months later(at the age of 70),a new ulcerative lesion suggestive of MALT lymphoma appeared in the gastric body,and six months later,a similar lesion was also found in the *** year later(4 years and 3 months after *** eradication),at the age of 72,the lesion in the gastric body had become deeper and had propagated.A biopsy revealed a pathological diagnosis of *** MALT lymphoma lesions in the ascending colon and DLBCL lesions in the stomach were positive for the t(11;18)(q21;q21)/API2-MALT1 translocation,and trisomy 18q21 was also *** 6 courses of R-CHOP(rituximab,cyclophosphamide,doxorubicin,vincristine and prednisone)chemotherapy,all of the above lesions disappeared[complete remission(CR)],and CR has been maintained for more than 3 *** addition,both the colonic and gastric lesions were proven to have the same *** Because the patient had a MALT1 translocation with trisomy 18q21,it was thought that this gastric MALT lymphoma developed independently of *** infection and progressed.

关键词： Gastric mucosa-associated lymphoid tissue lymphoma Transform Diffuse large B-cell lymphoma Colonic mucosa-associated lymphoid tissue lymphoma Helicobacter pylori eradication MALT1 translocation Case report

Anti-Obesity Effects of Dietary d-Allulose and Medium-Chain Triglycerides in High-Fat Diet-Fed Rats

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Food and Nutrition Sciences 2024年第8期15卷 701-710页

作者： Tatsuhiro Matsuo Chihiro yokoyama Takako Yamada Tetsuo Iida Susumu Mochizuki Akihide Yoshihara Kazuya Akimitsu Faculty of Agriculture Kagawa University Miki-cho Japan Research and Development Matsutani Chemical Industry Co. Ltd. Itami Japan

d-Allulose, a rare sugar, exerts anti-obesity effects by inhibiting hepatic lipogenesis and promoting energy expenditure. Medium-chain triglycerides (MCTs) consist of three medium-chain fatty acids connected by glycerol. MCTs have been extensively investigated for their ability to reduce body fat accumulation. We previously investigated the anti-obesity effects of a combination of dietary d-allulose and MCT (5% - 13%) in rats;however, we could not confirm the anti-obesity effects of MCT or observed synergetic effects between d-allulose and MCT on body fat loss. We speculated that our previous studies were influenced by the excessive amount of MCT in the diets. Therefore, in this study, we aimed to investigate the anti-obesity effects of the simultaneous intake of d-allulose and MCT in rats fed an obesity-inducing high-fat diet with a low amount of MCTs (2%). Thirty-two male Wistar rats (3-week-old) were randomly divided into four groups: control, d-allulose, MCT, and d-allulose + MCT groups. Rats in each group were fed ad libitum on a control (no d-Allulose or MCT), 5% d-allulose, 2% MCT, or 5% d-allulose + 2% MCT diets for 16 weeks. Abdominal adipose tissue weights were significantly lower in the d-allulose diet group than in the control group, whereas no differences were observed between results of the MCT-supplemented groups. The total body fat mass was significantly lower in the d-allulose and MCT diet groups than in the control group, but no differences were observed between the MCT-supplemented groups. These results suggested that anti-obesity effects of dietary d-allulose were observed, and the effects of dietary MCTs were weaker than those of d-allulose. Moreover, we confirmed the interaction between dietary d-allulose and MCT on indicators of obesity. Interestingly, their effects were not synergistic, as MCT supplementation offset the anti-obesity effects of dietary d-allulose. However, the specific mechanisms underlying those effects remain unknown, warran

关键词： Rare Sugar d-Allulose Medium-Chain Triglycerides Body Fat Rat

Specific immune responses induced by a multi-epitope antigen of hepatitis C virus in mice and rabbits

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Chinese Science Bulletin 2000年第10期45卷 903-908页

作者： KazunariK.yokoyama Tsukuba Life Science Center RIKEN3-1-1 KoyadaiTsukubaIbaraki 305-0074Japan

Five highly conserved and immunogenic epitopes of hepatitis C virus (HCV) have been chosen to form a multi-epitope antigen gene and fused with β-galactosidase gene to express a hybrid GZ-PCX antigen, which could be specifically recognized by human HCV sera. High level of anti-GZ-PCX IgG has been induced when mice or rabbits were immunized with GZ-PCX antigen emulsificated with complete Freund’s adjuvant or mixed with killed attenuated Salmonella typhimurium SL3261. The specific anti-GZ-PCX IgG reached a high liter of 10-6, which remained for several months. Specific cytotoxic T lymphocyte (CTL) effects, delayed type hypersensltivity reaction (DTH) and proliferation of peripheral lymphocytes have been induced by GZ-PCX antigen or synthetic peptides. High level of anti-GZ-PCX slgG has been detected in mice’s intestinal washing fluids, which indicates that the antigen induced mucosal immunity as well as systematic immunity. The studies show that the HCV multi-epitope antigen induces high level of specific immune responses without obvious toxicity, which might be able to provide protectivity to any HCV genotypes and isolates.

关键词： multi-epitope antigen vaccine immune response hepatitis C virus (HCV).

On a Kaehler Hypersurface with the Cyclic Ricci Semi-symmetric Tensor

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Acta Mathematica Sinica,English Series 2009年第10期25卷 1591-1594页

作者： Norifumi yokoyama Yoshio MATSUYAMA Department of Mathematics Chuo University

The purpose of the present paper is to prove that a Kaehler hypersurface with the cyclic Ricci semi-symmetric tensor is locally symmetric.

关键词： Kaehler hypersurfaces cyclic Ricci semi-symmetric tensor locally symmetric

Isolated liver metastasis detected 11 years after the curative resection of rectal cancer:A case report

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World Journal of Clinical Cases 2021年第29期9卷 8923-8931页

作者： Yoshikuni Yonenaga Satoshi yokoyama Department of Surgery Ako City HospitalAko 678-0232HyogoJapan Department of Surgery Japanese Red Cross Wakayama Medical CenterWakayama 640-8558WakayamaJapan

BACKGROUND The duration of surveillance after curative resection of colorectal cancer(CRC)is generally 5 *** overall incidence of recurrence more than 5 years after surgery for CRC in Japan has been reported to be 0.6%.Moreover,it is rare for CRC to have metachronous liver metastasis more than 10 years after ***,we present a case of liver metastasis detected 11 years after the curative resection of rectal *** SUMMARY A 72-year-old man was referred to our hospital after a liver tumor was detected by abdominal ultrasonography at another *** had undergone surgery for rectal cancer 11 years ***-enhanced computed tomography(CT)showed a tumor with a diameter of approximately 8 cm in the posterior segment,which was weakly and gradually enhanced.18F-fluorodeoxyglucose-positron emission tomography/CT showed an abnormally high uptake on the tumorous lesion,which showed that the tumor appeared to spread convexly along the intrahepatic bile *** cholangiocarcinoma was therefore diagnosed,and he had an extended right posterior sectionectomy and regional lymph node *** examination showed that the tumor was a moderately differentiated adenocarcinoma and showed the same pathological characteristics as the rectal *** examination showed that the cancer cells of both the liver tumor and rectal cancer were positive for cytokeratin(CK)20 and weakly positive for CK *** findings were consistent with the liver metastasis from the rectal *** It is possible that a liver tumor is metastatic in a patient with a previous history of CRC,even if it was more than 10 years earlier.

关键词： Liver metastasis Colorectal cancer Intrahepatic cholangiocarcinoma Late recurrence Case report

Analysis of molten metal spreading and solidification behaviors utilizing moving particle full-implicit method

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Frontiers in Energy 2021年第4期15卷 959-973页

作者： Ryo yokoyama Masahiro KONDO Shunichi SUZUKI Koji OKAMOTO Department of Nuclear Engineering and Management The University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-8656Japan Research Center for Computational Design of Advanced Functional materials(CD-FMat) Department of Materials and ChemistryNational Institute of Advanced Industrial Science and Technology(AIST)Central 21-1-1UmezonoTsukubaIbaraki 305-8568Japan Institute of Engineering Innovation School of EngineeringThe University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-8656Japan Nuclear Professional School The University of Tokyo2-22 ShirakataTokai-muraIbaraki 319-1188Japan

To retrieve the fuel debris in Fukushima Daiichi Nuclear Power Plants(1F),it is essential to infer the fuel debris *** particular,the molten metal spreading behavior is one of the vital phenomena in nuclear severe accidents because it determines the initial condition for further accident scenarios such as molten core concrete interaction(MCCI).In this study,the fundamental molten metal spreading experiments were performed with different outlet diameters and sample amounts to investigate the effect of the outlet for spreading-solidification *** the numerical analysis,the moving particle full-implicit method(MPFI),which is one of the particle methods,was applied to simulate the spreading *** the MPFI framework,the melting-solidification model including heat transfer,radiation heat loss,phase change,and solid fraction-dependent viscosity was developed and *** addition,the difference in the spreading and solidification behavior due to the outlet diameters was reproduced in the *** simulation results reveal the detailed solidification procedure during the molten metal *** is found that the viscosity change and the solid fraction change during the spreading are key factors for the free surface condition and solidified ***,it is suggested that the MPFI method has the potential to simulate the actual nuclear melt-down phenomena in the future.

关键词： molten metal spreading solidification particle method severe accident fuel debris decommissioning