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Enhancing Cybersecurity thro.gh Clo.d Co.puting So.utio.s in the United States

Intelligent Info.matio. Management 2024年第4期16卷 176-193页

作者： o.o.o.a F. Hassan Fo.o.unsho.o. Fatai o.uwadare Aderibigbe Abdullah o.ado.in Akinde To.ulo.e o.asanya Mariam Adeto.n Sanusi o.uwunmi o.uko.a Department o. Co.puter Science Austin Peay State University Clarksville USA Department o. Co.puter Science North Carolina Agricultural and Technical State University Greensboro USA Department o. Cybersecurity University of Texas Dallas USA Department o. Info.matio. Systems East Tennessee State University Johnson City USA

This study investigates ho. cybersecurity can be enhanced thro.gh clo.d co.puting so.utio.s in the United States. The mo.ive fo. this study is due to.the rampant lo.s o. data, breaches, and unautho.ized access o. internet criminals in the United States. The study ado.ted a survey research design, co.lecting data fro. 890 clo.d pro.essio.als with relevant kno.ledge o. cybersecurity and clo.d co.puting. A machine learning appro.ch was ado.ted, specifically a rando. fo.est classifier, an ensemble, and a decisio. tree mo.el. o.t o. the features in the data, ten impo.tant features were selected using rando. fo.est feature impo.tance, which helps to.achieve the o.jective o. the study. The study’s purpo.e is to.enable o.ganizatio.s to.develo. suitable techniques to.prevent cybercrime using rando. fo.est predictio.s as they relate to.clo.d services in the United States. The effectiveness o. the mo.els used is evaluated by utilizing validatio. matrices that include recall values, accuracy, and precisio., in additio. to.F1 sco.es and co.fusio. matrices. Based o. evaluatio. sco.es (accuracy, precisio., recall, and F1 sco.es) o. 81.9%, 82.6%, and 82.1%, the results demo.strated the effectiveness o. the rando. fo.est mo.el. It sho.ed the impo.tance o. machine learning algo.ithms in preventing cybercrime and bo.sting security in the clo.d enviro.ment. It reco.mends that o.her machine learning mo.els be ado.ted to.see ho. to.impro.e cybersecurity thro.gh clo.d co.puting.

关键词： Cybersecurity Clo.d Co.puting Clo.d So.utio.s Machine Learning Algo.ithm

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A review o. the scale-up o. high-shear wet granulatio. pro.esses and the impact o. pro.ess parameters

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Particuo.o.y 2024年第9期92卷 180-195页

作者： Ana Rita Alves Marta Filipe Simões Sérgio.Simões Jo.o.Go.es University o. Co.mbra CERESDepartment of Chemical EngineeringFaculty of Sciences and TechnologyRua Sílvio Lima3030-790CoimbraPortugal Bluepharma-Indústria Farmacêutica São Martinho do BispoCoimbra3045-016Portugal Faculty o. Pharmacy University of CoimbraAzinhaga de Santa Comba3000-548CoimbraPortugal

Wet granulatio. is o.e o. the mo.t impo.tant agglo.eratio. pro.esses,and high-shear granulatio.(HSG)o.e o. the mo.t emplo.ed techno.o.ies in the pharmaceutical *** mo.t critical pro.ess parameters o. HSG are discussed in this *** main co.cern in scaling up the wet granulatio. pro.ess is the differences between scales,which prevent the particles fro. having the same experience acro.s all *** scale-up o. wet granulatio. pro.esses is co.mo.ly divided into.two.catego.ies:engineering and attribute-based *** engineering-based scale-up appro.ch is a strategy based o. dimensio.al analysis and an attribute-based suppo.ted o. the principles o.“equifinality”,where pro.ess variables are adjusted to.o.tain equivalent granule *** wo.k presents the effect o. different HSG pro.ess parameters o. the scale-up,as well as the use o. pro.ess analytical to.ls(PAT)and mo.elling *** aim is to.review applied scale-up appro.ches in HSG and discuss benefits and *** is pro.en why the scale-up fo. o.al so.id pharmaceutical pro.ucts is still co.sidered a ho. to.ic and a very challenging task fo. develo.ment and engineering teams.

关键词： High-shear wetgranulatio. Parametric-based Attribute-based Physics-based mo.elling Impeller design Scale-up

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o.timizing artificial intelligence in sepsis management: o.po.tunities in the present and lo.king clo.ely to.the future

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Jo.rnal o. Intensive Medicine 2024年第1期4卷 34-45页

作者： Darragh o.Reilly Jennifer McGrath Ignacio.Martin-Lo.ches Department o. Intensive Care Medicine Multidisciplinary Intensive Care Research Organization(MICRO)St James’HospitalDublinIreland Department o. Respirato.y Intensive care Hospital ClinicUniversitat de BarcelonaIDIBAPSCIBERESBarcelonaSpain

Sepsis remains a majo. challenge internatio.ally fo. healthcare *** incidence is rising due to.po.r public awareness and delays in its reco.nitio. and subsequent *** sepsis,mo.tality increases with every ho.r left *** intelligence(AI)is transfo.ming wo.ldwide healthcare delivery at *** review has o.tlined ho. AI can augment strategies to.address this glo.al disease *** and machine learning(ML)algo.ithms can analyze vast quantities o. increasingly co.plex clinical datasets fro. electro.ic medical reco.ds to.assist clinicians in diagno.ing and treating sepsis earlier than traditio.al *** review highlights ho. these mo.els can predict the risk o. sepsis and o.gan failure even befo.e it *** gives pro.iders additio.al time to.plan and execute treatment plans,thereby avo.ding increasing co.plicatio.s asso.iated with delayed diagno.is o. *** po.ential fo. co.t savings with AI implementatio. is also.discussed,including impro.ing wo.kflo. efficiencies,reducing administrative co.ts,and impro.ing healthcare *** these advantages,clinicians have been slo. to.ado.t AI into.clinical *** o. the limitatio.s po.ed by AI so.utio.s include the lack o. diverse data sets fo. mo.el building so.that they are widely applicable fo. ro.tine clinical ***,the subsequent algo.ithms are o.ten based o. co.plex mathematics leading to.clinician hesitancy to.embrace such ***,we highlight the need fo. ro.ust po.itical and regulato.y framewo.ks in this area to.achieve the trust and appro.al o. clinicians and patients to.implement this transfo.matio.al techno.o.y。

关键词： Artificial intelligence Data science Machine learning Intensive care unit(ICU) Critical care Sepsis

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Blo.d bio.arkers o. Alzheimer’s disease:impo.tant co.sideratio.s fo. use in clinical practice

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Neural Regeneratio. Research 2025年第1期20卷 205-206页

作者： Sarah Fullam Sean o.Do.d Anto.nette o.Co.no. Department o. Neuro.o.y Tallaght University HospitalDublinIreland Academic Unit o. Neuro.o.y Trinity College DublinIreland

Intro.uctio.:Fluid and po.itro. emissio. to.o.raphy(PET)bio.arkers that enable the detectio. o. the hallmark pro.eins o. Alzheimer’s disease(AD)(amylo.d and tau)have revo.utio.ized o.r appro.ch to.the diagno.is o. *** evo.utio. o. AD diagno.tic criteria to.include bio.o.ical characterizatio.(Alzheimer’s Asso.iatio. Wo.king Gro.p,2023)pro.ides an appro.riate framewo.k to.reduce levels o. clinico.patho.o.ic mismatch and impro.e in-vivo.diagno.tic *** the therapeutic landscape fo. neuro.egenerative disease evo.ves,it is increasingly incumbent o. clinicians to.pro.ide timely,and patho.o.ically precise diagno.es fo. ***,the expensive and invasive nature o. these tests limits their scalability.

关键词： Blo.d Alzheimer diagno.is

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Public perspectives o. AI diagno.is o. mental illness

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General Psychiatry 2024年第3期37卷 348-351页

作者： Clio.hna o.Co.no. University Co.lege Dublin DublinIreland

To.the edito.:Psychiatric theo.y,po.icy and practice are currently grappling with the risks and o.po.tunities presented by artificial intelligence(AI)applicatio.s in mental *** data to.generate diagno.is is an aspect o. mental healthcare where AI is anticipated to.have the greatest and so.nest impact.1-4 While such techno.o.ies remain so.e distance fro. clinical applicatio.,preliminary evidence suggests AI-derived classificatio.s may predict certain treatment o.tco.es and clinical trajecto.ies,and co.ld so.n beco.e available to.supplement o. replace traditio.al manual-based diagno.tic assessment.

关键词： diagno.is replace edito.

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Perito.eal interpo.itio. flap reduces sympto.atic lympho.ele fo.lo.ing transperito.eal ro.o.-assisted radical pro.tatecto.y and pelvic lymph no.e dissectio.:An updated meta-analysis

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Current Uro.o.y 2024年第3期18卷 167-176页

作者： Jo.o.Henrique Sendrete de Pinho.Lo.rane Vieira Siqueira Riscado.Jo.o.Padua Manzano Faculty o. Medicine o. the Federal University o. Juiz de Fo.a Minas GeraisBrazil Faculty o. Medicine o. the Federal University o. São.Paulo São PauloBrazil

Backgro.nd Ro.o.-assisted radical pro.tatecto.y with intrao.erative pelvic lymph no.e dissectio. is the criterio. standard fo. surgical treatment o. no.metastatic intermediate-and high-risk pro.tate ***,this metho. is asso.iated with sympto.atic lympho.ele(SLC),which is an impo.tant mo.bidity *** o.erco.e this co.plicatio.,several mo.ificatio.s o. the technique have been develo.ed,including the perito.eal interpo.itio. flap(PIF).We perfo.med an updated systematic review and meta-analysis to.investigate the efficacy and safety o. this technique fo. preventing SLC and lympho.ele(LC)*** and metho.s Searches were perfo.med using databases and references fro. included studies and previo.s systematic *** rando.ized co.tro.led trials and no.rando.ized co.o.ts were *** o.tco.es were the incidence o. SLC and LC fo.matio.,and safety o.tco.es were defined as o.eratio. time,estimated blo.d lo.s,length o. ho.pital stay,and urinary *** assessment was perfo.med using the Newcastle-o.tawa Scale and Co.hrane Co.labo.atio.'s *** treatment effects were estimated using o.ds ratio. with 95%co.fidence intervals(CIs)fo. binary *** was examined using Co.hran's Q test and I2 statistics;p values25%were co.sidered significant fo. *** used Mantel-Haenszel fixed-effect mo.els in the analyses with lo. ***,the DerSimo.ian and Laird rando.-effects mo.el was *** The initial search yielded 510 *** the remo.al o. duplicate reco.ds and applicatio. o. the exclusio. criterio.,9 studies were fully reviewed fo. *** rando.ized co.tro.led trials and 5 retro.pective co.o.ts met all the inclusio. criteria,co.prising 2261 patients,o. who. 1073(47.4%)underwent *** studies repo.ted a significant reductio. in SLC in the PIF gro.p,and 3 o. the 4 studies repo.ted LC fo.matio. yielded significant results in preventing this co.plicatio..

关键词： Ro.o.-assisted radical pro.tatecto.y Lympho.ele Perito.eal reappro.imatio. Perito.eal interpo.ated flap Meta-analysis

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Energy and blast perfo.mance o. beryllium in a mo.el thermo.aric co.po.itio. in co.pariso. with aluminum and magnesium

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Defence Techno.o.y（防务技术） 2024年第6期36卷 13-19页

作者： Tho.as M.Klapo.ke Stanisław Cudziło.Waldemar A.Trzcinski Jo.ef Paszula Energetic Materials Research Department of ChemistryUniversity of Munich(LMU)Butenandtstrasse 5-13(D)81377MunichGermany Military University o. Techno.o.y Faculty of Advanced Technologies and ChemistrySylwester Kaliski Str.200-908WarsawPoland

A direct co.pariso. is made between the effectiveness o. Al,Mg,and Be po.ders as additio.al fuels in mo.el thermo.aric co.po.itio.s co.taining 20%fuel,20%ammo.ium perchlo.ate,and 60%RDX(1,3,5-Trinitro.1,3,5-triazacyclo.exane)passivated with *** determined calo.imetric measurements o. the heat o. deto.atio.,alo.g with the o.erpressure histo.ies in an explo.io. chamber filled with nitro.en,were used to.determine the quasi-static pressure(QSP)under anaero.ic *** measurements were also.perfo.med in a semi-clo.ed bunker,and all blast wave parameters generated after the deto.atio. o. 500 g charges o. the tested explo.ives were *** calo.imetry results,QSP values,and blast wave parameters(pressure amplitude,specific and to.al impulses)clearly indicate that Be is much mo.e effective as an additio.al fuel than either Al o. Mg in bo.h anaero.ic po.t-deto.atio. reactio.s as well as the subsequent aero.ic *** heat o. deto.atio. o. the RDXwax/AP/Be explo.ive mixture is o.er 40%and 50%higher than that o. the mixture co.taining aluminum and magnesium instead o. beryllium,***,the TNT equivalent o. the Be-co.taining co.po.itio. due to.the o.erpressure in the nitro.en-filled explo.io. chamber is 1.66,while the equivalent calculated using an air sho.k wave-specific impulse at a distance o. 2.5 m is equal to.*** high values o. these parameters co.firm the high reactivity o. beryllium in bo.h the anaero.ic and aero.ic stages o. the thermo.aric explo.io..

关键词： Thermo.aric explo.ives Beryllium Heat o. deto.atio. Quasi-static o.erpressure Blast wave parameters

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Stero.dal scaffo.d deco.atio.s in So.anum alkalo.d bio.ynthesis

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Mo.ecular Plant 2024年第8期17卷 1236-1254页

作者： Ro.alind Lucier Mo.amed o.Kamileen Yo.o.Nakamura So.iia Serediuk Ranjit Barbo.e Jens Wurlitzer Maritta Kunert Sarah Heinicke Sarah E.o.Co.no. Prashant D.So.awane Department o. Natural Pro.uct Bio.ynthesis Max Planck Institute for Chemical Ecology07745 JenaGermany Research Gro.p Bio.ynthesis and NMR Max Planck Institute for Chemical Ecology07745 JenaGermany Bio.hemical Sciences Divisio. CSIR-National Chemical LaboratoryPune 411008MaharashtraIndia

Stero.dal glyco.lkalo.ds(SGAs)are specialized metabo.ites pro.uced by hundreds o. So.anum species,including impo.tant vegetable cro.s such as to.ato.po.ato.and *** it has been kno.n that SGAs play impo.tant ro.es in defense in plants and“anti-nutritio.al"effects(e.g.,to.icity and bitterness)to.humans,many o. these mo.ecules have do.umented anti-cancer,anti-micro.ial,antiinflammato.y,anti-viral,and anti-pyretic *** these,α-so.aso.ine andα-so.amargine iso.ated fro. black nightshade(So.anum nigrum)are repo.ted to.have po.ent anti-tumo.,anti-pro.iferative,and anti-inflammato.y ***,α-so.aso.ine andα-so.amargine,alo.g with the co.e stero.dal aglyco.e so.aso.ine,are the mo.t widespread SGAs pro.uced amo.g the So.anum ***,it is still unkno.n ho. plants synthesize these bio.ctive stero.dal *** co.parative metabo.o.ictranscripto.e-guided appro.ch,bio.ynthetic lo.ic,co.binato.ial expressio. in Nico.iana benthamiana,and functio.al reco.binant enzyme assays,here we repo.t the disco.ery o. 12 enzymes fro. *** that co.verts the starting cho.estero. precurso.to.so.aso.ine aglyco.e,and the do.nstreamα-so.aso.ine,α-so.amargine,and malo.yl-so.amargine SGA *** further identified six enzymes fro. cultivated eggplant that catalyze the pro.uctio. o.α-so.aso.ine,α-so.amargine,and malo.yl-so.amargine SGAs fro. so.aso.ine aglyco.e via glyco.ylatio. and atypical malo.ylatio. *** wo.k pro.ides the gene to.l bo. and platfo.m fo. engineering the pro.uctio. o. high-value,stero.dal bio.ctive mo.ecules inhetero.o.o.sho.ts usingsyntheticbio.o.y.

关键词： stero.dal glyco.lkalo.ds So.anum bio.ynthetic pathway α-so.amargine malo.yl-so.amargine specialized metabo.ites

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Physico.mathematical mo.el o. the vo.tage−current characteristics o. light-emitting dio.es with quantum wells based o. the Sah−No.ce−Sho.kley reco.binatio. mechanism

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Jo.rnal o. Semico.ducto.s 2024年第8期45卷 25-33页

作者： Fedo. I.Manyakhin Dmitry o.Varlamo. Vladimir P.Krylo. Lyudmila o.Mo.ketso.a Arkady A.Skvo.tso. Vladimir K.Niko.aev Dinamics Strength of Machines and Resisance of MaterialsMoscow Polytechnic UniversityRussia Bio.edical and Electro.ic Means and Techno.o.ies Vladimir State UniversityRussia Co.puter-Aided Design and Engineering National University of Science and Technology"MISiS"Russia

Herein,a physical and mathematical mo.el o. the vo.tage−current characteristics o. a p−n hetero.tructure with quantum wells(QWs)is prepared using the Sah−No.ce−Sho.kley(SNS)reco.binatio. mechanism to.sho. the SNS reco.binatio. rate o. the co.rectio. functio. o. the distributio. o. QWs in the space charge regio. o. dio.e co.figuratio..A co.pariso. o. the mo.el vo.tage−current characteristics(VCCs)with the experimental o.es reveals their *** techno.o.ical parameters o. the structure o. the VCC mo.el are determined experimentally using a no.destructive capacitive appro.ch fo. determining the impurity distributio. pro.ile in the active regio. o. the dio.e structure with a pro.ile depth reso.utio. o. up to.10Å.The co.rectio. functio. in the expressio. o. the reco.binatio. rate sho.s the po.sibility o. determining the derivative o. the VCCs o. structures with QWs with a no.ideality facto. o. up to.4.

关键词： light-emitting dio.es with quantum wells vo.tage−current relatio. no.ideality facto. reco.binatio. mechanism Sah−No.ce−Sho.kley mo.el

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High-precisio. inverse po.entials fo. neutro.-pro.o. scattering using piece-wise smo.th Mo.se functio.s

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Chinese Physics C 2024年第10期48卷 201-213页

作者： Ayushi Awasthi Arushi Sharma Ishwar Kant o.S.K.S.Sastri Department o. Physics and Astro.o.ical Science Central University of Himachal PradeshDharmshala176215India

The aim o. this study is to.co.struct inverse po.entials fo. vario.s ℓ-channels o. neutro.-pro.o. scattering using a piece-wise smo.th Mo.se functio. as a *** phase equatio.s fo. single-channel states and the co.pled equatio.s o. multi-channel scattering are so.ved numerically using the 5^(th) o.der Runge-kutta *** emplo. a piece-wise smo.th reference po.ential co.prising three Mo.se functio.s as the initial *** a machine learning-based genetic algo.ithm,we o.timize the mo.el parameters to.minimize the mean-squared erro. between simulated and anticipated phase *** appro.ch yields inverse po.entials fo. bo.h single and multichannel scattering,achieving co.vergence to.a mean-squared erro.≤10^(-3).The resulting scattering lengths"a_(0)"and effective ranges"r"fo. ^(3)S_(1) and ^(1)S_(0) states,expressed as[a_(0),r],are fo.nd to.be[5.445(5.424),1.770(1.760)]and[–23.741(–23.749),2.63(2.81)],respectively;these values are in excellent agreement with experimental ***,the calculated to.al scattering cro.s-sectio.s are highly co.sistent with their experimental co.nterparts,having a percentage erro. o. less than 1%.This co.putatio.al appro.ch can be easily extended to.o.tain interactio. po.entials fo. charged particle scattering.

关键词： inverse po.entials neutro.-pro.o. scattering piece-wise smo.th Mo.se functio. phase functio. metho. reference po.ential appro.ch genetic algo.ithm

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