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Up-Regulation of Local TGF-β Contributes to a Decrease in Renal Tubular Na⁺-K⁺ ATPase and Hyperkalemia in a Mouse Model of Crush Syndrome

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Pharmacology & Pharmacy 2016年第12期7卷 481-492页

作者： Shinya Mizuno yoko Mizuno-Horikawa Department of Biochemistry Osaka University Graduate School of Medicine Suita Japan Department of Immunology and Microbiology Osaka University Graduate School of Medicine Suita Japan The Institute of Experimental Animal Sciences Suita Japan

Hyperkalemia is one of the most important risk factors in patients suffering from crush syndrome with rhabdomyolysis. Glycerol-injected animals have been used as an experimental model of rhabdomyolysis-induced acute kidney injury (AKI), but little information is available for the onset and molecular mechanism of hyperkalemia. In our murine model, plasma potassium levels increased after a single injection of 50%-glycerol solution (10 ml/kg, i.m.) during the progression of muscular and renal injuries. Renal tubular Na+-K+-ATPase functions as ion-exchange pomp for potassium clearance from blood into renal tubular epithelial cells. Renal histochemistry revealed an apparent decrease in the tubular Na+-K+-ATPase expression, especially at 24 hours post-glycerol challenge in our AKI model. In contrast to the loss in active Na+-K+-ATPase, there was a significant increase in the renal levels of transforming growth factor-β (TGF-β) that is known to suppress Na+-K+-ATPase production in vitro. When anti-TGF-β antibody was administered in mice after the glycerol challenge, the suppression of renal Na+-K+-ATPase activity was partially restored. As a result, hyperkalemia was improved in the TGF-β-neutralized AKI mice, associated with a significant decrease in plasma potassium concentration. Taken together, we predict that endogenous TGF-β is a key regulator for inhibiting Na+-K+-ATPase production and, in part, enhancing hyperkalemia during progression of rhabdomyolysis-induced AKI. This is, to our knowledge, the first report to determine a critical role of endogenous TGF-β in renal potassium metabolism during crush syndrome.

关键词： Rhabdomyolysis AKI Hyperkalemia Na+-K+-ATPase TGF-β

Spontaneous pneumomediastinum and Macklin effect:Overview and appearance on computed tomography

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World Journal of Radiology 2014年第11期6卷 850-854页

作者： Sadayuki murayama Shinji Gibo Department of Radiology Graduate School of Medical ScienceUniversity of the RyukyusOkinawa 903-0215Japan Department of Radiology Urasoe General HospitalOkinawa 901-2132Japan

Spontaneous pneumomediastinum(SPM) is described as free air or gas located within the mediastinum that is not associated with any noticeable cause such as chest *** has been associated with many conditions and triggers,including bronchial asthma,diabetic ketoacidosis,forceful straining during exercise,inhalation of drugs,as well as other activities associated with the Valsalva *** Macklin effect appears on thoracic computed tomography(CT) as linear collections of air contiguous to the bronchovascular *** the recent availability of multidetector-row CT,the Macklin effect has been seen in the clinical setting more frequently than *** aim of this review article is to describe the CT imaging spectrum of the Macklin effect in patients with SPM,focusing on the common appearance of the Macklin effect,pneumorrhachis,and persistent SPM with pneumatocele.

关键词： Pneumomediastinum Spontaneous pneumomediastinum Computed tomography Macklin effect Interstitial emphysema

Web-based GIS System for Real-time Field Data Collection Using Personal Mobile Phone

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Journal of Geographic Information System 2011年第4期3卷 382-389页

作者： Ko Ko Lwin Yuji murayama 不详

Recently, use of mobile communicational devices in field data collection is increasing such as smart phones and cellular phones due to emergence of embedded Global Position System GPS and Wi-Fi Internet access. Accurate timely and handy field data collection is required for disaster management and emergency quick responses. In this article, we introduce web-based GIS system to collect the field data by personal mobile phone through Post Office Protocol POP3 mail server. The main objective of this work is to demonstrate real-time field data collection method to the students using their mobile phone to collect field data by timely and handy manners, either individual or group survey in local or global scale research.

关键词： Web-Based GIS System Real-Time Field Data Collection Personal Mobile Phone POP3 Mail Server

Changes of gastric ulcer bleeding in the metropolitan area of Japan

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World Journal of Gastroenterology 2019年第42期25卷 6342-6353页

作者： yoko Kubosawa Hideki Mori Satoshi Kinoshita Yoshihiro Nakazato Ai Fujimoto Masahiro Kikuchi Toshihiro Nishizawa Masayuki Suzuki Hidekazu Suzuki Department of Gastroenterology National Hospital Organization Tokyo Medical CenterMeguroTokyo 152-8902Japan Division of Gastroenterology and Hepatology Department of Internal MedicineKeio University School of MedicineShinjukuTokyo 160-0016Japan Department of Clinical and Experimental Medicine Translational Research Center for Gastrointestinal Diseases(TARGID)University of LeuvenLeuven 3000Belgium Department of Gastroenterology Digestive Disease CenterInternational University of Health and WelfareMita HospitalMinatoTokyo 108-8329Japan Division of Gastroenterology and Hepatology Department of Internal MedicineTokai University School of MedicineIseharaKanagawa 259-1193Japan

BACKGROUND The two main causes of gastric ulcer bleeding are Helicobacter pylori(***)infection and ulcerogenic medicines,although the number of cases caused by each may vary with *** Japan,the rate of *** infection has fallen over the last decade and the number of prescriptions for non-steroidal anti-inflammatory drugs(NSAIDs)and antithrombotic drugs is increasing as the population *** of treatment for gastric ulcer bleeding have advanced with the advent of hemostatic forceps and potassium-competitive acid blocker(P-CAB).Thus,causes and treatments for gastric ulcer bleeding have changed over the last *** To examine the trends of gastric ulcer bleeding over 10 years in the metropolitan area of *** This is a single-center retrospective study.A total of 564 patients were enrolled from inpatients admitted to our hospital with gastric ulcer bleeding between 2006 and ***,medication history,*** infection,method of treatment,rate of rebleeding,and the length of hospitalization were *** associated with gastric ulcer bleeding were evaluated using Fisher’s exact test,Pearson’s Chi-squared test or Student’s t-test as *** Jonckheere-Terpstra test was used to evaluate trends.A per-protocol analysis was used to examine the rate of *** *** There was a significant increase in the mean age over time(P<0.01).The rate of *** infection tended to decrease over the study period(P=0.10),whereas the proportion of patients taking antithrombotic agents or NSAIDs tended to increase(P=0.07).Over time,the use of NSAIDs and antithrombotic drugs increased with *** contrast,the rate of *** infection during the study period fell with ***-induced ulcers accounted for the majority of cases in younger patients(<70 years old);however,the rate decreased with age(P<0.01).The method of treatment trend has changed significantly over *** main method of endoscopic hemostasis has changed from

关键词： Helicobacter pylori infection Gastric ulcer bleeding Non-steroidal antiinflammatory drugs Antithrombotic agents

Longitudinal Evaluation Nocturnal Sleep Behaviors of Healthy and Well Developed Children Born Prematurely

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Open Journal of Pediatrics 2016年第1期6卷 48-52页

作者： yoko Asaka Satoshi Takada Faculty of Health Sciences Hokkaido University Sapporo Japan Kobe University Graduate School of Health Sciences Kobe Japan

The aim of the study is to examine nocturnal sleep measures of healthy and well developed pre-term infants by birth weight when they were averaged 15 corrected months and became elementary school children. Sleep measures were collected by actigraphs (Micro-mini RC, Ambulatory Monitoring Inc., New York, USA). Nocturnal sleep quality of children born as extremely low birth weight (ELBW) was significantly inferior with that of children born as very low birth weight (VLBW) at 15 corrected months [number of night waking: 6.0 (4.5 - 8.0), ELBW 8.5 (7.0 - 10.3) (Z = 2.47, p < 0.01), wake after sleep onset: VLBW 99.0 (73.0 - 115.0) min, ELBW 146.5 (94.8 - 171.3) min (Z = 2.89, p < 0.01)]. However, these measures did not show any significant differences by birth weight at second data collection period [number of night waking: VLBW 0.0 (0.0-1.0), ELBW 1.0 (0.0 - 2.5) (Z = —0.62, n.s.), wake after sleep onset: VLBW 16.0 (8.0 - 27.0) min, ELBW 15.0 (6.0 - 32.5) min (Z = 0.00, n.s.)]. It was assumed that nocturnal measures were affected by the birth weight at the age of 15 corrected months in ELBW infants, but could not predict the future sleep problems at this point.

关键词： Nocturnal Sleep Longitudinal Evaluation Extremely Low Birth Weight Infant Actigraph

Gastro-protective action of lafutidine mediated by capsaicin-sensitive afferent neurons without interaction with TRPV1 and involvement of endogenous prostaglandins

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World Journal of Gastroenterology 2006年第19期12卷 3031-3037页

作者： Kazuhiro Fukushima yoko Aoi Shinichi Kato Koji Takeuchi Department of Pharmacology and Experimental Therapeutics Kyoto Pharmaceutical University MisasagiYamashinaKyoto 607-8414Japan

AIM： Lafutidine, a histamine H2 receptor antagonist, exhibits gastro-protective action mediated by capsaicinsensitive afferent neurons （CSN）. We compared the effect between lafutidine and capsaicin, with respect to the interaction with endogenous prostaglandins （PG）, nitric oxide （NO） and the afferent neurons, including transient receptor potential vanilloid subtype 1 （TRPV1）. METHODS： Male SD rats and C57BL/6 mice, both wildtype and prostacyclin IP receptor knockout animals, were used after 18 h of fasting. Gastric lesions were induced by the po administration of HCl/ethanol （60% in 150 mmol/L HCl） in a volume of 1 mL for rats or 0.3 mL for mice. RESULTS： Both lafutidine and capsaicin （1-10 mg/kg, po） afforded dose-dependent protection against HCI/ ethanol in rats and mice. The effects were attenuated by both the ablation of CSN and pretreatment with NG-nitro- L-arginine methyl ester, yet only the effect of capsaicin was mitigated by prior administration of capsazepine, the TRPV1 antagonist, as well as indomethacin. Lafutidine protected the stomach against HCl/ethanol in IP receptor knockout mice, similar to wild-type animals, while capsaicin failed to afford protection in the animals lacking IP receptors. Neither of these agents affected the mucosal PGE2 or 6-keto PGF1α contents in rat stomachs. Capsaicin evoked an increase in [Ca^2＋]i in rat TRPV1-transfected HEK293 cells while lafutidine did not. CONCLUSION： These results suggest that although both lafutidine and capsaicin exhibit gastro-protective action mediated by CSN, the mode of their effects differs regarding the dependency on endogenous PGs/IP receptors and TRPV1. It is assumed that lafutidine interacts with CSN at yet unidentified sites other than TRPV1.

关键词： Lafutidine A histamine H2-receptor antagonist Gastric protection Prostaglandin Capsaicin-sensirive afferent neuron TRPVt

Optimization of Crystal Structure Based on Experimentally Obtained XRD Patterns for Fluorescence of Sm³⁺-Doped TiO₂ Thin Films by Machine Learning

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Optics and Photonics Journal 2022年第6期12卷 147-155页

作者： Yuri Tamamoto Mariko murayama Xiwei Zhao Department of Physics Tokyo University of Science Tokyo Japan Research Institute of Industrial Technology Toyo University Saitama Japan Department of Materials Science and Engineering Xihua University Chengdu China

The luminescence intensity of rare-earth ion-doped luminescent materials is closely related to the configuration of the anions around the rare-earth ions added to the host material and the lattice defects. And it is expected that this information will be reflected in the XRD pattern. In this study, the lumines-cence data and XRD patterns of Sm-doped TiO2 accumulated by our group are used to construct a model to predict the integrated luminescence intensity. The model was confirmed to be able to predict the integrated luminescence in-tensity with high accuracy. Furthermore, we found that the integrated lumi-nescence intensity of this system is closely related to the change in the position of the peak on the (200) plane of TiO2.

关键词： Machine Learning Phosphor TiO2

Surgical Treatment of Patients with Unruptured Intracranial Aneurysms: Our Experience

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Surgical Treatment of Patients with Unruptured Intracranial ...

Infrasound Signals in Coastal Environment at Jang Bogo Station, Terra Nova Bay, Antarctica

2011中华医学会神经外科学学术会议

作者： Kato yoko Department of Neurosurgery Fujita Health University Hospital Toyoake Japan

Objective To present our experience with elective microsurgical clipping of unruptured intracranial aneurysms (UIAs) and analyze its management *** A total of 150 patients with UIAs were reviewed and data were collect... 详细信息

关键词： intracranial aneurysm unruptured clipping treatment

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International Journal of Geosciences 2022年第12期13卷 1103-1114页

作者： Masaki Kanao Takahiko murayama Yongcheol Park Research Organization of Information and Systems National Institute of Polar Research Tokyo Japan Japan Weather Association Tokyo Japan Korea Polar Research Institute Incheon Republic of Korea

Infrasound signals in Antarctica reflect physical interaction in the surface environments around the recorded area. In December 2015, an infrasound array by three sensors in the detectable frequency range of 0.1 - 200 Hz, combined with one broadband barometer was deployed at Jang Bogo Station, Terra Nova Bay, Antarctica. The two years of data by the broadband barometer contain characteristic signals that caused by surface environment nearby the station, mixing with local noises such as katabatic winds. Clear continuous signals by oceanic swells (microbaroms) were recorded with a predominant frequency of around 0.2 s. Variations of frequency context and amplitudes in the Power Spectral Density were considered as affected by sea-ice dynamics surrounding the Terra Nova Bay. Monitoring of microbaroms could contribute to understanding ocean wave climate, with other oceanographic, cryospheric and geophysical data in Antarctica. Infrasound data in Terra Nova Bay might be a new proxy for estimating environmental variations affected by global warming, cryosphere dynamics, together with volcanic eruptions in Victoria Land.

关键词： Infrasound Signals Antarctica Terra Nova Bay Microbaroms Surface Environment