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Retreatment of patients with treatment failure of directacting antivirals: Focus on hepatitis C virus genotype 1b

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World Journal of Gastroenterology 2017年第46期23卷 8120-8127页

作者： Tatsuo Kanda Kazushige Nirei Naoki Matsumoto Teruhisa Higuchi Hitomi Nakamura Hiroaki Yamagami Shunichi matsuoka Mitsuhiko Moriyama Division of Gastroenterology and Hepatology Department of Internal MedicineNihon University School of Medicine

The recent development of direct-acting antiviral agents(DAAs) against hepatitis C virus(HCV) infection could lead to higher sustained virological response(SVR) rates, with shorter treatment durations and fewer adverse events compared with regimens that include interferon. However, a relatively small proportion of patients cannot achieve SVR in the first treatment, including DAAs with or without peginterferon and/or ribavirin. Although retreatment with a combination of DAAs should be conducted for these patients, it is more difficult to achieve SVR when retreating these patients because of resistance-associated substitutions(RASs) or treatment-emergent substitutions. In Japan, HCV genotype 1 b(GT1 b) is founded in 70% of HCVinfected individuals. In this minireview, we summarize the retreatment regimens and their SVR rates for HCV GT1 b. It is important to avoid drugs that target the regions targeted by initial drugs, but next-generation combinations of DAAs, such as sofosbuvir/velpatasvir/voxilaprevir for 12 wk or glecaprevir/pibrentasvir for 12 wk, are proposed to be potential solution for the HCV GT1 b-infected patients with treatment failure, mainly on a basis of targeting distinctive regions. Clinicians should follow the new information and resources for DAAs and select the proper combination of DAAs for the retreatment of HCV GT1 b-infected patients with treatment failure.

关键词： Direct-acting antiviral agent Genotype 1b Hepatitis C virus Resistance-associated substitutions

Sentinel node navigation surgery for gastric cancer: Overview and perspective

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World Journal of Gastrointestinal Surgery 2015年第1期7卷 1-9页

作者： Masakazu Yashiro Tasuku matsuoka Department of Surgical Oncology Osaka City University Graduate School of Medicine Osaka 545-8585 Japan Oncology Institute of Geriatrics and Medical Science Osaka City University Graduate School of Medicine Osaka 545-8585 Japan

The sentinel node(SN) technique has been established for the treatment of some types of solid cancers to avoid unnecessary lymphadenectomy. If node disease were diagnosed before surgery, minimal surgery with omission of lymph node dissection would be an option for patients with early gastric cancer. Although SN biopsy has been well ascertained in the treatment of breast cancer and melanoma, SN navigation surgery(SNNS) in gastric cancer has not been yet universal due to the complicated lymphatic flow from the stomach. Satisfactory establishment of SNNS will result in the possible indication of minimally invasive surgery of gastric cancer. However, the results reported in the literature on SN biopsy in gastric cancer are widely divergent and many issues are still to be resolved, such as the collection method of SN, detection of micrometastasis in SN, and clinical benefit. The difference in the procedural technique and learning phase of surgeons is also varied the accuracy of SN mapping. In this review, we outline the current status of application for SNNS in gastric cancer.

关键词： Sentinel node navigation surgery Gastriccancer Micrometastasis Minimal surgery Review

Significance of peritoneal lavage cytology based on genetic signatures in gastric cancer

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Journal of Cancer Metastasis and Treatment 2018年第1期4卷 75-87页

作者： Tasuku matsuoka Masakazu Yashiro Department of Surgical Oncology Osaka City University Graduate School of Medic ineOsaka 545-8585Japan Molecular Oncology and Therapeutics Osaka City University Graduate School of MedicineOsaka 545-8585Japan

Perit on eal metastasis is the most comm on patter n of recurre nee and the most freque nt cause of death after surgery in patie nts with gastric can *** on eal free can cer cells dissem in ated from the primary lesi on site have bee n con sidered the main cause of perit on eal *** on eal lavage cytological exam in ati on(PLC)has bee n show n to be an in depe ndent predictor of gastric cancer relapse after curative resection and poor overall ***,the conventional cytological examinations have high rates of false-positive and false-negative *** improve the sensitivity,molecular-based methods using reverse transcriptase polymerase chain reaction have been developed for detecting cancer cells in peritoneal wash fluids of patients with gastric *** performed a PubMed search for articles describing PLC in gastric can *** nt articles were reviewed and data on available outcomes *** cli nical roles and attributes of PLC in gastric can cer were reviewed,and its future applicati on to this disease is discussed.

关键词： Gastric cancer peritoneal lavage cytology genetic detection reverse transcriptase polymerase chain reaction carcinoembryonic antigen

Accurate Extraction of Effective Gate Resistance in RF MOSFET

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Circuits and Systems 2015年第5期6卷 143-151页

作者： Ikkyun Jo Toshimasa matsuoka Graduate School of Engineering Osaka University Osaka Japan

This paper describes the gate electrode resistance of MOSFET and non-quasi-static (NQS) effect for RF operation. The vertical current paths between the silicide layer and poly-silicon are considered in the gate electrode. The vertical current paths are not effective in long-channel devices, but become more significant in short-channel devices. The gate resistance including vertical current paths can reproduce the practical RF characteristics well. By careful separation of the above gate electrode resistance and the NQS effect, the small-signal gate-source admittance can be analyzed with 130-nm CMOS process. Elmore constant (κ) of the NQS gate-source resistance is about five for long-channel devices, while it decreases down to about three for short-channel devices.

关键词： MOSFET NQS Effect Gate Electrode Resistance Elmore Constant

Effect of an extract of Ganoderma lucidum in men with lower urinary tract symptoms： a double-blind, placebo-controlled randomized and dose-ranging study

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Asian Journal of Andrology 2008年第4期10卷 651-658页

作者： Masanori Noguchi Tatsuyuki Kakuma Katsuro Tomiyasu Yoshiko Kurita Hiroko Kukihara Fumiko Konishi Shoichiro Kumamoto Kuniyoshi Shimizu Ryuichiro Kondo Kei matsuoka Departments of Urology Kurume University School of Medicine Kurume 830-0011 Japan Departments of Bio-statistics Kurume University School of Medicine Kurume 830-0011 Japan Research Laboratories Chlorella Industry Chikugo 833-0056 Japan Department of Forest and Forest Products Science Faculty of Agriculture Kyushu University Fukuoka 812-8582 Japan

Aim： To conduct a double-blind, placebo-controlled randomized and dose-ranging study to evaluate the safety and efficacy of the extract of Ganoderma lucidum （G. lucidum） in men with lower urinary tract symptoms （LUTS）. Methods： We enrolled male volunteers （〉 50 years） with an International Prostate Symptom Score （IPSS; questions 1-7）〉 5 and a prostate-specific antigen （PSA） value 〈 4 ng/mL. Volunteers were randomized into groups of placebo （n = 12）, G. lucidum of 0.6 mg （n = 12）, 6 mg （n = 12） or 60 mg （n = 14）, administered once daily. Efficacy was measured as a change from baseline in IPSS and the peak urine flow rate （Qmax）. Prostate volume and residual urine were estimated by ultrasonography, and blood tests, including PSA levels, were measured at baseline and at the end of the treatment. Results： The overall administration was well tolerated, with no major adverse effects. Statistical significances in the magnitude of changes between the experimental groups were observed at weeks 4 and 8. No changes were observed with respect to Qmax, residual urine, prostate volume or PSA levels. Conclusion： The extract of G. lucidum was well tolerated and an improvement in IPSS was observed. The recommended dose of the extract of G. lucidum is 6 mg in men with LUTS.

关键词： lower urinary tract symptoms phytotherapy outcome randomized trial

Randomized clinical trial of an ethanol extract of Ganoderma lucidum in men with lower urinary tract symptoms

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Asian Journal of Andrology 2008年第5期10卷 777-785页

作者： Masanori Noguchi Tatsuyuki Kakuma Katsuro Tomiyasu Akira Yamada Kyogo Itoh Fumiko Konishi Shoichiro Kumamoto Kuniyoshi Shimizu Ryuichiro Kondo Kei matsuoka Departments of Urology Kurume University School of Medicine Kurume 830-0011 Japan Departments of Bio-statistics Kurume University School of Medicine Kurume 830-0011 Japan Departments of Immunology Kurume University School of Medicine Kurume 830-0011 Japan Research Laboratories Chlorella Industry Co Ltd Chikugo 833-0056 Japan Department of Forest and Forest Products Science Faculty of Agriculture Kyushu University Fukuoka 812-8582 Japan

Aim： To evaluate the safety and efficacy of an extract of Ganoderma lucidum that shows the strongest 5α-reductase inhibitory activity among the extracts of 19 edible and medicinal mushrooms by a double-blind, placebo-controlled, randomized and dose-ranging study in men with lower urinary tract symptoms （LUTS）. Methods： In this trial, we randomly assigned 88 men over the age of 49 years who had slight-to-moderate LUTS to 12 weeks of treatment with G. lucidum extract （6 mg once a day） or placebo. The primary outcome measures were changes in the International Prostate Symptom Score （IPSS） and variables of uroflowmetry. Secondary outcome measures included changes in prostate size, residual urinary volume after voiding, laboratory values and the reported adverse effects. Results： G. lucidum was effective and significantly superior to placebo for improving total IPSS with 2.1 points decreasing at the end of treatment （mean difference, -1.18 points; 95% confidence interval, -1.74 to -0.62; P 〈 0.0001）. No changes were observed with respect to quality of life scores, peak urinary flow, mean urinary flow, residual urine, prostate volume, serum prostate-specific antigen or testosterone levels. Overall treatment was well tolerated with no severe adverse effects. Conclusion： The extract of G. lucidum was well tolerated and improved IPSS scores. These results encouraged a further, large-scale evaluation of phytotherapy for a long duration using the extract of G. lucidum on men with LUTS.

关键词： lower urinary tract symptoms phytotherapy outcome randomized trial Ganoderma lucidum

Metabolic regulation of <i>Escherichia coli</i>cultivated under anaerobic and aerobic conditions in response to the specific pathway gene knockouts

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Advances in Bioscience and Biotechnology 2013年第3期4卷 455-468页

作者： Yu matsuoka Kazuyuki Shimizu Department of Bioscience and Bioinformatics Kyushu Institute of Technology Fukuoka Japan Institute of Advanced Bioscience Keio University Tokyo Japan

Effect of the specific gene knockout on the main metabolism in Escherichia coli was reviewed, and the regulation mechanisms were clarified based on different levels of information such as gene expressions, enzyme activities, intracellular metabolite concentrations, and metabolic fluxes together with fermentation data. The effects of the knockout of such genes as pflA, pta, ppc, pykF, adhE, and ldhA on the metabolic changes were analyzed for the case under anaerobic condition. The effects of the knockout of such genes as pgi, zwf, gnd, ppc pck, pyk, and lpdA on the metabolic changes were also analyzed for the case under aerobic condition. The metabolic regulation analysis was made focusing on the roles of transcription factors.

关键词： Metabolic Regulation Single-Gene Knockout Mutant Escherichia coli

Safety evaluation of nanomaterials by a 13-week repeated dose intratracheal toxicity study in rats

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Safety evaluation of nanomaterials by a 13-week repeated dos...

Molecular targets for the treatment of pancreatic cancer:Clinical and experimental studies

中国生物医学工程学会成立30周年纪念大会暨2010中国生物医学工程学会学术大会

作者： Atsuko matsuoka National Institute of Health Sciences Division of Medical Devices

Recently,nanomaterials(NMs) have been used in industry,consequently arriving just around us as many kinds of *** are being used in medical devices as *** the amount of NMs contained in those products may be a little,we may need to pay attention to their safety because it may be different from that of their bulky *** present,not only OECD and ISO but also many other cooperative study groups are trying to establish test methods for NMs’ safety evaluation heading for the international cooperation on development and harmonization of the test *** this presentation,first I will talk about the particle size-dependent toxicity of polystyrene(PS) particles in vitro,and then introduce an in vivo test method performed with colloidal silica,silver and zinc *** particles were tested assuming them to be the aggregates of *** and genotoxicity of eleven size-different PS spheres with defined diameters ranging from 0.1 to 9.2 μm were tested in a Chinese hamster cell line,CHL[1].The 4.45-μm PS particles were most cytotoxic and smaller or larger particles showed less *** was a big toxicity difference between the 4.45-and 5.26-μm particles,although both precipitated and covered cells to the same extent in the *** analysis of particles and chemical analysis of dispersion vehicles did not show any difference between *** particles induced polyploidy in the chromosome aberration test and the intensity was correlated well with their *** images clearly showed the uptake of the 4.45-μm PS particles into CHL *** cytometric analysis seemed to measure the uptake of PS particles *** findings suggest that polyploidy may be induced by cytokinesis block due to particles *** are considering that such a size specific toxicity may be induced in the test with NM *** may need to provide information about aggregate sizes or some parameters indicating dispersion cond

关键词： Biomaterials silica,silver,zinc oxide intratracheal administration a 13-week repeated dose test

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World Journal of Gastroenterology 2016年第2期22卷 776-789页

作者： Tasuku matsuoka Masakazu Yashiro Department of Surgical Oncology Osaka City University Graduate School of MedicineOsaka 545-8585Japan Oncology Institute of Geriatrics and Medical Science Osaka City University Graduate School of MedicineOsaka 545-8585Japan

Pancreatic cancer is the fourth most common cause of cancer deaths worldwide. Although recent therapeutic developments for patients with pancreatic cancer have provided survival benefits, the outcomes for patients with pancreatic cancer remain unsatisfactory. Molecularly targeted cancer therapy has advanced in the past decade with the use of a number of pathways as candidates of therapeutic targets. This review summarizes the molecular features of this refractory disease while focusing on the recent clinical and experimental findings on pancreatic cancer. It also discusses the data supporting current standard clinical outcomes, and offers conclusions that may improve the management of pancreatic cancer in the future.

关键词： Pancreatic cancer Targeted therapy Tyrosinekinase inhibitors Microenvironment Cancer stem cell